Sujoy K Das, PhD, MRSC, FASCh
Infectious Diseases and Immunology
Bioinspired and biomimetic synthesis of nanomaterials, Functionalization of nanomaterials with antimicrobial peptide, Antibiofouling and antibacterial coating, Advanced healthcare material development, Photothermal therapy for wound infection
We work at the interface of biology and materials science and aiming to address the challenges of sustainable synthesis of nanomaterials, eradication of biofilm formation, novel healthcare materials development and treatment of wound infection. The current research focus is emphasized on designing and synthesis of bioinspired nanomaterials for healthcare and biomedical applications and it is divided into five research directions:
Fabrication of nanomaterials by bioinspired and biomimetic approach: About 500 million years ago organisms started growing inorganic materials like calcium carbonate, silica, bone and glass. The synthesis process occurs through a biologically guided process known as biomineralization. Inspiring from this natural occurring process, our research effort is focused on the development of novel strategies for the controlled nanomaterial synthesis using living organisms as natural nanofactory. We demonstrated for the first time that proteins played a crucial role in determining the size and shape of the metal nanoparticles and the biomolecules layer around the nanoparticles govern the structure function relationship.
Antibiofouling material and antibacterial coating: Bacterial colonization and subsequent biofilm formation is a major cause of death, disability, and socioeconomic loss for millions of people worldwide. Biofilm formation on medical devices is also a major concern in the healthcare industry. Owing to unique physicochemical properties, nanoparticles can strongly regulate their ability to interact and penetrate bacterial cells. Very recently, we have developed antimicrobial peptide coated nanocomposite material as novel anti-biofouling material to combat with bacterial biofilm formation. We also explored antimicrobial mechanism and demonstrated that reactive oxygen species (ROS) generation is the major reason for bactericidal activity. Physical damage of the cell membrane and oxidative decomposition of nucleic acids and proteins also contributed to some extent. The coating of nanobiocomposite material on various surfaces prevented bacterial adhesion and subsequent growth on the surfaces.
Advanced healthcare material: Deaths due to road accidents, terror attacks, and battle field casualties are a real menace of the contemporary times. Recent study revealed that uncontrolled haemorrhage is accounting ~10% of death per year, however, death can be prevented if the haemorrhage is controlled within few minutes of injury. To develop a quick blood clotting agent, we are exploring the potential application of nanomaterial and have formulated a novel hemostatic wound dressing scaffold, which stops the bleeding within minutes and speeding the wound healing process. This hemostatic wound dressing product has been demonstrated and validated in laboratory level for technology evaluation.
Smart hydrogel to stop bleeding and promote wound healing: Topical haemostats have been used to treat visible and accessible injuries. However, non-accessible vascular and internal injuries are life threatening and require immediate attention. The hydrogels has been found to be as promising candidate to serve as haemostat to prevent large volume of blood loss from vascular and internal injuries. Inspired by mother nature, we are exploring the preparation of mussel-inspired injectable hydrogel with haemostatic, tissue adhesive and wound healing properties.
Photodynamic therapy for wound infection: The complications related to bacterial infection at wound sites significantly reduces the wound healing time. Excessive use of antibiotics increased the emergence of drug resistant bacteria and therefore, the treatment of biofilm associated chronic wound infections remain a major challenge. Recent advancement in nanotechnology holds a promising approach for the treatment of biofilm associated wound infection through photothermal therapy. The photothermal ablation using near-IR (NIR) light converts absorbed light into local heat, which kills the bacterial cells with minimal damage to surrounding tissue. We are exploring the development of 3D hybrid hydrogel for non-invasive photothermal ablation of bacterial pathogen and infected wound care management.
