Snehasikta Swarnakar

Dr. Snehasikta Swarnakar

Senior Principal Scientist

Post Doc.,[1994 – 97] – University of California, Davis and Marine Biological Laboratory, Woods Hole
Research Scientist (SUNY @ Stony Brook, 1997-01)
Visiting Scientist (TSRI, San Diego, 2002 and UConn, USA,2007),
National Bioscience Award (2007), Fulbright Fellow, Emory University (USA,2013)

    1. Role of polymorphism in the promoter regions of MMPs along with the risk of gastric, ovarian and head & neck cancers.
    2. Understanding the biochemistry behind the mechanism of wound healing, gastric inflammation, gastric ulcers, cancers and effect of free as well as encapsulated lead bioactive molecules viz. curcumin, melatonin and antioxidants etc. on them in regard to angiogenesis, collagen synthesis, apoptosis and regulation of MMPs
    3. Elucidating the role of MMPs, growth factors, receptors and cell adhesion molecules in cancers, alcohol-induced liver damage, diabetes and endometriosis, Idiopathic pulmonary fibrosis (IPF), attenuating brain stroke and gastric ulcers induced by stress, alcohol, non-steroidal anti-inflammatory drug and infection by Helicobacter pylori. Effect of potential mediators like cytokines, growth factors and transcription factors for H. pylori infection
    1. Nillu Ghosh, SRF (CSIR)
    2. Sayantan Jana, Project Fellow (CSIR)
    3. Dharmendra Kumar Yadav, SRF (CSIR)
    4. Anirban Roy, Project Fellow (CSIR)
    5. Sugreev Verma, SRF (UGC)
    6. Kasturi Chatterjee, Project Fellow (CSIR)
    7. Nilanjana Deb , SRF (DRDO Project)
    8. Prithwish Barik, Project Fellow (CSIR)
    9. Anuradha Pandit, JRF ( CSIR)
    10. Preety Choudhury, Project Assistant (DRDO Project)
    11. Dr. Rajib Majumder RA(CSIR)
    1. Kesh K, Subramanian L, Ghosh N, Gupta V, Gupta A, Bhattacharya S, Mahapatra NR, Swarnakar S. (2015). Association of MMP7 -181A→G Promoter Polymorphism with Gastric Cancer Risk: influence of nicotine in differential allele-specific transcription via increased phosphorylation of camp-response element-binding protein (CREB). Journal of Biological Chemistry, 290(23):14391-406.
    2. Dey S, Ghosh N, Saha D, Kesh K, Gupta A and Swarnakar S. (2014) Matrix Metalloproteinase 1 (MMP1) Transcriptional Polymorphisms are Well Linked with Lower Stomach Tumor Formation in Eastern Indian Population. PLoS One. 5;9(2):e88040.
    3. Rudra DS, Pal U, Maiti NC, Reiter RJ, Swarnakar S. (2013) Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site. J Pineal Res. 2013 398-405 doi: 10.1111/jpi.
    4. Chakraborty S.; Stalin S.; Das N.; Thakur Choudhury S.; Ghosh S.; Swarnakar S. (2012) Biomaterials. 33, 2991-3001. The use of nano-quercertin to arrest mitochondrial damage and mmp-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.
    5. Dey S, Stalin S, Gupta A, Saha D, Kesh K, Swarnakar S. (2011) Mol Carcinog. Nov 28. doi: 10.1002/mc.21837. [Epub ahead of print] Matrix metalloproteinase-3 gene polymorphisms and their haplotypes are associated with gastric cancer risk in eastern Indian population.
    6. Jana S., Paul S., Swarnakar S. (2011) Biochemical Pharmacology. 83, 797-804. Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway.
    7. Sharma AV, Ganguly K, Paul S, Maulik N, Swarnakar S. (2011) Antioxid.Redox Signal. 16, 351-362. Curcumin Heals Indomethacin-Induced Gastric Ulceration by Stimulation of Angiogenesis and Restitution of Collagen Fibers via VEGF and MMP-2 Mediated Signaling.
    8. Mishra A, Paul S and Swarnakar S. (2011) Biochimie. 93, 854-866. Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice.
    9. Paul, S., Bhattacharya, P., Das Mahapatra, P. and Swarnakar, S. (2010) J. Pineal Res. 49, 156-168. Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
    10. Ganguly, K and Swarnakar, S (2009) J. Pineal Res. 47, 43-55. Induction of MMP-9 and-3 in nonsteroidal anti-inflammatory drug induced acute gastric ulcer in mice: Regulation by melatonin.
    11. Singh, L. P., Kundu, P., Ganguly, K., Mishra, A and Swarnakar, S. (2007) Free Rad. Biol. Med. 43, 289-299. A novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer.
    12. Kundu, P., Mukhopadhyay, K A., Patra, J., Banerjee, A., Berg, D.E. and Swarnakar, S. (2006) J. Biol. Chem. 281, 34651-34662. Cag negative Helicobacter pylori strain infection upregulates matrix metalloproteinase-9 expression and activity in mice.
    13. Ganguly, K., Kundu, P., Banerjee, A., Reiter, R.J. and Swarnakar, S. (2006) Free Rad. Biol. Med. 41, 911-925. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants.
    14. Swarnakar, S., Ganguly, K., Kundu, P., Banerjee, A., Maity, P. and Sharma, A.V. (2005) J. Biol. Chem. 280(10), 9409-15. Curcumin regulates expression and activity of matrix metalloproteinases –9 and –2 during prevention and healing of indomethacin- induced gastric ulcer.
    1. Vidavalur, R., Swarnakar, S. Thirunavukkarasu, M., Samuel, S M and Maulik, N. In vivo and in vitro approaches to study mechanisms of cardioprotection targeting Ischemia/Reperfusion (I/R) injury: useful technique for cardiovascular drug discovery. Curr. Drug Dis Tech. (2008) 5(4), 269-78.
    2. Williams, D. L., Connelly, M. A., Temel, R. E., Swarnakar, S., Phillips, M. C., de la Llera-Moya M and Rothblat, G. H. Scavenger receptor BI and cholesterol   trafficking. Curr. Opin. Lipidol. (1999) 10, 329-339.
    1. Swarnakar, S. (2009) Biotechnology Applications, edited by Dr. Pascale Champagne & Prof. S. K. Mishra. Chapter: Gastric ulceration in animals: A technique for studying biomarkers.
    2. Swarnakar, S, Roychoudhury, S and Mishra A. (2011) Advances in Studies on Matrix Metalloproteinase Inhibitors, edited by Satya P. Gupta, published by Springer-Verlag,Germany. Chapter: The gelatinases and their inhibitors: The structure –activity relationship.
    3. Swarnakar, S., Paul, S and Ganguly, K. (2012) Angiognesis: insight from a systemic overview, edited by Gaetano Santulli, Nova Science Publisher. Chapter: Promotion of angiogenesis during healing of gastric ulcer.
    1. Swarnakar, S. and Dhar, T.K., (2010) Assay Development: Fundamentals and Practices by Ge Wu, Published by John Wiley & Sons Inc., Hoboken.