Ramalingam Natarajan , Ph.D.

Principal Scientist
Organic & Medicinal Chemistry

Research Interest

  1. Design and synthesis of novel receptors, through dynamic combinatorial chemistry, towards selective recognition of biologically important targets
  2. Selective and tunable transport of inorganic ions and organic molecules across bilayer membrane by novel synthetic ion channels and carriers
  3. Crystal engineering of functional organic molecules towards biomedical applications


MSc (1998), Anna University, Chennai
PhD (2005) , Indian Institute of Technology, Kanpur (Prof. J Narasimha Moorthy)
Post-doctoral Fellow (2005-2006), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea (Prof. Kimoon Kim)
Post-doctoral Fellow (2006-2007) with Alexander von Humboldt Fellowship at University of Wuerzburg, Germany (Prof. Frank Wuerthner) 
Post-doctoral Fellow (2007-2010), University of Bristol, UK (Prof. Anthony P. Davis)
Research Assistant Professor (2011-2013), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea (Prof. Kimoon Kim)

Patents & Publications

  1. Samanta J, Natarajan R. Cofacial Organic Click Cage to Intercalate Polycyclic Aromatic Hydrocarbons. Org Lett. 2016 Jul 15;18(14):3394-7. doi: 10.1021/acs.orglett.6b01554. Epub 2016 Jul 1.
  2. Bhunia SK, Polley A, Natarajan R, Jana R. Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade. Chemistry. 2015 Nov 16;21(47):16786-91. doi: 10.1002/chem.201503474. Epub 2015 Oct 6.
  3. Bharitkar YP, Das M, Kumari N, Kumari MP, Hazra A, Bhayye SS, Natarajan R, Shah S, Chatterjee S, Mondal NB. Synthesis of Bis-pyrrolizidine-Fused Dispiro-oxindole Analogues of Curcumin via One-Pot Azomethine Ylide Cycloaddition: Experimental and Computational Approach toward Regio- and Diastereoselection. Org Lett. 2015 Sep 18;17(18):4440-3. doi: 10.1021/acs.orglett.5b02085. Epub 2015 Sep 2.
  4. Nayak DK, Baishya R, Natarajan R, Sen T, Debnath MC. Tricarbonyl (99m)Tc(i) and Re(i)-thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection. Dalton Trans. 2015 Sep 28;44(36):16136-48. doi: 10.1039/c5dt02264a.
  5. Mal K, Das S, Maiti NC, Natarajan R, Das I. ZnI2-Catalyzed Diastereoselective [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketothioesters with Olefins. J Org Chem. 2015 Mar 20;80(6):2972-88. doi: 10.1021/jo5024766. Epub 2015 Mar 9.
  6. Cucurbit[7]uril: A High-Affinity Host for Encapsulation of Amino Saccharides and Supramolecular Stabilization of Their α-Anomers in Water.
    Jung, Y; Natarajan, R.*; Ko, Y. H; Kim, K*. Angew. Chem. Int. Ed2014, 54, 1003-1007.
  7. Hollow Nanotubular Toroidal Polymer Microrings. Lee, J. L.; Baek. K.; Kim, M.; Yun, G.; Ko, Y. H.; Lee, N. -S.; Hwang, I; Kim, J.; Natarajan, R.; Park, C. G.; Sung, W.; Kim, K. Nature Chem. 20146, 97-103.
  8. Tunable Porous Organic Crystals: Structural Scope and Adsorption Properties of Nanoporous Steroidal Ureas.
    Natarajan, R.; Bridgland, L.; Sirikilkajorn, A.; Lee, J.-H.; Haddow, M. F.; Magro, G.; Ali, B.; Narayanan, S.; Strickland, P.; Charmant, J. P. H.; Orpen, A. G.; McKewon, N. B.; Bezzu, C. G.; Davis, A.P. J. Am. Chem. Soc. 2013135, 16912-16925.
  9. Tandem catalysis with a bifunctional site-isolated Lewis acid–Brønsted base metal–organic framework, NH2-MIL-101(Al)
    Srirambalaji, R.; Hong, S.; Natarajan, R.; Yoon, M.; Hota, R.; Kim, Y.; Ko, Y. H.; Kim, K. Chem. Commun201248, 11650-11652.
