Indu Bhusan Deb , Ph.D.

Senior Principal Scientist
Organic & Medicinal Chemistry
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Research Interest

  • Our research interests lie in the development of the new catalytic system using transition metal for C-H/C-X bond functionalization and the development of synthetic strategy employing C-H/C-X bond activation chemistry for the synthesis of bioactive small molecules. 
  • Electro-catalysis and electro-chemical synthesis of potential bioactive molecules.
  • Asymmetric catalysis using newly designed ligand and catalyst for the synthesis of biologically important molecules.
  • New and Cost-effective process for commercially available life-saving drugs and the intermediates (Make in India Initiative). 

 

Credentials

  • 2018- Present: Principal Scientist/Associate Professor(AcSIR), Indian Institute of Chemical Biology, Kolkata.
  • 2014- Jan 2018: Senior Scientist/Assistant Professor(AcSIR),.
  • 2013: Research Investigator-Process Chemistry (April, 2013-Dec, 2013), Bristol Myers Squibb –Biocon Research Center, Bangalore.
  • 2011-2013: Post Doctoral Research Associate, Nanyang Technological University, Singapore with professor NAOHIKO Yoshikai).
  • 2008-2010: Post Doctoral Research Associate, Rutgers – The State University of New Jersey, New Jersey, USA with professor Daniel Seidel).
  • 2009:Ph.D.Indian Institute of Technology Bombay (IIT Bombay), Mumbai, India with professor I. N. N. Namboothiri. Thesis submitted in 2008).

Honours & Awards

  • Star award in process chemistry for outstanding contribution (Bristol Myers Squibb–Biocon Research Center, Syngene, 2013)

Grants & Supports

  1. Approved by SERB, DST: 2020-2023.
  2. Approved by SERB, DST: from 2014-2017.
  3. Bristol Mayer Squibb research fellowship, the USA for 2017-2022
  4. INPROTICS –CSIR: Process for API-synthesis  2018-2021
  5. PAN-CSIR-Cancer Project:  CSIR-India 2022-

 

Patents & Publications

From IICB

36."Synergistic [4+1] Spiro-Annulation and Selective Ring-Opening Strategy towards g-Spirolactams"  Mondal, I.; Naskar, K.; Roy, S.; Purkait, A. and Deb I.* Org. Lett. 2024, (https://pubs.acs.org/doi/10.1021/acs.orglett.4c03669) 

35."Diastereoselective Intramolecular Spirocyclization via C(sp3)-H Bond Functionalization Towards the Synthesis of  2,7-Diazaspiro[4.5]decane-1,3-diones"Bhowmik, A.; Naskar, K.;  Roy, S.; Sahoo, A.;  Deb I,*Advanced Synthesis & Catalysis 2024,(https://onlinelibrary.wiley.com/doi/10.1002/adsc.202401169)

34."[3+2] Cascade Ring-Closing/Ring-Opening Strategy: Access to N-Indene-tethered Amino-alcohols"   Mondal, I.; Roy, S.; NAskar, K.; Karmakar, S.; Chowdhury, M. and Deb , I.* , Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c02975

33. "A condition-tuned unorthodox approach to indole-3-carboxylic acids and anthranilic acids via carbon atom translocation"     Bhowmik, A.; Naskar, K.; Roy, S.;  Karmakar, S.; Sarkar, W.; Mondal, I.; Sana, A.; and  Deb , I.*,  Chemical Communications, 2023,  DOI: doi.org/10.1039/D3CC04443B  

32. "Electrochemical C(sp3)-C(sp3) Cross-Dehydrogenative Coupling: Enabling   Access to 9-Substituted Fluorescent Acridanes", Roy, S.;  Karmakar, S.; Mondal, I.;  Naskar, K.;  Sarkar, W.;  Deb , I.*,  Chemical Communications, 2023,  DOI: 10.1039/D3CC02127K 

31. "Synthesis of Indene-fused Spiro-Dibenz(ox)azepines via Rh(III)-Catalyzed    Cascade Regioselective C−H Activation/Annulation",  Naskar, K.; Karmakar, S.; Mondal, I.; Sarkar, W.; Roy, S.; Roy, A.;   Deb , I.*,  Chemical Communications, 2023, https://doi.org/10.1039/D3CC01416A  (Selected as Cover Page)

30. "A Radical-Radical Cross-Coupling Reaction of Xanthene with Sulfonyl Hydrazides: Facile Access to Xanthen-9-sulfone Derivatives", Das, S.;  Roy, S.;  Bhowmik, A.;  Sarkar, W.;   Mondal, I.;  Mishra, A.;  Saha, S.; Karmakar, S.; Deb , I.* Chemical Communications, 2022, https://doi.org/10.1039/D1CC07143B

29.“An improved synthetic method for indole-3-carboxylic acid and its derivatives” Indubhusan Deb, Bhowmik, A.  PATENT: 202111047806(0163NF2021/IN dated 20/11/2021. PCT: PCT/IN2022/050940, 20/10/2022

28.“An improved synthetic method for 2,7-dihydroxyfluorenone in the manufacture of tilorone dihydrochloride salt” P. Jaisankar, Indubhusan Deb, P. Bhattacharjee. PATENT: 202111047809(0211NF2020/IN dated 20/11/2021, PCT/IN2022/050931, 19/10/2022.

