Nakul Chandra Maiti , Ph.D.
Senior Principal Scientist, Division of Structural Biology and Bioinformatics CSIR-Indian Institute of Chemical Biology and Professor, Academy of Scientific and Innovative Research (AcSIR)
Structural Biology & Bioinformatics
Research Focus
Research activities: structural intricacies of disease linked intrinsically disordered proteins (IDPs) such as amyloid beta (Aβ), α-synuclein. Understanding membrane less organelles and phase transition. Application of biological Raman spectroscopy FTIR, NMR, AFM EM and fluorescence spectroscopy and molecular dynamics simulations to understand the aggregation and phase transition of protein solution
Research Interest
The lack of a rigid and folded stable structure in IDPs (intrinsically disorder proteins) may provide large plasticity to interact them efficiently with different targets, and thus conformational flexibility aids good efficacy in cell cycle regulation, membrane transport, and different molecular recognition processes. In addition the inherited structural disorder and the hydrophobic patches in it play an important role in formation of membrane less organelles and the production of amyloid like aggregates that is implicated in several human neurological disorders. In our laboratory we attempt to define the role of protein disorder region in formation of membrane less organelles, amyloid aggregates and their implication in Alzheimer’s (AD) and Parkinson disease (PD). To address the role of protein aggregates in AD and PD we are now studying different type of protein oligomers under Raman microscope. In addition, we are involved deeply in developing methods (including multivariate analysis of Raman data) that could aid in the early detection of AD and PD based on Raman signature. We are also studying the formation and possible structure of membrane less organelles which are unique as cellular storage for hormones and neurotransmitters. Raman spectroscopy allows us to obtain very high quality Raman spectrum of protein crystals. We probe the hydration and dynamics of the disordered region and side chain residues in some of the globular proteins in their crystalline form. In addition our laboratory is also engaged in understanding the interaction pattern of IDPs and structured proteins with metal nano-composites. Our results established that porphyrin based inorganic nanoparticles induced helicity in α-synuclein and significantly reduced its fibrillation. Porphyrin-gold made nano-cargo also reduces the dose of doxorubicin and thereby showed improved efficacy towards killing of brain cancer cells.
Associated research interest is to target allosteric site (that include protein disorder region) of enzymes with small natural and synthetic molecules to modulates their activity, function and overall molecular mechanics. The allosteric modulators can fine-tune protein mechanics. Besides, allosteric sites are evolutionarily less conserved/more diverse even in very similarly related proteins, thus, provides high degree of specificity in targeting a particular protein. Therefore, targeting of allosteric sites is gaining attention as an emerging strategy in rational drug design. However, the experimental approaches provide a limited degree of characterization of new allosteric sites. Computational approaches are useful to analyze and select potential allosteric sites for drug discovery. We use molecular docking, which has become an integral part of the drug discovery process, to predict the drug- ability of novel allosteric sites as well as the active site on target proteins (e.g Dengue and COVID main proteases) by ligand screening and subsequent analysis by Raman microscopy.
Credentials
Academic Profile
- Ph.D. Chemistry, TIFR, Mumbai
- M. Sc. Chemistry, University of Calcutta, Calcutta, India
- B. Sc. Chemistry (honors), Presidency College, University of Calcutta
Employment Details
Grade/ Post |
Estt./ Lab/ Instt. |
From |
To |
Senior Principal Scientist |
Indian Institute of Chemical Biology, Kolkata |
May 2020 |
Present |
Principal Scientist |
Indian Institute of Chemical Biology, Kolkata |
