Chemistry Division

Dr. Arindam Talukdar

M.Pharmacy (1997) Medicinal Chemistry, Panjab University, Chandigarh, Indian (Prof. Tilak Raj Juneja).
Ph.D (2003) Organic Chemistry, National Chemical Laboratory, Pune, India (Dr. Mukund K Gurjar).
Post-doctoral Research Scholar (2004-2005), The Ohio State University, USA (Prof. Peng George Wang).
Post-doctoral Research Associate (2005-2009), Purdue University, USA (Prof. Mark Cushman).
Senior Research Scientist (2010-2012), Albany Molecular Research Inc. (AMRI) Singapore.

Contact - atalukdar@iicb.res.in / t_arindam@yahoo.com


Senior Scientist

Current Research Interest

Our lab aims to answer fundamental questions that lie at the interface of chemistry and biology by integrating the concept of organic chemistry, biochemistry and molecular modeling to perform structure-based design and synthesis of novel chemical entity to unravel the molecular mechanism and develop potential treatment for human diseases.

Epigenetic modifying enzymes as novel therapeutic targets: The main focus is to perform structure-based design and synthesis of small-molecule regulators of epigenetics modifying enzymes such as histone methyltransferases (HMT) as tools to unravel the complex biology of epigenetics and contribute towards epigenetic-based drugs for the treatment of a number of diseases such as cancer, autoimmunity, diabetes, or neurological disorders.

Probing Endosomal Toll-like Receptors (TLRs). TLRs are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defence for self-nonself discrimination by the host immune response. Aberrant endosomal TLR activation is implicated in autoreactive inflammation in different autoimmune diseases. The goal is to rationally design selective inhibitors for the nucleic acid-recognizing TLRs for devising novel therapeutic strategies in relevant clinical contexts.

 

 

Names of the group members including regular staff with designation and research fellows

1.Ayan Mukherjee SRF M.Sc IIT Chennai
2.Barnali Paul SRF M.Sc University of North Bengal
3.Swarnali Roy  SRF M.Sc University of North Bengal
4.Biswajit Kundu JRF M.Sc University of Calcutta
5.Namrata Roy  RA Ph.D Indian Association for the Cultivation of Science
6.Sourav Pal Project Asst (M.Pharm. GNIST, Kolkata)

 

Position Available: JRF

PATENTS

  1. Bicyclic Compound and Use Thereof for Inhibiting SUV39H2. PCT/US2016/0051350. Date of filing: 12th September, 2016.
  2. Blocking toll-like receptor 9 signaling with small molecule antagonist. Application No.:  201611009670. Date of filing: 21/03/2016.
  3. Preparation of 2,5-disubstituted pyrrolidines and tetrahydrothiophenes as leukotrine biosynthesis inhibitors. Chorghade, M. S.; Gurjar, M. K.; Radha Krishna, P.; Lalitha, S. V. S.; Sadalapure, K.; Adhikari, S.; Rao, B. V.; Arindam Talukdar; Islam, A.; Murugaiah, A. M. S.; Alla, V. R. (Millennium Pharm Inc., USA) PCT Int. Appl. WO 2000001670 A1 13 Jan 2000, 80 pp. European   Patent EP 1115702, 22 February 2002.

List of Publications:

  1. O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase. Arindam Talukdar, Y. Zhao, W. Lv, A. Bacher, B. Illarionov, M. Fischer, and Mark Cushman. J. Org. Chem., 2012, 77, 6239-6261.
  2. A Highly Efficient Oxidation of Benzyl Methyl Ethers with NBS Selectively Affords Either Aromatic Aldehydes or Aromatic Methyl Esters. Abdelrahman S. Mayhoub, Arindam Talukdar, and Mark Cushman. J. Org. Chem., 2010, 75, 3507-3510.
  3. Virtual Screening, Selection and Development of a Novel Structural Scaffold for Inhibition of Lumazine Synthase. Arindam Talukdar, Ekaterina Morgunova; Jianxin Duan; Winfried Meining; Lennart Nilsson; Adelbert Bacher; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Mark Cushman. Bioorg Med Chem., 2010, 18, 3518-3534.
  4. Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity. Arindam Talukdar, Meghan Breen, Adelbert Bacher, Boris Illarionov, Markus Fischer, Gunda Georg, Qi-Zhuang Ye, and Mark Cushman. J. Org. Chem., 2009, 74 (15), 5123–5134 (Feature JOC Article).
  5. Synthesis and enzyme inhibitory activity of the S-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase. Arindam Talukdar, Boris Illarionov, Adelbert Bacher, Markus Fischer, and Mark Cushman, J. Org. Chem., 2007,72, 7167-7175.
  6. Synthesis and Structure-Activity Relationship Study of Isoglobotrihexosylceramide Analogues. Wenlan Chen, Chengfeng Xia, Jinhua Wang, Prakash Thapa, Yusen Li, Arindam Talukdar, Janos Nadas, Wenpeng Zhang, Dapeng Zhou, Peng George Wang, J. Org. Chem. 2007, 72, 9914-9923.
  7. Regioselective synthesis of N-b-hydroxyethylaziridines by ring-opening reaction of epoxides with aziridine generated in situ. Ha Young Kim, Arindam Talukdar, and Mark Cushman, Organic Letters, 2006, 8, 1085.
  8. A divergent synthesis of uncommon sugars from furanaldehyde. Lizhi Zhu, Arindam Talukdar, Guisheng Zhang, James P. Kedenburg, Peng George Wang, Synlett, 2005, 1547.
  9. Synthesis of terminal disaccharide unit of Klebsiella pneumoniae. Gurjar, M. K.; Arindam Talukdar,Tetrahedron,2004, 60, 3267.
  10. Mutagenicity of Sulfoscanate: a comparative study. Juneja, T. R; Arindam Talukdar*, Gupta, R. L., Mutation Res., 2002, 518, 155-161.
  11. Effect of various alkyl and unsaturated substituents on the mutagenicity of some nitrophenyl thioethers. Juneja, T. R; Arindam Talukdar*, Nimish Mehta, Gupta, R. L., Mutation Res., 2001, 495, 97-102.

REVIEWS AND BOOK CHAPTER

  1. Luo S.; Zhu, L.; Arindam Talukdar, Mi, X.; Cheng, J-P.; Wang, P. G.  Recent Advances in Rear Earth-Metal Triflate catalyzed Organic Synthesis in Green Chemistry. Mini-Reviews in Organic Chemistry, 2005, 2, 546.
  2. Arindam Talukdar; Wang, P. G.  “N-Nitroso Compounds”. In Nitric Oxide Donors and its Applications Edited by Wang, P. G.; Cai, T. B.; Taniguchi, N. Wiley-VCH, Germany, 2004.
  3. Chorghade, M. S.; Gurjar, M. K.; Arindam Talukdar “Fascinating Excursions into Chiral Chemistry: An Insider’s Perspective” CHIMICA OGGI Chemistry Today, 2002, 20(10), 20.
 
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Updated on 11th January 2017


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