Amit kumar Srivastava

Dr. Amit kumar Srivastava


  • Ramalingaswami Fellow (April 2018-present)
  • Scientist, (October 2017-April 9, 2018) CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat
  • Post-Doctoral Fellow (July 2013-September 2017), The Ohio State University, Columbus, Ohio, USA
  • PhD (2008-2013) CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow
    • Exploring drug resistance mechanisms in cancer stem cells
    • Mechanisms and targeting of cancer stem cell plasticity
    • DNA damage and repair
    • miRNAs and their role in Cancer
    • Nanoparticles mediated drug-delivery
  • This is a new laboratory and ambitious researchers (preferably with their own Fellowship/ Funding) are welcome to join my group for pursuing PhD/Postdoc.

    1. Ramalingaswami fellowship award, Department of Biotechnology (DBT) (2017)
    2. Ramanujan Fellowship award, Science and Engineering Research Board (SERB-DST) (2017)
    3. Attended Nobel Prize series 2018 at RashtrapatiBhawan
    4. Best Postdoc Poster award by The Ohio State University, USA 2016
    5. Pelotonia Postdoctoral Fellowship 2014 by The Ohio State University, USA
    6. Young Scientist Award in XXXII Annual Meeting of Society of Toxicology (STOX), 2012, India.
    7. Seth Roop Lal Aggrawal Gold medal by Society of Toxicology (STOX), 2012, India.
    8. Best paper award by Environmental Mutagen Society of India (EMSI), 2010.
    9. Joint CSIR-UGC Junior Research Fellowship: CSIR New Delhi, India (2007)
    10. Qualified Graduate Aptitude Test in Engineering (GATE), 2006
    1. Cui T*, Srivastava AK*, Han C, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell E, Yang SM, Maloney D, Zheng Y, Wani A, Wu D and Wang Qi-en. DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1. Cell death and disease 2018 (*equal contribution) in press.
    2. Srivastava AK*, Rizvi A*, Cui T, Han C, Banerjee A, Naseem I, Zheng Y, Wani A and Wang Qi-en. Depleting ovarian cancer stem cells with calcitriol. Oncotarget. 16;9(18):14481-14491, 2018. (*equal contribution). PMID: 29581858
    3. Srivastava AK*, Mishra S* and Shukla Y. Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes via inhibition of NF-κB mediated oxidative stress Phytomedicine 23(7):714-24 2016 (*equal contribution) PMID:27235710.
    4. Zou N, Xie G, Cui T, Srivastava AK, Qu M, Yang L, Wei S, Zheng Y, Wang QE. DDB2 increases radioresistance of NSCLC cells by enhancing DNA damage responses. Tumour Biol. 2016 Oct;37(10):14183-14191. PMID: 27553023
    5. Mishra S, Rai G, Srivastava AK, Singh AK, Ahmad A, Suman S, Singh M, Reddy MKR, Tiwari BN, Gupta P, Gaur VK, Srivastava VK, Kumar V, Shukla Y. miR-34a Overexpression Induces Senescence Associated Secretory Phenotypes in Doxorubicin induced Pseudo-Senescent Triple Negative Breast Cancer cells via SOCS4-IL6-STAT3 axis. American Journal of Cancer Research 2017 (in press)
    6. Srivastava AK, Han C, Zhao R, Cui T, Dai Y, Mao C, Zhao W, Yu J and Wang Qi-en. Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells in Proceedings of the National Academy of Sciences U.S.A.   7;112(14):4411-6, 2015. PMID: 25831546
    7. Han C, Srivastava AK, Cui T, Wang QE, Wani AA. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 37(2):129-138 2015. PMID: 26717995.
    8. Qu MH, Han C, Srivastava AK, Cui T, Zou N, Gao ZQ, Wang QE. miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells. Tumour Biol. 37(4):5645-51 2015. PMID: 26581907
    9. Mishra S, Srivastava AK, Suman S and Shukla Y. Circulating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer in Cancer letter. 1; 369(1):67-75, 2015, PMID: 26276721.
    10. Zhao R, Han C, Zhang X, He J, Srivastava AK and Wani A and Wang Qi-en,. DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L. Nucleic Acid Research. 18; 43(16):7838-49, 2015. PMID: 26130719.
