Indu Bhusan Deb , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry

Research Interest

  • Our research interests lie in the development of new catalytic system using transition metal for C-H/C-X bond functionalization and development of synthetic strategy employing C-H/C-X bond activation chemistry for the synthesis of bioactive small molecules.
  • Asymmetric catalysis using newly designed ligand and catalyst.


2008: Ph.D. Indian Institute of Technology Bombay (IIT Bombay), Mumbai, India with professor I. N. N. Namboothiri)
2008-2010: Post Doctoral Research Associate, Rutgers – The State University of New Jersey, New Jersey, USA with professor Daniel Seidel)
2011-2013: Post Doctoral Research Associate, Nanyang Technological University, Singapore with professor NAOHIKO Yoshikai)
2013: Research Investigator (April, 2013-Dec, 2013), Bristol Mayer Squibb –Biocon Research Center, Bangalore
2014- Present: Senior Scientist, CSIR-Indian Institute of Chemical Biology, Kolkata

Patents & Publications

  1. Patents“Cobalt-Catalyzed Directed sp2 C-H Acetoxylation of Arenes Employing Mn(OAc)3. 2H2O as Acetoxy Source”. Writhabrata Sarkar, Arup Bhowmik, † Aniket Mishra, † Tripta Kumari Vats and Indubhusan Deb* Advanced Synthesis & Catalysis 2018 (in press) (contributed equally).

  1. “Rhodium-Catalyzed Direct and Selective ortho C-H Chalcogenation of N-(Hetero)‌aryl-7-azaindoles” Tripta Kumari Vats,† Aniket Mishra and Indubhusan Deb* Advanced Synthesis & Catalysis 2018 (in press) (contributed equally).

  1. “Ir(III)/MPAA-Catalyzed Mild And Selective C-H Amidation Of N-sulfonyl ketimines: An Access To Benzosultam Fused Quinazolines/Quinazolinones”Aniket Mishra,* Upasana Mukherjee, Tripta Kumari Vats, Mahesh P. Nair, Arindam Das and Indubhusan DebJournal of Organic Chemistry  2018 (in press) DOI: 10.1021/acs.joc.8b00125

  1. “Rhodium Catalyzed sp2 C-H Acetoxylation of N-Aryl Azaindoles/ N-Heteroaryl Indolines” 
     Aniket Mishra, Tripta Kumari Vats, Mahesh P. Nair, Arindam Das and Indubhusan DebJournal of  Organic Chemistry  2017,  82, 12406-12415 (contributed equally).

  1. “Ruthenium-Catalyzed Direct and Selective C–H Cyanation of N-(Hetero)aryl-7-azaindoles” Aniket Mishra, Tripta Kumari Vats and Indubhusan DebJournal of Organic Chemistry   81, 6525-6534 [Top 5 most read articles in July, 2016].

  1. Palladium-Catalyzed Oxidative Cyclization for the Synthesis of Indolyl/pyrrolyl-3-phosphonates” Aniket Mishra and Indubhusan DebAdvanced Synthesis & Catalysis 2016, 358, 2267-2272. [Top 15 most accessed articles in June, 2016].


  1. Facile Access to Ring-Fused Aminals via Direct α-Amination of Secondary Amines with ortho-Aminobenzaldehydes. Synthesis of Vasicine, Deoxyva-sicine, Deoxyvasicinone, Mackinazolinone and Ruteacarpine” Richers, M. T.; DebIndubhusan, Platonova, A. Y.; Zhang, C.: Seidel, Daniel. Synthesis 2013, 1730-1748.
  2. Conjugate Addition of Curcumins to Chalcones and Azodicarboxylates” Ayyagari, N.; Mehta A.; Deb, Indubhusan;Mobin, S. M.; Namboothiri, I. N. N. Tetrahedron 2013, 695973-5980.
  3. Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime” Deb, Indubhusan, Yoshikai,  Org. Lett. 201315, 4254-4257.
  4. Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones Wei, Ye; Deb, Indubhusan, Yoshikai,  J. Am. Chem. Soc. 2012134, 1201-1204.  [Highlighted in SYNFACTS 2012 and Angew Chem. Int Edu. 2013]
  5. Redox-Neutral Indole Annulation Cascades” Haibach, M. C.; DebIndubhusan; De, C. K.; Seidel, Daniel Am. Chem. Soc. 2011133, 2100-2103[Top 20 most downloaded articles in Feb, 2011 and Highlighted in SYNFACTS 2011, 440]
  6. Redox Isomerization via Azomethine Ylide Intermediates: N-Alkyl Indoles from Indolines and Aldehydes” DebIndubhusan; Das, D.; Seidel, Daniel . Lett. 201113, 812-815.
  7. Decarboxylative Formation of N-Alkyl Pyrroles from 4-Hydroxyproline” DebIndubhusan; Coiro, D.; Seidel, Daniel. Commun. 2011, 47, 6473-6475.
  8. Retro-Claisen Condensation vs Pyrrole Formation in Reactions of Amines and 1,3-Diketones” DebIndubhusan; Seidel, Daniel. Tetrahedron Lett201051, 2945-2947.
  9. Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines” Murarka, S.; DebIndubhusan; Zhang, C.; Seidel, Daniel. Am. Chem. Soc. 2009131, 13226-13227. [Highlighted in SYNFORM 2009/09 as well as SYNFACTS 2009(12), 352].
  10. Morita-Baylis- Hillman Reactions Between Conjugated Nitroalkenes or Nitrodienes and Carbonyl Compounds” Deb, Indubhusan; Shanbhag, P.; Mobin, S. M.; Namboothiri, I. N. N. EurJOrgChem. 2009, 4091-4101.
  11. Synthesis of Benzo-Fused Medium Ring Cyclic Ethers via Michael Addition-Ring Closing Metathesis Strategy Involving Nitroaliphatic Compounds” Deb, Indubhusan; John, S.; Namboothiri, I. N. N. Tetrahedron 2007, 63, 11991-11997.
  12. Hydroxyalkylation of Conjugated Nitroalkenes with Activated Nonenolizable Carbonyl Compounds” Deb, Indubhusan; Dadwal, M.; S. M Mobin; Namboothiri, I. N. N. Lett. 2006, 8, 1201-1204.
  1. Novel Anticancer Hydrazinoderivatives of Curcuminand Process for Preparation thereof” Namboothiri, I. N. N; Panda, D.; Deb, Indubhusan; Mehta, A.; Wardhan, V.PATENT No: IN-2008MU01568(1568/MUM/2008 dated 23/07/2008).