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Structural Biology & Bio-Informatics Division

Dr. Sujoy Mukherjee

Ramanujan Fellow

* Postdoctoral Fellow (2008 – 2011)  – The Ohio State University
* PhD (2008) – University of Illinois, Urbana-Champaign in Biophysics &  Computational Biology
* B-Tech (2003) – I.I.T. Kharagpur in Biotechnology & Biochemical Engineering.

Contact :- mukherjee.lab@gmail.com (preferred)/sujoy@csiriicb.in

Phone : +9133-24995715

Personal homepage: https://sites.google.com/site/mukherjeelab/ (please visit for most up-to-date information on our research, publications and vacancies)

Current Research Interest

The overall goal of this lab is to apply solution and solid-state Nuclear Magnetic Resonance (NMR) spectroscopy to probe the structure and dynamics of proteins undergoing conversion to amyloid fibrils as well as membrane proteins. Some of the ongoing as well as recently initiated research topics include: -

  • Solution NMR studies of pre-amyloidogenic states of proteins along the aggregation pathway.
  • Role of structure and dynamics of macromolecular systems responsible for cancer (p53), tuberculosis and other diseases.
  • Cloning, expression, purification and structural studies of G-protein coupled receptor (GPCR).

Names of the group members including regular staff with designation and research fellows :

Research Fellows

  1. Mr. Gopa Mahesh (SRF, DST INSPIRE FELLOW)
  2. Mr. Jitendra K Das (SRF, CSIR)
  3. Mr. Shyam S. Mall (SRF, ICMR)
  4. Ms. Juhi A. Rasquinha (SRF, UGC).
  5. Mr Aritra Bej (JRF, DST Inspire Fellow)

Positions Available :

Applicants are requested to visit the group website for most up-to-date information on vacancies and research activities. You may go through the publications (below) for a clear understanding of research work in our group.

In general, students from any branch of science and engineering with NET (CSIR/UGC) are welcome to apply by sending email mukherjee.lab AT gmail DOT com. Fellows having an interest in physical chemistry and structural biology, including the use of computational tools, are especially encouraged to apply

One (1) position is open for a research assistant to perform postdoctoral research in NMR. Candidates with previous experience in solution or solid-state NMR are encouraged to apply.

List of important Publications:

  1. Das, J. K.; Mall, S. S.; Bej, A.; Mukherjee, S., Conformational Flexibility Tunes the Propensity of Transthyretin to Form Fibrils Through Non-Native Intermediate States. Angew Chem Int Ed (Engl) (Early View, http://onlinelibrary.wiley.com/doi/10.1002/anie.201407323/abstract)

    PI’s publications before IICB

  2. Mukherjee, S.; Pondaven, S. P.; Jaroniec, C. P., Conformational Flexibility of a Human Immunoglobulin Light Chain Variable Domain by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy: Implications for Protein Misfolding and Amyloid Assembly Biochemistry 2011, 50, 5845-5857.
  3. Mukherjee, S.; Huang, C.; Guerra, F.; Wang, K.; Oldfield, E., Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model. J. Am. Chem. Soc. 2009, 131, (24), 8374-8375.
  4. Mukherjee, S.; Song, Y.; Oldfield, E., NMR Investigations of the Static and Dynamic Structures of Bisphosphonates on Bone: a Molecular Model. J. Am. Chem. Soc.2008, 130, (4), 1264-1273.
  5. Mao, J. H.; Mukherjee, S.; Zhang, Y.; Cao, R.; Sanders, J. M.; Song, Y. C.; Zhang, Y. H.; Meints, G. A.; Gao, Y. G.; Mukkamala, D.; Hudock, M. P.; Oldfield, E., Solid-state NMR, crystallographic, and computational investigation of Bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes. J. Am. Chem. Soc. 2006, 128, (45), 14485-1449.
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Updated on 8th October 2014
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