Chemistry Division

Dr. Chinmay Chowdhury

Ph.D., Jadavpur University (1998)
Postdoctoral Research:
a) University of Kentucky, Lexington, USA (1999-2000)
b) University of California, San Diego, USA (2000-2002)

Contact -

Principal Scientist

Current Research Interest

  1. Isolation & identification of bioactivity guided extracts, fractions and unique bioactive molecules from Indian medicinal plants
  2. Up scaling & process development for value added natural products
  3. Preparation of analogue library of lead phytomolecules through synthesis
  4. Technology development on novel phytopharmaceutials
  5. Palladium-catalyzed synthesis of novel nitrogen-heterocycles of biological importance.

Names of the group members including regular staff with designation and research fellows

Positions for qualified JRF `s are available
Fellow / RA / PA
Group Alumni & Ph.D. degree awarded
Miss Maumita Jash (JRF, UGC) Dr. Anup Kumar Sasmal (2012)
Miss Amrita Mondal ( JRF, CSIR) Dr. Sanjukta Mukherjee (2012)
Mr. Subhendu Pramanik (JRF, CSIR) Dr. Kaushik Brahma (2013)
Miss Sukanya De (JRF, CSIR) Dr. Bimolendu Das (2014)
  Dr. Biswajit Chakraborty (2015)
  Dr. Priyanka Kundu (2017) 

Our recenly published article in the cover page (inside)

List of important Publications


39. M. Jash, B. Das, S. Sen and C. Chowdhury. “Intramolecular Cycloaddition Approach to Fused Pyrazoles: Access to 4,5-Dihydro-2H-pyrazolo[4,3-c]quinolines, 2,8-Dihydroindeno[2,1-c]pyrazoles and 4,5-Dihydro-2H-benzo[e]indazoles”, Synthesis, 2017, in press.

38. M. Jash, B. Das and C. Chowdhury. "One-Pot Access to Benzo[a]carbazoles via Palladium(II)-Catalyzed Hetero- and Carboannulations", Journal of Organic Chemistry, 2016, 81, 10987-10999.

37. P. Kundu, A. Mondal and C. Chowdhury. “A Palladium-Catalyzed Method for the Synthesis of 2-(α-Styryl)-2,3-dihydroquinazolin-4-ones and 3-(α-Styryl)-3,4-Dihydro-1,2,4-benzothiadiazine-1,1-dioxide: Access to 2-(α-Styryl)quinazolin-4(3H)-ones and 3-(α-Styryl)-1,2,4-benzothiadiazine-1,1-dioxides”, Journal of Organic Chemistry, 2016, 81, 6596-6608.

36. D. Dutta, B. Chakraborty, A. Sarkar, C. Chowdhury and P. Das. “A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells”, BMC Cancer, 2016, 16: 23 (DOI: 10.1186/s12885 -016-2055-1).

35. P. Kundu, A. Mondal, B. Das and C. Chowdhury. “A Straightforward Approach for the stereoselective synthesis of (E)-2-aryl/vinylmethylidene-1,4-benzodiazepines and -1,4-benzodiazepin-5-ones through palladium/charcoal-catalyzed reactions”, Advanced Synthesis & Catalysis, 2015, 357,3737-3752.

34. D. Kumar, B. Das, R. Sen, P. Kundu, A. Manna, A. Sarkar, C. Chowdhury, M. Chatterjee and P. Das “Andrographolide analogue induces apoptosis and autophagy mediated cell death in U937 cells by inhibition of PI3K/Akt/mTOR pathway”, PLoS One, 2015, 10(10), e0139657 (DOI: 10.1371/journal.pone.0139657).

33. B. Chakraborty, D. Dutta, S. Mukherjee, S. Das, N. C. Maiti, P. Das and C. Chowdhury. “Synthesis and biological evaluation of a novel betulinic acid derivative as inducer of apoptosis in human colon carcinoma cells (HT-29)”, European Journal of Medicinal Chemistry, 2015,  102, 93-105

32. D. Dutta, A. Sarkar, B. Chakraborty, C. Chowdhury and P. Das. “Induction of apoptosis by a potent betulinic acid derivative in human colon carcinoma HT-29 cells”, International Journal of Scientific and Research Publications, February 2015, vol. 5, issue 2, ISSN 2250-3153.

31. R. Preet, B. Chakraborty, S. Siddharth, P. Mohapatra, D. Das, S. R. Satapathy, S. Das, N. C. Maiti, P. R. Maulik, C. N. Kundu, C. Chowdhury: “Synthesis and biological evaluation of andrographolide analogues as anti-cancer agents”, European Journal of Medicinal Chemistry, 2014, 85, 95-106.

