Cell Biology & Physiology Division

Vision

This division deals with systems and cell biology, investigating subcellular organelles and intracellular signaling events in normal physiology and in disease. Major interests are in the area of neurological diseases, reproductive physiology and control of reproduction, cardiac hypertrophy, diabetes and some metabolic and parasitic diseases.

Objectives

Under the section of neurological disorders, there are a number of projects that look into the structure and function of developing astrocytes with a view to study the mechanism of action of intrinsic regulators in the plasticity of astroglial cells, to understand the basis of narcotic addiction towards anti-addictive drug development, molecular basis of neurodegeneration and development of strategies for neuroprotection, and stem cells in corneal implantation and in neurodegenerative diseases.

Mechanisms of cardiac dysfunction by thyroid hormone and glucocorticoid are investigated in the Endocrinology section. In addition to these, molecular mechanism of insulin resistance and defect in insulin signaling in diabetes type 2, genetic basis of hypothyroid induced reproductive disorders with emphasis on the role of lysyl hydroxylases, MMPs and TIMPs and the role of homeodomain transcription factor in ovarian function and its development are investigated.

Under the reproductive biology section, biochemical basis of sperm motility and its function activities, elucidation of pathophysiologic mechanisms underlying reproductive malfunctions and development of a conceptual "over the counter" contraceptive modality with anti-HIV hallmark are investigated.

The causes, manifestation and management of anemia during visceral leishmaniasis, studies on host-pathogen interaction and genetics of human polyomavirus JCV and BKV natural isolates as well as the metagenomic analysis of microbial population, particularly extreamophiles from metal rich environments are also investigated in this division.