May 2015 |
May 2020 |
Senior Scientist |
Indian Institute of Chemical Biology, Kolkata |
May 2010 |
May 2015 |
Research Specialist |
LSU-Agcenter, Baton Rouge, USA |
Sept/ 2008 |
May/ 2010 |
Research Associate |
California State University Los Angeles |
June /2006 |
Aug/2008 |
Senior Research Associate |
Case W. R. University, Cleveland, USA |
Dec/2001 |
June/ 2006 |
Research associate |
UMKC, Kansas City, USA |
June/ 2000 |
Dec/2000 |
JSPS visiting scientist (postdoctoral) |
Inst. for Mole. Sci Japan |
Jan/1998 |
June/2000 |
Honours & Awards
- Raman Fellowship Award, 2012, CSIR, New Delhi, June 2012-Sept 2012
- International JSPS fellowship award, Japan Society for the Promotion of Science, Japan, 1998-2000
Grants & Supports
Sl.No | Title of the project | Project Type/Category | Amount | Source | Role |
1 | Role of Single Hydrogen bond in Enzyme Catalysis. Ribonuclease Activity - 41/3/EMPOWER/2010-PPD | EMPOWER (encouraging and motivating pursuit of world class exploratory research) grant, CSIR | Rs. 16 lakhs (sanctioned) | CSIR, New Delhi 2010-2012 | PI |
2 | α-Synuclein and Tau Interaction: Implication on Neurodegenerative Disease BT/PR4633/BRB/10/872/2010 | Basic Research Fund | Rs. 8380000 | DBT, New Delhi 2012-2015 | PI |
3 | SERB-international travel grant to attend a conference SB/ITS-S/05280/2014-2015 | Travel Grant | International (USA) travel fare SERB | New Delhi, 2015 | PI |
4 | Structural Implication of Amyloid Oligomers ... EMR/2016/006322 External | Basic Research Fund, SERB New Delhi | Rs. 2214000 | SERB New Delhi, 2018-2021 | PI |
5 | Translocation and regu. of an unusual novel PAS domain .. SERB/F/6293/2021-2022 | External Basic Research, SERB New Delhi | Rs. 1698250 | SERB New Delhi 2021-2023 | PI |
Patents & Publications
IMPORTANT PUBLICATIONS:
- Debsharma, S,; Pramanik, S.; Bindu, S., Mazumder, S.; Das, T.; Pal, U., Saha, D.; De, R.; Nag, S.; Banerjee, C.; Maiti, N. C.; Ghosh, Z. And Bandyopadhyay, U. NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell, iScience, 2024, https://doi.org/10.1016/j.isci.2024.109384
- Khamaru, K.; Pal, U.; Shee, S.; Lo, R.; Seal, K.; Ghosh, P.; Maiti, N. C.; Banerji, B., death Metal-free Activation of Molecular Oxygen by Quaternary Ammonium-based Ionic Liquid: A Detail Mechanistic Study, J. Am. Chem. Soc. 2024 doi.org/10.1021/jacs.3c14366,
- Dolui, S; Roy,R; Paul,U; Kundu, S; Pandit, E; Ratha,B.N; Pariary, R;Saha, A.; Bhunia, A; Maiti, N.C. Raman Spectroscopic Insights of Phase Separated Insulin Aggregates ACS Physical Chemistry Au, 2024, doi.org/10.1021/acsphyschemau.3c00065,
- Kundu, S.; Maity, A.; Misra, R.; Pal, U. and Maiti, N.C. Therapeutics for Neurodegenerative Diseases. In Pratik Talukder, Ritesh Tandon, Uttam Pal (Ed) Exploring Medical Biotechnology- in vivo, in vitro, in silico Biotechnology from Labs to Clinics and Basic to Advanced (2024) 1: DOI: ISBN 9781032295558. DOI: 10.1201/9781003302131-11
- Maity, A.; Misra, R.; Kundu, S.; Bera, K. Mandal, P. P. Pal, U. and Maiti, N.C. Theranostic Application of Nanomaterial in Human Health and Disease. In Pratik Talukder, Ritesh Tandon, Uttam Pal (Ed) Exploring Medical Biotechnology- in vivo, in vitro, in silico Biotechnology from Labs to Clinics and Basic to Advanced (2024) 1: DOI: ISBN 9781032295558. DOI: 10.1201/9781003302131-
- Misra, R.; Kundu, S.; Maity, A.; Pal, U. and Maiti, N.C. Drug Discovery Approaches Targeting Dengue NS2B/ NS3 Protease A Comprehensive Review on Recent Developments In Pratik Talukder, Ritesh Tandon, Uttam Pal (Ed) Exploring Medical Biotechnology- in vivo, in vitro, in silico Biotechnology from Labs to Clinics and Basic to Advanced (2024) 1: DOI: ISBN 9781032295558. DOI: 10.1201/9781003302131-4
- Mondal, A.; Dolui, S,; Dhabal, S.; Kundu, S.; Das, L .; Bhattacharjee, A. and Maiti, N.C., Structure specific neuro-toxicity of α-synuclein oligomer, International Journal of Biological Macromolecules, (2023), 253, 126683,
- Maity, A.; Mandal, A.; Kundu, S.; Shome, G.; Misra, R.; Maiti, Maiti, N.C. Naringenin-Functionalized Gold Nanoparticles and Their Role in Synuclein Stabilization. Langmuir. 2023; 39 (21), 7231-7248.
