Surajit Ghosh, Ph.D.

Principal Scientist
Organic & Medicinal Chemistry
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Research Focus

1. Chemical Neuroscience (Neurogenesis, Neuroprotection, Traumatic Brain Injury, Therapeutics for Alzheimer's Diseases); 2. Biochemistry and Chemical Biology (Cell Penetrating Peptide, Modulator for Microtubule Function, ROS & Stem Cells); 3. iReconstitution of Biocompatible Platform

Research Interest

Microtubule is one of the key cytoskeleton components in the eukaryotic cell and plays crucial role in cell division, cell proliferation, signal transduction and function of neurons. Therefore, this filament has been the key target for the development of anticancer drugs as well as neuroprotective agents. Our research focuses on the development of chemical modulators targeting microtubule in the context of both cancer and neurodegenerative disease. Highlight of our contributions in the above-mentioned areas are summarized below:

1. Chemical Neuroscience:

i. In the area of chemical neuroscience, we have computationally designed an interesting library consisting of ~500 peptides. From this library, we screened around 20 peptides using computational and various in vitro experiments. Currently, we found few peptides with excellent neuroprotective activities; we have filed for US patent for one of the peptides. Other peptides are in the process of patenting. Interestingly, in order to overcome the potential proteolytic degradation of peptides in vivo, we have designed peptoids based on these lead peptides. In fact, these lead peptoids are showing excellent neuroprotection (Unpublished Data). Further, we are now designing small molecules from those lead peptides and peptoids. Overall, in this chemical neuroscience area, we have already few lead molecules, having high translational potential; some of the results have already been published in high visibility journals. [Ref: Mondal et al., ACS Chem. Neurosci., 2018, Pal et al. Chem. Sci. 2017, Biswas et al., ACS Chem Neuroscience, 2015; Biswas et al., Chem. Commun.  2014, Ghosh et al., US patent filed; Ghosh et al., PCT patent Filed; Ghosh et al., PCT patent Filed; Saha et al., Chem. Commun. 2013, Saha et al., Chem. Commun. 2015].

ii. Recently, we developed an easy and efficient strategy to culture cortical and hippocampal primary neurons from the E14-E16 embryo of Sprague−Dawley rat. This generates spontaneous neurospheres within 6-7 days of primary neuron culture of E14-E16 embryo. It further proliferates and forms radial glia-like structures, which are known to be the primary neural progenitor cells that differentiate into neurons, astrocytes, and oligodendrocytes. Interestingly, neurospheres lead to the formation of large projection neurons and radial glia, which mimic the early stage of cortical development in an in vivo system. Overall, this new, facile, strategic mixed primary neuron culture method offers a potential platform for understanding the effect of neurochemical modulators, which has tremendous future implications in the screening of neurotherapeutics. This work has already published in the ACS Chemical Neuroscience, 2018 and highlighted in the front cover of the issue.

iii. In the area of traumatic brain injury, we have developed an injectable hydrogel with acetylcholine-functionalized graphene oxide and poly(acrylic acid). Results revealed that this hydrogel is non-cytotoxic, promotes neurite outgrowth, stabilizes microtubule networks, and enhances the expression of some key neural markers in rat cortical primary neurons. Further, this hydrogel exhibits significant potential in neuro-regeneration and also promotes fast recovery of the sham injured mice brain. Moreover, we found significant enhancement of reactive astrocytes in the hippocampal dentate gyrus region of the sham injured brain, indicating its excellent potential in neural repair of the damaged brain. Finally, above results clearly indicate that this neuro-regenerative hydrogel is highly capable of maintaining the cholinergic balance through local release of acetylcholine in the injured brain, which is crucial for brain repair. This work has already published in the ACS Chemical Neuroscience, 2018.

2. Biochemistry and Chemical Biology:

i. Recently, we tried to understand the exact role of a tetrapeptide “Glu-Thr-Trp-Trp” (ETWW) derived from a long CPP “Pep1”. It is a top-down approach to show how spatial positions of two tryptophans regulate the cellular entry and nuclear localization. This leads to the discovery of a short non-toxic tetrapeptides with excellent potential of cell penetration and nuclear localization. Through various experimental techniques, we showed that this CPP enters into the cancer cell following endocytic pathway and binds at major groove of nuclear DNA, where successive tryptophans plays major role. Subsequently, we showed that it is not a P-gp substrate and non-toxic to PC12 derived neurons, suggesting its excellent potential as CPP. Furthermore, its potential as CPP has been validated in stem cell like multi-cellular 3D cell culture (spheroid) and in in vivo mice model. This study provides major fundamental insights about the positional importance of tryptophan and opens new avenues towards development of next generation CPP and major groove specific anticancer drugs. (Bhunia et. al. J. Am. Chem. Soc, 2018, 140, 1697-1714)

ii. In the area of modulation of tubulin/microtubule structure and function, using in vitro assays, 2D and 3D-Spheroid cell culture-based assays and in vivo mice model, we developed peptides and various small molecules for controlling microtubule dynamics. Our work has been published in top international journals in chemical biology area. [Ref: Jana et al. Langmuir 2018, Mahapatra et al., Adv. Health Care Mater. 2017, Jana et al., ACS App. Mater. Interface, 2016, Adak et al., Chem. Commun. 2016, Saha et al., RSC Adv. 2015, Jana et al., Chem. Commun. 2015, Mohapatra et al., Chem. Commun. 2015]

