Arun Bandyopadhyay , Ph.D., FNASc, FAScT

Director
Cell Biology & Physiology
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Research Interest

  1. Identification of Protein Biomarker for Risk Assessment of Cardiovascular Disease
  2. Understanding Biochemical Basis of Compromised Reverse Cholesterol Transport in Humans 
  3. Inflammation Resolution in Plaque Stability and Implications in Atherosclerosis
  4. Unveiling Mitochondrial Dynamics in Cardiac Hypertrophy
  5. miRNA Mediated Molecular Regulation of Mitochondrial Dysfunction in Cardiac Hypertrophy
  6. Identification of Small Molecules for the Management of Respiratory Diseases

 

Translocation of Multiple AnxA6 clusters in cardiomyocytes, J.Biol.Chem 2014

Credentials

Ph.D.

Honours & Awards

FNASc, FAScT

Patents & Publications

List of Research Publications: 
https://doi.org/10.1016/j.jprot.2020.103796 https://doi.org/10.1016/j.jmb.2020.07.006

                                                                                                 

  1. Mukherjee D, Chander V and Bandyopadhyay A. Novel Regulation of PGC and Mitochondrial Biogenesis in Cardiomyocytes. Mol Cell Biol (under revision)
  2. Guha Ray A, Roy Choudhury K, Chakraborty S, Chakravarty D, Chander V, Jana B, Siddiqui KN and Bandyopadhyay A. Novel Mechanism of Cholesterol Transport by ABCA5 in Macrophages and Its Role in Dyslipidemia. J Mol Biol, 2020, 432,4922-4941
  3. Das AA, Roychoudhury K, Jagadeeshaprasad M G, Kulkarni MJ, Mondal PC and Bandyopadhyay A. Proteomic Analysis Detects Dysregulated Reverse Cholesterol Transport in Human Subjects with ST-Segment Elevation Myocardial Infarction. J Proteomics. 2020, 30,103796.
  4. Das AA, Chakravarty D, Bhunia  D, Ghosh S,   Mandal PC,  Siddiqui KN  and Bandyopadhyay A. Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signaling in coronary artery disease. Clin Science, 2019, 133 (22), 2283-2299.
  5. Kar, D and Bandyopadhyay A. Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes. Cell Phyiol. Biochem, 2018, 49, 245-259.
  6. Mastorci F , Vassalle C, Chatzianagnostou K , Marabotti C , Siddiqui K , Eba AO, Sidi Mhamed SA , Bandyopadhyay A , Nazzaro MS , Passera M and Pingitore A. Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies. Antioxidant, 2017, 6, 41
  7. Mukherjee S and Bandyopadhyay A. Proteomics in India: the clinical aspect. Clin Proteomics 2016, 13:21.
  8. Banerjee T, Kar Dipak, …….. Bandyopadhyay A. A novel triazine-aryl-bis-indole derivative inhibits both phosphodiesterase IV and expression of cell adhesion molecules. RSC Adv., 2015, 5, 70271–70281
  9. Banerjee, P, Chander V, Bandyopadhyay, A. Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes. Cell Death Dis (NpG). 2015;6:e1873.
  10. Banerjee P and Bandyopadhyay A. Cytosolic dynamics of annexin A6 triggers feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes. J.Biol.Chem. 2014, 289, 5371-5385.
  11. Banerjee T, Mukherjee, S, Ghosh, S, Biswas M, Dutta S, Pattari S, Chatterjee S, Bandyopadhyay A. Clinical Significance of Markers of Collagen Metabolism in Rheumatic Mitral Valve Disease. PLOS ONE. 2014, 9: e90527.
  12. Mukherjee, S, Jagadeeshaprasad, MG, Banerjee T, Ghosh, SK, Biswas M, Dutta S, Kulkarni M, Pattari S, Bandyopadhyay A. Proteomic analysis of human plasma in Chronic Rheumatic Mitral Stenosis reveals proteins involved in the Complement and Coagulation cascade. Clin. Proteom. 2014, 11:35.
  13. Bhattacharjee P, Paul S, Banerjee M, Patra D, Banerjee P, Ghoshal N, Bandyopadhyay A, Giri AK. Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2. Sci Rep.(NPG) 2013;3:2704.
  14. Banerjee N, Paul S, Sau TJ, Das JK, Bandyopadhyay A, Banerjee S, Giri AK.Epigenetic modifications of DAPK and p16 genes contribute to arsenic-induced skin lesions and nondermatological health effects. Toxicol Sci. 2013;135:300-308.
  15. Maity S, Kar D, De K, Chander V Bandyopadhyay A. Hyperthyroidism causes cardiac dysfunction by mitochondrial impairment and energy depletion. J. Endocrinol, 2013, 217:215-228.
