Ranjan Jana , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry

Research Interest

  • Design and development of novel ligands for the metal-catalyzed enantioselective synthesis of medicinal scaffolds.
  • Identification of highly selective kinase inhibitors via late-stage C-H activation/ functionalization of heterocycles.
  • Photo-affinity and activity based protein profiling for the identification of biological target of small molecules.
  • Development of radiopharmaceuticals for PET imaging for the early detection of breast cancer and neurodegenerative diseases.
  • Exploring biocompatiblechemical reactivity for posttranslational modifications (PTMs) of proteins. 


Ramanujan Fellow
Ph.D (2007) Organic Chemistry, Indian Association for the Cultivation of Science (IACS), Kolkata with Prof. B. C. Ranu
Postdoctoral Research (2007-2008) Bar-Ilan University, Israel with Prof. S. Braverman
Postdoctoral Research (2008-2010) University of Kansas, USA with Prof. J. A. Tunge
Postdoctoral Research (2010-2012) University of Utah, USA with Prof. M. S. Sigman

Patents & Publications

  • Exceedingly Fast, Direct Access to Dihydroisoquinolino[1,2-b]quinazolinones through a Ruthenium(II)-Catalyzed Redox-Neutral C–H Allylation/Hydroamination Cascade-Bairy, G.; Das, S.; Begam, H. M.; Jana, R. Org. Lett2018ASAP.

  • Palladium-Catalyzed Ortho C−H Arylation of Aniline Carbamates with Diazonium Salts under Mild Conditions: Expedient Synthesis of Carbazole Alkaloids- Arghya Polley, A.; Varalaxmi, K.; Jana, R. ACS Omega20183, 14503-14516.

  • Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N, or O-Difluoromethylation, N-Ethylation and S-(ethoxycarbonyl) difluoromethylation- Polley, A.; Bairy, G.; Das, P.; Jana, R. Adv. Synth. Catal2018360, 416-4167.

  • Sterically Controlled Ru(II)-Catalyzed Divergent Synthesis of 2-Methylindoles and Indolines through a C–H Allylation/Cyclization Cascade- Manna, M. K.; Bairy, G.; Jana, R. J. Org. Chem2018, ASAP.

  • CuI/AgI-Promoted Decarboxylative Alkynylation of ortho-Nitro Benzoic Acids- Hossian, A.; Manna, K.; Das, P.; Jana, R. ChemistrySelect20183, 4315-4318.

  • Ligand-Promoted γ‑C(sp3)-H Arylation and Unsymmetrical Diarylation to Access Unnatural Amino Acid Derivatives- Das, S.; Bairy, G.; Jana, R. Org. Lett. 2018, 20, 2667–2671.

  • A General Copper/Manganese Cocatalyzed C-H Selenation of Arenes, Heteroarenes, and Alkenes under Air- Singh, B. K.; Bairy, G.; Jana, R, ChemistrySelect, 2017, 2, 9227-9232.


  • Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature-Manna, M. K.; Bairy, G.; Jana, R, Org. Biomol. Chem. 2017, 15, 5899-5903.

  • Palladium-catalyzed decarboxylative, decarbonylative and dehydrogenative C(sp2)-H acylation at room temperature- Hossian, A.; Manna, M. K.; Manna, K.; Jana, R, Org. Biomol. Chem. 2017, 15, 6592-6603.

  • Ruthenium(II)-Catalyzed Intermolecular Synthesis of 2-Arylindolines through C-H Activation/Oxidative Cyclization Cascade- Manna, M. K.; Bhunia, S. K.; Jana, R Chem. Commun. 2017, 53, 6906-6909.

  • Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement- Hossian, A.; Jana, R. Org. Biomol. Chem. 2016, 14, 9768-9779.

  • Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines- Singh, B. K.; Polley, A.; Jana, R, J. Org. Chem. 2016, 81, 4295-4303.

  • Substrate-Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature- Hossian, A.; Bhunia, S. K.; Jana, R, J. Org. Chem. 2016, 81, 2521-2533.