iii. Development of nanomedicine platform: Functionalized nanomaterials have huge applications in bio-nanotechnological research and targeted delivery of therapeutic molecules. We have developed chemically functionalized graphene oxide nanoparticles for reconstitution of kinesin-driven cargo transport and targeted delivery of anticancer molecules. In addition, we have developed a few novel cancer cell specific nano-liposome-based drug delivery vehicles, which are already tested in 2D, 3D spheroid and in vivo mice model of melanoma cancer. Our work has already published in high-quality internationally peer-reviewed journals and two patents are under preparation. [Ref: Jana et al., Chem. Commun. 2015, Mohapatra et al., Unpublished data]

iv. Affordable targeted liposomal formulation for melanoma: Very recently, we developed an affordable novel liposomal formulation of edible plant extract for melanoma therapy. This formulation was fully evaluated in in vivo melanoma mice model and currently, we are preparing for performing preclinical studies. [Ref: Ghosh et al., Indian and PCT Patent Filed; Saha et al., ACS Appl. Mater Interface 2017]  

v. Inverse association of Alzheimer’s and Cancer: It has been statistically shown that AD patients do not suffer from brain cancer. On the contrary brain tumor patients does not suffer from AD. There was no clue for this inverse association. Our group showed a clue about this inverse association. We have showed that Aβ interacts with tubulin at vinblastine and GTP/GDP binding sites and causes apoptotic death of cancer cell. This is the direct clue, which shed light on this inverse association.

3. Reconstitution of Biocompatible Platform for studying biological events:

Highly biocompatible platforms are a prerequisite for studying bio-molecular interactions. We developed novel biocompatible chemically functionalized 2D micropattern surfaces for reconstitution of chromosome and centrosome surface. Further, we also developed an artificial cell-like system using bilayer liposome where we reconstituted the amyloid β-peptide aggregation and its propagation. Our work has already published in international journals and few of them highlighted in cover-page of the issue [Ref: Biswas et al., ChemBioChem, 2013, Soft Matter, 2014, Saha et al., Chem. Commun.  2013] 

Credentials

  • Associate Professor, Academy of Scientific and Innovative Research (AcSIR) [Current]
  • Adjunct Faculty, National Institute of Pharmaceutical and Education Research (NIPER), Kolkata [Current]
  • Associate Editor, Royal Society of Chemistry-Advances, UK [Current]
  • Editorial Board Member-Frontiers in Chemistry (Chemical Biology) [2018-till date]                     
  • Associate Editor, Royal Society of Chemistry-Advances, UK [2015-till date]
  • Principal Scientist, CSIR-IICB, Kolkata [2014-till date]                    
  • Visiting Scientist in Rudolph Virchow Centre, University of Wurzburg, Germany [2012]
  • Ramanujan Fellow at CSIR-IICB, Kolkata [2011-2015]
  • Alexander von Humboldt Fellow, EMBL-Heidelberg [2009-2010]                       
  • Postdoctoral Fellow in Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany [2008-2009]                 
  • Ph.D (Chemistry), Indian Institute of Technology Kanpur [2004-2008]
  • Scientist, BIOCON, Bangalore, India [2001 − 2004]
  • MSc.(Organic Chemistry), University of Calcutta, India [1998-2000]
  • BSc.(Chemistry), University of Calcutta, India [1995-1998]

Honours & Awards

  • Elected Fellow of the West Bengal Academy of Science and Technology [2018]
  • Asima Chatterjee Young Scientist Award [2018]
  • Syamasri Gupta Memorial Young Scientist Award [2017]
  • Council Member, International Chemical Biology Society (ICBS) [2017]
  • Travel Grant Award by International Chemical Biology Society for Invited Lecture at Shanghai, China[2017]                              
  • Young Scientist Award from Indian Peptide Society [2017]
  • Fellow of Royal Society of Chemistry (FRSC), UK [2016]
  • Associate Editor, Royal society of Chemistry-Advances, UK [2015]
  • Ramanujan Fellow (2011-2015) [2010]
  • Travel grant by DBT/ Wellcome Trust for attending meeting at Baecelona [2010]          
  • Alexander Von Humboldt Fellow [2009]
  • EMBL Fellow [2008]
  • Travel Grant by BASF Company for attending in International, Singapore [2007]               
  • Biocon Tribute award for important contribution (Biocon India Group) [2002]

Grant Supports

  1. SERB, Department of Science and Technology, India

  2. Department of Biotechnology, India
     
  3. CSIR-Mission Mode Project

  4. India-Japan Cooperative Science Programme (IJCSP)

Patents & Publications

 PATENTS 
  1. Nonapeptide of formula I, pharmaceutical compositions and methods for preparation thereof. By Ghosh, Surajit; Mondal, Prasenjit; Das, Gaurav; Khan, Juhee; Pradhan, Krishnangsu. Indian Pat. Appl. (2018), IN 201811020565.

  2. Peptoid of formula I, pharmaceutical compositions and method for preparation thereof. By Ghosh, Surajit; Pradhan, Krishnangsu; Das, Gaurav; Mondal, Prasenjit; Barman, Surajit; Ghosh, Subhajit. Indian Pat. Appl. (2018), IN 201811016874.

  3. A LDV peptide liposomal formulation of Photosystem-1 for treatment of cancer. By Ghosh, Surajit; Saha, Abhijit; Ghosh, Subhajit; Mohapatra, Saswat; Jana, Batakrishna; Bhunia, Debmalya. PCT Int. Appl. (2018), WO 2018065993 A1 20180412.

