Infectious Diseases & Immunology Division

Dr. Upasana Ray

Ramalingaswamy fellow

Ramanujan Fellow, Indian Institute of Technology (IIT), Kharagpur (2016-2017)
Post-doctoral Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States (2012-2015)
Research Associate, Indian Institute of Science (IISc), Bangalore (2011-2012)
PhD., IISc, Bangalore (2006-2011)

Contact - upasana.ray@iicb.res.in / ray.upasana@gmail.com

 

Awards and Honors

  1. Membership of Indian National Young Academy of Science (INYAS)-INSA
  2. Ramalingaswamy fellowship award, Department of Biotechnology (DBT) (2016)
  3. Full membership of OWSD (Organization for women in science in the developing world) (2016)
  4. Research support for INSA young scientist medal awardee, Indian national science academy (INSA) (2016)
  5. Ramanujan Fellowship award, Science an d Engineering Research Board (SERB-DST) (2015)
  6. INSA Medal for Young Scientists, Indian National Science Academy (INSA) (2015)
  7. Federal Technology Transfer Award, Center for Cancer research, National Institutes of Health (NIH) (2014)
  8. Fellows Award for Research Excellence, National Institutes of Health (NIH) (2013)
  9. Visiting Fellowship, National Cancer Institute (NCI), National Institutes of Health (NIH) (2012)
  10. Travel Award for the International Centre of Genetic Engineering and Biotechnology (ICGEB)-IUBMB workshop on ‘Human RNA Viruses’ held in New Delhi, India (2010).
  11. Best poster award in the “1st virology meeting” (IISc Centenary Symposium on Biology and Pathogenesis of viruses: Molecular Insights) at Indian Institute of Science, Bangalore (2009).
  12. Council of Scientific and Industrial Research (CSIR) Junior Research Fellowship (JRF) (2006).
  13. Credit certificate for International Competition for Schools (Mathematics) from The University of New South Wales (1996).

Current Research Interest

1. Understanding virus assembly process and exploring novel bio-molecular platforms for self assembly, displaying viral proteins (Virus like particles or VLPs). VLPs would be designed with an objective to make vaccine candidates or for drug delivery

2. Exploring virus mediated horizontal gene transfer and its possible implications.

3. Studying viral entry process and viral tropism

4.Dissecting molecular interactions between viral proteins and host cell with an aim to design antiviral candidates.

Currently, the focus of the laboratory is Dengue virus.

Group

This is a new laboratory and applications are welcome from candidates interested in pursuing PhD and post doctoral research. Candidates should have their own fellowships. Desirable skills: Experience in cloning and mutagenesis, cell culture, basic bioinformatics. For post-doctoral position a candidate must commit for at least one year.

 

List of Publications

Publications in journals

First Author

  1. Ray, U. 2016. Virus like nanoparticles: Display matters.Proceedings of Indian National Science Academy (DOI: 10.16943/ptinsa/2016/48580).
  2. Ray, U.,Cinque, P., Gerevini, S., Longo, V., Lazzarin, A., Schippling, S., Martin, R., Buck, C.B., and Pastrana, D.V. 2015. JC polyomavirus mutants escape antibody-mediated neutralization. Science Translational Medicine. 7(306):306ra151(PMID:26400912)
  3. Ray, U., Roy, C. L., Kumar, A. , Mani, P., Joseph, A. P., Sudha, G., Sarkar, D. P., Srinivasan, N., and Das, S. 2013. Inhibition of the interaction between NS3 protease and HCV IRES with a small peptide: A novel therapeutic strategy. Molecular Therapy (Nature Publishing Group). 21(1):57-67.(PMID:22910295)
  4. Ray, U.,Ray, P. S. and Das, S. 2012 Ribosome-RNA interaction: A potential target for developing antiviral against hepatitis C virus. Current Science. Vol 102; No. 3. (Review)
  5. Ray, U., and Das, S. 2011. Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus. Scientific Reports (Nature Publishing Group)1:1. (PMID:22355520)
  6. *Mondal, T., *Ray, U., Manna, A. K., Gupta, R., Roy, S., and Das, S. 2008. Structural determinant of human La protein critical for internal initiation of translation of hepatitis C virus RNA. Journal of Virology82:11927-38. (*joint first authors) (PMCID:18829760) (Cover page article).

Second Author

  1. Kumar, A., Manna, A. K., Ray, U., Mullick, R., Basu, G., Das, S. and Roy, S. 2014.Specific sequence of a beta-turn in human La protein may contribute to species specificity of Hepatitis C virus. Journalof Virology 88(8):4319-27 (PMID:24478427)
  2. 8. Pastrana, D. V., Ray, U., Magaldi, T. G., Schowalter, R., M., Cuburu, N., and Buck, C. B. 2013. BK polyomavirus genotypes represent distinct serotypes with distinct entry tropism. Journalof Virology 87(18):10105-13 (PMID:23843634)
  3. Kumar, A., Ray, U. and Das, S. 2013. Human La protein Interaction with GCAC near the initiator AUG enhances HCV RNA replication by Promoting Linkage Between 5'-and 3'- untranslated regions. Journalof Virology87(12):6713-26 (PMID:23552417)
  4. Manna, A. K., Kumar, A., Ray, U., Das, S., Basu, G. and Roy, S. 2013. A cyclic peptide mimic of an RNA recognition motif of human La protein is a potent inhibitor of hepatitis C virus. Antiviral Research97(3):223-226. (PMID:23291201)
  5. Ravikumar, Y. S., Ray, U., Nandhitha, M., Perween, A., Raja Naika, H., Khanna, N. and Das, S. 2011. Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source. Virus Research158:89-97. (PMID:21440018)

Patents filed/ technology transfer

1. Treating or Inhibiting JC polyomavirus infection and JC polyomavirus-associated progressive multifocal leukoencephalopathy. Christopher Buck, Upasana Ray, Diana Pastrana (US Application number: 61/919,043)

2. Compositions, method and formulations for peptide based inhibitors of Hepatitis C virus replication. Saumitra Das, Upasana Ray, Debi P. Sarkar, Chaitrali Laha Roy, N. Srinivasan. (Application number: 4033/CHE/2011 A)

3. Small antiviral peptides against Hepatitis C virus. Saumitra Das, Siddhartha Roy, Upasana Ray, Tanmoy Mondal, Asit Kumar Manna, Romi Gupta. (US Application number: 2009/0233868A1)

Book Chapters

1. Upasana Ray, Saumitra Das (2009) Role of Human La protein in Translation and Replication of Hepatitis C Virus. Mechanisms of Microbial Pathogenesis.TATA McGraw-Hill publication.

2. Upasana Ray, Chaitrali Laha Roy, Saumitra Das (2011) Viruses and our fight against them. UGC-sponsored national seminar on microbiology: development and challenges in basic and applied research (organized by department of microbiology, Ramakrishna Mission Vidyamandira, Belur Math in collaboration with Bose Institute, Kolkata)

Research Highlight/ Coverage

1. Therapeutic opportunity knocks (2015): Science (Vol. 349; Issue: 6255; page-1501)

2. Studies propose vaccination for troublemaking virus (2015): Multiple Sclerosis Discovery Forum

3. Closing “blind spots” in patients’ immune response to lethal brain infection (2015): EurekaAlert

4. Researchers work towards vaccination for PML(2015): MS UN Master Cylinder (Breaking News)

5. Possible JC virus vaccination offers important implications for MS treatment (2015): Multiple Sclerosis News Today

6. Hep C viral switch (2011): Nature India (doi:10.1038/nindia.2011.83)

 

Updated on 18th October, 2017


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