27.“Regio- and Diastereoselective [3 + 2]-Spiroannulation of Benzoxazines with Chalcones: A Rh(III)-Catalyzed Redox-Neutral Approach to α-Aroyl Spiro-Indanamines” Sarkar, W.; Naskar, K.; Roy, S.;  Mondal, I.;  Karmakar, S.; Mishra, A.;Indubhusan Deb* Journal of Organic Chemistry 2022, 87, 9988-10002.

26.“A Metal-free Oxidative C(sp3)-H Cross-Coupling Reaction of Xanthene with Sulfonyl Hydrazides: Facile Access to Xanthen-9-sulfone Derivatives” Das, S.; Roy, S.; Bhowmik, A.; Sarkar, W.; Mondal, I.; Mishra, A.; Saha, S.; Karmakar, S; Indubhusan Deb*Chem. Commun. 2022, 58, 2902-2905.

25. “Copper- Catalyzed Direct Sp2 C-H Silylation of Arylamides Using Disilanes” Writhabrata Sarkar; Arup Bhowmik; Aniket Mishra; Indubhusan Deb * Org. Lett. 2021, 23, 4521-4526. doi.org/10.1021/acs.orglett.1c01129  (Selected as Cover page).

24.“Straight forward Access to Anthrone Functionalized Benzylic Amines via Organocatalytic 1,2-Addition of Anthrones to Imines at Ambient Temperature”  Sumit Das; Arup Bhowmik; Writhabrata Sarkar;  Aniket Mishra; Indubhusan Deb* Journal of Organic Chemistry 2021, 86, 4131-4142 doi.org/10.1021/acs.joc.0c02959

23.“Diastereoselective Spirocyclization via Intramolecular C(sp3)-H Bond Functionalization Triggered  by Sequential [1,5]-Hydride Shift/Cyclization Process: Approach to Spiro-tetrahydroquinolines” Arup Bhowmik,  Writhabrata Sarkar, K. M. Saidalavi, Aniket Mishra, Anupama Roy, and Indubhusan Deb* Advanced Synthesis & Catalysis 2021, 363, 826-832.: doi.org/10.1002/adsc.202001011

22.Diastereoselective Spirocyclization of Benzoxazines with Nitroalkenes via Rhodium-Catalyzed C-H Functionalization/Annulation Cascade under Mild Conditions”Aniket Mishra, Arup Bhowmik, Siddhartha Samanta, Writhabrata Sarkar, Sumit Das, and Indubhusan Deb* Org. Lett. 2020, 22,1340-1344, doi.org/10.1021/acs.orglett.9b04652.

21.“Diastereoselective Spirocyclization of Cyclic N-Sulfonyl Ketimines with Nitroalkenes via Iridium-Catalyzed Redox Neutral Cascade” Reaction Aniket Mishra, Upasana Mukherjee, Writhabrata Sarkar, Sudha Lahari Meduri, Arup Bhowmik and Indubhusan Deb* Org. Lett.  2019, 21, 2056-2059 DOI: 10.1021/acs.orglett.9b00295  (Selected as Cover page).

20.“Iridium-Catalyzed Direct C-H Arylation of Cyclic N-Sulfonyl Ketimines with Arylsiloxanes at Room Temperature” Writhabrata Sarkar, Arup Bhowmik, Sumit Das, Aiswarya, B. S., Aniket Mishra and Indubhusan Deb* Org. Biomol. Chem. 2020 https://doi.org/10.1039/D0OB01212B (Selected as Cover page).

 

19. “Copper-Mediated Direct and Selective C-H Thiolation of Quinazolinones” Writhabrata Sarkar, † Aniket Mishra, † Arup Bhowmik and Indubhusan Deb*Asian J. Org. Chem. 2019 (Accepted). (†contributed equally). https://doi.org/10.1002/ajoc.201900199

18.“Cobalt-Catalyzed Directed sp2 CH Acetoxylation of Arenes Employing Mn(OAc)3. 2H2O as Acetoxy Source” Writhabrata Sarkar, Arup Bhowmik, † Aniket Mishra, † Tripta Kumari Vats and Indubhusan Deb* Advanced Synthesis & Catalysis 2018, 360, 3228-3232 https://doi.org/10.1002/adsc.201800398 (†contributed equally).

17.“Rhodium-Catalyzed Direct and Selective ortho C-H Chalcogenation of N-(Hetero)aryl-7-azaindoles” Tripta Kumari Vats,† Aniket Mishra† and Indubhusan Deb* Advanced Synthesis & Catalysis 2018, 360, 2291-2296 https://doi.org/10.1002/adsc.201800090  (†contributed equally).