- Senior Scientist (August 2015-Continue), CSIR-Indian Institute of Chemical Biology, Kolkata
- Assistant Professor, Biological Science, Academy of Scientific and Innovative Research (AcSIR)
- Scientist (August 2011-August 2015), CSIR-Central Leather Research Institute, Chennai
- Postdoc (2009-2011): School of Biotechnology, Dublin City University, Ireland
- Postdoc (2008-2009): Biotechnology Centre, Technical University Dresden, Germany
- Ph.D. (2003-2008): Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata
- M.Sc. (2002): Biochemistry, Calcutta University
Honours & Awards
- Fellow of Academy of Science, Chennai (FASCh)
- Member of Royal Society of Chemistry (MRSC, UK): 2018
- Editorial Board Member of General Chemistry (2018-till date)
- Young Scientist Award 2017 in Biological Sciences received from Academy of Science, Chennai
- Member of American Chemical Society (ACS, USA):2017
- Life Member of National Academy of Biological Science, Chennai, India: 2017
- Guest Editor: Enzyme and Microbial Technology for a Special Issue on “Biosynthetic Nanoparticles and their Applications”
- Received Certificate of Recognition from Elsevier, and ACS for Reviewing Papers
- Reviewers of various International Journals viz. ACS, RSC, Scientific Report, Elsevier, Willey, Spinger-Verlag, etc.
- Award of appreciation from CSIR-CLRI for publication in high impact factor journals
- Member of Institutional (CSIR-CLRI) Statutory Committee of Intellectual Property (IP) Management: 2014-2018
- Member of Board of Studies of Chettinad University, Chennai: 2014-2017
- Life Member of Indian Association for the Cultivation of Science, Kolkata, India : 2015
- Member of Management Council (CSIR-CLRI) during the year 2014-2016
- DST First Track Young Scientist Research Grant: 2012
- Rapid Grant for Young Investigators (RGYB): DBT 2012
- Member of Society for Science and Nature: 2012
- Postdoctoral Research Fellowship: Irish Research Council for Science, Engineering and Technology (IRCSET), EMPOWER Government of Ireland Postdoctoral Fellowship
- Postdoctoral Research Fellowship: FCT-Government of Portugal Postdoctoral Fellowship
- Life Member of Indian Society of Surface Science and Technology, Kolkata, India : 2008
Grants & Supports
Fabrication of 3D Hybrid Hydrogel: A Novel Safe-by-Design Concept with Effective Photothermal Ablation of Bacterial Infection
Funding Agency: SERB, Govt. of India
Project cost: 41,00,000 INR (approx.)
Nanomaterial based water and wastewater disinfectant (Nanobiotic)
Funding Agency: CSIR, Govt. of India
Project cost: 28,00,000 INR (approx.)
Biomolecules Immobilized Inorganic Carrier Matrix for Wastewater Treatment
Funding Agency: CSIR, Govt. of India
Project cost: 16,00,000 INR
Duration: April 2012-March 2017
Bioinspired Magnetic and Noble Metal-Based Hybrids Nanomaterials (MNHs): Synthesis, Functionalization and its Application to Biomedical and Environmental Biotechnology
Funding Agency: DBT, Govt. of India
Project cost: 42,00,000 INR (approx.)
Duration: February 2013-August 2016
Synthesis, Characterization and Application of Bio-inspired Magnetic Nanomaterials
Funding Agency: DST, Govt. of India
Project cost: 24,00,000 INR (approx.)
Duration: January 2013-December 2015
Green Chemical Approach for Synthesis of Gold Nanoparticles: Characterization and Mechanistic Aspect
Funding Agency: IRCSET, Govt. of Ireland
Project cost: 156,000 Euro (approx.)
Duration: November 2009-October 2011
Protein Mediated Synthesis of Gold Nanoparticle: A Green Chemical Approach
Funding Agency: National Access Point, Govt. of Ireland
Project cost: 83,500 Euro (approx.)
Duration: April 2010-March 2011
Patents & Publications
- Bio-Reduced Graphene Oxide as a Nanoscale Antimicrobial Coating for Medical Devices. Priyadarshani Choudhary, and Sujoy K. Das*. ACS Omega 2019, 4, 387-397 (Invited Article)
- Facile Synthesis, Biofilm Eradication and Biocompatibility Studies of Poly-cationic Peptide Functionalized Graphene-Silver Nanocomposite. Thanusu Parandhaman, and Sujoy K. Das*. Biomater. Sci. 2018, 6, 3356-3372 (I.F. 5.83).