  4. A LDV peptide liposomal formulation of Photosystem-1 for treatment of cancer. By Ghosh, Surajit; Saha, Abhijit; Ghosh, Subhajit; Mohapatra, Saswat; Jana, Batakrishna; Bhunia, Debmalya. Indian Pat. Appl. (2018), IN 201611034058 A 20180406.

  5. Hexapeptide for neuroprotection against a beta toxicity. By Ghosh, Surajit; Biswas, Atanu; Jana, Batakrishna; Mohapatra, Saswat; Biswas, Subhas Chandra; Saleem, Suraiya; Mondal, Prasenjit; Adak, Anindyasundar; Ghosh, Subhajit; Saha, Abhijit; et al. U.S. Pat. Appl. Publ. (2017), US 20170253631 A1 20170907.

  6. Method of distinguished imaging of lipid droplets in cancer cells & non-malignant cells, and a medical kit thereof. By Bhattacharyya, Kankan; Ghosh, Surajit; Chowdhury, Rajdeep; Chattoraj, Shyamtanu; Ghosh, Shirsendu; Jana, Batakrishna; Saha, Abhijit. Indian Pat. Appl. (2016), IN 2014KO01283 A 20160826. 

 

PUBLICATIONS
  1. Surajit Barman, Gaurav Das, Prasenjit Mondal, Krishnangsu Pradhan,  Batakrishna Jana, Debmalya Bhunia, Abhijit Saha, Chirantan Kar, and Surajit Ghosh.* Tripodal Molecular Propeller Perturbs Microtubule Dynamics: Indole acts as a Blade and Plays Crucial Role in Anticancer Activity. Chem. Commun. , 2019 , DOI 10.1039/C9CC00074G
  2. Gaurav Das and Surajit Ghosh.* "Why Microtubule should be Considered as one of the Supplementary Target for Designing Neuro-therapeutics?" ACS Chem Neuroscience , 2019 , DOI 10.1021/acschemneuro.9b00002
  3. Tanushree Mahata, Prasenjit Mondal, Debmalya Bhunia, Somen Nandi, Prashant Kurkute, Kankan Bhattacharyya* and Surajit Ghosh.* Self-assembly of Antimitotic Peptide at Membranes: Computational and Experimental Investigation . ACS OMEGA , 2019 , 4 , 745–754 , DOI 10.1021/acsomega.8b01568
  4. Surajit Barman, Gaurav Das, Prasenjit Mondal, Krishnangsu Pradhan, Debmalya Bhunia, Juhee Khan, Chirantan Kar, and Surajit Ghosh.* Power of Tyrosine Assembly in Microtubule Stabilization and Neuroprotection Fuelled by Phenol Appendages. ACS Chem Neuroscience , 2018 , DOI 10.1021/acschemneuro.8b00497
  5. Gaurav Das, Varsha Gupta and Surajit Ghosh.* "Glial-Neuron Transformation by “Chemical Cocktail”. ACS Chem Neuroscience , 2018 , DOI 10.1021/acschemneuro.8b00684
  6. Krishnangsu Pradhan, Gaurav Das, Juhee Khan, Varsha Gupta, Surajit Barman, Anindyasundar Adak, and Surajit Ghosh.* Neuro-Regenerative Choline Functionalized Injectable Graphene Oxide Hydrogel Repairs Focal Brain Injury. ACS Chem Neuroscience , 2018 , 9 , PMID 30427662 , DOI 10.1021/acschemneuro.8b00514
  7. Krishnangsu Pradhan, Gaurav Das, Varsha Gupta, Prasenjit Mondal, Surajit Barman, Juhee Khan, and Surajit Ghosh.* Discovery of Neuro-regenerative Peptoid from Amphibia Neuropeptide Inhibits Aβ Toxicity and Crossed Blood-Brain Barrier. ACS Chem Neuroscience , 2018, PMID 30408415 , DOI 10.1021/acschemneuro.8b00427
  8. Juhee Khan, Gaurav Das, Varsha Gupta, Saswat Mohapatra, Subhajit Ghosh, and Surajit Ghosh.* Neurosphere Development from Hippocampal and Cortical Embryonic Mixed Primary Neuron Culture: A Potential Platform for Screening Neuro-Chemical Modulator. ACS Chem Neuroscience , 2018 , 9 , 2870–2878 , PMID 30346714 , DOI 10.1021/acschemneuro.8b00414
  9. Debmalya Bhunia, Krishnangsu Pradhan, Gaurav Das, Subhajit Ghosh, Prasenjit Mondal, Surajit Ghosh.* Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs. Chem. Commun , 2018 , 54 , 9309--9312 , PMID 30070277 , DOI 10.1039/C8CC05687K
  10. Krishnangsu Pradhan, Gaurav Das, Prasenjit Mondal, Juhee Khan, Surajit Barman, Surajit Ghosh.* Genesis of Neuroprotective Peptoid from Aβ30-34 Inhibits Aβ Aggregation and AChE Activity. ACS Chem Neuroscience , 2018 , PMID 30036464 , DOI 10.1021/acschemneuro.8b00071
  11. Prasenjit Mondal, Varsha Gupta, Gaurav Das, Krishnangsu Pradhan, Juhee Khan, Prabir Kumar Gharai and Surajit Ghosh.* Peptide-based Acetylcholinesterase Inhibitor Crosses Blood-Brain Barrier and Promotes Neuroprotection. ACS Chem Neuroscience , 2018 , 9 , 2838–2848 , PMID 30015476 , DOI 10.1021/acschemneuro.8b00253
  12. Somen Nandi, Surajit Ghosh,* Kankan Bhattacharyya.* Live Cell Microscopy: A Physical Chemistry Approach. J Phys Chem B. , 2018 , 122 , 3023–3036 , PMID 29389140 , DOI 10.1021/acs.jpcb.7b11689
  13. Debmalya Bhunia, Prasenjit Mondal, Gaurav Das, Abhijit Saha, Pallabi Sengupta, Jagannath Jana, Saswat Mohapatra, Subhrangsu Chatterjee, and Surajit Ghosh* Spatial Position Regulates Power of Tryptophan: Discovery of Major Groove Specific Nuclear Localizing Cell Penetrating Tetrapeptide. J Am Chem Soc , 2018 , 140 , 1697−1714 , PMID 29283563 , DOI 10.1021/jacs.7b10254
