Parasuraman Jaisankar

Dr. Parasuraman Jaisankar

Chief Scientist
HOD, Organic & Medicinal Chemistry Division

Ph.D. Jadavpur University, 1995,
Raman Research Fellow – Prof. M. Kitamura, Nagoya University, Japan (2010),
RCMS Fellow – Nobel Laureate Prof. R. Noyori, & Prof. M. Kitamura, Japan (2001-02),
DAAD Fellow – Ulm University, Germany (1996-98).

+91 33 24995790
    1. Development of chiral ligands and their transition metal complexes for asymmetric organic transformations.
    2. Synthesis of Lead Compounds and their analogues having various biological activities, with special focus on anticancer and anti-asthmatic, anti-microbial, and anti-inflammatory compounds.
    3. Development of synthetic strategy for the generation of structurally unique bioactive molecules especially nitrogen heterocycles.
    4. Identification and structure elucidation of antibiotics isolated from marine actinobacterium.Search for safe drugs from herbal sources.
    1. Chatterjee S, Hintermann L, Mandal M, Achari A, Gupta S, Jaisankar P. Fiaud’s Acid: A Brønsted Acid Catalyst for Enantioselective Friedel-Crafts Alkylation of Indoles with 2-Alkene-1,4-diones. Org Lett. 2017 Jul 7;19(13):3426-3429. doi: 10.1021/acs.orglett.7b01383. Epub 2017 Jun 13.
    2. Gupta SJ, Dutta S, Gajbhiye RL, Jaisankar P, Sen AK. Synthesis, in vitro evaluation and molecular docking studies of novel amide linked triazolyl glycoconjugates as new inhibitors of α-glucosidase. Bioorg Chem. 2017 Jun;72:11-20. doi: 10.1016/j.bioorg.2017.03.006. Epub 2017 Mar 18.
    3. Vinayagam J, Gajbhiye RL, Mandal L, Arumugam M, Achari A, Jaisankar P. Substituted furans as potent lipoxygenase inhibitors: Synthesis, in vitro and molecular docking studies. Bioorg Chem. 2017 Apr;71:97-101. doi: 10.1016/j.bioorg.2017.01.016. Epub 2017 Jan 24.
    4. Saha S, Acharya C, Pal U, Chowdhury SR, Sarkar K, Maiti NC, Jaisankar P, Majumder HK. A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6281-93. doi: 10.1128/AAC.00352-16. Print 2016 Oct.
    5. Mishra A, Vinayagam J, Saha S, Chowdhury S, Roychowdhury S, Jaisankar P, Majumder HK. Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response. Pharmacol Res Perspect. 2014 Dec;2(6):e00070. doi: 10.1002/prp2.70. Epub 2014 Aug 24.
    6. Basu A, Jaisankar P, Kumar GS. Binding of novel 9-O-N-aryl/arylalkyl amino carbonyl methyl berberine analogs to poly(U)-poly(A)·poly(U) triplex and comparison to the duplex poly(A)-poly(U). Mol Biol Rep. 2014 Aug;41(8):5473-83. doi: 10.1007/s11033-014-3421-1. Epub 2014 May 30.
    7. Basu A, Jaisankar P, Suresh Kumar G. Interaction of 9-O-N-aryl/arylalkyl amino carbonyl methyl berberine analogs with single stranded ribonucleotides. J Photochem Photobiol B. 2014 May 5;134:64-74. doi: 10.1016/j.jphotobiol.2014.03.024. Epub 2014 Apr 12.
    8. Chowdhury S, Mukherjee T, Chowdhury SR, Sengupta S, Mukhopadhyay S, Jaisankar P, Majumder HK. Disuccinyl betulin triggers metacaspase-dependent endonuclease G-mediated cell death in unicellular protozoan parasite Leishmania donovani. Antimicrob Agents Chemother. 2014;58(4):2186-201. doi: 10.1128/AAC.02193-13. Epub 2014 Jan 27.
    9. Chaudhuri J, Chowdhury AA, Biswas N, Manna A, Chatterjee S, Mukherjee T, Chaudhuri U, Jaisankar P, Bandyopadhyay S. Superoxide activates mTOR-eIF4E-Bax route to induce enhanced apoptosis in leukemic cells. Apoptosis. 2014 Jan;19(1):135-48. doi: 10.1007/s10495-013-0904-9.Saha S, Mukherjee T, Chowdhury S, Mishra A, Chowdhury SR, Jaisankar P, Mukhopadhyay S, Majumder HK. The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo. Biochem Pharmacol. 2013 Dec 15;86(12):1673-87. doi: 10.1016/j.bcp.2013.10.004. Epub 2013 Oct 14.
    10. Chowdhury AA, Chaudhuri J, Biswas N, Manna A, Chatterjee S, Mahato SK, Chaudhuri U, Jaisankar P, Bandyopadhyay S. Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. PLoS One. 2013 Sep 9;8(9):e73672. doi: 10.1371/journal.pone.0073672. eCollection 2013.