    11. Cui T, Srivastava AK, Han C, Yang L, Zhao R, Zou N, Qu M, Duan W, Zhang X and Wang Qi-en. XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. Oncotarget. 30;6(12):10060-72, 2015. PMID: 25871391
    12. Jiang Q, Pentz K, Zhu Q, Wang Qi-en, He J, Srivastava AK and Wani A. USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability. Oncogene. 3;34(36):4791-6, 2014, PMID: 25435364.
    13. Bhatnagar P, Patnaik S, Srivastava AK, Mudiam KRM, Shukla Y, Panda AK, Pant AB, Kumar P, and Gupta KC. Anti-Cancer Activity of Bromelain Nanoparticles by Oral Administration. Journal of Biomedical Nanotechnology 10(12):3558-75, 2014. PMID: 26000370
    14. Han C, Zhao R, Liu X, Srivastava AK, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang Qi-en. DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. Molecular Cancer Research. 12(5):784-94, 2014. PMID: 24574518.
    15. Srivastava AK, Singh M, Bhatnagar P, Mishra S, Kumar P, Shukla Y, Gupta KC, Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage. International Journal of Nanomedicine. 8:1451-62. PMID: 23717041
    16. Srivastava AK, Srivastava PK, Khedhairy AA, Musarrat J, Shukla Y. Allethrin induced genotoxicity and oxidative stress in Swiss albino mice. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 30;747(1):22-8, 2012. PMID: 22475934.
    17. Srivastava AK, Ali W, Singh R, Bhui K, Tyagi S, Srivastava PK, Khedhairy AA, Musarrat J, Shukla Y. Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes. Life Sciences. 90(21-22):815-24, 2012. PMID: 22289270.
    18. George J,Srivastava AK, Singh R, Shukla Y. Cypermethrin exposure leads to regulation of proteins expression involved in neoplastic transformation in mouse skin. Proteomics. 11(22):4411-21, 2011. PMID: 21919204
    19. George J, Singh M, Srivastava AK, Bhui K, Roy P, Chaturvedi PK, Shukla Y. Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One. 6(8): e23395, 2011. PMID: 21887248
    20. George J, Singh M, Srivastava AK, Bhui K, Shukla Y. Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NF-ĸB and reduced cell proliferation. Food and Chemical Toxicology. 49(7):1511-2, 2011. PMID: 21443920
    21. Bhui K, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y.Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis. Molecular Carcinogensis. 51(3):231-43, 2011. PMID: 21432909
    1. Srivastava AK and Wang Qi-en. Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy. Molecular & Cellular Oncology 2016 Jan; 3(1): e1043482. PMID: 27308560
    2. Zhou G, Yang L, Gray A, Srivastava AK, Li C, Zhang G, Cui T. The role of desmosomes in carcinogenesis. Onco Targets Ther. 2017 10:4059-4063. PMID: 28860814.
    1. Kulpreet Bhui, Amit Kumar Srivastava and Yogeshwer ShuklaCytotoxic Action of Natural Pentacyclic Triterpenes on Cancer Cells: Lupane-type Compounds” in Pentacyclic Triterpenes as Promising Agents in Cancer, Nova publication, pp.49-87, 2010.
    2. Madhulika Singh, Amit Kumar Srivastava & Yogeshwer Shukla “Molecular Signatures of Infectious Agents: Application in Human Cancer Control” in Cancer Biomarker, Nova publication, pp. 57-104, 2010
    1. Cui T, Srivastava AK, Han C, Gao Z, Zhang X, Wani AA and Wang Qi-En. Regulation of ovarian cancer stem cell population by DDB2. Cancer Research 2017; 77; 13
    2. Han C, Zhao R, Liu X, Srivastava AK, Gong Li, Mao H, Qu M, Zhao W, Yu J and Wang Qi-en. Loss of DDB2 enhances the tumorigenicity of ovarian cancer cells through expanding cancer stem-like cell population. Cancer Research. 74; 3874. 2014.
    3. Singh M, Bhatnagar P, Srivastava AK, Kumar P, Shukla Y, Gupta KC. Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles. Journal of Biomedical Nanotechnology, 2011; 7(1): 202