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Cell Biology & Physiology Division

Dr. Sib Sankar Roy

Metabolic Disorder Laboratory
PhD, Bose Institute, Kolkata
Post Doc: Harvard School of Public Health, Boston.

Contact: sibsankar@iicb.res.in /sibsankar1967@gmail.com

Sr.Principal Scientist

Fellow of The National Academy of Sciences, India (FNASc)

Fellow of the West Bengal Academy of Science and Technology (FAScT)

Current Research Interest

A) Understanding the molecular mechanisms associated with ovarian cancer.

  • Interplay and cross-talks among different factors and pathways in ovarian cancer.
  • Role of the signaling network and the transcription factors regulating MMPs responsible for invasion, migration and metastasis in ovarian carcinoma.
  • Study of different factors and/or signaling pathways inducing EMT.
  • Investigating the role of different genes in ovarian disorders with emphasis on collagen metabolism.

B) Investigation on molecular mechanisms behind the insulin resistance and diabetes type 2 (T2DM)

  • The molecular mechanism of fatty acid induced insulin resistance is being investigated.
  • The role of mitochondrial dysfunction in diabetes is being investigated in suitable model.
  • Role of oxidative stress in the pathogenesis of T2DM
  • Identifying pharmacological agents and their mode of action in improving FFA induced insulin resistance.

C) To study the role of Homeodomain Transcription factors in diseases:

  • The role of homeodomain transcription factor, Pitx2, in maintaining ovarian structure and function is under investigation.
  • The involvement of Pitx2 in promoting ovarian cancer through the activation of growth factor gene and /or signaling pathways are being investigated.
Names of the group members including regular staff with designation and research fellows:
Ms. Nabanita Das
Ms. Upasana Ray
Ms. Tulika Mitra
Mr. Ashok Mandala

Mr. Rahul Bhattacharya



Ms. Eshani Karmakar DST-Inspire JRF


Mr. Parash Prasad CSIR-JRF


Ms. Sampurna Ghosh UGC-JRF


Ms. Shreya Roy Chowdhury
Project Fellow
Ms. Shreya Bandopadhyay
Project Fellow
Mr. Shakilur Rahman
Project Fellow
Mr. Prabir Kumar Dey
Project Asst


List of important Publications:


  1. Upasana Ray, Shreya Roy Chowdhury, MadavanVasudevan, Kiran Bankar, SusantaRoychoudhury and Sib Sankar Roy* (2017) Gene regulatory networking reveals the molecular cue to lysophosphatidic acid-induced metabolic adaptations in ovarian cancer cells. Molecular Oncology. Feb 25. doi: 10.1002/1878-0261.12046.
  2. Shreya Roychowdhury, Upasana Ray, B.P Chatterjee and Sib Sankar Roy* (2017) Targeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucusnigra agglutinin. Cell Death & Disease (Nature Publishing Group, In Press).
  3. Nabanita Das, Ashok Mandala, ShamreenNaaz, Suresh Giri, Mukul Jain, DebasishBandyopadhyay, Russel J. Reiter, Sib Sankar Roy* (2017) Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. J. Pineal Research. May; 62(4). doi: 10.1111/jpi.12404.
  4. Ray U, Chowdhury SR, Roy SS*. (2017) Lysophosphatidic Acid Promotes Epithelial to Mesenchymal Transition in Ovarian Cancer Cells by Repressing SIRT1. Cell Physiol. Biochem. 41:795-805. DOI: 10.1159/000458744.
  5. TulikaMitra and Sib Sankar Roy* (2017) Co-activation of TGFβ and Wnt signalling pathways abrogates EMT in ovarian cancer cells. Cell Physiol. Biochem. Mar 9;41(4):1336-1345. doi: 10.1159/000464436.
  6. Nabanita Das, Ashok Mandala, SudarshanBhattacharjee, Debasri Mukherjee, DebasishBandyopadhyay and Sib Sankar Roy* (2017) Dietary fat proportionately enhances oxidative stress and glucose intolerance followed by impaired expression of genes associated with mitochondrial biogenesis. Food Function. Apr 19;8(4):1577-1586. doi: 10.1039/c6fo01326k.
  7. Datta S, Choudhury D, Das A, Das Mukherjee D, Das N, Roy S S, Chakrabarti G. (2017) Paclitaxel resistance development is associated with biphasic changes in reactive oxygen species, mitochondrial membrane potential and autophagy with elevated energy production capacity in lung cancer cells: A chronological study. Tumour Biol. 39(2):1010428317694314. doi: 10.1177/1010428317694314.


