Anirban Manna, Ph.D.

Senior Technician, CIF and P&I Division
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Research Focus

To study the molecular mechanisms of CML in cell cycle phases on the generation of ROS, oxidative stress, activations of transcription factors, receptors, gene expression, cell migration and invasion, tumor suppressor genes and oncogenes, DNA damage and repair, cell cycle regulation, apoptosis utilizing signal transduction pathways such as MAPK/ERKs/JNKs/Akt/PI-3K metabolic disorders including microarray analysis, real time RT-PCR, protein and gene sequencing etc. for characterizations and to standardize the redox regulation of cancer cells in in vitro and in vivo model.

Research Interest

Understanding the molecular mechanisms behind leukemia:

  • Interactions between various blood cancer-related variables and pathways. 
  • The function of transcription factors and the signaling network in controlling blood malignancy.
  • The molecular mechanism of CML using natural compounds. 
  • Role of oxidative and nitrosative stress in CML.
  • Identifying pharmacological agents and their mode of action in CML.
  • Phytocompounds as anticarcinogenic potential medication using an in silico experiment.

Credentials

  • Ph.D. (Biotechnology), CSIR-IICB, Kolkata, University of Calcutta
  • M.Sc. (Zoology), Vidyasagar University
  • B.Sc. (Hons.), University of Calcutta

Patents & Publications

 

Publications:

  1. Manna, A., Roy, T., Das, T., Bandyopadhyay, S., & Swarnakar, S. (2022) Potency of phytocompounds as hydroxychavicol and plumbagin in combination to fight against leukemia via activation of MAPK-mediated apoptotic pathway: An in vitro approach. Int J Pharm Sci Drug Res. 14(1): 122-129.
  2. Chaudhuri, J., Chowdhury, A.A., Biswas, N., Manna, A., Chatterjee, S., Mukherjee, T., Chaudhuri, U., Jaisankar, P., & Bandyopadhyay, S. (2014) Superoxide activates mTOR-eIF4E-Bax route to induce enhanced apoptosis in leukemic cells. Apoptosis. 19(1): 135-148.
  3. Chowdhury, A.A., Chaudhuri, J., Biswas, N., Manna, A., Chatterjee, S., Mahato, S.K., Chaudhuri, U., Jaisankar, P., & Bandyopadhyay, S. (2013) Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. PloS One. 8(9): e73672.
  4. Biswas, N., Mahato, S.K., Chowdhury, A.A., Chaudhuri, J., Manna, A., Vinayagam, J., Chatterjee, S., Jaisankar, P., Chaudhuri, U., & Bandyopadhyay S. (2012) ICB3E induces iNOS expression by ROS-dependent JNK and ERK activation for apoptosis of leukemic cells. Apoptosis. 17(6): 612-626.
  5. Chakraborty, J.B., Mahato, S.K., Joshi, K., Shinde, V., Rakshit, S., Biswas, N., Choudhury Mukherjee, I., Mandal, L., Ganguly, D., Chowdhury, A.A., Chaudhuri, J., Paul, K., Pal, B.C., Vinayagam, J., Pal, C., Manna, A., Jaisankar, P., Chaudhuri, U., Konar, A., Roy, S., & Bandyopadhyay, S. (2012) Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance. Cancer Sci. 103(1): 88-99.
  6. Rakshit, S., Mandal, L., Pal, B.C., Bagchi, J. Biswas, N., Chaudhuri, J., Chowdhury, A.A., Manna, A., Chaudhuri, U., Konar, A., Mukherjee, T., Jaisankar, P., & Bandyopadhyay, S. (2010) Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Biochem Pharmacol. 80(11): 1662-1675.

 

Patents:

  1. Inhibitors of phosphatidylinositol-3-kinase (PI3) and inducers of nitric oxide (NO)
    • United States Patent Application 20120190738
    • Type: Grant
    • Filing Date: January 12, 2010
    • Publication Date: July 26, 2012
    • Assignee: Coucil of Scientific & Industrial Research
    • Inventors: Bandyopadhyay, S., Pal, B.C., Jaisankar, P., Roy, S., Bagchi Chakrabotry, J., Choudhury Mukherjee, I., Mahato, S.K., Konar, A., Rakshit, S., Mandal, L., Ganguly, D., Paul, K., Manna, A., Vinayagam, J., & Pal, C.
  2. Substituted cathechols as inhibitors of IL-4 and IL-5 for the treatment of bronchial asthma 
    • United States Patent Application 20140135393
    • Type: Grant
    • Filing Date: April 11, 2012
    • Publication Date: May 05, 2014
    • Assignee: Council of Scientific & Industrial Research
    • Inventors: Bandyopadhyay, S., Ghosh, B., Jaisankar, P., Pal, B.C., Roy, S., Paul, B., Ram, A., Mabalirajan, U., Ali, N., Bandopadhyay, A., Konar, A., Bagchi Chakraborty, J., Choudhury Mukherjee, I., Chaudhuri, J., Mahato, S.K., Manna, A., Sinha R., Bhattacharya, P., Vinayagam, J., Jana, D.P., & Chowdhury, S.
  3. Extract of Piper betel leaves for the treatment of human malignancies by inducing oxidative stress
    • United States Patent Application 20110142969
    • Type: Grant
    • Filing Date: December 02, 2008
    • Publication Date: June 16, 2011
    • Applicant: Council of Scientific & Industrial Research
    • Inventors: Bandyopadhyay, S., Pal, B.C., Bagchi Chakraborty, J., Rakshit, S., Mandal, L., Paul, K., Biswas, N., & Manna, A.

 

Book Chapters:

  1. Deb N, Mallick S, Jaiswal A, Manna A, Mabalirajan U and Swarnakar S. (2019) Role of MMPs and Oxidants in Lung Diseases in the Book Oxidative Stress in Lung Diseases. Vol. 1:149-169. Springer Nature.

 

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