- Microcapsule from Diverse Polyfuctional materials: Synergistic Instructions for Sharp Response by pH change. Nagaraju Pentela, N. Duraipandy, Nikhil Sainath, Thanusu Parandhaman, M. S. Kiran, Sujoy K. Das, S. N. Jaisankar, Debasis Samanta. New J. Chem. 2018, 42, 8366-8373 (I.F. 3.201). Cover Page (Inside Front) Article
- Biomaterial Functionalized Graphene-Magnetite Nanocomposite: A Novel Approach for Simultaneous Removal of Dyes and Heavy-Metal Ions. Baskaran Ramalingam, Thanusu Parandhaman, Priyadarshani Choudhary, and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2018, 6, 6328-6341 (I.F. 6.14).
- Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?- Rekha Yamini Kosuru, Amrita Roy, Sujoy K. Das, Soumen Bera. Mol. Nutr. Food Res. 2018, 62, 1700699 (I.F. 5.15).
- Fabrication of Non-toxic reduced Graphene Oxide Protein Nano-framework as Sustained Antimicrobial Coating for Biomedical Application. Priyadarshani Choudhary, Thanusu Parandhaman, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran, Sujoy K. Das*. ACS Appl. Mater. Interfaces, 2017, 9, 38255–38269. (I.F. 8.097) (Highlighted in Nature India).
- Fabrication of Nanoporous Sodium Niobate Coating on 316L SS for Orthopaedics. K. Saranya, S. Thirupathi Kumara Raja, R. S. Subhasree, A. Gnanamani, Sujoy K. Das, N. Rajendran. Ceram. Int. 2017, 43, 11569-11579 (I.F. 3.05).
- Metal Nanoparticle Loaded Magnetic-Chitosan Microsphere: Water Dispersible and Easily Separable Hybrid Metal Nano-Biomaterial for Catalytic Applications. Thanusu Parandhaman, Nagaraju Pentela, Baskaran Ramalingam, Debasis Samanta and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2017, 5, 489−501 (I.F. 6.14).
- Fungal surface protein mediated one-pot synthesis of stable and hemocompatible gold nanoparticles. M Kitching, P Choudhary, S Inguva, Y Guo, M Ramani, Sujoy K. Das*, Enrico Marsili*. Enz. Microb. Technol. 2016, 95, 76-84 (I.F. 2.932).
- Effect of gemini surfactant (16-6-16) on the synthesis of silver nanoparticles: A facile approach for antibacterial application. AM Siddiq, T Parandhaman, AF Begam, Sujoy K. Das, Md. Sayem Alam. Enz. Microb. Technol. 2016, 95, 118-127 (I.F. 2.932).
- Antibacterial Effects of Biosynthesized Silver Nanoparticles on Surface Ultrastructure and Nanomechanical Properties of Gram-Negative Bacteria viz. Escherichia coli and Pseudomonas aeruginosa Baskaran Ramalingam, Thanusu Paranthaman, and Sujoy K. Das*. ACS Appl. Mater. Interfaces 2016, 8, 4963-4976 (I.F. 8.097).
- Cationic Surfactant (CTAC) Assisted Synthesis of Silver Nanoparticles with Controlled Size: Optical, Morphological and Bactericidal Studies. Md. Sayem Alam, AM Siddiq, SS Narayanan, Debasis Samanta, Sujoy K. Das. J. Nanoeng. Nanomanufac. 2015, 5, 124-131.
- Facile Synthesis of Silver Nanoparticles Decorated Magnetic-Chitosan Microsphere for Efficient Removal of Dyes and Microbial Contaminants. Baskaran Ramalingam, Md. Motiar R Khan, Bholanath Mondal, Asit Baran Mandal*, and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2015, 3, 2291–2302 (I.F. 6.14).
- Green Synthesis of Nanomaterials with Special Reference to Environmental and Biomedical Application. Sujoy K. Das* and Asit Baran Mandal*. Current Sci. 2015, 108, 1999-2002 (Cover Page Article) (I.F. 0.843).