16.“Ir(III)/MPAA-Catalyzed Mild And Selective C-H Amidation Of  N-sulfonyl ketimines: An Access To Benzosultam Fused Quinazolines/Quinazolinones”  Aniket Mishra,* Upasana Mukherjee, Tripta Kumari Vats and Indubhusan Deb* Journal of Organic Chemistry  2018, 83, 3756-3767  DOI: 10.1021/acs.joc.8b00125

15.“Rhodium-Catalyzed sp2 C-H Acetoxylation of N-Aryl Azaindoles/ N-Heteroaryl Indolines”  Aniket Mishra,† Tripta Kumari Vats,† Mahesh P. Nair, Arindam Das and Indubhusan Deb* Journal of  Organic Chemistry  2017,  82, 12406-12415 (†contributed equally).

14.“Ruthenium-Catalyzed Direct and Selective C–H Cyanation of N-(Hetero)aryl-7-azaindoles” Aniket Mishra, Tripta Kumari Vats and Indubhusan Deb* Journal of  Organic Chemistry  2016.  81, 6525-6534 [Top 5 most read articles in July, 2016].

13.“Palladium-Catalyzed Oxidative Cyclization for the Synthesis of Indolyl/pyrrolyl-3-phosphonates” Aniket Mishra and Indubhusan Deb* Advanced Synthesis & Catalysis 2016, 358, 2267-2272. [Top 15 most accessed articles in June, 2016]. 

 

From Postdoc-PhD

  1. “Facile Access to Ring-Fused Aminals via Direct α-Amination of Secondary Amines with ortho-Aminobenzaldehydes. Synthesis of Vasicine, Deoxyva-sicine, Deoxyvasicinone, Mackinazolinone and Ruteacarpine” Richers, M. T.; Deb, Indubhusan, Platonova, A. Y.; Zhang, C.: Seidel, Daniel. Synthesis 2013, 1730-1748.
  2. “Conjugate Addition of Curcumins to Chalcones and Azodicarboxylates” Ayyagari, N.; Mehta A.; Deb, Indubhusan; Mobin, S. M.; Namboothiri, I. N. N. Tetrahedron 2013, 69, 5973-5980.
  3. “Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime” Deb, Indubhusan, Yoshikai,  Naohiko.  Org. Lett. 2013, 15, 4254-4257. 
  4. “Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones” Wei, Ye; Deb, Indubhusan, Yoshikai,  Naohiko.  J. Am. Chem. Soc. 2012, 134, 1201-1204.  [Highlighted in SYNFACTS 2012 and Angew Chem. Int Edu. 2013]
  5. “Redox-Neutral Indole Annulation Cascades” Haibach, M. C.; Deb, Indubhusan; De, C. K.; Seidel, Daniel J. Am. Chem. Soc. 2011, 133, 2100-2103. [Top 20 most downloaded articles in Feb, 2011 and Highlighted in SYNFACTS 2011, 440]
  6. “Redox Isomerization via Azomethine Ylide Intermediates: N-Alkyl Indoles from Indolines and Aldehydes” Deb, Indubhusan; Das, D.; Seidel, Daniel . Org. Lett. 2011, 13, 812-815.
  7. “Decarboxylative Formation of N-Alkyl Pyrroles from 4-Hydroxyproline” Deb, Indubhusan; Coiro, D.; Seidel, Daniel.  Chem. Commun. 2011, 47, 6473-6475. 
  8. “Retro-Claisen Condensation vs Pyrrole Formation in Reactions of Amines and 1,3-Diketones” Deb, Indubhusan; Seidel, Daniel. Tetrahedron Lett. 2010, 51, 2945-2947.
  9. “Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines” Murarka, S.; Deb, Indubhusan; Zhang, C.; Seidel, Daniel.  J. Am. Chem. Soc. 2009, 131, 13226-13227. [Highlighted in SYNFORM 2009/09 as well as SYNFACTS 2009(12), 352].
  10. “Morita-Baylis- Hillman Reactions Between Conjugated Nitroalkenes or Nitrodienes and Carbonyl Compounds” Deb, Indubhusan; Shanbhag, P.; Mobin, S. M.; Namboothiri, I. N. N. Eur. J. Org. Chem. 2009, 4091-4101. 
  11. “Synthesis of Benzo-Fused Medium Ring Cyclic Ethers via Michael Addition-Ring Closing Metathesis Strategy Involving Nitroaliphatic Compounds” Deb, Indubhusan; John, S.; Namboothiri, I. N. N. Tetrahedron 2007, 63, 11991-11997. 
  12. “Hydroxyalkylation of Conjugated Nitroalkenes with Activated Nonenolizable Carbonyl Compounds” Deb, Indubhusan; Dadwal, M.; S. M Mobin; Namboothiri, I. N. N.  Org. Lett. 2006, 8, 1201-1204.

 

PATENT 

  1. “Novel Anticancer Hydrazinoderivatives of Curcumin and Process for Preparation thereof” Namboothiri, I. N. N; Panda, D.; Deb, Indubhusan; Mehta, A.; Wardhan, V. PATENT No: IN-2008MU01568 (1568/MUM/2008 dated 23/07/2008).

 

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