  1. Ashok Mandala, Nabanita Das, SudarshanBhattacharjee, Bidisha Mukherjee, SatinathMukhopadhyay* and Sib Sankar Roy* (2016) Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle. BiochemBiophys Res Commun. 2016 Oct 28;479(4):933-939. doi: 10.1016/j.bbrc.2016.09.168. Epub 2016 Oct 1.
  2. A Pradhan et al, S. S. Roy, S. Maiti Choudhury (2016). Gold nanoparticles from indole-3-carbinol exhibit cytotoxic, genotoxic and antineoplastic effects through the induction of apoptosis. RSC Advances. 2016, 6, 56435; DOI: 10.1039/c6ra05591e
  3. AtanuNaskar, SusantaBera, Rahul Bhattacharya, PritamSaha, Sib Sankar Roy, Tuhinadri Sen and Sunirmal Jana (2016) Synthesis, characterization and antibacterial activity of Ag incorporated ZnO-graphene nanocomposites. RSC Advances, 6, 88751-88761. DOI: 10.1039/c6ra14808e.
  4. Sujata Roy Moulik, Puja Pal, SuraviMajumder, BuddhadevMallick, Shreyasi Gupta, PayelGuha, Sib Sankar Roy and Dilip Mukherjee (2016) Gonadotropin and sf-1 regulation of cyp19a1a gene and aromatase activity during oocyte development in the rohu, L. rohita. Comp BiochemPhysiol, part-A; 196:1-10; doi: 10.1016/j.cbpa.2016.02.004.


  1. AtanuNaskar, SusantaBera, Rahul Bhattacharya, Sib Sankar Roy and Sunirmal Jana (2015) Synthesis, characterization and cytotoxicity of polyethylene glycol coupled zinc oxide–chemically converted graphene nanocomposite on human OAW42 ovarian cancer cells. Polymers for Advanced Technologies, DOI: 10.1002/pat.3689.
  2. MoitriBasu, Rahul Bhattacharya, Upasana Ray, SatinathMukhopadhyay, Uttara Chatterjee and Sib Sankar Roy* (2015) Invasion of ovarian cancer cells is induced by PITX2-mediated activation of TGF-β and Activin-A. Molecular Cancer 14:162: 1-15, DOI 10.1186/s12943-015-0433-y.
  3. SudarshanBhattacharjee, Nabanita Das, Ashok Mandala, SatinathMukhopadhyay and Sib Sankar Roy* (2015) Fenofibrate Reverses Palmitate Induced Impairment in Glucose Uptake in Skeletal Muscle Cells by Preventing Cytosolic Ceramide Accumulation. Cell PhysiolBiochem; 37:1315-1328; DOI: 10.1159/000430399.


  1. High cAMP attenuation of insulin-stimulated meiotic G2-M1 transition in zebrafish oocytes: Interaction between the cAMP-dependent protein kinase (PKA) and the MAPK3/1 pathways. Maitra S, Das D, Ghosh P, Hajra S, Roy SS, Bhattacharya S. Mol Cell Endocrinol. (2014) Jun 20; 393(1-2):109-119. doi: 10.1016/j.mce.2014.06.008.
  2. MoitriBasu, SatinathMukhopadhyay, Uttara Chatterjee and Sib Sankar Roy (2014) FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of MAPK signaling pathway. J. Biol. Chem. 289:1415-1428.
  3. Chatterjee D, Bhattacharya P, Sau TJ, Das JK, Sarma N, Bandyopadhyay AK, Sib Sankar Roy, Giri AK (2014) Arsenic exposure through drinking water leads to senescence and alteration of telomere length in humans: A case-control study in West Bengal, India. Mol. Carcinog. Doi: 10.1002/mc.22150.