- Total Elimination of Polluting Chrome Shavings, Chrome, and Dye Exhaust Liquors of Tannery by a Method Using Keratin Hydrolysate. Govindaswamy Ramamurthy, Baskaran Ramalingam, Mohammed Farhan Katheem, Thottapalli Parvathaleswara Sastry, Sundaramurthy Inbasekaran, Vasiya Thanveer, Sengamalai Jayaramachandran, Sujoy K. Das, and Asit Baran Mandal. ACS Sustainable Chem. Eng. 2015, 3, 1348-1358 (I.F. 6.14).
- Antimicrobial Behavior of Biosynthesized Silica–Silver Nanocomposite for Water Disinfection: A Mechanistic Perspective. Thanusu Paranthaman, Anisha Das, B. Ramalingam, Debasis Samanta, T. P. Sastry, Asit Baran Mandal*, and Sujoy K. Das*. J. Hazard. Mater. 2015, 290, 117-126 (I.F. 6.434).
- Impact of Surface Functionalization of AgNPs on Binding and Conformational Change of Hemoglobin (Hb) and Hemolytic Behavior. L. Bhavani Devi, Sujoy K. Das, and Asit Baran Mandal*. J. Phys. Chem. C 2014, 118, 29739–29749 (I.F. 4.484).
- Understanding the Biosynthesis and Catalytic Activity of Pd, Pt, and Ag Nanoparticles in Hydrogenation and Suzuki Coupling Reactions at the Nano-Biointerface. Sujoy K. Das*, Thanusu Paranthaman, Pentela Nagaraju, A. K. M. Maidul Islam, Asit Baran Mandal*, and Manabendra Mukherjee. J. Phys. Chem. C 2014, 118, 24623–24632 (I.F. 4.484).
- Synthesis and Association of Ag(0) Nanoparticles in Aqueous Nonionic Surfactant Triton X-100 Solution: A Facile Approach for Antibacterial Activity. Md. Sayem Alam, A. Mohammed Siddiq, S. Sriman Narayanan, Sujoy K. Das, Debasis Samanta and Asit Baran Mandal. Materials Focus 2014, 3,156-162.
- Bio-inspired Fabrication of Silver Nanoparticles on Naostructured Silica: Characterization and Application as a Highly Efficient Hydrogenation Catalyst. Sujoy K. Das*, Md. Motiar R. Khan, Arun K. Guha, Nityananda Naskar. Green Chem. 2013, 15, 2548-2557 (I.F. 8.586).
- Nano-Silica Fabricatd with Silver Nanoparticles: Antifouling Adsorbent for Efficient Dye Removal, Effective Water Disinfection and Biofouling Control. Sujoy K. Das*, Md. Motiar R. Khan, Thanusu Paranthaman, Fathima R. Laffir, Arun K. Guha, G. Sekaran, and Asit Baran Mandal*. Nanoscale 2013, 5, 5549–5560, [Highlighted in several International Nanotechnology blogs and forum like Nature India, Genesis Nano Technology, Nanowerk, Great thing from small things, BioPortFolio, Before It's News, Nanochemistry, and Times of India]. (I.F. 7.233)
- Silver-Nano Biohybrid Material: Synthesis, Characterization and Application in Water Purification. Sujoy K. Das*, Md. Motiar R. Khan, Arun K. Guha, Akhil R. Das, and Asit Baran Mandal. Bioresource Technol. 2012, 124, 495-499 (I.F. 5.807).
- “Click” Polymerization on Self-assembled Monolayer: A Convenient Approach to Functionalize Various Surfaces with Polytriazole. Debasis Samanta, P. Murugan, S. J. Ananthakrishnan, N. Somanathan, Sujoy K. Das, S. N. Jaisankar, and Asit Baran Mandal. Chem. Comm. 2012, 48, 12068-12070 (I.F. 6.29).
- Biomineralization Mechanism of Gold by Zygomycete Fungi Rhizopus oryzae. Sujoy K. Das*, Jinni Liang, Michael Schmidt, Fathima Lafir, and Enrico Marsili*. ACS Nano 2012, 6, 6165-6173. [Highlighted in Mycology Research Today] (I.F. 13.709).
- Synthesis, Characterization and Catalytic Application of Bioinspired Gold Nanoparticles. Sujoy K. Das, Calum Dickinson, Fathima Lafir, Dermot F. Broughan, and Enrico Marsili. Green Chem. 2012, 14, 1322-1334 (I.F. 8.586).
