Arindam Talukdar , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry
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Research Interest

Our lab aims to answer fundamental questions that lie at the interface of chemistry and biology by integrating the concept of organic chemistry, biochemistry and molecular modeling to perform structure-based design and synthesis of novel chemical entity to unravel the molecular mechanism and develop potential treatment for human diseases.

Probing Endosomal Toll-like Receptors (TLRs). TLRs are members of the larger family of evolutionarily conserved pattern recognition receptors which are critical first line of defence for self-nonself discrimination by the host immune response. Aberrant endosomal TLR activation is implicated in autoreactive inflammation in different autoimmune diseases. The goal is to rationally design selective inhibitors for the nucleic acid-recognizing TLRs for devising novel therapeutic strategies in relevant clinical contexts. 

Epigenetic modifying enzymes as novel therapeutic targets: The main focus is to perform structure-based design and synthesis of small-molecule regulators of epigenetics modifying enzymes such as histone methyltransferases (HMT) as tools to unravel the complex biology of epigenetics and contribute towards epigenetic-based drugs for the treatment of a number of diseases such as cancer, autoimmunity, diabetes, or neurological disorders.

Credentials

  • Senior Research Scientist (2010-2012), Albany Molecular Research Inc. Singapore
  • Post-doctoral Research Associate (2005-2009), Purdue University, USA (Prof. Mark Cushman).
  • Post-doctoral Research Scholar (2004-2005), The Ohio State University, USA (Prof. Peng George Wang).
  • M.Pharmacy (1997) Medicinal Chemistry, Panjab University, Chandigarh, India (Prof. Tilak Raj Juneja).

Patents & Publications

PUBLICATIONS
  1. Ayan Mukherjee, Snehasis Mishra, Kotla Naveen Kumar, Krishnendu Manna; Swarnali Roy, Biswajit Kundu, Debomita Bhattacharya, Krishna Das Saha, Arindam Talukdar*, Semisynthetic Quercetin Derivatives with Potent Antitumor Activity in Colon Carcinoma (2019) ACS-Omega,In Press
  2. Biswajit Kundu, Subhendu Kumar Das, Srijita Paul Chowdhuri, Sourav Pal, Dipayan Sarkar, Arijit Ghosh, Ayan Mukherjee, Debomita Bhattacharya, Benu Brata Das, and Arindam Talukdar*, Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity. (2019) Journal of Medicinal Chemistry, 62, 3428−3446, https://doi.org/10.1021/acs.jmedchem.8b01938
  3. Biswajit Kundu, Dipayan Sarkar, Namrata Ray, Arindam Talukdar*, Understanding the riboflavin biosynthesis pathway for the development of antimicrobial agents (2019) Medicinal Research Reviews, 1_34, https://doi.org/10.1002/med.21576
  4. Sourav Pal, Vinay Kumar, Biswajit Kundu, Debomita Bhattacharya, Nagothy Preethy, Mamindla Prashanth Reddy, Arindam Talukdar*, Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors (2019) Computational and Structural Biotechnology Journal, 17, 291-310, https://doi.org/10.1016/j.csbj.2019.02.006
  5. Barnali Paul, Oindrila Rahaman, Swarnali Roy, Sourav Pal, Sohal Satish, Ayan Mukherjee, Amrit R. Ghosh, Deblina Raychaudhuri, Roopkatha Bhattacharya, Sunny Goon, Dipyaman Ganguly and Arindam Talukdar*, Activity-guided Development of Potent and Selective Toll-like Receptor 9 Antagonists (2018) European Journal of Medicinal Chemistry, 159, 187-205, https://doi.org/10.1016/j.ejmech.2018.09.058
  6. Chinky Shiu Chen Liu, Deblina Raychaudhuri, Barnali Paul, Yogaditya Chakrabarty, Amrit Raj Ghosh, Oindrila Rahaman, Arindam Talukdar and Dipyaman Ganguly, Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation (2018) Journal of Immunology, 200(4), 1255-1260, https://doi.org/10.4049/jimmunol.1701118
  7. Swarnali Roy, Barnali Paul, Ayan Mukherjee, Biswajit Kundu and Arindam Talukdar*, Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine (2017) RSC Advances, 7, 44366-44370, https://doi.org/10.1039/C7RA08482J
  8. Swarnali Roy, Ayan Mukherjee, Barnali Paul, Oindrila Rahaman, Shounak Roy, Gundaram Maithri, Bandaru Ramya, Sourav Pal, Dipyaman Ganguly and Arindam Talukdar*, Design and Development of Benzoxazole Derivatives with Toll-like Receptor 9 Antagonism (2017) European Journal of Medicinal Chemistry, 134, 334-347, https://doi.org/10.1016-j.ejmech.2017.03.086
  9. Arindam Talukdar, Y. Zhao, W. Lv, A. Bacher, B. Illarionov, M. Fischer, and Mark Cushman, O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase (2012) Journal of Organic Chemistry, 77, 6239-6261, https://doi.org/10.1021-jo1004313
  10. Abdelrahman S. Mayhoub, Arindam Talukdar, and Mark Cushman, A Highly Efficient Oxidation of Benzyl Methyl Ethers with NBS Selectively Affords Either Aromatic Aldehydes or Aromatic Methyl Esters (2010) Journal of Organic Chemistry, 75(10), 3507-3510, https://doi.org/10.1021-jo1004313
  11. Arindam Talukdar, Ekaterina Morgunova, Jianxin Duan, Winfried Meining, Lennart Nilsson, Adelbert Bacher, Boris Illarionov, Markus Fischer, Rudolf Ladenstein, Mark Cushman, Virtual Screening, Selection and Development of a Novel Structural Scaffold for Inhibition of Lumazine Synthase (2010) Bioorganic Medicinal Chemistry, 18, 3518-3534, https://doi.org/10.1016/j.bmc.2010.03.072
  12. Arindam Talukdar, Meghan Breen, Adelbert Bacher, Boris Illarionov, Markus Fischer, Gunda Georg, Qi-Zhuang Ye, and Mark Cushman, Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity (2009) Journal of Organic Chemistry, 74(15), 5123–5134, https://doi.org/10.1021/j0900238q
  13. Arindam Talukdar, Boris Illarionov, Adelbert Bacher, Markus Fischer, and Mark Cushman, Synthesis and enzyme inhibitory activity of the S-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase (2007) Journal of Organic Chemistry, 72, 7167-7175, https://doi.org/10.1021/jo0709495
  14. Wenlan Chen, Chengfeng Xia, Jinhua Wang, Prakash Thapa, Yusen Li, Arindam Talukdar, Janos Nadas, Wenpeng Zhang, Dapeng Zhou, Peng George Wang, Synthesis and Structure-Activity Relationship Study of Isoglobotrihexosylceramide Analogues (2007) Journal of Organic Chemistry, 72, 9914-9923, https://doi.org/10.1021/jo701539k
  15. Ha Young Kim, Arindam Talukdar, and Mark Cushman, Regioselective synthesis of N-b-hydroxyethylaziridines by ring-opening reaction of epoxides with aziridine generated in situ (2006) Organic Letters, 8(6), 1085-1087, https://doi.org/10.1021/c10529703
  16. Lizhi Zhu, Arindam Talukdar, Guisheng Zhang, James P. Kedenburg, Peng George Wang, A divergent synthesis of uncommon sugars from furanaldehyde. (2005) Synlett, 10, 1547-1550, https://doi.org/10.1055/s-2005-869846
  17. Gurjar M. K., Arindam Talukdar, Synthesis of terminal disaccharide unit of Klebsiella pneumoniae, (2004) Tetrahedron, 60, 3267-3271, https://doi.org/10.1016/j.tet.2004.02.017
  18. Arindam Talukdar, Unusual conversion of sugar oximes to sugar nitriles with ruthenium catalysts. (2002) Synthetic Communications,32(22),3503
  19. Gurjar M. K., Arindam Talukdar, Heck reaction of (S)-N-Cbz-allyl glycine tert-butyl ester with aromatic halides (2002) Synthesis,315
  20. Juneja T. R., Arindam Talukdar*, Gupta R. L., Mutagenicity of Sulfoscanate: a comparative study. (2002) Mutation Res. ,518,1.      155-161
  21. T. R., Juneja, Arindam Talukdar*, Nimish Mehta, Gupta R. L., Effect of various alkyl and unsaturated substituents on the mutagenicity of some nitrophenyl thioethers. (2001) Mutation Res. , 495, 97-102, https://doi.org/10.1016/s13835718(01)00201-7.
  22. Gurjar M. K., Sadalapure K., Adhikari S., Sarma B. V. N. B. S., Arindam Talukdar, Chorghade , M. S. Kinetic resolution of aryl glycidyl ethers (1998) Heterocycles,48,1471

