G. Senthil Kumar , Ph.D.

Scientist
Structural Biology & Bioinformatics
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Research Interest

  • Role of DNA methylation in retinal neurodegeneration
  • Integrative analysis of multi-omics data and dissecting the functional genomic basis of retinal diseases
  • Systems biology approach for early prognostic/diagnostic biomarker discovery
  • Strategizing and designing novel diagnosis and drug development strategies based on the above approaches.

Credentials

Ph.D. Genetics (2016) University of Madras (collaboration with University of Chicago, USA)

Grants & Supports

  1. Council of Scientific & Industrial Research (CSIR)
  2. CSIR-Indian Institute of Chemical Biology (IICB) 
  3. Indian Council of Medical Research (ICMR)
  4. National Institute of Genetics-International Joint Research grant - 2021, Shizuoka, JAPAN

Patents & Publications

  1. Kumari N, Karmakar A, Ahamad Khan MM, Ganesan SK. The potential role of m6A RNA methylation in diabetic retinopathy. Exp Eye Res. 2021 May 9;208:108616. doi: 10.1016/j.exer.2021.108616. Epub ahead of print. PMID: 33979630.
  2. Devarajan N, Manjunathan R, Ganesan SK. Tumor hypoxia: the major culprit behind cisplatin resistance in cancer patients. Crit Rev Oncol Hematol. 2021 Apr 13:103327. doi: 10.1016/j.critrevonc.2021.103327. Epub ahead of print. PMID: 33862250.
  3. Devarajan N, Jayaraman S, Mahendra J, Venkatratnam P, Rajagopal P, Palaniappan H, Ganesan SK. Berberine-A potent chemosensitizer and chemoprotector to conventional cancer therapies. Phytother Res. 2021 Feb 8. doi: 10.1002/ptr.7032. Epub ahead of print. PMID: 33559280.
  4. Jayaraman S, Devarajan N, Rajagopal P, Babu S, Ganesan SK, Veeraraghavan VP, Palanisamy CP, Cui B, Periyasamy V, Chandrasekar K. β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats. Molecules. 2021 Apr 6;26(7):2101. doi: 10.3390/molecules26072101. PMCID: PMC8038823.
  5. Kumari N, Karmakar A, Chakrabarti S, Ganesan SK. Integrative Computational Approach Revealed Crucial Genes Associated With Different Stages of Diabetic Retinopathy. Front Genet. 2020 Nov 12;11:576442. doi: 10.3389/fgene.2020.576442. PMID: 33304382; PMCID: PMC7693709.
  6. Ganesan SK, Venkatratnam P, Mahendra J, Devarajan N. Increased mortality of COVID-19 infected diabetes patients: role of furin proteases. Int J Obes (Lond). 2020 Dec;44(12):2486-2488. doi: 10.1038/s41366-020-00670-9. Epub 2020 Sep 1. PMID: 32873908; PMCID: PMC7461147.
  7. Kumari N, Karmakar A, Ganesan SK. Targeting epigenetic modifications as a potential therapeutic option for diabetic retinopathy. J Cell Physiol. 2020 Mar;235(3):1933-1947. doi: 10.1002/jcp.29180. Epub 2019 Sep 17. PMID: 31531859.
  8. Nalini D, Selvaraj J, Ganesan SK. Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia. J Cancer Res Clin Oncol. 2020 Jan;146(1):1-18. doi: 10.1007/s00432-019-03068-x. Epub 2019 Nov 13. PMID: 31724069.
  9. Ganesan SK, Dinesh Kumar K, Minogue PJ, Berthoud VM, Kannan R, Beyer EC, Santhiya ST. The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family. Open Access J Ophthalmol. 2016;1(1):106. Epub 2016 Jul 28. PMID: 28530003; PMCID: PMC5438206.
  10. K. Dinesh Kumar, Ganesan SK, A. Sathya, Palani Raj, G. Jayaraman, S.T. Santhiya.V235L mutation of human BEST1 gene, in association with Best macular dystrophy and predictions on the possibility of altered CERES Function. Journal of Clinical & Experimental Ophthalmology. 01/2015;06:50.
  11. Ganesan SK, Kyle JW, Minogue PJ, Dinesh Kumar K, Vasantha K, Berthoud VM, Beyer EC, Santhiya ST. An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract. Exp Eye Res. 2013 May;110:136-41. doi: 10.1016/j.exer.2012.10.010. Epub 2012 Oct 29. PMID: 23116563; PMCID: PMC3570674.
  12. Kumar KD, Ganesan SK, Santhiya ST. Nonspecific PCR amplification of CRYBB2-pseudogene leads to misconception of natural variation as mutation. Invest Ophthalmol Vis Sci. 2012 Aug 22;53(9):5770. doi: 10.1167/iovs.12-10575. PMID: 22915216.
  13. Santhiya ST, Ganesan SK, Sudhakar P, Gupta N, Klopp N, Illig T, Söker T, Groth M, Platzer M, Gopinath PM, Graw J. Molecular analysis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms. Mol Vis. 2010 Sep 10;16:1837-47. PMID: 21031021; PMCID: PMC2956670.