30. K. Brahma, B. Das, C. Chowdhury: “A palladium-catalyzed facile and general method for the stereoselective synthesis of (E)-3-arylidene-3,4-dihydro-2H-1,4-benzoxazines and their naphthoxazine analogues”, Tetrahedron, 2014, 70, 5863–5871.

29. B. Das, P. Kundu and C. Chowdhury: “Facile synthesis of 2-arylmethylindoles and 2-vinylic indoles through palladium-catalyzed heteroannulations of 2-(2-propynylaniline and 2-(2-propynyl)tosylanilides”, Organic and Biomolecular Chemistry, 2014, 12, 741-748.[appeared as cover (inside) article].

28. K. Brahma, B. Achari and C. Chowdhury:  “Facile synthesis of [1,2,3]-triazole-fused isoindolines, tetrahydroisoquinolines, benzoazepines and benzoazocines  by palladium-copper catalysed heterocyclisation”,  Synthesis, 2013, 545-555.

27. R. Roy, D. Kumar, B. Chakraborty, C. Chowdhury and  P.  Das: “Apoptotic and autophagic effects of Sesbania grandiflora flowers in human leukemic cells”, PLoS One, 2013, 8, e71672.

26. R. Roy, D. Kumar, C. Chowdhury and  P. Das: “Autophagic and apoptotic mechanisms of death Induced by Sesbania grandiflora flowers in human leukemic cells” Eur. J. Cancer, 2012, 48, suppl.5, S27.

25. P. Das, D. Kumar, R. Roy, C. Chowdhury, M. Chatterjee: “Andrographolide analogue induces apoptosis and autophagy mediated cell death in U937 cells”, Eur. J. Cancer, 2012, 48, suppl.5, S156.

24. C. Chowdhury,  B. Das, S. Mukherjee and B. Achari : “Palladium-catalyzed approach for the general synthesis of (E)-2-arylmethylidene-N-tosylindolines and (E)-2-arylmethylidene-N-tosyl/nosyltetrahydroquinolines: Acess to 2-Substituted Indoles and Quinolines”,  Journal of Organic Chemistry , 2012, 77, 5108-5119.

23. K. Brahma, A. K. Sasmal and C. Chowdhury: “An efficient strategy for the general synthesis of 3-aryl substituted pyrazolo[5,1-c][1,4]benzoxazines and pyrazolo[1,5-a][1,4]benzodiazepin-6(4H)-ones”,  Organic  & Biomolecular Chemistry , 2011, 9, 8422-8429.

22. C. Chowdhury, S. Mukherjee, B. Chakraborty and B. Achari: “A rapid and facile method for the general synthesis of 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues”, Organic & Biomolecular Chemistry, 2011, 9, 5856-5862.

21. C. Chowdhury,  A. K. Sasmal and   B. Achari : “An expedient and facile  route for the general synthesis of 3-aryl substituted 1,2,3-triazolo[1,5-a][1,4]benzodiazepin-6-ones and 1,2,3-triazolo[1,5-a][1,5]benzodiazocin-7-ones”, Organic & Biomolecular Chemistry, 2010, 8, 4971-4977.

20. C. Chowdhury,  K. Brahma, S. Mukherjee  and A. K. Sasmal : “Totally regio- and stereoselective synthesis of (E)-3-arylidene-3,4-dihydro-2H-1,4-benzoxazines under palladium catalyst”, Tetrahedron Letters, 2010, 51, 2859-2861.

19. B. Das,  C. Chowdhury,  D. Kumar,  R. Sen,  R. Roy, P. Das and  M. Chatterjee:               “Synthesis, cytotoxicity, and structure-activity relationship (SAR)  studies of andrographolide analogues as  anti-cancer agent”,  Bioorganic & Medicinal Chemistry Letters; 2010,  20, 6947-6950.

18. C.Chowdhury, S. Mukherjee, B. Das and B. Achari : "Expedient and rapid synthesis of 1,2,3-triazolo [5,1-c] morpholines through palladium-copper catalysis", Journal of Organic Chemistry,2009, 74, 3612-3615.

17. C. Chowdhury, A. Sasmal and P. K. Dutta : "Efficient synthesis of 1,2,3-triazolo [5,1-c][1,4] benzoxazines through palladium-copper catalysis", Tetrahedron Letters,2009, 50, 2678-2681.
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Updated on 15th Nov, 2017

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