    11. Basu A, Jaisankar P, Kumar GS. Photophysical and calorimetric studies on the binding of 9-O-substituted analogs of the plant alkaloid berberine to double stranded poly(A). J Photochem Photobiol B. 2013 Aug 5;125:105-14. doi: 10.1016/j.jphotobiol.2013.05.009. Epub 2013 Jun 4.
    12. Bhowmik A, Das N, Pal U, Mandal M, Bhattacharya S, Sarkar M, Jaisankar P, Maiti NC, Ghosh MK. 2,2′-diphenyl-3,3′-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway. PLoS One. 2013;8(3):e59798. doi: 10.1371/journal.pone.0059798. Epub 2013 Mar 28.
    13. Basu A, Jaisankar P, Suresh Kumar G. Binding of the 9-O-N-aryl/arylalkyl amino carbonyl methyl substituted berberine analogs to tRNA(phe.). PLoS One. 2013;8(3):e58279. doi: 10.1371/journal.pone.0058279. Epub 2013 Mar 19.
    14. Nandi D, Besra SE, Vedasiromoni JR, Giri VS, Rana P, Jaisankar P. Anti-leukemic activity of Wattakaka volubilis leaf extract against human myeloid leukemia cell lines. J Ethnopharmacol. 2012 Dec 18;144(3):466-73. doi: 10.1016/j.jep.2012.08.021. Epub 2012 Oct 13.
    15. Chowdhury S, Mukherjee T, Mukhopadhyay R, Mukherjee B, Sengupta S, Chattopadhyay S, Jaisankar P, Roy S, Majumder HK. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4(10):1126-43. doi: 10.1002/emmm.201201316.
    16. Mukherjee T, Chowdhury S, Kumar A, Majumder HK, Jaisankar P, Mukhopadhyay S. Saracoside: a new lignan glycoside from Saraca indica, a potential inhibitor of DNA topoisomerase IB. Nat Prod Commun. 2012 Jun;7(6):767-9.
    17. Mukherjee T, Sarkar T, Paul P, Chakraborty AK, Jaisankar P, Mukhopadhyay SB. Putralone, a novel 10alpha-hydroxy-25-nor D:A friedo-oleanane triterpenoid from Putranjiva roxburghii. Nat Prod Commun. 2012 Apr;7(4):511-3.
    18. Basu A, Jaisankar P, Suresh Kumar G. Synthesis of novel 9-O-N-aryl/aryl-alkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects. Bioorg Med Chem. 2012 Apr 15;20(8):2498-505. doi: 10.1016/j.bmc.2012.03.006. Epub 2012 Mar 8.
    19. Biswas N, Mahato SK, Chowdhury AA, Chaudhuri J, Manna A, Vinayagam J, Chatterjee S, Jaisankar P, Chaudhuri U, Bandyopadhyay S. ICB3E induces iNOS expression by ROS-dependent JNK and ERK activation for apoptosis of leukemic cells. Apoptosis. 2012 Jun;17(6):612-26. doi: 10.1007/s10495-011-0695-9.
    20. Roy A, Chowdhury S, Sengupta S, Mandal M, Jaisankar P, D’Annessa I, Desideri A, Majumder HK. Development of derivatives of 3, 3′-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons. PLoS One. 2011;6(12):e28493. doi: 10.1371/journal.pone.0028493. Epub 2011 Dec 12.
    21. Chakraborty JB, Mahato SK, Joshi K, Shinde V, Rakshit S, Biswas N, Choudhury Mukherjee I, Mandal L, Ganguly D, Chowdhury AA, Chaudhuri J, Paul K, Pal BC, Vinayagam J, Pal C, Manna A, Jaisankar P, Chaudhuri U, Konar A, Roy S, Bandyopadhyay S. Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance. Cancer Sci. 2012 Jan;103(1):88-99. doi: 10.1111/j.1349-7006.2011.02107.x. Epub 2011 Nov 7.
    22. Kumari R, Meyyappan A, Selvamani P, Mukherjee J, Jaisankar P. Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi. J Ethnopharmacol. 2011 Oct 31;138(1):256-9. doi: 10.1016/j.jep.2011.09.007. Epub 2011 Sep 16.
    23. Mandal M, Kumar D, Roy R, Sen R, Das P, Chatterjee M, Jaisankar P. Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity. Bioorg Med Chem Lett. 2011 May 15;21(10):3084-7. doi: 10.1016/j.bmcl.2011.03.028. Epub 2011 Mar 16.
    24. Kumari R, Meyyappan A, Nandi D, Agrawalla BK, Chowdhury AA, Selvamani P, Latha S, Giri VS, Mukherjee J, Bandyopadhyay S, Jaisankar P. Antioxidant and antibacterial activities of bark extracts from Commiphora berryi and Commiphora caudata. Nat Prod Res. 2011 Sep;25(15):1454-62. doi: 10.1080/14786411003752052. Epub 2011 Jul 11.
    25. Parasuraman Jaisankar, Tanaka S, Kitamura M. Catalytic Dehydrative S-Allylation of Cysteine Containing Peptides in Aqueous Media toward Lipopeptide Chemistry. J. Org. Chem. 76, 1894-1897 (2011).