  14. Prasenjit Mondal, Gaurav Das, Juhee Khan, Krishnangsu Pradhan, and Surajit Ghosh*, Crafting of Neuroprotective Octapeptide from Taxol-Binding Pocket of β-Tubulin. ACS Chem Neuroscience , 2018 , 9 , 615–625 , PMID 29155559 , DOI 10.1021/acschemneuro.7b00457
  15. Batakrishna Jana, Prasenjit Mondal , Abhijit Saha, Anindyasundar Adak, Gaurav Das, Saswat Mohapatra, Prashant Kurkute, and Surajit Ghosh.* Designed Tetrapeptide Interacts with Tubulin and Microtubule. Langmuir , 2018 , 34 , 1123–1132 , PMID 28558224 , DOI 10.1021/acs.langmuir.7b01326
  16. Gaurav Das, Shyamtanu Chattoraj,  Somen Nandi, Prasenjit Mondal,  Abhijit Saha, Kankan Bhattacharyya* and Surajit Ghosh* Probing the conformational dynamics of photosystem I in unconfined and confined spaces. Phys Chem Chem Phys. , 2017 , 20 , 449-455 , PMID 29211079 , DOI 10.1039/C7CP07375E
  17. Nibedita Nandi, Kousik Gayen, Sandip Ghosh, Debmalya Bhunia, Steven Kirkham, Sukanta Kumar Sen, Surajit Ghosh, Ian W. Hamley, and Arindam Banerjee*. Amphiphilic Peptide-based Supramolecular, Non-Cytotoxic Stimuli-responsive Hydrogels with Antibacterial Activity. Biomacromolecules , 2017 , 18 , 3621–3629 , PMID 28953367 , DOI 10.1021/acs.biomac.7b01006
  18. Parag Savla, Gaurav Das, Prasenjit Mondal, Rahul Laxman Gajbhiye, Parasuraman Jaisankar, Surajit Ghosh.* Methanolic Extract of Papaya Leaves Shows Neuroprotective Effect. Chemistry SELECT , 2017 , 2 , 9454-9457 , DOI 10.1002/slct.201701656
  19.  Hilal Ahmad Pal,  Saswat Mohapatra,  Varsha Gupta,  Surajit Ghosh  and  Sandeep Verma.* Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth. Chem Sci. , 2017 , 8 , 6171-6175 , PMID 28989648 , DOI 10.1039/C6SC05017D
  20. Asif Amin, Somen Nandi, Prasenjit Mondal, Tanushree Mahata, Surajit Ghosh*, and Kankan Bhattacharyya.* Physical Chemistry in a Single Live Cell: Confocal Microscopy. Phys Chem Chem Phys. , 2017 , 19 , 12620-12627 , PMID 28489114 , DOI 10.1039/C7CP02228J
  21. Anindyasundar Adak, Gaurav Das, Surajit Barman, Saswat Mohapatra,  Debmalya Bhunia, Surajit Ghosh.* Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug. ACS Appl Mater Interfaces. , 2017 , 9 , 5067–5076 , PMID 28090777 , DOI 10.1021/acsami.6b12114
  22. Abhijit Saha, Saswat Mohapatra, Gaurav Das, Batakrishna Jana, Subhajit Ghosh, Debmalya Bhunia, and Surajit Ghosh.* Cancer cell specific delivery of Photosystem I through integrin targeted liposome shows significant anticancer activity. ACS Appl. Mater. Interfaces , 2017 , 9 , 176–188 , PMID 27996239 , DOI 10.1021/acsami.6b13352
  23. Saswat Mohapatra, Abhijit Saha, Prasenjit Mondal, Batakrishna Jana, Subhajit Ghosh, Atanu Biswas and Surajit Ghosh*. Synergistic anticancer effect of peptide-docetaxel nano-assembly targeted to tubulin: Towards development of dual warhead containing nanomedicine. Adv Healthcare Mater , 2017 , 6 , , PMID 27782376 , DOI 10.1002/adhm.201600718
  24. Debmalya Bhunia,# Abhijit Saha,# Anindyasundar Adak, Gaurav Das and Surajit Ghosh* A dual functional liposome specifically targets melanoma cells through integrin and ephrin receptors. RSC Adv. , 2016 , 6 , 113487-113491 , DOI 10.1039/C6RA23864E
  25. Subhajit Ghosh,  Saswat Mohapatra,  Anisha Thomas, Debmalya Bhunia, Abhijit Saha, Gaurav Das, Batakrishna Jana and Surajit Ghosh* Apoferritin-nanocage delivers combination of microtubule and nucleus targeting anticancer drugs. ACS Appl. Mater. Interfaces , 2016 , 8 , 30824–30832 , PMID 27782381 , DOI 10.1021/acsami.6b11798
  26. Soumen Chakraborty, Gaurav Das, Surajit Ghosh and Dipakranjan Mal* Regioselective synthesis of naphthoquinone/naphthoquinol–carbohydrate hybrids by [4 + 2] anionic annulations and studies on their cytotoxicity. Org. Biomol. Chem , 2016 , 14 , 10636-10647 , PMID 27782276 , DOI 10.1039/C6OB02154A
  27. Soumen Nandi,# Prasenjit Mondal,# Rajdeep Chowdhury,# Abhijit Saha, Surajit Ghosh* and Kankan Bhattacharyya*. Amyloid Beta Peptide inside a Reconstituted Cell-like Liposomal System: Aggregation, FRET, Fluorescence Oscillations and Solvation Dynamics. Phys Chem Chem Phys. , 2016 , 18 , 30444-30451 , PMID 27781218 , DOI 10.1039/c6cp06143e
  28. Debmalya Bhunia#, Saswat Mohapatra#, Prashant Kurkute, Subhajit Ghosh, Batakrishna Jana, Prasenjit Mondal, Abhijit Saha, Gaurav Das and Surajit Ghosh* Novel Tubulin-targeted Cell Penetrating Antimitotic Octapeptide. Chem. Commun., , 2016 , 52 , 12657-12660 , PMID 27713939 , DOI 10.1039/C6CC05110C