 

BOOK CHAPTERS
  1. Luo S., Zhu, L., Arindam Talukdar, Mi, X., Cheng, J-P., Wang P. G. "Recent Advances in Rear Earth-Metal Triflate catalyzed Organic Synthesis in Green Chemistry". (2005) Mini-Reviews in Organic Chemistry. 2, 546
  2. Arindam Talukdar, Wang P. G. "N-Nitroso Compounds”. In Nitric Oxide Donors and its Applications Edited by Wang, P. G.; Cai, T. B.; Taniguchi, N.(2004)Wiley-VCH, Germany
  3. Chorghade M. S., Gurjar M. K., Arindam Talukdar. “Fascinating Excursions into Chiral Chemistry: An Insider’s Perspective” (2002) CHIMICA OGGI Chemistry Today 20(10), 20

 

PATENTS
  1. Bicycle Topoisomerase I Inhibiting Compounds, Process For Preparation And Use Thereof. Application No.: 0031NF2018 Date of filing: 29.05.2018
  2. Purine Based Compounds As Toll-Like Receptor 9 Antagonist. Application No.: PCT/IN2018/050714 Date of filing: 8.10.2017
  3. Bicyclic Compound and Use Thereof for Inhibiting SUV39H2. Application No.: PCT/US2016/0051350 Date of filing: 12.09.2016
  4. Blocking toll-like receptor 9 signaling with small molecule antagonist. Application No.: WO2017163264A4 Date of filing: 20.03.2016
  5. Preparation of 2,5-disubstituted pyrrolidines and tetrahydrothiophenes as leukotrine biosynthesis inhibitors. Application No.: EP 1115702 Date of filing: 22.02.2002