Structural Biology & Bio-Informatics Division

Dr. Chitra Dutta

PhD, Calcutta University,1984


Chief Scientist & Head

Current Research Interest

  • Computational analysis of microbial genome sequences with a view to study.
    • Trends and anomalies in nucleotide/amino acid usage patterns in eubacteria, archaea and viruses.
    • Codon adaptation in extremophiles.
    • Evolution of bacterial pathogenesis through gene loss/acquisition.
  • In silico characterization of the selection forces governing protein composition in human.
  • Clustering of protein families & taxonomic distribution of domains.
  • Development of novel software tools or algorithms for genome / proteome analysis.

Names of the group members including regular staff with designation and research fellows


  1. Dr.(Ms) Subhagata Ghosh, Senior Technical Officer-3
  2. Dr.(Mrs.) Aparna Laskar , Senior Technical Officer-3


Fellows / RA

  1. Ms. Munmun Sarkar, JRF, CSIR-GATE

List of important Publications

  1. Gupta VK, Chaudhari NM, Iskepalli S, Dutta C.
    Divergences in gene repertoire among the reference Prevotella genomes derived from distinct body sites of human. BMC Genomics 2015; (in press)
  2. Saha, SK, Goswami A, Dutta C.
    Association of purine asymmetry, strand-biased gene distribution and PolC within Firmicutes and beyond: a new appraisal. BMC Genomics 2014;15:430
  3. Roy Chowdhury A, Dutta C
    A pursuit of lineage-specific and niche-specific proteome features in the world of archaea. BMC Genomics 2012; 13: 236.
  4. Pradhan S, Sengupta M, Dutta A, Bhattacharyya K, Bag SK, Dutta C, Ray K.
    Indian genetic disease database. Nucl. Acids Res. 2011; 39(suppl 1): D933-D938
  5. Paul S, Bag SK, Das S, Harvill ET, Dutta C.
    Molecular signature of hypersaline adaptation Insights from genome and proteome composition of prokaryotes Genome Biol. 2008 9(4), R63
  6. Bag SK, Paul S, Ghosh S, Dutta C
    Reverse polarization in amino acid anducleotide substitution patterns between human-mouse orthologs of two compositional extrema. DNA Res. 2007; 14: 141-54.
  7. Das S, Paul S, Bag S. K., Dutta C.
    Analysis of Nanoarchaeum equitans genome and proteome composition: Indications for hyperthermophilic and parasitic adaptation. BMC Genomics. 2006; 7:186
  8. Chanda I, Pan A, Dutta C.
    Proteome composition in Plasmodium falciparum: Higher usage of GC-rich nonsynonymous codons in highly expressed genes.
    J Mol Evol. 2005; 61(4):513-23.
  9. Basu S, Pan A, Dutta C, Das J.
    Chaos game representation of proteins. J Mol Graph Model. 1997;15(5):279-89
  10. Dutta C, Das J.
    Mathematical characterization of Chaos Game Representation. New algorithms for nucleotide sequence analysis. J Mol Biol. 1992 ; 228(3):715-9.
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Updated on 6th March 2015

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