  29. Saswat Mohapatra#, Soumen Nandi#, Rajdeep Chowdhury#, Gaurav Das, Surajit Ghosh* and Kankan Bhattacharyya*. Spectral Mapping of 3D Multi-cellular Tumor Spheroid: Time-resolved Confocal Microscopy. Phys Chem Chem Phys. , 2016 , 18 , 18381-18390 , PMID 27336201 , DOI 10.1039/c6cp02748b
  30. Catherine Ghosh, Debmalya Bhunia, Shirsendu Ghosh, Batakrishna Jana, Surajit Ghosh* and Kankan Bhattacharyya.* Fluorescence Probing of Fluctuating Microtubule using a Covalent Fluorescent Probe: Effect of Taxol. Chemistry SELECT , 2016 , 1 , 1841-1847 , DOI 10.1002/slct.201600353
  31.  Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Surajit Barman, Krishnangsu Pradhan, Abhijit Saha and Surajit Ghosh* α-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell. ACS Appl. Mater. Interfaces , 2016 , 8 , 13793–13803 , PMID 27228201 , DOI 10.1021/acsami.6b03474
  32.  Anindyasundar Adak#, Saswat Mohapatra#, Prasenjit Mondal, Batakrishna Jana and Surajit Ghosh.* Design of novel microtubule targeted peptide vesicle for delivering different anticancer drugs. Chem. Commun. , 2016 , 52 , 7549-7552 , PMID 27153208 , DOI 10.1039/C6CC01769J
  33. Kingshuk Basu, Abhishek Baral, Shibaji Basak, Ashkan Dehsorkhi, Jayanta Nanda, Debmalya Bhunia, Surajit Ghosh, Valeria Castelletto, Ian W. Hamley, and Arindam Banerjee* Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s). Chem.Commun , 2016 , 52 , 5045-5048 , PMID 26987440 , DOI 10.1039/C6CC01744D
  34. Jyothi B. Nair,# Manu M. Joseph,# Saswat Mohapatra, M. Safeera, Surajit Ghosh,* T. T. Sreelekha,* and Kaustabh Kumar Maiti*. A Dual-Targeting Octaguanidine–Doxorubicin Conjugate Transporter for Inducing Caspase-Mediated Apoptosis on Folate-Expressing Cancer Cells. ChemMedChem , 2016 , 11 , 702-712 , PMID 26990462 , DOI 10.1002/cmdc.201600029
  35. Shyamtanu Chattoraj, Md. Asif Amin, Saswat Mohapatra, Surajit Ghosh* and Kankan Bhattacharyya* Cancer Cell Imaging by In Situ Generated Gold Nano-clusters. ChemPhysChem , 2016 , 17 , 61-68 , PMID 26437799 , DOI 10.1002/cphc.201500731
  36. Shyamtanu Chattoraj, Md. Asif Amin, Batakrishna Jana, Saswat Mohapatra, Surajit Ghosh* and Kankan Bhattacharyya* Selective Killing of Breast Cancer Cells by Doxorubicin Loaded Fluorescent Gold Nano-Cluster: Confocal Microscopy and FRET. ChemPhysChem , 2016 , 17 , 253-259 , PMID 26615975 , DOI 10.1002/cphc.201500982
  37. Abhijit Saha#, Saswat Mohapatra#, Prashant Kurkute, Batakrishna Jana, Jayita Sarkar, Prasenjit Mondal and Surajit Ghosh* Targeted delivery of novel peptide-docetaxel conjugate to MCF-7 cell through Neuropilin-1 receptor: Reduced toxicity and enhanced efficacy of docetaxel. RSC Adv. , 2015 , 5 , 92596-92601 , DOI 10.1039/C5RA16741H
  38.  Debmalya Bhunia#, Rajdeep Chowdhury#, Kankan Bhattacharyya* and Surajit Ghosh*. Fluorescence Fluctuation of Antigen-Antibody Complex: Circular Dichroism, FCS and smFRET of Enhanced GFP and its Antibody. Phys Chem Chem Phys , 2015 , 17 , 25250-25259 , PMID 26353083 , DOI 10.1039/c5cp04908c
  39. Atanu Biswas, Prashant Kurkute, Suraiya Saleem, Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Anindyasundar Adak, Subhajit Ghosh, Abhijit Saha, Debmalya Bhunia, Subhash Chandra Biswas, and Surajit Ghosh* Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chem Neuroscience , 2015 , 6 , 1309–1316 , PMID 26147391 , DOI 10.1021/acschemneuro.5b00149
  40. Batakrishna Jana, Jayita Sarkar, Prasenjit Mondal, Surajit Barman, Saswat Mohapatra, Debmalya Bhunia, Krishnangsu Pradhan, Abhijit Saha, Anindyasundar Adak, Subhajit Ghosh and Surajit Ghosh* A short GC rich DNA derived from microbial origin targets tubulin/microtubule and induces apoptotic death of cancer cell . Chem.Commun. , 2015 , 51 , 12024-12027 , PMID 26121245 , DOI 10.1039/C5CC03432A
  41. Prasenjit Mondal#, Shyamtanu Chattoraj#, Rajdeep Chowdhury#, Debmalya Bhunia, Surajit Ghosh* and Kankan Bhattacharyya* Direct observation of the growth and shrinkage of microtubules by single molecule Forster resonance energy transfer†. Phys Chem Chem Phys. , 2015 , 17 , 6687-6690 , PMID 25655478 , DOI 10.1039/C4CP06031H
  42. Jyothi B Nair#, Saswat Mohapatra#, Surajit Ghosh*, Kaustabh K Maiti*. Novel Lysosome Targeted Molecular Transporter Built On Guanidinium-Poly-(propylene imine) Hybrid Dendron for Efficient Delivery of Doxorubicin into Cancer Cells. Chem.Commun , 2015 , 51 , 2403-2406 , PMID 25564099 , DOI 10.1039/C4CC09829C
