Malini Sen , Ph.D.

Senior Principal Scientist & Deputy Head
Cancer Biology & Inflammatory Disorder

Research Interest

  • Deciphering the role of mesenchymal stem cell factors including Wnts in various aspects of immune homeostasis, immune response to infection and inflammation.
  • Functional analysis of WISP3 (Wnt induced secreted protein 3) in the context of PPRD (Progressive pseudo Rheumatoid Dysplasia), a connective tissue disorder of genetic origin.


  • PhD, Albert Einstein College of Medicine, NY, USA 
  • Postdoctoral Associate, RWJ Pharmaceutical Research Institute, La Jolla, CA, USA 
  • Project Scientist and Arthritis Investigator, Medicine Department, University of California – San Diego, USA

Patents & Publications

  1. Padhan, D.K., Sengupta,  A., Patra, M., Ganguly, A., Mahata, S.K., and Sen, M. CCN6 regulates mitochondrial respiratory complex assembly and activity.  FASEB J. 2020, doi: 10.1096/fj.202000405RR
  2. Jati, S., & Sen, M. (2019). Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens. In Macrophage at the Crossroads of Innate and Adaptive Immunity. IntechOpen.
  3. Chakraborty, A., Maity, S., & Sen, M. (2019). Wnt5a signaling antagonizes Leishmania donovani infection. In Leishmaniasis-from Basic Research to the Field. IntechOpen.
  4. Jati, S., Sarraf, T. R., Naskar, D., & Sen, M. (2019). Wnt Signaling: Pathogen Incursion and Immune Defense. Frontiers in immunology, 10, 2551.
  5. Jati, S., Kundu, S., Chakraborty, A., Mahata, S. K., Nizet, V., Sen, M. (2018). Wnt5a signaling Promotes Defense against Bacterial Pathogens by activating a host autophagy circuit. Frontiers in Immunology, 9, 679.
  6. Chakraborty, A., Kurati, S. P., Mahata, S. K., Sundar, S., Roy, S., & Sen, M. (2017). Wnt5a Signaling Promotes Host Defense against Leishmania donovani Infection. The Journal of Immunology, 199 (3), 992-1002.
  7. Patra, M., Mahata, S. K., Padhan, D. K., & Sen, M. (2016). CCN6 (Wnt induced signaling protein–3) regulates mitochondrial function. J Cell Sci, jcs-186247
  8. Ghosh, G., & Sen, M. (2016). A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity. Molecular Cell, 63(4), 544-546.
  9. Guha, I., Naskar, D., & Sen, M. (2015). Macrophage as a mediator of immune response: Sustenance of immune homeostasis. Macrophage, 2.
  10. Naskar, D., Maiti, G., Chakraborty, A., Roy, A., Chattopadhyay, D., & Sen, M. (2014). Wnt5a–Rac1–NF-κB homeostatic circuitry sustains innate immune functions in macrophages. The Journal of Immunology, 192(9), 4386-4397.
  11. Repudi, S. R., Patra, M., & Sen, M. (2013). WISP3–IGF1 interaction regulates chondrocyte hypertrophy. J Cell Sci, 126(7), 1650-1658.
  12. Maiti, G., Naskar, D., & Sen, M. (2012). The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proceedings of the National Academy of Sciences, 109(41), 16600-16605.
  13. Sen M and Ghosh G. Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunology 2008, 181: 4441 – 5.
  14. Miller DS and Sen M. 2007.  Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species. BBRC 355: 156 – 61.
  15. Davis L, Chen Y and Sen M. 2006. WISP3 functions as a ligand and promotes superoxide dismutase activity. BBRC 342: 259 – 65.
  16. Sen M. 2005. Wnt Signaling in Rheumatoid Arthritis. Rheumatology 44: 708 – 713.
  17. Sen M, Cheng Yu-Ho, Goldring MB, Lotz M and Carson DA. 2004. WISP-3 dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheumatism 50: 488 – 97.
  18. Lu D, Zhao Y, Tawatao R, Cottam H, Sen M, Leoni L, Kipps TJ, Corr M and Carson DA. 2004. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. PNAS 101: 3118 – 23.
  19. Sen M, Reifert J, Lauterbach K, El-Gabalawy H, Rubin JS, Wolf V, Corr M and Carson DA. 2002. WNT signaling in rheumatoid arthritis synoviocytes regulates fibronectin and metalloproteinase expression. Arthritis Rheumatism 46: 2867 – 77.
  20. Rhee CS, Sen M, Wu C, Leoni L, Rubin J, Corr M and Carson DA. 2002. Wnt and Frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas.  Oncogene 21: 6598 – 605.
  21. Sen M, Chamorro M, Reifert J, Corr M, and Carson DA. 2001. Blockade of Wnt-5A / Frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheumatism 44: 772-781.
  22. Schmid M, Sen M, Rosenbach MD, Carrera CJ, Friedman H and Carson DA.  2000. A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.  Oncogene 19: 5747-5754.
  23. Sen M,Lauterbach K, El-Gabalawy H, Firestein GS, Corr M and Carson DA. 2000. Expression and function of wingless and frizzled homologs in rheumatoid arthritis.  PNAS 97: 2791-2796.