- Misra R; Maity, A; Kundu, S; Bhunia, M; Nanda, B; Maiti, N.C; Pal,U. Loop Dynamics And Conformational Flexibility in Dengue Serine Protease Activity :Noninvasive Perturbation by Solvent Exchange. Journal of Chemical Information and Modeling. 2023, 63(7),2122-2132.
- Pandit E.; Das, L; Das,AK; Dolui,S; Saha, S; Pal,U; Mondal, A; Chowdhury,J; Biswas, S. Maiti, N.C. Single Point Mutations at S129 Residue of α-Synuclein and Their Effect on Structure, Aggregation and Neurotoxicity. Frontiers in Chemistry. 2023. 11, 1145877.
- Pariary, R; Dolui, S; Shome,G; Mohid ,SA; Ratha, BN; Harikishore, A; Jana K; Mandal A.K; Bhunia A; Maiti,N.C. Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin; Chemical communication. 2023. 59 (52), 8095-8098.
- Kumar,S.; Maiti, A.;B.N Ratha.;,Biswas, R., Maiti N.C.; Mandal A.K.; Bhunia A. Modulatory role of copper on hIAPP aggregation and toxicity in presence of insulin, International Journal of Biological Macromolecule.2023, 241, 124470.
- Rudra, DS.; Chatterjee, S.; Pal, U.; Bhunia, M; Maiti, N.C.; Jaishankar, P.; Swarnakar, S. Newly synthesized 3-Indol Furanoid Inhibits Matrix Metalloproteinase-9 Activity and Prevents Nonsteroidal Anti-inflammatory, Journal of Medicinal Chemistry.;2023,
- Choudhury, A; Saha, S; Maiti,N.C; Dutta ,S . Exploring Structural Features and Potential Lipid Interaction of Pseudomonas aeruginosa PemB by S Spectroscopic and Calorimetric Experiment, Protein Science, 2023.e4627.
- Majumder,L; Bera,K; Khamaru, K; Pal,U; Maiti,N.C; Banerji, B. NMR and Vibrational Spectroscopic Studies on the Structure and SelfAssembly of Two de novo Dipeptides in Methanol;Journal of Molecular Structure;2022,1266,133455.
- Rudra, DS; Pal,U; Chowdhury, N; Maiti,N.C; Bagchi,A; Swarnakar,S. Omeprazole Prevents Stress Induced Gastric Ulcer by Direct Inhibition of MMP-2/TIMP-3 Interaction; Free Radical Biology and Medicine.;2022, 181,221-234.
- Bhattacharyya,D; Ratha,BN; Chakraborty, I; Shome, G; Pariary, R; Nayak, C; Singha, A; Kalawar, A; Maiti, N.C; Mandal, A.K; Madak, A; Bhunia, A; Biophysical Analysis of Water Exposed to the Meditative Energy Field: Plausible Correlation to Neurophysiological Observations?Water Journal, 2022
- Srinath, R.; Manna, A.; Shee, S.; Pathi, V.B.; Ghosh, S.; Khamaru, K.; Maiti, N.C.; Banerji, B. Synthesis of N-Fused Triazole−Piperazine−Quinazolinones via One-Pot Tandem Click Reaction and Cross-Dehydrogenative Coupling. Org. Lett. 2021, 23, 9365−9370.
- Uday, R.V.S; Misra, R.; Harika, A.; Dolui, S.; Saha, A.; Pal, U.; Ravichandiran, V.; Maiti, N.C.. Dabrafenib, idelalisib and nintedanib act as significant allosteric modulators for dengue NS3 protease. PLoS ONE 2021, 16(9): e0257206.
- Dolui, S.; Bera, K.; Mondal, A; Khamaru, K.; Maiti, N.C. Application of Raman Spectroscopy in Amyloid Research. In Swati Jain, Sruti Chattopadhyay (Ed) Surface Enhanced Raman Spectroscopy: Biosensing and Diagnostic Technique for Healthcare Applications. (2021) 1: 91-130. DOI: 10.2174/97898150391151210101.