  43. Abhijit Saha, Saswat Mohapatra, Prashant Kurkute, Batakrishna Jana, Prasenjit Mondal, Debmalya Bhunia, Subhajit Ghosh and Surajit Ghosh.* Interaction of Aβ peptide with tubulin causes inhibition of tubulin polymerization and apoptotic death of cancer cells . Chem. Commun. , 2015 , 51 , 2249-2252 , PMID 25567764 , DOI 10.1039/C4CC09390A
  44. Subhasish Roy†, Abhishek Baral†, Rameswar Bhattacharjee,  Batakrishna Jana,  Ayan Datta, Surajit Ghosh  and Arindam Banerjee* . Preparation of Multi coloured Different sized Fluorescent Gold Clusters from Blue to NIR, Structural Analysis of the Blue Emitting Au7 Cluster and Cell-Imaging by the NIR Gold Cluster. Nanoscale , 2015 , 7 , 1912-1920 , PMID 25529745 , DOI 10.1039/C4NR04338C
  45. Rajdeep Chowdhury, Abhijit Saha, Amit Kumar Mandal, Batakrishna Jana, Surajit Ghosh,* and Kankan Bhattacharyya.* Excited State Proton Transfer in the Lysosome of Live Lung Cells: Normal and Cancer Cell. J. Phys. Chem. B, , 2015 , 119 , 2149–2156 , PMID 24867269 , DOI 10.1021/jp503804y
  46.  Batakrishna Jana, Atanu Biswas, Saswat Mohapatra, Abhijit Saha and Surajit Ghosh.* Single functionalized graphene oxide reconstitutes kinesin mediated intracellular cargo transport, delivers multiple cytoskeleton proteins and therapeutic molecule into the cell. Chem. Commun. , 2014 , 50 , 11595-11598 , PMID 25140914 , DOI 10.1039/C4CC04924A
  47. Anirban Ghosh, Rajiv Kumar Kar, Jagannath Jana, Abhijit Saha, Batakrishna Jana, Janarthanan Krishnamoorthy, Dinesh Kumar, Surajit Ghosh,*Subhrangsu Chatterjee,* and Anirban Bhunia.* Indolicidin Targets Duplex DNA: Structural and Mechanistic Insight through a Combination of Spectroscopy and Microscopy. ChemMedChem. , 2014 , 9 , 2052-20258 , PMID 25044630 , DOI 10.1002/cmdc.201402215
  48. Shruti Khanna, Batakrishna Jana, Abhijit Saha, Prashant Kurkute, Surajit Ghosh,* Sandeep Verma.* Targeting Cytotoxicity and Tubulin Polymerization by Metal-Carbene Complexes on a Purine Tautomer Platform. Dalton Transactions , 2014 , 43 , 9838-9842 , PMID 24854090 , DOI 10.1039/c4dt00529e
  49. Rajdeep Chowdhury, Batakrishna Jana, Abhijit Saha, Surajit Ghosh,* and Kankan Bhattacharyya.* Confocal Microscopy of Cytoplasmic Lipid Droplets in a Live Cancer Cell: Number, Polarity, Diffusion and Solvation Dynamics. MedChemComm. , 2014 , 5 , 536-539 , DOI 10.1039/C3MD00269A
  50. Atanu Biswas, Prashant Kurkute, Batakrishna Jana, Aparna Laskar and Surajit Ghosh.* Amyloid inhibitor octapeptide forms amyloid type fibrous aggregate and affect in microtubule motility. Chem. Commun. , 2014 , 50 , 2604-2607 , PMID 24468974 , DOI 10.1039/C3CC49396B
  51. Abhishek Baral, Subhasish Roy, Ashkan Dehsorkhi, Ian W Hamley, Saswat Mohapatra, Surajit Ghosh and Arindam Banerjee.* Assembly of an Injectable Non-Cytotoxic Peptide-based Hydrogelator for Sustained Release of Drugs. Langmuir , 2014 , 30 , 929–936 , PMID 24397440 , DOI 10.1021/la4043638
  52. Atanu Biswas#, Abhijit Saha#, Dhruba Ghosh, Batakrishna Jana and Surajit Ghosh.* Co- and distinct existence of Tris-NTA and biotin functionalities on individual and adjacent micropatterned surfaces generated by photo-destruction. Soft Matter , 2014 , 10 , 2341-2345 , PMID 24623362 , DOI 10.1039/C3SM53000K 
  53. Batakrishna Jana, Goutam Mondal, Atanu Biswas, Indrani Chakraborty, Abhijit Saha, Prashant Kurkute and Surajit Ghosh.* Dual functionalised graphene oxide serves as a carrier for delivering oligo-histidine and biotin tagged biomolecules into cell. Macromol Biosci. , 2013 , 13 , 1478-1484 , PMID 23894114 , DOI 10.1002/mabi.201300129
  54. Jagannath Jana, Rajiv Kumar Kar, Anirban Ghosh, Atanu Biswas, Surajit Ghosh, Anirban Bhunia* and Subhrangsu Chatterjee.* Human Cathelicidin Peptide LL37 Binds Telomeric G-Quadruplex. Mol. Biosyst. , 2013 , 9 , 1833-1836 , PMID 23636272 , DOI 10.1039/C3MB70030E
  55. Indrani Chakraborty, Abhijit Saha and Surajit Ghosh.*Fabrication of Biotinfunctionalised SiO2 EM grid for studying biotin tagged biomolecules. IJC-A Special issue: ‘Complex Chemical Systems’ ,2013
  56.  Batakrishna Jana, Goutam Mondal, Atanu Biswas, Indrani Chakraborty and Surajit Ghosh.* Functionalised TiO2 nanoparticles deliver oligo-histidine andavidin tagged biomolecules simultaneously into the cell. RSC Adv. , 2013 , 3 , 8215-8219 , DOI 10.1039/C3RA41068D
  57. Abhijit Saha, Goutam Mondal, Atanu Biswas, Indrani Chakraborty, Batakrishna Jana and Surajit Ghosh.* In vitro reconstitution of a cellular like environment using liposome for amyloid beta peptide aggregation and its propagation. Chem. Commun. , 2013 , 49 , 6119-6121 , DOI 10.1039/C3CC41287C
