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Chemistry Division

Dr. Ranjan Jana

Senior Scientist
Ph.D (2007) Organic Chemistry, Indian Association for the Cultivation of Science (IACS), Kolkata with Prof. B. C. Ranu
Postdoctoral Research (2007-2008) Bar-Ilan University, Israel with Prof. S. Braverman
Postdoctoral Research (2008-2010) University of Kansas, USA with Prof. J. A. Tunge
Postdoctoral Research (2010-2012) University of Utah, USA with Prof. M. S. Sigman

Contact - rjana@iicb.res.in / janaegra@gmail.com

My research focus will be at the interface of Chemistry and Chemical Biology. Chemical tools such as affinity and activity-based protein profiling will be developed to harness biological targets. Different cell imaging techniques will be integrated for better mechanistic understanding of neurodegenerative diseases.


Current Research Interest

  • Design and development of novel ligands for the metal-catalyzed enantioselective synthesis of medicinal scaffolds.
  • Identification of highly selective kinase inhibitors via late-stage C-H activation/ functionalization of heterocycles.
  • Photo-affinity and activity based protein profiling for the identification of biological target of small molecules.
  • Development of radiopharmaceuticals for PET imaging for the early detection of breast cancer and neurodegenerative diseases.
  • Exploring biocompatiblechemical reactivity for posttranslational modifications (PTMs) of proteins. 

Positions Available:   JRF

Names of the group members including regular staff with designation and research fellows:
Fellow/RA Staff Others
  1. Bijaya Kumar Singh    JRF
  2. Asik Hossian  JRF
  3. Manash Kumar Manna JRF
  4. Samir Kumar Bhunia  JRF
  5. Arghya Polley  JRF

List of important Publications

1.Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines- Singh, B. K.; Polley, A.; Jana, R* J. Org. Chem.ASAP.

2. Substrate-Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature- AsikHossian, Samir Kumar Bhunia, and Ranjan Jana*, J. Org. Chem. 2016 81, 2521-2533

3. A Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers- Bijaya Kumar Singh and Ranjan Jana*, J. Org. Chem.2016, 81, 831–841

4.Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade Samir Kumar Bhunia,ArghyaPolley, Ramalingam Natarajan, and Ranjan Jana* Chemistry- A European Journal 21, 16786-16791.

5.Chemo-, regio-, and stereoselectiveHeck–Matsuda arylation of allylic alcohols under mild conditions Chaudhari, T. Y.;Hossian, A.;Manna, M. K.; Jana, R.* Org. Biomol. Chem. 2015, 13, 4841-4845.
6. Merging C−H Activation and Alkene Difunctionalization at Room Temperature: A Palladium-Catalyzed Divergent Synthesis of Indoles and Indolines- Manna, M. K.; Hossian, A.; Jana, R.* Org. Lett. 2015, 17, 672-675.

7. Palladium(0)-Catalyzed IntramolecularDecarboxylativeAllylation of Ortho Nitrobenzoic Esters.Hossian, A.; Singha, S.; Jana, R.* Org. Lett. 2014, 16, 3934-3937.

8. Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity-Braverman, S.; Cherkinsky, M.; Kalendar, Y.; Jana, R.; Sprecher, M.; Goldberg, I. Synthesis, 2014, 46, 119-125.
9. The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress-Vaden R. M.; Gligorich K. M.; Jana R.; Sigman M. S; Welm B. E. Breast Cancer Res.2014, 16, 472.
10. Pd(0)-Catalyzed 1,1-Diarylation of Ethylene and Allylic Carbonates- Saini, V.;  Liao, L.; Wang, Q.; Jana, R. Sigman, M. S. Org. Lett. 2013, 15, 5008-5011.
11. Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives- Jana, R.; Pathak, T. P.; Jensen, K. H.; Sigman, M. S. Org. Lett. 2012, 14, 4074-4077.
12. Migratory Decarboxylative Coupling of Coumarins: Synthetic and Mechanistic Aspects- Jana, R.; Partridge, J. J.; Tunge, J. A.  Angew. Chem. Int. Ed. 2011, 50, 5157-5161.
13. A Palladium-Catalyzed Three Component Cross-Coupling of Conjugated Dienes or Terminal Alkenes with Vinyl Triflates and Boronic Acids- Liao, L.; Jana, R.; Urkalan, K. B.; Sigman, M. S. J. Am. Chem. Soc. 2011, 133, 5784-5787.
14. Advances in Transition Metal (Pd, Ni, Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners- Jana, R.; Pathak, T. P.; Sigman, M. S. Chem. Rev. 2011, 111, 1417-1492. (The most read article in 2011).
15. Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation- Chattopadhyay, K.; Jana, R.; Day, V.; Douglas, J.; Tunge, J. A.  Org. Lett. 2010, 12, 3042-3045.
16. Formation of N-alkylpyrroles via Intermolecular Redox Amination- Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009, 131, 16626-16627. (Highlighted in Synform).
17. Mild Decarboxylative Allylation of Coumarins- Jana, R.; Trivedi, R.; Tunge, J. A.  Org. Lett. 2009, 11, 3434-3436.
18. A Homogeneous, Recyclable Rhodium(I) Catalyst for the Hydroarylation of Michael Acceptors- Jana, R.; Tunge, J. A. Org. Lett. 2009, 11, 971-974. (Developed a novel catalyst JanaPhos).
19. An Improved Procedure for the Three Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid- B. C. Ranu; Jana, R.; Sowmiah, S. J. Org. Chem. 2007, 72. 3152- 3154.
20. Catalysis by Ionic Liquid. A Green Protocol for the Stereoselective Debromination of vicinal- Dibromides by [pmIm]BF4 under Microwave Irradiation – Ranu, B. C.; Jana, R. J. Org. Chem. 2005, 70, 8621-8624.


  1. Polymer-supported Transition Metal Catalyst Complexes and Methods of Use- Tunge, J. A.; Subramaniam, B.; Fang, J.; Jana, R. U.S. Patent, No WO 2010057099.


Detail list of Publications upto June 2014 ==>> Click here


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Updated on 16th May, 2016
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