Amit Kumar Srivastava , Ph.D.

Scientist
Cancer Biology & Inflammatory Disorder
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Research Interest

  • Exploring drug resistance mechanisms in cancer stem cells
  • Mechanisms and targeting of cancer stem cell plasticity
  • DNA damage and repair
  • miRNAs and their role in Cancer
  • Nanoparticles mediated drug-delivery

Credentials

  • Ramalingaswami Fellow (April 2018-present)
  • Scientist, (October 2017-April 9, 2018) CSIR-North East Institute of Science and Technology (CSIR-NEIST), Jorhat
  • Post-Doctoral Fellow (July 2013-September 2017), The Ohio State University, Columbus, Ohio, USA
  • PhD (2008-2013) CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow

Honours & Awards

  1. Ramalingaswami fellowship award, Department of Biotechnology (DBT) (2017)
  2. Ramanujan Fellowship award, Science and Engineering Research Board (SERB-DST) (2017)
  3. Attended Nobel Prize series 2018 at RashtrapatiBhawan
  4. Best Postdoc Poster award by The Ohio State University, USA 2016
  5. Pelotonia Postdoctoral Fellowship 2014 by The Ohio State University, USA
  6. Young Scientist Award in XXXII Annual Meeting of Society of Toxicology (STOX), 2012, India.
  7. Seth Roop Lal Aggrawal Gold medal by Society of Toxicology (STOX), 2012, India.
  8. Best paper award by Environmental Mutagen Society of India (EMSI), 2010.
  9. Joint CSIR-UGC Junior Research Fellowship: CSIR New Delhi, India (2007)
  10. Qualified Graduate Aptitude Test in Engineering (GATE), 2006

Patents & Publications

  1. Cui T*, Srivastava AK*, Han C, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell E, Yang SM, Maloney D, Zheng Y, Wani A, Wu D and Wang Qi-en. DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1. Cell death and disease 2018 (*equal contribution) in press.
  2. Srivastava AK*, Rizvi A*, Cui T, Han C, Banerjee A, Naseem I, Zheng Y, Wani A and Wang Qi-en. Depleting ovarian cancer stem cells with calcitriol. Oncotarget16;9(18):14481-14491, 2018. (*equal contribution). PMID: 29581858
  3. Srivastava AK*, Mishra S* and Shukla Y. Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes via inhibition of NF-κB mediated oxidative stress Phytomedicine 23(7):714-24 2016 (*equal contribution) PMID:27235710.
  4. Zou N, Xie G, Cui T, Srivastava AK, Qu M, Yang L, Wei S, Zheng Y, Wang QE. DDB2 increases radioresistance of NSCLC cells by enhancing DNA damage responses. Tumour Biol. 2016 Oct;37(10):14183-14191. PMID: 27553023
  5. Mishra S, Rai G, Srivastava AK, Singh AK, Ahmad A, Suman S, Singh M, Reddy MKR, Tiwari BN, Gupta P, Gaur VK, Srivastava VK, Kumar V, Shukla Y. miR-34a Overexpression Induces Senescence Associated Secretory Phenotypes in Doxorubicin induced Pseudo-Senescent Triple Negative Breast Cancer cells via SOCS4-IL6-STAT3 axis. American Journal of Cancer Research 2017 (in press)
  6. Srivastava AK, Han C, Zhao R, Cui T, Dai Y, Mao C, Zhao W, Yu J and Wang Qi-en. Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells in Proceedings of the National Academy of Sciences U.S.A.   7;112(14):4411-6, 2015. PMID: 25831546
  7. Han C, Srivastava AK, Cui T, Wang QE, Wani AA. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 37(2):129-138 2015. PMID: 26717995.
  8. Qu MH, Han C, Srivastava AK, Cui T, Zou N, Gao ZQ, Wang QE. miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells. Tumour Biol.37(4):5645-51 2015. PMID: 26581907
  9. Mishra S, Srivastava AK, Suman S and Shukla Y. Circulating miRNAs revealed as surrogate molecular signatures for the early detection of breast cancer in Cancer letter. 1; 369(1):67-75, 2015, PMID: 26276721.
  10. Zhao R, Han C, Zhang X, He J, Srivastava AK and Wani A and Wang Qi-en,. DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L. Nucleic Acid Research. 18; 43(16):7838-49, 2015. PMID: 26130719.
  11. Cui T, Srivastava AK, Han C, Yang L, Zhao R, Zou N, Qu M, Duan W, Zhang X and Wang Qi-en. XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. Oncotarget. 30;6(12):10060-72, 2015. PMID: 25871391
  12. Jiang Q, Pentz K, Zhu Q, Wang Qi-en, He J, Srivastava AK and Wani A. USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability. Oncogene. 3;34(36):4791-6, 2014, PMID: 25435364.
  13. Bhatnagar P, Patnaik S, Srivastava AK, Mudiam KRM, Shukla Y, Panda AK, Pant AB, Kumar P, and Gupta KC. Anti-Cancer Activity of Bromelain Nanoparticles by Oral Administration. Journal of Biomedical Nanotechnology 10(12):3558-75, 2014. PMID: 26000370
  14. Han C, Zhao R, Liu X, Srivastava AK, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang Qi-en. DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. Molecular Cancer Research. 12(5):784-94, 2014. PMID: 24574518.
  15. Srivastava AK, Singh M, Bhatnagar P, Mishra S, Kumar P, Shukla Y, Gupta KC, Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage. International Journal of Nanomedicine. 8:1451-62. PMID: 23717041
  16. Srivastava AK, Srivastava PK, Khedhairy AA, Musarrat J, Shukla Y. Allethrin induced genotoxicity and oxidative stress in Swiss albino mice. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 30;747(1):22-8, 2012. PMID: 22475934.
  17. Srivastava AK, Ali W, Singh R, Bhui K, Tyagi S, Srivastava PK, Khedhairy AA, Musarrat J, Shukla Y. Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes. Life Sciences. 90(21-22):815-24, 2012. PMID: 22289270.
  18. George J,Srivastava AK, Singh R, Shukla Y. Cypermethrin exposure leads to regulation of proteins expression involved in neoplastic transformation in mouse skin. Proteomics. 11(22):4411-21, 2011. PMID: 21919204
  19. George J, Singh M, Srivastava AK, Bhui K, Roy P, Chaturvedi PK, Shukla Y. Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One. 6(8): e23395, 2011. PMID: 21887248
  20. George J, Singh M, Srivastava AK, Bhui K, Shukla Y. Synergistic growth inhibition of mouse skin tumors by pomegranate fruit extract and diallyl sulfide: evidence for inhibition of activated MAPKs/NF-ĸB and reduced cell proliferation. Food and Chemical Toxicology. 49(7):1511-2, 2011. PMID: 21443920
  21. Bhui K, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y.Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis. Molecular Carcinogensis. 51(3):231-43, 2011. PMID: 21432909