    26. Regioselective One Pot Synthesis of 3, 3′-Diindolylethylene Derivatives and Study of their Cytotoxic activity, Madhumita Mandal, Deepak Kumar, Rajneeta Roy, Rupashree Sen, Padma Das, Mitali Chatterjeec and Parasuraman Jaisankar, Bioorganic & Medicinal Chemistry Lett. 21, 3084-3087 (2011).
    27. 2-Methyl-pyran-4-one-3-O-β-d-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFα-induced cell adhesion molecules expression by blocking nuclear transcription factor-κB (NF-κB), Sakshi Balwani, Debkumar Nandi, ParasuramanJaisankar and Balaram Ghosh, Biochimie,93, 921-930 (2011).
    28. Lewis Acid-Catalyzed One-Pot, Three-Component Route to Chiral 3,3′-Bipyrroles:  Dey, S., Pal, C., Nandi, D., Giri, V. S., Zaidlewicz, M., Krzeminski, M., Smentek, L., Hess, B. A., Gawronski, J., Kwit, M., Babu, N. J., Nangia, A., and Jaisankar, P. Organic  Lett., 10(7), 1373 – 1376 (2008).
    29. Mitochondria dependent ROS-mediated programmed cell death (PCD) induced by 3,3′-Diindolylmethane (DIM) through Inhibition of FoF1-ATP synthase in unicellular protozoan parasite Leishmania donovani: A. Roy, A. Ganguly, S. BoseDasgupta, B. B. Das, C. Pal, P. Jaisankar, H. K. Majumder, Molecular Pharmacology, 74 (5), 1292-1307 (2008).
    30. Asymmetric synthesis of N-1-(heteroaryl)ethyl-N-hydroxyureas: Mariusz J. Bosiak, Marek P. Krzemiński, P. Jaisankar and Marek Zaidlewicz, Tetrahedron: Asymmetry, 19, 956-963 (2008).
    31. Asymmetric synthesis of N-substituted N-hydroxyureas: Krzysztof Z. Łączkowski, Marcin M. Pakulski, Marek P. Krzemiński, P. Jaisankar and Marek Zaidlewicz, Tetrahedron: Asymmetry, 19, 788-795 (2008).
    32. Indium trichloride catalyzed efficient one-pot synthesis of highly substituted Furans: S. Dey, D. Nandi, P. K. Pradhan, V. S. Giri and P. Jaisankar, Tetrahedron Lett. 48, 2573-2575 (2007).
    33. Eco-friendly synthesis and study of new plant growth promoters: 3,3´- Diindolylmethane and its derivatives: C. Pal, S. Dey, S. K. Mahato, J. Vinayagam, P. K. Pradhan, V. S. Giri, P. Jaisankar, T. Hossain, S. Baruri, D. Ray and S. Mandal Biswas, Bioorganic & Medicinal Chemistry Lett. 17, 4924-4928 (2007).
    34. InCl3-HMTA as a Methylene Donor: One-Pot Synthesis of Diindolylmethane (DIM) and its Derivatives, P. K. Pradhan, S. Dey, V. S. Giri, and P. Jaisankar, Synthesis, 1779-1782 (2005).
    35. First Indium Trichloride Catalyzed Self-addition of Indoles: One Pot Synthesis of Indolylindolines, B. Pal, V. S. Giri, and P. Jaisankar, Catalysis Commun. 6, 711-715 (2005).
    36. Unusual Formation of Chiral b-Carboline Dimers Under Bischler-Napieralski Reaction Conditions: An Old Reaction With A New Direction: B. Pal, P. Jaisankar, and V. S. Giri, Tetrahedron Lett. 45, 6489-6492 (2004).
    37. Selective Reduction of Aldehydes to Alcohols Using Alumina with a Catalytic amount of Base Under Microwave Irradiation: P. K. Pradhan, P. Jaisankar, B. Pal, S. Dey, and V. S. Giri, Synth. Commun, 35, 2863-2872 (2004).
    38. Versatile Reagent for Reduction of Azides to Amines: B. Pal, P. Jaisankar, V. S. Giri, Synth. Commun, 34, 1317 (2004).
    39. First Triphenylphosphine Promoted Reduction of Maleimides to Succinimides: B. Pal, P. K. Pradhan, P. Jaisankar, and V. S. Giri, Synthesis, 1549 (2003).
    40. Synthetic studies in Indoloquinolizidine system: V. S. Giri, P. Jaisankar, R. K. Manna, J. N. Shoolery, P. Keifer, Tetrahedron, 51, 10101 (1995).
    41. Unusual formation of a Novel Pyrrolo[1′,2′:1,2]pyrido[3,4]-indole, V. S. Giri, S. K. Das and P. Jaisankar, J. Heterocyclic  Chemistry, 29, 767 (1992).
    42. Synthesis of alkaloids (±)-Deplancheine and Flavopereirine, P. Jaisankar, S. K. Das and V. S. Giri, Heterocycles, 32, 1109 (1991).