  10. Nanoporous Organic Alloys.
    Natarajan, R.; Magro, G.; Bridgland, L. N.; Sirikulkajorn, A.; Narayanan, S.; Ryan, L. E.; Haddow, M. F.; Orpen, A. G.; Charmant, J. P. H.; Hudson, A. J. Davis, A. P. Angew. Chem., Int. Ed. 201150, 11386-11390.
    Highlight: Rational Design of Multifunctional Nanopores by Mixing Matching Molecules. Mastalerz, M. Angew. Chem., Int. Ed.201251, 584-586..
  11. Water Chains in Hydrophobic Crystal Channels: Nanoporous Materials as Supramolecular Analogs of Carbon Nanotubes.
    Natarajan, R.; Charmant, J. P. H.; Orpen, A. G.; Davis, A. P. Angew. Chem., Int. Ed. 201049, 5125-5129.
  12. Influence of Weaker Interactions on the Self-Assembly of Rigid Molecular Scaffolds Based on Tetraarylbimesityls.
    Moorthy, J. N.; Natarajan, R.; Savitha, G.; Venugopalan, P. Cryst. Growth Des. 20066, 919-924
  13. Anion Driven Self-Assembly of Tetrapyridyl Ligand with a Twist.
    Moorthy, J. N.; Natarajan, R.; Savitha, G.; Suchopar, A.; Richards, R. M. J. Mol. Struct. 2006796, 216-222.
  14. Three-Dimensional Organic Scaffolds with a Twist: Synthesis and Self-Assembly.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. J. Org. Chem. 200570, 8568-8571.
  15. Corundum, Diamond and PtS Metal-Organic Frameworks (MOFs) with a Difference: Self-Assembly with a Unique Pair of 3-Connecting D2d-Symmetric 3,3’,5,5’-Tetrakis(4-pyridyl)bimesityl.
    Natarajan, R.; Savitha, G.; Dominiak, P.; Wozniak, K.; Moorthy, J. N. Angew. Chem., Int. Ed. 200544, 2115-2119.
  16. Identification of New Supramolecular Synthon in o-Anisaldehydes: Molecular Self-Assembly into Tapes and Staircases.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. J. Mol. Struct. 2005741, 107-114.
  17. Self-Assembly of a Unique Extended-Tetrahedral 3,3’,5,5’-Tetrakis(4-pyridyl) Ligand into Discrete Supramolecular Cubes by Face Directed Metal Coordination.
    Natarajan, R.; Savitha, G.; Moorthy, J. N.Cryst. Growth Des. 20055, 69-72.
  18. Polymorphism of an o-Anisaldehyde: A Novel Example of Channel-Type Organization Sustained by Weak C-H∙∙∙O and C-H∙∙∙N Hydrogen Bonds.
    Moorthy, J. N.; Natarajan, R.; Mal, P.; Venugopalan, P. New J. Chem. 2004, 1416-1419.
  19. Characterization of Planar Cyclic Form of Water Hexamer in an Organic Supramolecular Complex: An Unusual Self-Assembly of Bimesityl-3,3’-dicarboxylic Acid.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. Angew. Chem., Int. Ed. 200241, 3417-3420.
  20. Helical Self-Assembly of Substituted Benzoic Acids: Influence of Weaker X∙∙∙X and C-H∙∙∙X Interactions.
    Moorthy, J. N.; Natarajan, R.; Mal, P.; Venugopalan, P. J. Am. Chem. Soc. 2002124, 6530-6531.
  21. Efficient Photocyclization of o-Alkylbenzaldehydes in the Solid State: Direct Observation of E-Xylyenols en route to Benzocyclobutenols.
    Moorthy, J. N.; Mal, P.; Natarajan, R.; Venugopalan, P. J. Org. Chem. 200166, 7013-7019.
  22. Solid-State Photochromism and Photoreactivity of o- and p-Anisaldehydes. Remarkable Stabilization of o-Xylyenols.
    Moorthy, J. N.; Mal. P.; Natarajan, R.; Venugopalan, P. Org. Lett. 20013, 1579-1582.
  23. Indium Trichloride-Catalyzed Imino Diels-Alder Reactions: Synthesis of New Indolylquinoline Derivatives.
    Babu, G.; Nagarajan, R.; Natarajan, R.; Perumal, P. T. Synthesis2000, 661-666.