- Chakraborty, I.; Kar, R.K.; Sarkar, D; Kumar, S; Maiti, N.C.; Mandal, A.K.; Bhunia, A. Solvent Relaxation NMR: A Tool for Real-Time Monitoring Water Dynamics in Protein Aggregation Landscape. ACS Chem. Neurosci. 2021, 12, 2903−2916.
- Bardhan, M.; Dolui, S.; Chaudhuri, S.; Paul, U.; Bhattacharjee, G.; Ghosal, M.; Maiti, N. C.; Mukhopadhyay, D. and Senapati, D.; Impact of porous nanomaterials on inhibiting protein aggregation behavior, RSC Adv., 2021, 11, 3354.
- Saha, S.; De, A; Ghosh, A; Bera, K.; Das, K. S.; Akhtar, S.; Maiti, N. C.; Das, A. K.; Das, B. B. and Mondal, R., Pyridine-pyrazole based Al(III) ‘turn on’ sensor for MCF7 cancer cell imaging and detection of picric acid, RSC Adv., 2021, 11, 10094.
- Khanppnavar, B; Roy,A.; Chandra, K.; Uversky, V. N.; Maiti, N.C; Datta, S., Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding in type-III protein secretion, International Journal of Biological Macromolecules, 159, 2020, 18–33
- Bera, K, Mondal, A., Pal, U., and Maiti, N.C., Porphyrin-Armored Gold Nanospheres Modulate the Secondary Structure of α-Synuclein and Arrest Its Fibrillation, J. Phys. Chem. C 2020, 124, 11, 6418-6434
- Dolui, S., Mondal, A. Roy, A., Pal, U. Das, S., Saha, A. and Maiti, N.C., Order, Disorder, and Reorder State of Lysozyme: Aggregation Mechanism by Raman Spectroscopy, J. Phys. Chem. B, 2020, 124, 50-60
- Ratha, B. N.; Kar, R.K.; Bednarikova, Z.; Gazova, Z.; Kotler,S.A.; Raha, S.; De, S.; Maiti, N. C and Bhunia, A., Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation By NMR and Raman Spectroscopic Analysis, J. Phys. Chem. B, 2020, 124, 1125−1136.
- Chowdhury, T.; Bera, K.; Samanta, D.; Dolui, S.; Maity, S.; Maiti, N. C.; Ghosh, P. K.; and Das, D., Unveiling the binding interaction of zinc (II) complexes of homologous Schiff-base ligands on the surface of BSA protein: A combined experimental and theoretical approach, Appl. Organometal Chem., 2020,34, e5556
- Majumder, L.; Chatterjee, M.; Bera, K.; Maiti, N. C.; Banerji, B., Solvent-Assisted Tyrosine-Based Dipeptide Forms Low-Molecular Weight Gel: Preparation and Its Potential Use in Dye Removal and Oil Spillage Separation from Water, Acs Omega, 2019, 4, 14411−14419
- Mondal, A. and Maiti, N. C. Divulging Characteristic Features of the Novel A-Synuclein Oligomers Augmenting Parkinson’s Disease, Biophysical Journal, 2019, 16, 185a
- Dolui, S; Mondal, A; Roy, A; Pal, U; Das,S; Saha, A; Maiti, NC; Order, disorder, and reorder state of lysozyme: aggregation mechanism by Raman spectroscopy, The Journal of Physical Chemistry B, 2019, 50-60;
- Maity, M.; Bera, K.; Pal, U.; Khamaru, K. and Maiti N. C., Sensing of Fe(III) Ion via Modulation of Redox Potential on Biliverdin Protected Silver Nanosurface, ACS Appl. Nano Mater, 2018, 1, 6099–6111
- Mondal A.; Pal U., Roy A. and Maiti, N. C., Structural Intricacy of Disordered Regions in Transcription Factors Imparting Colon Cancer, J. Proteins Proteomics, 2018, 9, 169-184.
- Bera K.; Maiti, S. Maity,; M. Mandal C. and Maiti N. C., Porphyrin−Gold Nanomaterial for Efficient Drug Delivery to Cancerous Cells, ACS Omega 2018, 3, 4602−4619.
- Dolui S.; Roy A.; Pal U.; Saha A. and Maiti N. C., Structural Insight of Amyloidogenic Intermediates of Human Insulin, ACS Omega 2018, 3, 2452−2462.