  58. Abhijit Saha,# Indrani Chakraborty,# Christian Kraft, Shashi Bhushan* and Surajit Ghosh.* Microtubule nucleation from a functionalised SiO2 EM grid. RSC Adv. , 2013 , 3 , 7688-7691 , DOI 10.1039/C3RA40273H
  59. Atanu Biswas, Abhijit Saha, Batakrishna Jana, Prashant Kurkute, Goutam Mondal and Surajit Ghosh.* Facile generation of biotin micropatterned surface by photo destruction serves as a novel platform for microtubule organisation and DNA hybridisation. ChemBioChem , 2013 , 14 , 689-694 , PMID 23520125 , DOI 10.1002/cbic.201300027
  60. Surajit Ghosh, Lihi Adler-Abramovich, Ehud Gazit,* Sandeep Verma.* Spacer driven morphological twist in Phe-Phe dipeptide  conjugates. Tetrahedron , 2013 , 69 , 2004-2009 , DOI 10.1016/j.tet.2012.12.063
  61. Surajit Ghosh, Christian Hentrich, and Thomas Surrey.* Micropattern-Controlled Local Microtubule Nucleation, Transport, and Mesoscale Organization. ACS Chem. Biol. , 2013 , 8 , 673–678 , PMID 23294267 , DOI 10.1021/cb300583p
  62. Vadapalli Chandrasekhar,* Loganathan Nagarajan, Sakiat Hossain, Kandasamy Gopal, Surajit Ghosh, Sandeep Verma. Multicomponent Assembly of Anionic and Neutral Decanuclear Copper(II) Phosphonate Cages. Inorg. Chem. , 2012 , 51 , 5605–5616 , PMID 22574912 , DOI 10.1021/ic202510d
  63. Sudipta Mondal, Surajit Ghosh, Sandeep Verma.*Bottom-up Synthesis of Ferrocenylated Soft Spherical Structures: Ultrastructural Characterization and Electroresponsitivity.Tet. Lett. ,2010
  64. Maniraj Bhagawati,# Surajit Ghosh,# Annett Reichel, Klaus Froehner, Thomas Surrey, Jacob Piehler.* Organization of motor proteins into functional micropatterns fabricated by a photo-induced Fenton reaction. Angew. Chem. Int. Ed. , 2009 , 48 , 9188-9191 , PMID 19882610 , DOI 10.1002/anie.200904576
  65.  Vadapalli Chandrasekhar,* Loganathan Nagarajan, Rodolphe Clérac, Surajit Ghosh, Tapas Senapati, and Sandeep Verma. Barrel- and Crown-Shaped Dodecanuclear Copper(II) Cages Built from Phosphonate, Pyrazole, and Hydroxide Ligands. Inorg. Chem. , 2008 , 47 , 5347–5354 , PMID 18484717 , DOI 10.1021/ic800509f
  66. Surajit Ghosh, Sandeep Verma.* Solvent mediated morphological transformation of peptide-based soft structures. Tetrahedron , 2008 , 64 , 6202-6208 , DOI 10.1016/j.tet.2008.05.003
  67. Vadapalli Chandrasekhar,* Ramachandran Azhakar, Tapas Senapati, P. Thilagar, Surajit Ghosh, Sandeep Verma, Ramamoorthy Boomishankar, Alexander Steiner and Paul Kögerler. Synthesis, structure, magnetism and nuclease activity of tetranuclear copper(II) phosphonates containing ancillary 2,2 -bipyridine or 1,10-phenanthroline ligands. Dalton Transaction , 2008 , 0 , 1150-1160 , DOI 10.1039/B712876B
  68. Vadapalli Chandrasekhar,* Loganathan Nagarajan, Rodolphe Clérac, Surajit Ghosh, Sandeep Verma. A Distorted Cubic Tetranuclear Copper(II) Phosphonate Cage with a Double-Four-Ring-Type Core. Inorg. Chem. , 2008 , 47 , 1067–1073 , PMID 18183972 , DOI 10.1021/ic701948g
  69. Surajit Ghosh, Arindam Mukherjee, Peter. J. Sadler.* Sandeep Verma.* Periodic Iron Nanomineralization in Human Serum Transferrin Fibrils. Angew. Chem. Int. Ed , 2008 , 47 , 2217-2221 , PMID 18256996 , DOI 10.1002/anie.200705723
  70. Surajit Ghosh, Sandeep Verma.* Templated growth of hybrid structures at peptide-peptide interface. Chem. Eur. J. , 2008 , 14 , 1415-1419 , PMID 18165958 , DOI 10.1002/chem.200701736
  71. Surajit Ghosh, Prabhpreet Singh, Sandeep Verma.* Morphological Consequences of Metal ion-Peptide Vesicle Interaction. Tetrahedron , 2008 , 64 , 1250-1256 , DOI 10.1016/j.tet.2007.11.077
  72.  Sandeep Verma,* K. B. Joshi, Surajit Ghosh. Peptide-based soft materials as potential drug delivery vehicles. Med. Chem. , 2007 , 3 , 605-611 , PMID 18045211 , DOI 10.2174/157340607782360371
  73. Surajit Ghosh, SukhmaniKaur Singh, Sandeep Verma.* Self-assembly and potassium ion triggered disruption of peptide-based soft structures. Chem. Commun. , 2007 , 0 , 2296-2298 , PMID 17534522 , DOI 10.1039/B701665D
  74. Surajit Ghosh, Sandeep Verma.* Phased Fiber Growth in a Peptide Conjugate: Aggregation and Disaggregation Studies. J. Phys. Chem. B , 2007 , 111 , 3750–3757 , PMID 17388532 , DOI 10.1021/jp066546a
  75. Surajit Ghosh, Sandeep Verma.* Metalated peptide fibers derived from a natural metal-binding peptide motif. Tet. Lett. , 2007 , 48 , 2189-2192 , DOI 10.1016/j.tetlet.2007.01.089
  76. Surajit Ghosh, Meital Reches, Ehud Gazit,* Sandeep Verma.* Bioinspired design of nanocages by self-assembling triskelion peptide elements. Angew. Chem. Int. Ed. , 2007 , 46 , 2002-2004 , PMID 17286330 , DOI 10.1002/anie.200604383

