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Infectious Diseases & Immunology Division

Dr. Rukhsana Chowdhury

Senior Principal Scientist
PhD, Calcutta University,1989
Contact - rukhsana@iicb.res.in

Current Research Interest

1. Pathogenesis and Evolution of Vibrio cholerae

  • Modulation of virulence regulatory pathways by physico chemical parameters
  • Effect of host cell contact on bacterial gene expression and regulatory mechanisms
  • Emergence of the El Tor biotype

2. The gastric pathogen Helicobacter pylori

  • Host cell contact dependent modulation of virulence gene expression
  • Role of sRNAs

3. Correlation between the composition of the gastric microbiome and clinical  outcome of H. pylori infection 

4. Effect of tobacco chewing on the composition of the oral microbiota and role in oral cancer

Names of the group members including regular staff with designation and research fellows:

Research Fellows

Dr. Maitreyee Mandal   Research Associate (DBT)

Sreejana Ray                      Senior Research Fellow (CSIR)

Saurabh Bhattacharya    SRF Shyama Prasad Mukherjee Fellow (CSIR)

Chrantana Sengupta       Senior Research Fellow (CSIR)


List of important Publications:

  1. Baidya AK, Bhattacharya S, Chowdhury R. 2014 Role of the flagellar hook length control protein FliK and sigma-28 in cagA expression in gastric cell adhered Helicobacter pylori.  J. Infect Dis  (in press)
  2. Raghwan, Chowdhury R. 2014 Host Cell Contact Induces Fur-dependent Expression of Virulence Factors CagA and VacA in Helicobacter pylori. Helicobacter.  19:17-25. Selected for F1000 Prime
  3. Chakraborti S*, Bhattacharya S*, Chowdhury R1, Chakrabarti P1. 2013 The molecular basis of inactivation of metronidazole-resistant Helicobacter pylori using polyethyleneimine functionalized zinc oxide nanoparticles.  PLoS One. 2013  8(8):e70776 1Corresponding aauthors *Equal contribution
  4. Ray S*, Chatterjee E*, Chatterjee A, Paul K, and R. Chowdhury. 2011 A fadD mutant of Vibrio cholerae is impaired in the production of virulence factors and membrane localization of the virulence regulatory protein TcpP.      Infect Immun.  79:258-66.   * Equal contribution
  5. Pradhan S*, Baidya AK*, Ghosh A, Paul K,  and  R. Chowdhury. 2010  The El Tor        biotype of Vibrio cholerae exhibits a growth advantage in the stationary phase in   mixed cultures with the classical biotype.      J Bacteriol.    192 :955-63.  * Equal contribution
  6. Chatterjee A and R. Chowdhury 2008 Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat labile enterotoxin to GM1 receptor. Antimicrob. Agents  Chemother    52: 220-224
  7. Chatterjee A., P.K. Dutta and R. Chowdhury. 2007.  Effect of fatty acids and cholesterol present in bile on expression of virulence factors and motility of Vibrio cholerae  Infect. Immun. 75: 1946-1953
  8. Ghosh, A., K. Paul and R. Chowdhury 2006 Role of H-NS in colonization, motility and bile dependent repression of virulence gene expression in Vibrio cholerae. Infect. Immun. 74: 3060-3064
  9. Chatterjee, A., S. Chaudhuri, G. Saha, S. Gupta, and R. Chowdhury. 2004 Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae. J. Bacteriol. 188: 6809-6814
  10. Paul, K., A. Ghosh, N. Sengupta and R. Chowdhury. 2004 Competitive growth advantage of non-toxigenic mutants in the stationary phase in archival cultures of pathogenic Vibrio  cholerae strains.
    Infect. Immun. 72: 5478-5482
  11. Krishnan, H. H., A. Ghosh, K. Paul and R. Chowdhury. 2004. Effect of  anaerobiosis on expression of virulence factors in Vibrio cholerae.    Infect. Immun.  72: 3961-3967 

Detail list of Publications upto December'2014 ==>> Click here


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