- Ghosh S.; Mallick S.; Das U.; Verma A.; Pal U.; Chatterjee S.; Nandy A.; Saha K.D.; Maiti, N. C.; Baishya B.; Kuma G. S. and Gmeiner,Curcumin Stably Interacts with DNA Hairpin Through Minor Groove Binding and Demonstrates Enhanced Cytotoxicity in Combination with FdU Nucleotides, BBA - General Subjects 2018, 1862, 485–494
- Pal U. and Maiti N. C., Pattern Based Detection of Potentially Druggable Binding Sites by Ligand Screening, J. Proteins Proteomics, 2017, 9, 1-9
- Roy A.; Chandra K.; Dolui S. and Maiti N. C., Envisaging the Structural Elevation in the Early Event of Oligomerization of Disordered Amyloid β Peptide, ACS Omega, 2017, 2, 4316−4327.
- Yadav D.K.; Bharitkar Y.P.; Hazra A.; Pal U.; Verma S., Jana S.; Singh U.P.; Maiti N.C.; Mondal N.B. and Swarnakar S., Tamarixetin 3-O-β-d-Glucopyranoside from Azadirachta indica Leaves: Gastroprotective Role through Inhibition of Matrix Metalloproteinase-9 Activity in Mice, J. Nat. Prod., 2017, 80, 1347−1353.
- Banerji B., Chatterjee M.; Pal U. and Maiti N.C., Formation of Annular Protofibrillar Assembly by Cysteine Tripeptide: Unraveling the interactions with NMR, FTIR and Molecular Dynamics, J. Phys. Chem. B, 2017, 121, 6367–6379.
- Pal, U., Roy A.; Das S.; Das S.; Kundu M.; Bagga K.; Maiti N. C., Origin of Protein Aggregation: Identification of Some Characteristic Traits in Structured and Intrinsically Disordered Proteins, J. Proteins and Proteomics, 2016, 7, 259-268
- Das S.; Pa, U.; Chatterjee M.; Pramanik S. K.; Banerji B.; Maiti N. C. Envisaging Structural Insight of a Terminally Protected Proline Dipeptide by Raman Spectroscopy and DFT Analyses, J. Phys. Chem. A, 2016, 120, 9829-9840
- Das S.; Pal U.; and Maiti N. C., Metal ions provide structural stability and compactness to tetrameric purothionin, RSC Advances, 2016, 6, 90690-90700.
- Das S.; Das S.; Roy A.; Pal U. and Maiti N. C., Orientation of tyrosine side chain in neurotoxic Aβ differs in two different secondary structures of the peptide,2016, R. Soc. Open Sci. 2016, 3, 160112
- Saha S.; Acharya C.; Pal U.; Roy Chowdhury S.; Sarkar K.; Maiti N.C.; Jaisankar P. and Majumder H.K., A novel spirooxindole derivative inhibits the growth of Leishmania donovani parasite both in vitro and in vivo by targeting type IB topoisomerase, Antimicrob Agents Chemother, 2016, 60, 6281-93.
- Talapatra S.; Talukder P.; Pal U.; Maiti N.C. and Swarnakar S., Interaction of T-state haemoglobin and phytochemicals of Hygrophila spinosa T. Anders: an approach by molecular docking, World Journal of Pharmaceutical Research, 2016,5, 1354-1369
- Pal U.; Pramanik S; Bhattacharya B.; Banerji B and Maiti N. C., Binding interaction of a gamma-aminobutyric acid derivative with serum albumin: An insight by fluorescence and molecular modeling analysis, Springerplus, 2016, 5, 1121.
