Prem Tripathi , Ph.D.

Scientist
Cell Biology & Physiology
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Research Interest

  • Role of endogenous neuronal progenitors in neurogenesis following neurodegeneration
  • Regulation of adult neural stem cell fate by small molecules/natural products.
  • Nanobiosensor for early detection of neurodegenerative diseases.
  • Functional dissection of H3K27 demethylase in hippocampus and dentate gyrus development.

Credentials

  • PhD, Scuola Normale Superiore, Pisa, Italy (2007-2010)
  • Postdoctoral Research, European Institute of Oncology, Campus IFOM IEO, Milan, Italy (2010-2013).
  • Postdoctoral Researcher, Seattle Children’s Research Institute, Seattle, United States (2014-2015)
  • Assistant Professor, Amity University, Noida, India (2016- 2017)

Honours & Awards

  • Early career research award from Department of Science and Technology (DST), 2018.
  • Awarded 3 years Postdoctoral Scholarship from AIRC, Italy (2011- 13).
  • Full fellowship to participate in Developmental Neurobiology DNC course, Japan (2012).
  • Scored 70/70 cum laude (merit) for PhD thesis defense (2010).
  • Awarded 3.5 years full fellowship from SNS, Pisa, Italy for doctoral studies (2007- 10).
  • Fellowship to participate to the Gordon research conferences (GRC), on Mechanisms of epilepsy & neuronal Synchronization, Waterville, USA (2008).
  • Full fellowship to participate in workshop on Gradient & Signaling, OIST, Japan (2008).

Patents & Publications

Publications

From IICB:

  1. Chandra Sc, Alam MT, Dey J, Chakrapani BPS, Ray U, Srivastava AK, Gandhi S, Tripathi PP*. (2020) Healthy gut, healthy brain: The gut microbiome in neurodegenerative disorders. Topics in Medicinal Chemistry (In Press) 
  2. Dey J, Alam MT, Chandra S, Gandhi S, Tripathi PP*. (2019) Recalibrating the Existence of New Neurons in Adult Brain. ACS Chem Neurosci. 10:2091-2093  
  3. Roberts A, Tripathi PP, Gandhi S. (2019) Graphene nanosheets as an electric mediator for ultrafast sensing of urokinase plasminogen activator receptor-A biomarker of cancer. Biosens Bioelectron. 141:111398
  4. Gandhi S*, Gupta J, Tripathi PP*. (2019) The Curious Case of Human Hippocampal Neurogenesis. ACS Chem Neurosci. 10:1131-1132 
  5. Tripathi PP*, Arami H, Banga I, Gupta J, Gandhi S*. (2018) Cell penetrating peptides in preclinical and clinical cancer diagnosis and therapy. Oncotarget. 9(98):37252-37267. (* equal corresponding author)
  6. Singh S, Mishra P, Banga I, S Parmar A, Tripathi PP, Gandhi S. (2018) Chemiluminescence based immunoassay for the detection of heroin and its metabolites. Bioimpacts. 8(1):53-58. 

 

Before Joining IICB:

  1. Seungshin H, Tripathi PP, Raza RA, Hevner RF, Beier DR (2019) Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis bioRxiv, (Preprint, by Cold Spring Harbor Laboratory)
  2. Seungshin H, Tripathi PP, Mihalas AB, Hevner RF, Beier DR (2017) C-terminal region truncation of RELN disrupts an interaction with VLDLR causing abnormal development of the cerebral cortex and hippocampus. The Journal of neuroscience 37(4):960-971.
  3. Tripathi PP*, Bozzi Y (2015) The role of dopaminergic and serotonergic systems in neurodevelopmental discorders: a focus on epilepsy and seizure susceptibility. BioImpacts 5(2):97-102 (* corresponding author) (Article selected for cover page story) 
  4. Provenzano G, Clementi E, Genovesi S, Scali M, Tripathi PP, Sgado P, Bozzi Y (2014) GH Dysfunction in Engrailed-2 Knockout Mice, a Model for Autism Spectrum Disorders. Frontiers in pediatrics 2:92. 
  5. Tripathi PP, Di Giovannantonio LG, Sanguinetti E, Acampora D, Allegra M, Caleo M, Wurst W, Simeone A, Bozzi Y (2014) Increased dopaminergic innervation in the  brain  of  conditional  mutant  mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility. Neuroscience 261:173-183.
  6. Sgado P, Genovesi S, Kalinovsky A, Zunino G, Macchi F, Allegra M, Murenu E, Provenzano G, Tripathi PP, Casarosa S, Joyner AL, Bozzi Y (2013) Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null  mutant  mice:  implications  for  autism  spectrum  disorders.   Experimental neurology  247:496-505.
  7. Burgold T, Voituron N*, Caganova M*, Tripathi PP*, Menuet C, Tusi BK,  Spreafico  F,  Bevengut  M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G (2012) The H3K27 demethylase  JMJD3 is  required for  maintenance of  the embryonic  respiratory neuronal network, neonatal breathing, and survival. CELL reports 2:1244-1258. (*Authors contributed equally to work) 
  8. Thangavelu SR, Tripathi PP, Arya U, Mishra HK,  Subramaniam  JRPD  (2011)  ALS  associated  mutant SOD1 impairs the motor neurons and astrocytes and wild type astrocyte secreted-factors  reverse  the impaired motor neurons. Annals of neurosciences 18:48-55.
  9. Tripathi PP, Santorufo G, Brilli E, Borrelli E, Bozzi Y (2010) Kainic acid-induced seizures activate GSK- 3beta in the hippocampus of D2R-/- mice. Neuroreport 21:846-850. 
  10. Tripathi PP, Sgado P, Scali M, Viaggi C, Casarosa S, Simon HH, Vaglini F, Corsini GU, Bozzi Y (2009) Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice. Neuroscience 159:842-849.
  11. Tripathi PP, P.; Corsini, G.U.; Simone, A.; Bozzi, Y.; (2009) Developmental basis of seizure susceptibility: A focus on dopaminergic and serotonergic systems. Current trends in Neurology 3:93-101.
  12. Teixidor GT, Gorkin RA, 3rd, Tripathi PP, Bisht GS, Kulkarni M, Maiti TK, Battacharyya TK, Subramaniam JR, Sharma A, Park BY, Madou M (2008) Carbon microelectromechanical systems as a substratum for cell growth. Biomedical materials (Bristol, England) 3:034116.
  13. Tripathi PP, Di Giovannantonio LG, Viegi A, Wurst W, Simeone A, Bozzi Y (2008) Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience  28:9271-9276.
 
Patents

Gandhi S, Tripathi PP. FTO/AuNPs- based nanosensor for Chlorpyrifos detection in fruits and vegetables”. Patent application number 2017/11044750, National filing date 14 December 2017.