Indu Bhusan Deb , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry
details-banner

Research Interest

  • Our research interests lie in the development of the new catalytic system using transition metal for C-H/C-X bond functionalization and development of synthetic strategy employing C-H/C-X bond activation chemistry for the synthesis of bioactive small molecules. 
  • Asymmetric catalysis using newly designed ligand and catalyst for the synthesis of biologically important molecules.

 

Credentials

  • 2014- Present: Senior Scientist/Assistant Professor(AcSIR)
  • 2013: Research Investigator (April, 2013-Dec, 2013), Bristol Myers Squibb –Biocon Research Center, Bangalore
  • 2011-2013: Post Doctoral Research Associate, Nanyang Technological University, Singapore with professor NAOHIKO Yoshikai)
  • 2008-2010: Post Doctoral Research Associate, Rutgers – The State University of New Jersey, New Jersey, USA with professor Daniel Seidel)
  • 2009: Ph.D. Indian Institute of Technology Bombay (IIT Bombay), Mumbai, India with professor I. N. N. Namboothiri. Thesis submitted in 2008)

Honours & Awards

  • Star award in process chemistry for outstanding contribution (Bristol Myers Squibb–Biocon Research Center, Syngene, 2013)

Grant Supports

  1. Approved by DST, India from 2014-2017.
  2. Bristol Mayer Squibb research fellowship, 2015-2020

 

Patents & Publications

SELECTED PUBLICATIONS

  1. “Diastereoselective Spirocyclization of Cyclic N-Sulfonyl Ketimines with Nitroalkenes via Iridium-Catalyzed Redox Neutral Cascade” Reaction Aniket Mishra, Upasana Mukherjee, Writhabrata Sarkar, Sudha Lahari Meduri, Arup Bhowmik and Indubhusan Deb* Org. Lett.  2019, 21, 2056-2059 DOI: 10.1021/acs.orglett.9b00295  (Selected as Cover page).
  2. 19. “Copper-Mediated Direct and Selective C-H Thiolation of Quinazolinones” Writhabrata Sarkar, † Aniket Mishra, † Arup Bhowmik and Indubhusan Deb*Asian J. Org. Chem. 2019 (Accepted). (†contributed equally). https://doi.org/10.1002/ajoc.201900199
  3. “Cobalt-Catalyzed Directed sp2 CH Acetoxylation of Arenes Employing Mn(OAc)3. 2H2O as Acetoxy Source” Writhabrata Sarkar, Arup Bhowmik, † Aniket Mishra, † Tripta Kumari Vats and Indubhusan Deb* Advanced Synthesis & Catalysis 2018, 360, 3228-3232 https://doi.org/10.1002/adsc.201800398 (†contributed equally).
  4. “Rhodium-Catalyzed Direct and Selective ortho C-H Chalcogenation of N-(Hetero)aryl-7-azaindoles” Tripta Kumari Vats,† Aniket Mishra† and Indubhusan Deb* Advanced Synthesis & Catalysis 2018, 360, 2291-2296 https://doi.org/10.1002/adsc.201800090  (†contributed equally).
  5. “Ir(III)/MPAA-Catalyzed Mild And Selective C-H Amidation Of  N-sulfonyl ketimines: An Access To Benzosultam Fused Quinazolines/Quinazolinones”  Aniket Mishra,* Upasana Mukherjee, Tripta Kumari Vats and Indubhusan Deb* Journal of Organic Chemistry  2018, 83, 3756-3767  DOI: 10.1021/acs.joc.8b00125
  6. “Rhodium-Catalyzed sp2 C-H Acetoxylation of N-Aryl Azaindoles/ N-Heteroaryl Indolines”  Aniket Mishra,† Tripta Kumari Vats,† Mahesh P. Nair, Arindam Das and Indubhusan Deb* Journal of  Organic Chemistry  2017,  82, 12406-12415 (†contributed equally).
  7. “Ruthenium-Catalyzed Direct and Selective C–H Cyanation of N-(Hetero)aryl-7-azaindoles” Aniket Mishra, Tripta Kumari Vats and Indubhusan Deb* Journal of  Organic Chemistry  2016.  81, 6525-6534 [Top 5 most read articles in July, 2016].
  8. “Palladium-Catalyzed Oxidative Cyclization for the Synthesis of Indolyl/pyrrolyl-3-phosphonates” Aniket Mishra and Indubhusan Deb* Advanced Synthesis & Catalysis 2016, 358, 2267-2272. [Top 15 most accessed articles in June, 2016]. 