 

 * Corresponding Author, # Equal Contribution

 

 Our Recent Works Accepted in Cover Page

  • “Neurosphere Development from Hippocampal and Cortical Embryonic Mixed Primary Neuron Culture: A Potential Platform for Screening Neuro-Chemical Modulator. ACS Chem Neurosci. 2018,Just Accepted”

  • “Discovery of Neuro-regenerative Peptoid from Amphibian Neuropeptide Inhibits Aβ Toxicity and Crossed Blood-Brain Barrier. ACS Chem Neurosci. 2018, Just Accepted"

  • "Synergistic anticancer effect of peptide-docetaxel nano-assembly targeted to tubulin: Towards development of dual warhead containing nanomedicine" (Adv Healthcare Mater 2016)

  • "Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs" (Chem Comm 2016)

  • "Cancer Cell Imaging by In Situ Generated Gold Nano-clusters" (ChemPhysChem 2016)

  • “Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection” (ACS Chem. Neurosci.2015)

  • “Interaction of Aβ peptide with tubulin causes inhibition of tubulin polymerization and apoptotic death of cancer cells” (Chem Comm 2015)

  • "Co-and distinct existence of Tris-NTA and biotin functionalities on individual and adjacent micropatterned surfaces generated by photo-destruction” (Soft Matter 2014)

  • "Dual functionalised graphene oxide serves as a carrier for delivering oligo-histidine and biotin tagged biomolecules into cell" (Macromol. Biosci. 2013)

  • “In vitro reconstitution of a cellular like environment using liposome for amyloid beta peptide aggregation and its propagation” (Chem Comm 2013)

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  • Melanoma Targeted Hydrogel

  • Neuroprotective peptide and peptoid