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Molecular & Human Genetics Division

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Dr.Debabrata Biswas

Wellcome-Trust DBT Intermediate Fellow
Principal Scientist, CSIR-Indian Institute of Chemical Biology
Associate Professor, Academy of Scientific and Innovative Research (AcSIR)
2014  Principal Scientist, CSIR-Indian Institute of Chemical Biology and
Associate Professor, AcSIR
2012-2014  DBT- Ramalingaswami Fellow, Indian Institute of Chemical Biology, Kolkata, India
2009 – 2012  Leukemia and Lymphoma Society Career Development Fellow, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, USA
2008 – 2009  Mary Jose and Henry Kravis Fellow, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, USA
2007 – 2008  Postdoctoral Fellow, Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, USA
2006 – 2007  Postdoctoral Fellow, Department of Pathology, University of Utah, Salt Lake City, Utah, USA
2001 – 2006  Graduate thesis research, Molecular Biology program, University of Utah, Salt Lake City, Utah, USA

 


Contact -
dbiswas@iicb.res.in / dbiswasslc@gmail.com

At the core, our research interest lies in understanding molecular mechanisms of eukaryotic transcriptional regulation. Various forms of human cancers (both hematopoietic as well as solid tumors) are associated with misregulation of transcriptional regulatory pathways. Thereby, a detailed understanding of molecular mechanisms of these regulatory pathways could lead towards designing various forms of targeted drugs for combating these human cancers.

Current Research Interest

  • Mechanistic understanding of transcriptional regulation by key factors that are directly involved in formation of various forms acute human leukemia.
  • Mechanistic understanding of epigenetic landscape changes and their implications in regulating various chromatin related events that are directly involved in formation of various forms of human cancers.
  • Mechanistic understanding of transcriptional regulation by recently described long non-coding(lnc) RNAs

Positions available: Those having an interest in Cancer Biology and related events and are willing to learn and work in this exciting field, are encouraged to apply. Candidates who have qualified for NET (CSIR/UGC) or any other forms of fellowships are encouraged to contact directly by email.
Postdoctoral positions are also available for the postdoctoral researchers. Those who have strong background of working on various chromatin-related projects and are interested working on transcriptional regulatory mechanisms, are encouraged to contact directly by email

Names of the group members including regular staff with designation and research fellows:
Staff: Fellow/RA

 

  1. Mahesh Barad, CSIR-JRF
  2. Dipika Yadav, CSIR-JRF
  3. Dheerendra Pratap Mall, DBT-JRF
  4. Nidhi Kumari,  UGC-JRF
  5. Koushik Ghosh,  CSIR-JRF
  6. Subham Basu,  UGC-JRF
  7. Abul Hassan, CSIR-JRF

List of important Publications:

  1. Geng H, Brennan S, Milne TA, Chen WY, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Müschen M, Paietta E, Elemento O, Melnick AM. Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia. Cancer Discov. 2012 Nov;2(11):1004-1023. Epub 2012 Oct 29.
  2. Akalin A, Garrett-Bakelman FE, Kormaksson M, Busuttil J, Zhang L, Khrebtukova I, Milne TA, Huang Y, Biswas D, Hess JL, Allis CD, Roeder RG, Valk PJ, Löwenberg B, Delwel R, Fernandez HF, Paietta E, Tallman MS, Schroth GP, Mason CE, Melnick A, Figueroa ME. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet. 2012;8(6):e1002781. Epub 2012 Jun 21.
  3. Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KS, Allis CD, Roeder RG. Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15751-6. Epub 2011 Sep 6.
  4. Biswas D *, Takahata S *, Stillman D. J., Different Genetic Functions for the Rpd3(L) and Rpd3(S) Complexes Suggest Competition Between NuA4 and Rpd3(S). Mol Cell Biol. 28:4445-58, (2008).
  5. Biswas D, Takahata S, Xin H, Dutta-Biswas R, Yu Y, Formosa T, Stillman D. J., A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae. Genetics. 178:649-59, (2008).
  6. Biswas D, Dutta-Biswas R, Stillman D. J., Chd1 and yFACT act in opposition in regulating transcription. Mol Cell Biol. 27:6279-87, (2007).  
  7. Biswas D, Dutta-Biswas R, Mitra D, Shibata Y,  Strahl B.D, Formosa T, Stillman D. J., Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. EMBO Journal. 25:4479-89, (2006). 
  8. Shivaprasad PV, Thomas M, Balamani V, Biswas D, Vanitharani R, Karthikeyan AS, Veluthambi K., Factors contributing to deletion within Mungbean yellow mosaic virus partial dimers in binary vectors used for agroinoculation. J Virol Methods. 137:72-81, (2006).
  9. Biswas D, Yu Y, Mitra D, Stillman D. J., Genetic Interactions Between Nhp6 and Gcn5 with Mot1 and the Ccr4-Not Complex that Regulate TBP binding in Saccharomyces cerevisiae. Genetics. 172:837-49, (2006).
  10. Biswas D, Yu Y, Prall M, Formosa T, Stillman DJ.,  The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol. 25:5812-22, (2005)
  11. Biswas D, Imbalzano AN, Eriksson P, Yu Y, Stillman DJ., Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex. Mol Cell Biol. 24:8312-21, (2004).
  12. Eriksson P, Biswas D, Yu Y, Stewart JM, Stillman DJ. TATA-binding protein mutants that are lethal in the absence of the Nhp6 high-mobility-group protein. Mol Cell Biol. 24:6419-29, (2004).

            (* equal contribution)

 

 

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