  16. Banerjee T, Mukherjee, S, Biswas M, Dutta S, Chatterjee S, Pattari S, Nanda, S. Bandyopadhyay A. Circulating Carboxy-terminal Propeptide of Type I Procollagen is Increased in Rheumatic Heart Disease. Int. J. Cardiology 2012, 156:117-119.
  17. Dwivedi,S K D, Singh N,Kumari, R, Mishra S, Tripathi S, Banerjee P, Shah P,et al Bile Acid Receptor Agonist GW4064 Regulates PPARCoactivator-1 Expression Through EstrogenReceptor-Related Receptor.  Mol Endocrinol, 2011, 25(6):922-932.
  18. De P, Ghose Roy S, Kar D and Bandyopadhyay A. Excess of glucocorticoid induces myocardial remodeling and alteration of calcium signaling in cardiomyocytes. J. Endocrinol. 2011; 209:109-114.
  19. Mishra S, Chander V, Banerjee P, Oh JG, Lifirsu E, Park WJ, Kim DH and  Bandyopadhyay A. Interaction of annexin A6 with alpha actinin in cardiomyocytes. BMC Cell Biol. 2011; 12:7
  20. Member of the The Indian Genome Variation Consortium. Aggarwal S, et. Al. Proc, Natl Acad Sci. USA 2010;107:18961-18966.
  21. Paul S, Kundu S, Pramanick K, Bandyopadhyay A, Mukherjee D. Regulation of ovarian steroidogenesis in vitro by gonadotropin in common carp Cyprinus carpio: interaction between calcium- and adenylate cyclase-dependant pathway and involvement of ERK signaling cascade. J Mol Endocrinol. 2010. [Epub ahead of print].
  22. Mukherjee D, Roy SG, Bandyopadhyay A, Chattopadhyay A, Basu A, Mitra E, Ghosh AK, Reiter RJ, Bandyopadhyay D. Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. J Pineal Res. 2010 48(3):251-62.
  23. P. Venkatesh, Pulok K. Mukherjee, Satheesh Kumar N, Neelesh K. Nema, A. Bandyopadhyay, Hiroyuki Fukui, Hiroyuki Mizuguchi. Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes. J Ethnopharmacol 2009, 126:434-436.
  24. Roy SG, De P, Mukherjee D, Chander V, Konar A, Bandyopadhyay D and Bandyopadhyay A. Excess of Glucocorticoid induces cardiac dysfunction via activating Angiotensin II pathway. Cell. Physiol. Biochem. 2009, 24(1-2):1-10.
  25. Paul S, Pramanick K, Kundu S, Bandyopadhyay A and Mukherjee D. Involvement of PI3 kinase and MAP kinase in IGF-I and insulin-induced oocyte maturation in Cyprinus carpio. Mol. Cell. Endocrinol. 2009, 309(1-2):93-100.
  26. Zhao W, Fan GC, Zhang ZG, Bandyopadhyay A, Zhou X and Kranias EG. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic Res. Cardiol. 2009, 104(4):377-89.
  27. Member of The Indian Genome variation Consortium. Genetic landscape of the people of India: a canvas for disease gene exploration. J. Genetics. 2008, 87(1): 3-20.
  28. Raja S, Ahamed N, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol, 2007, 109(1):41-47.
  29. Ghose Roy S, Mishra S, Ghosh G and Bandyopadhyay A. Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase. Matrix Biol. 2007, 26:269-279.
  30. Ghosh G, De K, Maity S, Bandyopadhyay D, Bhattacharya S, Reiter RJ and Bandyopadhyay A. Melatonin protects against oxidative damage and restores GLUT4 expression in hyperthyroid rat heart. J. Pineal Res. 2007, 42:71-82.
  31. Mahata B, Mukherjee S, Mishra S, Bandyopadhyay A and Adhya S. Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells. Science. 2006, 314:471-474.
  32. Sinha S, Pal BC, Jagadeesh S, Banerjee PP, Bandyopadhyay A and Bhattacharya S. Mahanine inhibits growth and induces apoptosis in prostrate cancer cells through the deactivation of Akt and activation of caspases. The Prostrate. 2006, 66:1257-1265.
  33. Dey D, Basu D, Roy SS, Bandyopadhyay A and Bhattacharya S. Involvement of of novel PKC isoforms in FFA induced defects in insulin signaling. Mol. Cell. Endocrinol. 2006, 246:60-4.
  34. Sundararajan R, Haja NA, Venkatesan K, Mukherjee K, Saha BP, Bandyopadhyay A and Mukherjee PK. Cytisus scoparius link--a natural antioxidant. BMC Complement Altern Med. 2006, 6: 8.
  35. Dey D, Mukherjee M, Basu D, Datta M, Roy SS, Bandyopadhyay A and Bhattacharya S. Inhibition of insulin receptor gene expression and insulin signaling by fatty acid: interplay of PKC isoforms therein. Cell. Physiol. Biochem. 2005, 16:217-28.