 

From Postdoc-PhD

  1. “Facile Access to Ring-Fused Aminals via Direct α-Amination of Secondary Amines with ortho-Aminobenzaldehydes. Synthesis of Vasicine, Deoxyva-sicine, Deoxyvasicinone, Mackinazolinone and Ruteacarpine” Richers, M. T.; Deb, Indubhusan, Platonova, A. Y.; Zhang, C.: Seidel, Daniel. Synthesis 2013, 1730-1748.
  2. “Conjugate Addition of Curcumins to Chalcones and Azodicarboxylates” Ayyagari, N.; Mehta A.; Deb, Indubhusan; Mobin, S. M.; Namboothiri, I. N. N. Tetrahedron 2013, 69, 5973-5980.
  3. “Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime” Deb, Indubhusan, Yoshikai,  Naohiko.  Org. Lett. 2013, 15, 4254-4257. 
  4. “Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones” Wei, Ye; Deb, Indubhusan, Yoshikai,  Naohiko.  J. Am. Chem. Soc. 2012, 134, 1201-1204.  [Highlighted in SYNFACTS 2012 and Angew Chem. Int Edu. 2013]
  5. “Redox-Neutral Indole Annulation Cascades” Haibach, M. C.; Deb, Indubhusan; De, C. K.; Seidel, Daniel J. Am. Chem. Soc. 2011, 133, 2100-2103. [Top 20 most downloaded articles in Feb, 2011 and Highlighted in SYNFACTS 2011, 440]
  6. “Redox Isomerization via Azomethine Ylide Intermediates: N-Alkyl Indoles from Indolines and Aldehydes” Deb, Indubhusan; Das, D.; Seidel, Daniel . Org. Lett. 2011, 13, 812-815.
  7. “Decarboxylative Formation of N-Alkyl Pyrroles from 4-Hydroxyproline” Deb, Indubhusan; Coiro, D.; Seidel, Daniel.  Chem. Commun. 2011, 47, 6473-6475. 
  8. “Retro-Claisen Condensation vs Pyrrole Formation in Reactions of Amines and 1,3-Diketones” Deb, Indubhusan; Seidel, Daniel. Tetrahedron Lett. 2010, 51, 2945-2947.
  9. “Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines” Murarka, S.; Deb, Indubhusan; Zhang, C.; Seidel, Daniel.  J. Am. Chem. Soc. 2009, 131, 13226-13227. [Highlighted in SYNFORM 2009/09 as well as SYNFACTS 2009(12), 352].
  10. “Morita-Baylis- Hillman Reactions Between Conjugated Nitroalkenes or Nitrodienes and Carbonyl Compounds” Deb, Indubhusan; Shanbhag, P.; Mobin, S. M.; Namboothiri, I. N. N. Eur. J. Org. Chem. 2009, 4091-4101. 
  11. “Synthesis of Benzo-Fused Medium Ring Cyclic Ethers via Michael Addition-Ring Closing Metathesis Strategy Involving Nitroaliphatic Compounds” Deb, Indubhusan; John, S.; Namboothiri, I. N. N. Tetrahedron 2007, 63, 11991-11997. 
  12. “Hydroxyalkylation of Conjugated Nitroalkenes with Activated Nonenolizable Carbonyl Compounds” Deb, Indubhusan; Dadwal, M.; S. M Mobin; Namboothiri, I. N. N.  Org. Lett. 2006, 8, 1201-1204.

 

PATENT 

  1. “Novel Anticancer Hydrazinoderivatives of Curcumin and Process for Preparation thereof” Namboothiri, I. N. N; Panda, D.; Deb, Indubhusan; Mehta, A.; Wardhan, V. PATENT No: IN-2008MU01568 (1568/MUM/2008 dated 23/07/2008).