- Biotechnological Potential of Soil Isolate, Flavobacterium mizutaii for Removal of Azo Dyes: Kinetics, Isotherm, and Microscopic Study. Sujoy K. Das*, Ishita Shome, and Arun K. Guha. Sep. Sci. Technol. 2012, 47, 1913-1925 (I.F. 1.24).
- Surface Functionalization of Aspergillus versicolor Mycelia: in situ Fabrication of Cadmium Sulphide Nanoparticles and Removal of Cadmium Ions from Aqueous Solution. Sujoy K. Das,* Ishita Shome, and Arun K. Guha. RSC Adv. 2012, 2, 3000-3007 (I.F. 2.936).
- A Green Chemical Approach for the Synthesis of Gold Nanoparticles: Characterization and Mechanistic Aspect. Sujoy K. Das, and Enrico Marsili. Rev. Environ. Sci. Bio/Technol. 2010, 9, 199-204 (I.F. 5.716).
- Microbial Synthesis of Multi-Shaped Gold Nanostructures. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. Small 2010 6, 1012–1021 (I.F. 9.59). [Highlighted in Nature India]
- Interaction of Malathion, an Organophosphorus Pesticide with Rhizopus oryzae Biomass. Subhankar Chatterjee, Sujoy K. Das, Rajdeep Chakravarty, Adrita Chakrabarti, Subrata Ghosh and Arun K. Guha. J. Hazard. Mater. 2010, 174, 47-53 (I.F. 6.434).
- A Study on Lead Adsorption by Mucor ruxii Biomass. Shraboni S. Majumdar,≠ Sujoy K. Das,≠Rajdeep Chatterjee, Tarashankar Bandyopadhyoy, and Arun K. Guha. Desalination 2010, 251, 96-102 (≠both have equal authorship) (I.F. 6.603).
- Gold Nanoparticles: Microbial Synthesis and Application in Water Hygiene Management. Sujoy K. Das,* Akhil R. Das, and Arun K. Guha. Langmuir 2009, 25, 8192- 8199 (I.F. 3.789). [Highlighted in Nature India, UKessays.com]
- Adsorption Behavior of Lindane on Rhizopus oryzae Biomass: Physico-Chemical Studies’-Subrata Ghosh, Sujoy K. Das, Arun K. Guha, and Asis K. Sanyal. J. Hazard. Mater. 2009, 172, 485-490 (I.F. 6.434).
- Structural and and Nanomechanical Properties of Termitomyces clypeatus Cell Wall and Interaction with Chromium. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. J. Phys. Chem. B 2009,113, 1485–1492 (I.F. 3.146).
- Biosorption of Hexavalent Chromium by Termitomyces clypeatus Biomass: Kinetics and Transmission Electron Microscopic Study. Sujoy K. Das, Arun K. Guha. J. Hazard. Mater. 2009,167, 685-691 (I.F. 6.434).
- Adsorption Behavior of Mercury on Functionalized Aspergillus versicolor Mycelia: Atomic Force Microscopic Study. Sujoy K. Das, Akhil R. Das and Arun K. Guha. Langmuir 2009, 25, 360-366 (I.F. 3.789).
- Jute Stick Powder as a Potential Biomass for the Removal of Congo Red And Rhodamine B from their Aqueous Solution. Gopal C. Panda,≠ Sujoy K. Das,≠ Arun K. Guha. J. Hazard. Mater. 2009, 164, 374–379. (≠ both have equal authorship) (I.F. 6.434).
- Interaction of Chromium with Resistant Strain Aspergillus versicolor: Investigation with Atomic Force Microscopy and Other Physical Studies. Sujoy K. Das, Manabendra Mukherjee and Arun K. Guha. Langmuir 2008, 24, 8643-8650 (I.F. 3.789).
- Adsorption of Rhodamine B on Rhizopus oryzae: Role of Functional Groups and Cell Wall Components. Sujoy K. Das, Piyasa Ghosh, Indrajit Ghosh and Arun K. Guha. Colloids Surf. B: Biointerfaces 2008, 65, 30-34 (I.F. 3.887).
