Cancer Biology & Inflammatory Disorder Division

Dr. Malini Sen

PhD, Albert Einstein College of Medicine, NY, USA
Postdoctoral Associate, RWJ Pharmaceutical Research Institute, La Jolla, CA, USA
Project Scientist and Arthritis Investigator, Medicine Department, University of California – San Diego, USA

Contact -

Principal Scientist

Current Research Interest

        Elucidating the molecular mechanisms of immune homeostasis and pathogenesis of inflammatory disorders including cancer:

        1. Deciphering the role of mesenchymal stem cell factors including Wnts in various aspects of immune homeostasis, immune response and inflammation.
        2. Evaluating the role of WISP3 (Wnt induced secreted protein 3) in the regulation of oxidative stress and fibrosis in cancer.
        3. Investigating means for inhibition of inflammation, oxidative stress and fibrosis.

Names of the group members including regular staff with designation and research fellows

I have positions open for hardworking research oriented individuals with NET (CSIR/UGC), ICMR and DBT fellowships.


  1. Dr. Suman Kundu (DBT-RA,

  2. Dr. Kaushiki BIswas (SERB-RA,

  3. Dr. Archya Sengupta (DBT-RA,

  4. Milan Patra (SRF,

  5. Arijit Chakraborty (SRF,

  6. Suborno Jati (SRF,

  7. Debosruti Nath (SRF,

  8. Indrani Das (JRF,

  9. Deepesh Kumar Padhan (JRF,

  10. Tresa Rani Sarraf (JRF,

Past Members

Dr.R.Srinivasa Rao

Dr.Debdut Naskar

Dr.George Mait



List of important Research Articles

  1. Patra, M., Mahata, S. K., Padhan, D. K., & Sen, M. (2016). CCN6 (Wnt induced signaling protein–3) regulates mitochondrial function. J Cell Sci, jcs-186247
  2. Ghosh, G., & Sen, M. (2016). A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity. Molecular Cell, 63(4), 544-546.
  3. Guha, I., Naskar, D., & Sen, M. (2015). Macrophage as a mediator of immune response: Sustenance of immune homeostasis. Macrophage, 2.
  4. Naskar D, Maiti G, Chakraborty A, Roy A, Chattopadhyay DJ and Sen M. Wnt5a – Rac1 – NFkB homeostatic circuitry sustains innate immune functions in macrophages. J Immunology,2014,192(9):9386-97.
  5. Repudi SR, Patra M and Sen M. WISP3 – IGF1 interaction regulates chondrocyte hypertrophy. J Cell Sci 2013, 126: 1650 – 8.
  6. Maiti G, Naskar D and Sen M. The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. PNAS 2012, 109: 16600 -5.
  7. Sen M and Ghosh G. Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunology 2008, 181: 4441 – 5.
  8. Miller DS and Sen M. 2007.  Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species. BBRC 355: 156 – 61.
  9. Davis L, Chen Y and Sen M. 2006. WISP3 functions as a ligand and promotes superoxide dismutase activity. BBRC 342: 259 – 65.
  10. Sen M. 2005. Wnt Signaling in Rheumatoid Arthritis. Rheumatology 44: 708 – 713.
  11. Sen M, Cheng Yu-Ho, Goldring MB, Lotz M and Carson DA. 2004. WISP-3 dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheumatism 50: 488 – 97.
  12. Lu D, Zhao Y, Tawatao R, Cottam H, Sen M, Leoni L, Kipps TJ, Corr M and Carson DA. 2004. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. PNAS 101: 3118 – 23.
  13. Sen M, Reifert J, Lauterbach K, El-Gabalawy H, Rubin JS, Wolf V, Corr M and Carson DA. 2002. WNT signaling in rheumatoid arthritis synoviocytes regulates fibronectin and metalloproteinase expression. Arthritis Rheumatism46: 2867 – 77.
  14. Rhee CS, Sen M, Wu C, Leoni L, Rubin J, Corr M and Carson DA. 2002. Wnt and Frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas.  Oncogene 21: 6598 – 605.
  15. Sen M, Chamorro M, Reifert J, Corr M, and Carson DA. 2001. Blockade of Wnt-5A / Frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheumatism44: 772-781.
  16. Schmid M, Sen M, Rosenbach MD, Carrera CJ, Friedman H and Carson DA.  2000. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.  Oncogene 19: 5747-5754.
  17. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M and Carson DA. 2000. Expression and function of wingless and frizzled homologs in rheumatoid arthritis.  PNAS 97: 2791-2796.
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Updated on 7th September,2016

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