  36. Member of The Indian Genome variation Consortium. The Indian Genome variation database (IGVdb): a project overview. Human Genetics. 2005, 118(1):1-11.
  37. De K, Ghosh G, Datta M, Konar A, Bandyopadhyay J, Bandyopadhyay D, Bhattacharya S and Bandyopadhyay A. Analysis of Differentially expressed genes in hyperthyroid-induced hypertrophied heart by cDNA microarray. J. Endocrinol. 2004, 182:304-314.
  38. Bandyopadhyay D, Ghosh G, Bandyopadhyay A and Reiter RJ. Melatonin protects against piroxicam-induced gastric ulceration. J. Pineal Res. 2004, 36: 195-203
  39. Bandyopadhyay J, Lee J, and Bandyopadhyay A. Regulation of calcineurin, a calcium-calmodulin-dependent protein phosphatase, in C. elegans. Molecules and Cells 2004, 18 (1): 10-16. 
  40. Bandyopadhyay D, Bandyopadhyay A, Das PK and Reiter RJ. Melatonin protects against ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J. Pineal Res. 2002, 32:1-7.
  41. Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim DH, Cho C, Liu LO, Snyder SH and Jung YK. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium triggered cell death. Proc. Natl. Acad. Sci. USA. 2002, 99:9870-9875.
  42. Shin DW, Pan Z, Bandyopadhyay A, Bhatt M, Kim DH and Ma J. Calcium dependent interaction between FKBP12 and calcineurin regulates activity of the Ca release channel in skeletal muscles. Biophys. J. 2002, 83: 2539-2549.
  43. Bandyopadhyay A, Shin DW and Kim DH. Regulation of ATP-induced calcium release in COS-7 cells by calcineurin. Biochem J. 2000, 348:173-181.
  44. Bandyopadhyay A, Shin DW, Ahn JO and Kim DH. Calcineurin regulates ryanodine receptor/Ca channels in rat heart. Biochem. J. 2000, 352:61-70.
  45. Bandyopadhyay J, Bandyopadhyay A, Choi HS, Kwon HB, Kang HK. Cloning and Characterization of cDNA Encoding Cdc2 Kinase, a Component of Maturation-Promoting Factor, in Rana dybowskii. Gen Comp  Endocrinol. 2000, 117(2):313-322.
  46. Bandyopadhyay A, Bandyopadhyay J, Chung JK, Choi HS, Kwon HB. Inhibition of S6 Kinase by Rapamycin Blocks Maturation ofRana dybowskii Oocytes. Gen Comp Endocrinol. 1999, 113(2):230-239.
  47. Bandyopadhyay A,  Bandyopadhyay J, Choi HH, Choi HS, Kwon HB. Plasma Membrane Mediated Action of Progesterone in Amphibian (Rana dybowskii) Oocyte Maturation. Gen Comp Endocrinol. 1998, 109(3):293-301.
  48. Bandyopadhyay A, Roy P and Bhattacharya S. Thyroid hormone induces the synthesis of a putative protein in the rat granulosa cell which stimulates progesterone release. J. Endocrinol., 1996, 150: 309 - 318.
  49. Bhattacharya S, Guin S, Bandyopadhyay A, Jana NR, and Halder S. Thyroid hormone induces the generation of a novel putative protein in piscine ovarian follicle that stimulates the conversion of pregnenolone to progesterone. Eur. J. Endocrinol., 1996, 134: 128 - 135.
 
List of Patents: 

Sl.No.

Title

Patent No. / Filing No.

Translational Research Contributions

1

RIAZINE-ARYL-BIS-INDOLES AND PROCESS FOR PREPARATION THEREOF

Patent no. 9085559

Granted: 21/07/2015

Novel PDE4 inhibitor targeted for lung disease therapy as a bronchidilator. Preclinical lab level validations done

2

Inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma

Patent no. 9302967

Granted 05/04/2016

Novel anti-inflammatory compound, targeted for combination therapy with PDE4 inhibitor. Preclinical lab level validations done

3

A molecule from herbal origin for the treatment of bronchial asthma.

Appl No. 0267DEL2011, Prov Filing Dt. 4/2/2011

A plant source of PDE 4 inhibitor. Alternate medicine for asthma and COPD

4

Biomarker for valvular heart disease

Appl No. AP/2013/006853

Blood based marker for detection of rheumatic heart disease. Prototype is ready.

 

BR

BR/1120130087013

 

IN

IN/2440DEL2010

 

PCT

PCT/IB2011/002400

 

ZA (granted)

2013/02538

 

Products

Prototype for Detection of Rheumatic Heart Disease

Prototype for Detection of Rheumatic Heart Disease