Dr. Dipyaman Ganguly
2017: Swarnajayanti Fellowship, Department of Science & Technology, India
2017: NASI-Scopus Young Scientist Award in Medicine
2013: Ramanujan Fellowship, SERB, Department of Science & Technology, India
2010: S.L.E. Foundation Postdoctoral Fellow, College of Physicians & Surgeons, Columbia University Medical Center, New York City, USA.
2010: PhD (Immunology & Biomedical Sciences), University of Texas MD Anderson Cancer Center, Houston, USA.
2006: PhD (Biotechnology), Indian Institute of Chemical Biology, Kolkata, India.
2002: MBBS (Medical College & Hospitals, Calcutta), Calcutta University, Kolkata, India.
The basic premise for immune algorithm is distinguishing self from nonself. This is achieved by different modules of host immune system. The ‘innate’ immune system recognizes the nonself based on predominantly nonself-associated molecular patterns (PAMPs), while the ‘adaptive’ immune axis adapts to the nonself molecular determinants. These two work together toward an effective immune response. An effective immune response to an invading pathogen (nonself) leads to protective immunity and a defective response leads to overt infection. On the other hand, an unintended response to the self-entities leads to autoimmune disorders, while a misjudged tolerance to the altered self contributes to tumorigenesis. Our research broadly concentrates on role of innate immune axis in the crossroads of infection, autoimmunity and cancer. Dendritic cells (DCs) are the innate cells with most of the decision-making responsibilities for an ensuing immune response or tolerance. We try to decipher the governing principles of self-nonself discrimination by the germline-encoded invariant pattern recognition receptors (PRRs) expressed by DCs and how they work in a given clinical context. Broadly the research directions of our lab are:
- Innate immune regulation and molecular mechanisms of dendritic cell function
- Role of innate immune deregulation in autoreactive inflammation
- Deciphering the role and modulation of dendritic cells in tumor microenvironment
- History and philosophy of self-nonself recognition
Ours is a relatively new laboratory in IICB (located in the IICB-Translational Research Unit of Excellence, Salt Lake Campus) that promises a lot of fun and exciting science, which will be achieved through hard work of all its members. Feel free to contact Dipyaman if you feel like sharing the excitement.
Amrit Raj Ghosh, M.Sc.,
Roopkatha Bhattacharya, M.Sc.,
Oindrila Rahaman, M.Sc.,
Deblina Raychaudhuri, M.Sc.,
CSIR Shyama Prasad Mukherjee Fellow (JRF)
Chinky Shiu Chen Liu, M.Sc.,
Purbita Bandopadhyay, M.Sc.
Dr. Subhasis Barik, Ph.D.
At this point of time our laboratory cannot accommodate any more fellows. But from time to time we look for individuals with excellent academic credentials and predoctoral [NET (CSIR/UGC] or postdoctoral fellowships — candidates with some background in human physiology, or immunology with exposure to molecular biology techniques are preferred. Medical graduates/postgraduates (MBBS/MD) interested in biomedical research should also feel free to discuss possibilities of joining the team. Interested candidates may contact directly at email@example.com along with curriculum vita and a brief statement on research interests.
Liu CSC, Raychaudhuri D, Paul B, Chakrabarty Y, Ghosh AR, Rahaman O, Talukdar A, Ganguly D. Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. Journal of Immunology. 2018 Jan 12. pii: ji1701118.
Nargis T, Kumar K, Ghosh AR, Sharma A, Rudra D, Sen D, Chakrabarti S, Mukhopadhyay S, Ganguly D, Chakrabarti P (#Corresponding authors). KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. Molecular Metabolism. 2017 Nov;6(11):1529-1539.
Ganguly D. Do type I interferons link systemic autoimmunities and metabolic syndrome in a pathogenetic continuum? Trends in Immunology. 2018 Jan;39(1):28-43.
Roy S, Mukherjee A, Paul B, Rahaman O, Roy S, Maithri G, Ramya B, Pal S, Ganguly D#, Talukdar A# (#Corresponding authors). Design and Development of benzoxazole derivatives with toll-like receptor 9 antagonism. European Journal of Medicinal Chemistry. 2017. 134:334-347.
Ghosh AR, Bhattacharya R, Bhattacharya S, Nargis T, Rahaman O, Duttagupta P, Raychaudhuri D, Chen Liu CS, Roy S, Ghosh P, Khanna S, Chaudhuri T, Tantia O, Haak S, Bandyopadhyay S, Mukhopadhyay S, Chakrabarti P, Ganguly D. Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation. Diabetes. 2016. 65 (11): 3440-3452.
(In media: http://indianexpress.com/article/lifestyle/health/why-the-obese-are-prone-to-diabetes-a-protein-gives-a-clue/; http://www.ndtv.com/health/indian-scientists-discover-link-between-obesity-diabetes-1455710 ; http://www.hindustantimes.com/health-and-fitness/why-does-obesity-cause-diabetes-indian-scientists-just-found-an-explanation/story-M2ExSvGoD4DjjSodszeVrL.html ; http://www.anandabazar.com/lifestyle/do-we-get-diabetic-with-the-increase-of-fat-1.476272# ; https://www.telegraphindia.com/1160908/jsp/nation/story_107007.jsp#.WN9XljuGPIW )
Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M. T helper 17 cells promote microbial killing and innate immune sensing of DNA via interleukin-26. Nature Immunology. 2015. 16(9):970-9.
Sisirak V*, Ganguly D*, Lewis KL, Couillault C, Tanaka L, Bolland S, D’Agati V, Elkone KB, Reizis B (*equal contribution). Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. Journal of Experimental Medicine. 2014. 211(10):1969-76.
Ganguly D, Haak S, Sisirak V, Reizis B. Role of dendritic cells in autoimmunity. Nature Reviews Immunology. 2013. 13(8):566-77.
Di Domizio J, Dorta-Estremera S, Gagea M, Ganguly D, Meller S, Li P, Zhao B, Tan FK, Bi L, Gilliet M, Cao W. Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity. Proc Natl Acad Sci U S A. 201. 109(36):14550-5.
Lande R, Ganguly D, Facchinetti V, Frasca L, Conrad C, Gregorio J, Meller S, Chamilos G, Sebasigari R, Riccieri V, Bassett R, Amuro H, Fukuhara S, Ito T, Liu YJ, Gilliet M. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Science Translational Medicine. 2011. 3(73):73ra19.
(Commentary in New England Journal of Medicine, 2011, 365(8):758-60; featured in Nature Reviews Key Advances in Medicine, 2012.)
Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, Homey B, Barrat FJ, Zal T, Gilliet M. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. Journal of Experimental Medicine. 2009. 206(9):1983-94.