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Chemistry Division

Dr. Ranjan Jana

Senior Scientist
Ph.D (2007) Organic Chemistry, Indian Association for the Cultivation of Science (IACS), Kolkata with Prof. B. C. Ranu
Postdoctoral Research (2007-2008) Bar-Ilan University, Israel with Prof. S. Braverman
Postdoctoral Research (2008-2010) University of Kansas, USA with Prof. J. A. Tunge
Postdoctoral Research (2010-2012) University of Utah, USA with Prof. M. S. Sigman


Contact - rjana@iicb.res.in / janaegra@gmail.com

My research focus will be at the interface of Chemistry and Chemical Biology. Chemical tools such as affinity and activity-based protein profiling will be developed to harness biological targets. Different cell imaging techniques will be integrated for better mechanistic understanding of neurodegenerative diseases.

 

Current Research Interest

  • Design and development of novel ligands for the metal-catalyzed enantioselective synthesis of medicinal scaffolds.
  • Identification of highly selective kinase inhibitors via late-stage C-H activation/ functionalization of heterocycles.
  • Photo-affinity and activity based protein profiling for the identification of biological target of small molecules.
  • Development of radiopharmaceuticals for PET imaging for the early detection of breast cancer and neurodegenerative diseases.
  • Exploring biocompatiblechemical reactivity for posttranslational modifications (PTMs) of proteins. 

Positions Available:   JRF

Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff Others
  1. Samir Kumar Bhunia SRF
  2. ArghyaPolley SRF
  3. GurupadaBairy JRF
  4. Kartic Manna JRF
  5. Pritha Das JRF
  6. Hasina Mamataj Begum JRF
  7. Dr. Ashok Behera RA
  8. Dr.Suvankar Das N-PDF
 

List of important Publications

1. A General Copper/Manganese Cocatalyzed C-H Selenationof Arenes, Heteroarenes, and Alkenes under Air-Singh, B. K.; Bairy, G.; Jana, R.*Chemistry Select 2017, 2, 9227-9232.

2. Palladium-catalyzed decarboxylative,decarbonylative and dehydrogenative C(sp2)–Hacylation at room temperature-Hossian, A.; Manna, M. K.; Manna, K.; Jana, R.*Org. Biomol. Chem.2017, 15, 6592–6603.

3. Dual visible-light photoredox and palladium(II)catalysis for dehydrogenative C2-acylation ofindoles at room temperature- Manna, M. K.; Bairya, G.; Jana, R.*Org. Biomol. Chem.2017, 15, 5899-5903.

 

4.Ruthenium(II)-Catalyzed Intermolecular Synthesis of 2-Arylindolines through C-H Activation/Oxidative Cyclization Cascade- Manna, M. K.; Bhunia, S. K.; Jana, R.* Chem. Comm. 2017, 53, 6906-6909.

5.Carboxyl Radical-Assisted 1,5-Aryl Migration through Smiles Rearrangement-Hossian, A.; Jana, R.*Org. Biomol. Chem. 2016, 14, 9768–9779.

6.Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines- Singh, B. K.; Polley, A.; Jana, R* J. Org. Chem., 2016, 81 (10), pp 4295–4303

7. Substrate-Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature- AsikHossian, Samir Kumar Bhunia, and Ranjan Jana*, J. Org. Chem. 2016 81, 2521-2533


8. A Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers- Bijaya Kumar Singh and Ranjan Jana*, J. Org. Chem.2016, 81, 831–841



9.Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade Samir Kumar Bhunia,ArghyaPolley, Ramalingam Natarajan, and Ranjan Jana* Chemistry- A European Journal 21, 16786-16791.



10.Chemo-, regio-, and stereoselectiveHeck–Matsuda arylation of allylic alcohols under mild conditions Chaudhari, T. Y.;Hossian, A.;Manna, M. K.; Jana, R.* Org. Biomol. Chem. 2015, 13, 4841-4845.

11. Merging C−H Activation and Alkene Difunctionalization at Room Temperature: A Palladium-Catalyzed Divergent Synthesis of Indoles and Indolines- Manna, M. K.; Hossian, A.;Jana, R.* Org. Lett. 2015, 17, 672-675.


12. Palladium(0)-Catalyzed IntramolecularDecarboxylativeAllylation of Ortho Nitrobenzoic Esters.Hossian, A.; Singha, S.; Jana, R.* Org. Lett. 2014, 16, 3934-3937.

13. Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity-Braverman, S.; Cherkinsky, M.; Kalendar, Y.; Jana, R.; Sprecher, M.; Goldberg, I. Synthesis, 2014, 46, 119-125.
14. The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress-Vaden R. M.; Gligorich K. M.; Jana R.; Sigman M. S; Welm B. E. Breast Cancer Res.2014, 16, 472.
15. Pd(0)-Catalyzed 1,1-Diarylation of Ethylene and Allylic Carbonates- Saini, V.;  Liao, L.; Wang, Q.; Jana, R. Sigman, M. S. Org. Lett. 2013, 15, 5008-5011.
16. Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives- Jana, R.; Pathak, T. P.; Jensen, K. H.; Sigman, M. S. Org. Lett. 2012, 14, 4074-4077.
17. Migratory Decarboxylative Coupling of Coumarins: Synthetic and Mechanistic Aspects- Jana, R.; Partridge, J. J.; Tunge, J. A.  Angew. Chem. Int. Ed. 2011, 50, 5157-5161.
18. A Palladium-Catalyzed Three Component Cross-Coupling of Conjugated Dienes or Terminal Alkenes with Vinyl Triflates and Boronic Acids- Liao, L.; Jana, R.; Urkalan, K. B.; Sigman, M. S. J. Am. Chem. Soc. 2011, 133, 5784-5787.
19. Advances in Transition Metal (Pd, Ni, Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners- Jana, R.; Pathak, T. P.; Sigman, M. S. Chem. Rev. 2011, 111, 1417-1492. (The most read article in 2011).
20. Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation- Chattopadhyay, K.; Jana, R.; Day, V.; Douglas, J.; Tunge, J. A.  Org. Lett. 2010, 12, 3042-3045.
21. Formation of N-alkylpyrroles via Intermolecular Redox Amination- Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009, 131, 16626-16627. (Highlighted in Synform).
22. Mild Decarboxylative Allylation of Coumarins- Jana, R.; Trivedi, R.; Tunge, J. A.  Org. Lett. 2009, 11, 3434-3436.
23. A Homogeneous, Recyclable Rhodium(I) Catalyst for the Hydroarylation of Michael Acceptors- Jana, R.; Tunge, J. A. Org. Lett. 2009, 11, 971-974. (Developed a novel catalyst JanaPhos).
24. An Improved Procedure for the Three Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid- B. C. Ranu; Jana, R.; Sowmiah, S. J. Org. Chem. 2007, 72. 3152- 3154.
25. Catalysis by Ionic Liquid. A Green Protocol for the Stereoselective Debromination of vicinal- Dibromides by [pmIm]BF4 under Microwave Irradiation – Ranu, B. C.; Jana, R. J. Org. Chem. 2005, 70, 8621-8624.

Patent:

  1. Polymer-supported Transition Metal Catalyst Complexes and Methods of Use- Tunge, J. A.; Subramaniam, B.; Fang, J.; Jana, R. U.S. Patent, No WO 2010057099.

 

Detail list of Publications ==>> Click here

 

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Updated on 17th October, 2017
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