- Naiya G.; Raha P.; Mondal M. K.; Pal U.; Saha R.; Choudhury S.; Batabyal S.; Pal S. K.; Bhattacharyya D.; Maiti N. C. and Roy S., Conformational Selection Underpins Recognition of Multiple DNA Sequences by Proteins and Consequent Functional Actions, Phys.Chem.Chem.Phys, 2016, 18, 21618-21628
- Banerji B.; Chandrasekhar K.;KilliS. K.; Pramanik S.; Pal U.; Sen S.; Maiti N. C., Silver-Catalyzed Azide–Alkyne Cycloaddition (AgAAC): Assessing the Mechanism by DFT, R. Soc. open sci., 2016,
- Mitra P.; Pal U.; Maiti N. C.; Ghosh A.; Bhunia A.; and Basu S. Identification of Modes of Interactions Between 9-Aminoacridine Hydrochloride Hydrate and Serum Proteins by Low and High Resolution Spectroscopy and Molecular Modeling, RSC Adv., 2016, 6, 53454
- Banerji B.; Chatterjee M. Paul U. and Maiti N. C., Molecular Details of Acetate Binding to a New Diamine Receptor by NMR and FT-IR Analyses, J. Phy. Chem. A. 2016, 120, 2330-2341
- Pal U,; Maity M.; Khot N.; Das S.; Das S.; Dolui S. and Maiti N. C., Statistical insight of binding regions in disordered human proteome, J. Proteins and Proteomics 2016, 7, 47-60
- Maity M.; Dolui S. and Maiti N. C., Hydrogen bonding plays a significant role in the binding of coomassie brilliant blue-R to hemoglobin: FT-IR, fluorescence and molecular dynamics studies, Phys.Chem.Chem.Phys., 2015, 17, 31216
- Pal U.; Pramanik. S.; Bhattacharya B.; Banerji B and Maiti N. C., Binding interaction of a novel fluorophore with serum albumins: steady state fluorescence perturbation and molecular modeling analysis, SpringerPlus, 2015, 4, 548
- Chakraborty B.; Dutta D.; Mukherjee S.; Das S.; Maiti N.C.; Das P. and Chowdhury, C., Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29), . Eur. J. Med. Chem. 2015, 102, 93–105.
- Maiti N. C.; Mondal P. and Das S., Role of Cyclophilin on Amyloid Formation and Protein Disaggregation, The FASEB Journal, 2015, Supplement 881.7
- Mal K.; Das S.; Maiti N. C.; Natarajan R.; and Das I., ZnI2-Catalyzed Diastereoselective [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketothioesters with Olefins, J. Org. Chem., 2015, 80, 2972−2988
- Maity M.; Das S. and Maiti N. C., Stability and Binding Interaction of Bilirubin on Gold Nano-surface: Steady State Fluorescence and FT-IR Investigation. Phys. Chem. Chem. Phys. 2014, 16, 20013-22
- Preet R.; Chakraborty B.; Siddharth S.; Mohapatra P.; Das D.; Satapathy S. R.; Das S.; Maiti N. C.; Maulik P. R.; Kundu C. N. and Chowdhury, C. Synthesis and biological evaluations of andrographolide analogues as anti-cancer agents. Eur. J. Med. Chem. 2014, 85, 95-106
- Banerji B,; Pramanik S. K,; Pal U.; Maiti N. C., Binding of hemoglobin to ultrafine carbon nanoparticles: a spectroscopic insight into a major health hazard. RSC Adv. 2014, 4, 22536-22541
- Maity ,M; Pramanik, SK; Pal, U; Banerji, ; Maiti N C; Copper (I) oxide nanoparticle and tryptophan as its biological conjugate: a modulation of cytotoxic effects. Journal of nanoparticle research, 2014.
- Pal U.; Sen S. and Maiti N. C., Cα-H Carries Information of Hydrogen Bond Involving Geminal Hydroxyl Group: A Case Study With Hydrogen Bonded Complex of HFIP and Tertiary Amines, J. Phy. Chem. A. 2014, 118, 1024-1030
- Bhattacharya, D; Ghorai, A; Pal, U; Maiti, NC; Chattopadhyay, P; Stereoselective domino azidation and [3+ 2] cycloaddition: a facile route to chiral heterocyclic scaffolds from carbohydrate derived synthons, RSC Advances, 2014.
- Das S.; Pal U.; Das S.; Bagga K.; Roy A.; Mrigwani A.; Maiti N. C. Sequence Complexity of Amyloidogenic Regions in Intrinsically Disordered Human Proteins. PLOS ONE, 2014, 9, e 89781
- Sen S.; Pal U.; Maiti N. C., pKa Determination of D-Ribose by Raman Spectroscopy, J. Phys. Chem. B. 2014, 118, 909-914
- Das S.; Pal U.; Das S.; Maiti N. C., Chaperone action of cyclophilin on lysozyme and its aggregate, Journal of Proteins and Proteomics, 2013, 4, 129.
