Subrata Adak , Ph.D.

Principal Scientist
Structural Biology & Bioinformatics
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Research Interest

  • The biochemistry of metalloproteins in relation to structure-function relationship and molecular mechanism of catalysis.
  • Oxidative stress responses in Leishmania.

Credentials

PhD, Jadavpur University, 1997 
Fellow of American Heart Association, USA, 2000 
Raman Research Fellow under CSIR, India, 2009-10

Patents & Publications

  1. Roy J, Sen Santara S, Adhikari A, Mukherjee A, Adak S. Control of catalysis in globin coupled adenylate cyclase by a globin-B domain. Arch Biochem Biophys. 2015 Aug 1;579:85-90. doi: 10.1016/j.abb.2015.06.007. Epub 2015 Jun 18.
  2. Dolai, S., and Adak, S. Endoplasmic reticulum stress responses in Leishmania (2014) Mol. Biochem. Parasitol. 197, 1-8.
  3. Roy, J., Sen Santara, S., Bose, M., Mukherjee, S., Saha, R., and Adak, S. The ferrous-dioxy complex of Leishmania major globin coupled heme containing adenylate cyclase: The role of proximal histidine on its stability. (2014) Biochim. Biophys. Acta. 1844, 615-622
  4. Saha, R., Bose, M., Santara, S. S., Roy, J. and Adak, S. Identification of proximal and distal axial ligands in Leishmania major pseudoperoxidase (2013) Biochemistry 52, 8878−8887.
  5. Santara, S. S., Roy, J. Mukherjee, S., Bose, M., Saha, R., and Adak, S. Globin coupled heme containing oxygen sensor soluble adenylate cyclase in Leishmania prevents cell death during hypoxia (2013) Proc. Natl. Acad. Sci. U.S.A. 110, 16790–16795
  6. Adak, S. and Pal, S.: Ascorbate peroxidase acts as a novel determiner of redox homeostasis in Leishmania. (2013) Antioxid Redox Signal. 19, 746-754
  7. Saha, R., Bose, M., Santara, S. S., Roy, J. Yadav, R.K., and Adak, S. Effect of distal His mutation on the peroxynitrite reactivity of Leishmania major peroxidase (2013) Biochim. Biophys. Acta. 1834, 2057-2063
  8. Saha, R., Bose, M. and Adak, S. Mutation of Val90 to His in the pseudoperoxidase from Leishmania major enhances peroxidase activity (2013) Biochim. Biophys. Acta. 1834, 651-657
  9. Mukherjee, S., Santara, S. S., Das, S., Bose, M., Roy, J. and Adak, S. NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. (2012) J. Biol. Chem. 287, 34992-35003
  10. Bose, M., Saha, R., Santara, S. S., Mukherjee, S., Roy, J. and Adak, S. Protection against peroxynitrite by pseudoperoxidase from Leishmania major. (2012) Free. Radic. Biol. Med. 53, 1819–1828
  11. Pal, S., Yadav, R.K. and Adak S.: Role of K+ binding residues in stabilization of heme spin state of Leishmania major peroxidase. (2012) Biochim. Biophys. Acta. 1824, 1002–1007
  12. Dolai, S., Pal, S., Yadav, R.K. and Adak S. Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism (2011) J. Biol. Chem. 286, 13638-13646
  13. Yadav, R.K., Pal, S., Dolai, S. and Adak S.: Role of proximal methionine residues in Leishmania major peroxidase. (2011) Arch. Biochem. Biophys. 515, 21–27. Cover page article.