  • A Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers- Singh, B. K.; Jana, R, J. Org. Chem. 2016, 81, 831-841.

  • Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade- Bhunia, S. K.; Polley, A.; Natarajan, R.; Jana, R, Chem.- Eur. J. 2015, 21, 16786-16791.

  • Merging C-H Activation and Alkene Difunctionalization at Room Temperature: A Palladium-Catalyzed Divergent Synthesis of Indoles and Indolines- Manna, M. K.; Hossian, A.; Jana, R. Org. Lett. 2015, 17, 672-675.

  • Chemo-, regio-, and stereoselectiveHeck–Matsuda arylation of allylic alcohols under mild conditions Chaudhari, T. Y.; Hossian, A.; Manna, M. K.; Jana, R. Org. Biomol. Chem. 2015, 13, 4841-4845.

  • Palladium(0)-Catalyzed Intramolecular Decarboxylative Allylation of ortho Nitrobenzoic Esters- Hossian, A.; Singha, S.; Jana, R, Org. Lett. 2014, 16, 3934-3937.

  • Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity-Braverman, S.; Cherkinsky, M.; Kalendar, Y.; Jana, R.; Sprecher, M.; Goldberg, I. Synthesis2014, 46, 119-125.
  • The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress-Vaden R. M.; Gligorich K. M.; Jana R.; Sigman M. S; Welm B. E. Breast Cancer Res.2014, 16, 472.
  • Pd(0)-Catalyzed 1,1-Diarylation of Ethylene and Allylic Carbonates- Saini, V.;  Liao, L.; Wang, Q.; Jana, R. Sigman, M. S. Org. Lett201315, 5008-5011.
  • Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives- Jana, R.; Pathak, T. P.; Jensen, K. H.; Sigman, M. S. Org. Lett. 201214, 4074-4077.
  • Migratory Decarboxylative Coupling of Coumarins: Synthetic and Mechanistic Aspects- Jana, R.; Partridge, J. J.; Tunge, J. A.  Angew. Chem. Int. Ed201150, 5157-5161.
  • A Palladium-Catalyzed Three Component Cross-Coupling of Conjugated Dienes or Terminal Alkenes with Vinyl Triflates and Boronic Acids- Liao, L.; Jana, R.; Urkalan, K. B.; Sigman, M. S. J. Am. Chem. Soc.2011133, 5784-5787.
  • Advances in Transition Metal (Pd, Ni, Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners- Jana, R.; Pathak, T. P.; Sigman, M. S. Chem. Rev. 2011111, 1417-1492. (The most read article in 2011).
  • Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation- Chattopadhyay, K.; Jana, R.; Day, V.; Douglas, J.; Tunge, J. A.  Org. Lett. 201012, 3042-3045.
  • Formation of N-alkylpyrroles via Intermolecular Redox Amination- Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009131, 16626-16627. (Highlighted in Synform).
  • Mild Decarboxylative Allylation of Coumarins- Jana, R.; Trivedi, R.; Tunge, J. A.  Org. Lett. 200911, 3434-3436.
  • A Homogeneous, Recyclable Rhodium(I) Catalyst for the Hydroarylation of Michael Acceptors- Jana, R.; Tunge, J. A. Org. Lett. 200911, 971-974. (Developed a novel catalyst JanaPhos).
  • An Improved Procedure for the Three Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid- B. C. Ranu; Jana, R.; Sowmiah, S. J. Org. Chem200772. 3152- 3154.
  • Catalysis by Ionic Liquid. A Green Protocol for the Stereoselective Debromination of vicinal– Dibromides by [pmIm]BF4 under Microwave Irradiation – Ranu, B. C.; Jana, RJ. Org. Chem. 200570, 8621-8624.
  1. Polymer-supported Transition Metal Catalyst Complexes and Methods of Use- Tunge, J. A.; Subramaniam, B.; Fang, J.; Jana, R. U.S. Patent, No WO 2010057099.