Cell Biology & Physiology Division

Dr. Rupasri Ain

Associate Professor, AcSIR (2013- to date)
PhD, Indian Institute of Science, 1998

Post-doctoral research:
1) Research Associate, Freie Universitaet, Berlin, Germany (1998)
2) Post-doctoral Fellow, University of Kansas School of Medicine, Kansas City, KS, USA (1998-2003)

Contact - rupasri@iicb.res.in


Principal Scientist

2007-2012: Head, Mouse Genetics Facility, National Centre for Biological Sciences, Bangalore, India
2003-2006: Research Assistant Professor, Department of Molecular and Integrated Physiology, University of Kansas Medical Center, USA
2000-2002: Post-doctoral Fellowship, American Heart Association, USA.
1999: Post-doctoral Fellowship, KUMC Biomedical Research Training Program, USA
1993-1997: Research Fellow, Indian Institute of Science, Bangalore, India

Current Research Interest

Regulations of angiogenesis, differentiation of trophoblast stem cells and spiral artery remodelling at the maternal-fetal interface

Our laboratory focuses on utero-placental development during the most vulnerable period of mammalian life. We work on the fascinating transient endocrine organ, called placenta, in particular, the placenta derived molecules that regulate placental vasculature and trophoblast cell phenotype. We are also interested in the regulation of trophoblast stem cell differentiation and signaling pathways controlling their fate. In addition, we are working on the regulation of spiral artery remodelling by uterine Natural Killer cells and invasive trophoblast cells. We use the tools and concepts of molecular biology, cell and developmental biology, genetics, microscopy to further our understanding of trophoblast stem cell differentiation, angiogenesis and placental development. Finally, the goal of our laboratory is to translate our laboratory findings into developing bio-markers for early detection of IUGR/preeclampsia that affects a considerable proportion of Indian population.

 

Names of the group members including regular staff with designation and research fellows

  1. Dr. Abhishek Jaiswal, DST-NPDF, PhD from NICED, Kolkata.
  2. Sarbani Saha, CSIR-SRF, B.Sc. and M.Sc. in Microbiology from University of Calcutta.
  3. Shreeta Chakraborty, UGC-SRF, B.Sc (St. Xavier’s College) and M.Sc. (VIT University) in Microbiology.
  4. Trishita Basak, CSIR-SRF, Integrated M.Sc. in Biotechnology from St. Xavier’s College.
  5. Debdyuti Nandy, CSIR-SRF, B.Sc. (Scotish Church College) and M.Sc. (St. Xavier’s College) in Microbiology.
  6. Nanda Singh, UGC-JRF, B.Sc. in Zoology (Burdwan Raj College) and M.Sc. in Biological Sciences (Presidency University).
  7. Rumela Bose,  CSIR-JRF, Integrated M.Sc. in Biotechnology from St. Xavier’s College.
  8. Safirul Islam, Project Assistant, DST, M.Sc. in Microbiology from St. Xavier’s College.

Post-doctoral positions are available:
If you’ve consistently good academic record and recently (as in the last one year) completed your Ph.D  or will be completing soon and wish to apply for a post-doctoral position in my lab, send me (rupasri@iicb.res.in) an enquiry with your CV and career goal.  Medical graduates/postgraduates (MBBS/MD) interested in biomedical research are also welcome.

List of Publications

From IICB:

  1. Chakraborty S and Ain R (2017) Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling. J Biol Chem. 292(16):6600-6620.
  2. Joshi R, Quadros R, Drumm M, Ain R, Panicker M (2017) Sedative effect of Clozapine is a function of 5-HT2A and environmental novelty. Eur Neuropsychopharmacol. 27(1):70-81.
  3. Chakraborty S and Ain R (2016) “Endothelial Cell Biology: Assessment of Endothelial Cell Function” in Trends in Experimental Biology, Volume-II. L. Kma ed. pp. 1-27. Excel India Publishers, New Delhi, India.
  4. Saha S, Choudhury J and Ain R (2015) MicroRNA-141-3p and miR-200a-3p regulate Insulin-like growth factor-II during mouse placental development. Molecular and Cellular Endocrinology 414:186-193.

Before joining IICB:

  1. Rosario GX*, Ain R*, Konno T and Soares MJ (2009) Intrauterine fate of invasive trophoblast cells. Placenta 30 (5): 457-463. *Equal contribution
  2. Chaturvedi G, Simone PD, Ain R, Soares MJ and Wolfe MW (2009) Noggin maintains pluripotency of human embryonic stem cells grown on matrigel. Cell Proliferation 42 (4): 425-433.
  3. Soares MJ, Alam SMK, Konno T and Ain, R. (2007) The prolactin family: regulators of uterine biology. In: Endometrium-2, J. Aplin, A. Fazleabas, S.R. Glasser, L. Giudice (eds), Taylor and Francis Publishers, London, pp. 342-353
  4. Ain R*, Konno T, Canham LN and Soares MJ (2006) Phenotypic analysis of the rat placenta. In: Soares MJ and Hunt JS (eds) Placental and trophoblast biology: Methods in Molecular Medicine, vol.I, Humana Press, Inc. 121:295-313. *Corresponding Author
  5. Alam SM, Ain R, Konno T, Ho-Chen JK, Soares MJ (2006) The rat prolactin gene family locus: species-specific gene family expansion. Mammalian Genome. 17(8): 858-877
  6. Ho-Chen JK, Ain R, Alt AR, Gonzalez NC, Wood JG and Soares MJ (2006) Hypobaric Hypoxia as a Tool to Study Pregnancy-Dependent Responses at the Maternal-Fetal Interface. In: Soares MJ and Hunt JS (eds) Placental and trophoblast biology: Methods in Molecular Medicine, vol. II, Humana Press, Inc. 122:427-434.
  7. Ain R*, Canham LN and Soares MJ (2005) Glucocorticoid induced intrauterine growth restriction impacts placental prolactin family and IGF-II/Akt signaling pathway. Journal of Endocrinology. 185:253-263. *Corresponding Author
  8. Ain R, Dai G, Godwin AR, Dunmore J and Soares MJ (2004) A prolactin family paralog regulates reproductive adaptations to a physiological stressor.Proc Natl Acad Sci. USA, 101(47): 16543-16548.
  9. Ain R*, Trinh M-L, and Soares MJ (2004) Interleukin-11 signaling is required for the differentiation of Natural Killer Cells at the Maternal-Fetal interface. Developmental Dynamics 231(4): 700-708. *Corresponding Author
  10. Ain R* and Soares MJ (2004) Is the metrial gland really a gland? Journal of Reproductive Immunology 61(2): 127-129. *Corresponding Author
  11. Pijnenborg R, Aplin JD, Ain R, Bevilacqua E, Bulmer JN, Cartwright J, Hüppertz B, Knöfler M, Maxwell C and Vercruysse L (2004) Trophoblast and the Endometrium––A Workshop Report. Placenta, 25: S42-S44.
  12. Ain R, Canham LN and Soares MJ (2003) Gestation stage-dependent intrauterine trophoblast cell invasion in the mouse and the rat: novelendocrine phenotype and regulation. Developmental Biology 260: 176-190.
  13. Ain R, Tash JS and Soares MJ (2003)Prolactin-like protein-A is a functional modulator of Natural Killer cells at the maternal-fetal interface. Molecular and Cellular Endocrinology 204:65-74.
  14. Wiemer D*, Ain R*, Ohboshi S and Soares MJ (2003) Migratory trophoblast cells express a newly identified member of the prolactin gene. Journal of Endocrinology 179: 335-346. *Equal Authorship
  15. Wiemer D, Shao L, Ain R, Dai G and Soares MJ (2003) Mouse Prolactin Family Gene Locus. Endocrinology. 144:313-325.
  16. Ain R, Tash JS, and Soares MJ (2002) A Simple method for the in situ detection of eosinophils. Journal of Immunological Methods 260: 273-278.
  17. Ain R, Muller H, Sahgal N, Dai G and Soares MJ (2002) Uteroplacental Prolactin Family: Immunological Regulators of Viviparity. In: Matera L and Rapaport R (eds) Growth and Lactogenic Hormones: Neuroimmune Biology, vol. 2, pp 187-202, Elsevier Science Publisher.
  18. Dutta B, Ain R, Seshagiri PB and Karande AA (2001). Differential influence of recombinant non-glycosylated and glycosylated glycodelin on human sperm function: comparative studies with hamster spermatozoa. Reproduction Fertility and Development 13: 111-118.
  19. Ain R, K Uma, S Shivaji and P B Seshagiri (1999). Pentoxifylline stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signaling molecules.(1999) Molecular Human Reproduction 5(7):618-626.
  20. Ain R, J Rao, A T Peter, H Sridhar, B R Vijaykumar and P B Seshagiri (1998). Bacterial infection and endotoxin levels in the female reproductive tract in rat: Correlation with the developmental status of preimplantation embryos. Indian Journal of Experimental Biology 36 (9): 867-874.
  21. Ain R and P B Seshagiri (1997). Succinate and malate improve development of hamster eight-cell embryos in vitro: confirmation of viability by embryo transfer. Molecular Reproduction and Development 44: 440-447.
  22. Ain R and P B Seshagiri (1997). Micromolar concentration of pentoxifylline improves in vitro development of hamster 8-cell embryos: Confirmation of viability by embryo transfer. Reproduction Fertility and Development 9: 697-702.
  23. Ain R, D Jayaprakash, A T Peter, M S Sreenivasa, M Kumar and P B Seshagiri (1995). Pentoxifylline improves sperm capacitation and affects in vitro fertilization of oocytes in the golden hamster. Theriogenology 44:553-562.
  24. Ain R, K R Shivkumar, B R Sreenath and P B Seshagiri (1995). Assessment of developmental retardation and abnormality of in vivo produced preimplantation embryos in the rat. Indian Journal of Experimental Biology. 33: 911-926.
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Updated on 28th June 2017


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