- Maity M; Pramanik SK.; Pal U; Banerji B and Maiti N. C., Copper (I) oxide nanoparticle and tryptophan as its biological conjugate: a modulation of cytotoxic effects, Journal of Nanoparticle Research, 2013, 16, 2179
- Chattopadhyay P.; Bhattacherjee D; Ghorai A.; Pal U.; Maiti N. C.,Stereoselective Domino Azidation and (3+2) Cycloaddition: A Facile Route To Chiral Heterocyclic Scaffolds From Carbohydrate Derived Synthons; RSC Advances, 2013 (accepted) , 4, 4155-4162
- Mukherjee D.; Patra H.; Laskar A.; Dasgupta A.; Maiti N. C. and Datta A.K. Cyclophilin-mediated reactivation pathway of inactive adenosine kinase aggregates, Archives of Biochemistry and Biophysics, 2013, 537, 82-90
- Bhowmik A.; Das N.; Pal U.; Mandal M.; Bhattacharya S.; Sarkar M.; Jaisankar P.; Maiti N. C. and Ghosh M. K., 7. 2,29-Diphenyl-3,39-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway, PLOS ONE, 2013, 8, 59798
- Banerji B,; Pramanik S. K,; Pal U.; Maiti N. C., Potent Anticancer Activity of Cystinebased Dipeptides and Their Interaction with Serum Albumins, Chemistry Central Journal, 2013, 7, 91
- Rudra D. S.; Pal U.; Maiti N. C.; Jeiter, R. J.; Swarnakar, S., Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site J. Pineal Res.; 2013 54; 398–405
- Banerji B.; Pramanik S. K.; Pal U.; Maiti N. C. and Chaudhuri K., Dipeptide derived from benzylcystine forms unbranched nanotubes in aqueous solution.Journal Of Nanostructure in Chemistry, 2013 3:12.
- Maity M.; Maiti N. C., Sequence composition of binding sites in natively unfolded human proteins, J. Proteins and Proteomics, 2012, 3, 117-125
- Banerji B.; Pramanik S. K.; Pal U.; Maiti N. C.,Conformation and cytotoxicity of a tetrapeptide constellated with alternative D- and L-proline.RSC Advances, 2012, 2, 6744-6747
- Alam A.; Halder S.; Thulasiram H. V.; Kumar R.; Goyal M.; Iqbal M. S.; Pal C.; Dey S.; Bindu S.; Sarkar S.; Pal U.; Maiti N. C.; Bandyopadhyay U., Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor.J. Biol. Chem., 2012, 287, 24844-24861
- Banerji B,; Pramanik S. K,; Mandal S.; Maiti N. C. and Chaudhuri K., Synthesis, characterization and cytotoxicity study of magnetic (Fe3O4) nanoparticles and their drug conjugate.RSC Adv., 2012, 2, 2493-2497.
- Alam A.; Pal C.; Goyal M.; Kundu M.K.; Kumar R.; Iqbal M.S.; Dey S.; Bindu S.; Sarkar S.; Pal U. Maiti N.C.; Adhikari S.; and Bandyopadhyay U., Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent, Bioorganic & Medicinal Chemistry , 2011, 19, 7365-7373
- Maiti N. C.; Jiang D.; Wain A.J., Dinh KL.; Patel S.; Zhou F., (2008) Mechanistic Studies of Cu(II) Binding to Amyloid-β Peptides and the Fluorescence and Redox Behaviors of the Resulting Complexes, J. Phys. Chem. B, 2008, 112, 8406–8411.
- Maiti N. C.; Zhu Y.; Carmichael I.; Serianni AS.; Anderson Vernon E., (2006) ,CH Correlates with Alcohol H-bond Strength, J. Org. Chem. 71, 2878-2880.
- Kun H.; Maiti N. C.; Phillips N. B.; Carey P. R.; Weiss M. A., (2006) StructureSpecific Effects of Protein Topology on Cross-β Assembly: Studies of Insulin Fibrillation, Biochemistry 45, 10278-10293.
- Apetri M. M.; Maiti N. C.; Zagorski M.G.; Carey P.R.; Anderson V.E. (2006) Secondary Structure of α-Synuclein Oligomers: Characterization by Raman and Atomic Force Microscopy, J. Mol. Biol. 355, 63-71.