- Adsorption Behavior of Copper Ions on Mucor rouxii Biomass through Microscopic and FTIR Analysis. Shraboni S. Majumdar, Sujoy K. Das, Tapan Saha, Gopal C. Panda, Tarashankar Bandyopadhyoy, Arun K. Guha. Colloids Surf.B: Biointerfaces 2008, 63, 138–145 (I.F. 3.887).
- Biosorption of Cadmium and Nickel by Functionalized Husk of Lathyrus Sativus. Gopal C. Panda, Sujoy K. Das and Arun K.Guha. Colloids Surf. B: Biointerfaces 2008, 62, 173-179 (I.F. 3.887).
- A Study on the Adsorption Mechanism of Mercury on Aspergillus versicolor Biomass. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. Environ. Sci. Technol. 2007, 41, 8281-8287 (I.F. 6.653).
- Biosorption of Chromium by Termitomyces clypeatus. Sujoy K. Das, Arun K. Guha. Colloids Surf. B: Biointerfaces 2007, 60, 46–54 (I.F. 3.887).
- Adsorption of Nickel on Husk of Lathyrus sativus: Behavior and Binding Mechanism. Gopal C. Panda, Sujoy K. Das, Tarashankar Bandopadhyay and Arun K.Guha. Colloids Surf. B: Biointerfaces 2007, 57, 135-142 (I.F. 3.887).
- Adsorption of Cadmium on Husk of Lathyrus sativus: Physico-chemical Study. Gopal C. Panda, Sujoy K. Das, Sandipan Chatterjee, Palash.B. Maity, Tarashankar Bandopadhyay and Arun K. Guha.Colloids Surf. B: Biointerfaces 2006, 50, 49-54 (I.F. 3.887).
- Adsorption Behavior of Rhodamine B on Rhizopus oryzae Biomass. Sujoy K. Das, Jayati Bhowal, Akhil R. Das, and Arun K. Guha. Langmuir 2006, 22, 7265-7272 (I.F. 3.789).
* Corresponding Author, # Equal Contribution
- A Novel Multifunctional Graphene Reinforced Biomaterial as Hemostatic and Wound Dressing Material and its Process for Preparation Thereof. Sujoy K Das, Subhasree R Subramanian, Priyadarshani Choudhary, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran. Indian Patent Application: 201711044089; Filed on: 08/12/2017.
- A novel Polycationic Peptide Conjugated Graphene-Metal Nanocomposite and A Process for Preparation thereof. Sujoy K Das, Thanusu Paranthaman, Debasis Samanta, Md. Sayem Alam, G. Sekaran, and Asit Baran Mandal. Indian Patent Application: 1886DEL2015, Filed on: 26/06/2015.
- Novel Ruthenium Benzylidene Poly[N-Isopropylacrylamide] Compounds and A Process for the Preparation Thereof. Debasis Samanta, P. Nagaraju, P. Murugan, Md. Sayem Alam, Sujoy K. Das, Asit Baran Mandal. Indian Patent Application: 2725DEL2014, Filed on: 8/10/2014
Biosynthetic nanoparticles for biotechnological and biomedical applications. Enrico Marsili, Sujoy K. Das. Enz. Microb. Technol. 2016, 95, 1-3.
- Sustainable Nanostructured Materials for Culturing of Various Biological Cells. Manash Deep Dey, Rpak Mukhopadhyay, and Sujoy K Das*. In "Dynamics of Advanced Sustainable Nanomaterials and their Related Nanocomposites at the Bio-Nano Interface", Elsevier, 2019
- Bioinspired Metal Nanoparticle: Synthesis, Properties and Application. Sujoy K. Das and Enrico Marsili. Nanomaterials, ISBN 978-953-307-913-4. InTech, 2011
1. Antibacterial and Antibiofouling Nanocomposite Material
(Patent Application: 1886DEL2015, Filed on: 26/06/2015)
2. Hemostatic pad
(Patent Application: 201711044089; Filed on: 08/12/2017)
3. Wound healing scaffold
(Patent Application: 201711044089; Filed on: 08/12/2017)