  1. MoitriBasu and Sib Sankar Roy* (2013) Wnt/β-Catenin Pathway Is Regulated by PITX2 Homeodomain Protein and Thus Contributes to the Proliferation of Human Ovarian Adenocarcinoma Cell, SKOV-3. J BiolChem 288:4355-4367.


  1. Sonali Ghosh, MoitriBasu and Sib Sankar Roy* (2012) ETS-1 Regulates Vascular Endothelial Growth Factor-induced Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 Expression in Human Ovarian Carcinoma Cell SKOV-3. J BiolChem287:15001-15015.


  1. ShyamSundar Nandi, Pamela Ghosh and Sib Sankar Roy* (2011): Expression of PITX2 Homeodomain Transcription Factor during Rat Gonadal Development in a Sexually Dimorphic Manner. Cell PhysiolBiochem 27:159-170.


  1. Biswas A, Bhattacharya S, Dasgupta S, Kundu R, Roy SS, Pal BC, Bhattacharya S (2010): Insulin resistance due to lipid-induced signalling defects could be prevented by mahanine. Mol Cell Biochem 336:97-107.


  1. Barma P, Bhattacharya S, Bhattacharya A, Kundu R, Dasgupta S, Biswas A, Bhattacharya S, Roy SS, Bhattacharya S (2009): Lipid induced overexpression of NF-kappaB in skeletal muscle cells is linked to insulin resistance. BiochimBiophysActa 1792:190-200.


  1. Pamela Ghosh, Samir Kumar Saha, ShyamSundar Nandi, Samir Bhattacharya and Sib Sankar Roy* (2007): Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders. Cell PhysiolBiochem 20:887-898.
  2. Ghosh P, Saha SK, Bhattacharya S, Bhattacharya S, Mukherjee S, Roy * (2007): Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary. Cell PhysiolBiochem 20:357-368.
  3. Samir Kumar Saha, Pamela Ghosh, DebanjaliMitra, Satinath Mukherjee, Samir Bhattacharya and Sib Sankar Roy* (2007) Localization and thyroid hormone influenced expression of collagen II in ovarian tissue. Cell PhysiolBiochem 19:67-76.
  4. Dey D, Pal BC, Biswas T, Roy SS, Bandyopadhyay A, Mandal SK, Giri BB and Bhattacharya S (2007) A Lupinoside prevented fatty acid induced inhibition of insulin sensitivity in 3T3 L1 adipocytes. Mol Cell Biochem 300(1-2):149-57.
  5. Samir Kumar Saha, Pamela Ghosh, Samir Bhattacharya and Sib Sankar Roy* (2007) Procollagen synthesis is increased in hypothyroid rat ovary by a parallel and compensatory pathway. Cell Physiology Biochem 19:313-322.
  6. DebleenaDey, Anirban Bhattacharya, Sib Sankar Roy and Samir Bhattacharya (2007) Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Ce. BiochemBiophys Res Commun 357: 474-479.
  7. Ghosh P, Saha SK, Bhattacharya S, Bhattacharya S, Mukherjee S, Roy SS* (2007): Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary. Cell PhysiolBiochem 20:357-368.


  1. Dey D, Basu D, Roy SS, Bandyopadhyay A and Bhattacharya S (2006). Involvement of novel PKC isoforms in FFA induced defects in insulin signaling. Mol Cell Endocrinol. 246(1-2):60-4.


  1. Samir kumarSaha, Pamela Ghosh, Aditya Konar, Samir Bhattacharya and Sib Sankar Roy* (2005) Differential expression of Procollagen Lysine 2-Oxoglutarate 5-Deoxygenase and Matrix Metalloproteinase Isoforms in Hypothyroid Rat Ovary and Disintegration of Extracellular Matrix. Endocrinology 146(7): 2963-2975.
  2. DebleenaDey, Mohua Mukherjee, DipanjanBasu, MalabikaDatta, Sib Sankar Roy, ArunBandyopadhyay and Samir Bhattacharya (2005). Inhibition of Insulin Receptor Gene Expression and Insulin Signalling by Fatty Acid: Interplay of PKC Isoforms Therein. Cellular Physiology and Biochemistry; 16:217-228.

Detail list of Publications upto April 2017 ==>> Click here


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Updated on 12th May,2017
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