- Jarmelo S.; Maiti N. C; Anderson V.E.; Carey P. R.; Fausto R. (2005) Cα-H Bond-Stretching Frequency in Alcohols as a Probe of Hydrogen-Bonding Strength: A Combined Vibrational Spectroscopic and Theoretical Study of α-[1-D] Propanol, J. Phys. Chem. A 109, 2069-2077.
- Overman S. A.; Bondre P.; Maiti N. C.; Thomas G. J. Jr., (2005) Structural Characterization of the Filamentous Bacteriophage PH75 from Thermus thermophilus by Raman and UV-Resonance Raman Spectroscopy, Biochemistry, 44, 3091-3100.
- Maiti N.C.; Apetri M.M.; Zagorski M.G.; Carey P.R.; Anderson V.E. (2004) Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein, J. Am. Chem. Soci.126, 2399-2408.
- Minkler P.E.; Anderson V.E.; Maiti N. C.; Kerner J.; Hoppel C.L. (2004) Isolation and Identification of Two Isomeric Forms of Malonyl-coenzyme A in commercial malonyl-coenzyme-A, Anal. Biochem. 328, 203-209.
- Maiti N. C.; Carey P.R.; Anderson V.E., (2003) Correlation of an Alcohol's αC-D Stretch with Hydrogen Bond Strength in Complexes with Amines, J. Phys. Chem. A 107, 9910-9917.
- Maiti N. C.; Tomita T.; Kitagawa T.; Okamoto K.; Nishino T., (2003) Resonance Raman studies on xanthine oxidase: observation of Mo (VI)-ligand vibrations, J. Biol.Inor. Chem. 8, 327-333.
- Maity H.; Maiti N. C.; Jarori G.K., (2000) Time-resolved fluorescence of tryptophans in yeast hexokinase-PI: effect of subunit dimerization and ligand binding, J. Photochem. Photobio. B: Biology. 55, 20-26.
- Prasad S.; Maiti N. C.; Mazumdar S.; Mitra S., (2002) Reaction of hydrogen peroxide and peroxidase activity in carboxymethylated cytochrome c: spectroscopic and kinetic studies, Biochimica et Biophysica Acta (2002), 1596, 63-75.
- Aziz A.; Narasimhan K. L.; Periasamy N.; Maiti N. C., (1999) Electrical and optical properties of porphyrin monomer and its J-aggregate. Philosophical Magazine B: Physics of Condensed Matter: Statistical Mechanics, Electronic, Optical and Magnetic Properties,79, 993-1004.
- Maiti N. C.; Mazumdar S.; Periasamy N., (1998) J- and H-aggregates of porphyrins with surfactants: fluorescence, stopped flow and electron microscopy studies, Journal of Porphyrins and Phthalocyanines 2, 369-376.
- Maiti N. C.; Mazumdar S.; Periasamy N., (1998) J- and H-Aggregates of Porphyrin-Surfactant Complexes: Time-Resolved Fluorescence and Other Spectroscopic Studies, Journal of Physical Chemistry B 102, 1528-1538.
- Maiti N. C.; Krishna M. M. G.; Britto P. J.; Periasamy N., (1997), Fluorescence Dynamics of Dye Probes in Micelles, Journal of Physical Chemistry B, 101, 11051-11060.
- Maiti N. C.; Ravikanth M., (1996), Fluorescence study of some deformed zinc (II) porphyrins, Journal of Photochemistry and Photobiology, A: Chemistry 101, 7-10.
- Maiti N. C.; Mazumdar S.; Periasamy N., (1996), Controlled J-aggregation of porphyrins by cationic surfactants. Current Science 70, 997-999.
- Maiti N. C.; Ravikanth M., (1996), Effects of non-planarity and β-substitution on the singlet-excited-state properties of basket-handle porphyrins, Journal of the Chemical Society, Faraday Transactions 92, 1095-100.
- Maiti N. C.; Ravikanth M., (1995), Photophysical properties of structurally deformed basket-handle porphyrins, Journal of the Chemical Society, Faraday Transactions 91, 4369-73.
- Maiti N. C.; Ravikanth M.; Mazumdar S.; Periasamy N., (1995), Fluorescence Dynamics of Noncovalently Linked Porphyrin Dimers, and Aggregates, Journal of Physical Chemistry 99, 17192-97.
- Maiti Nakul C.; Mazumdar S.; Periasamy N., Dynamics of Porphyrin Molecules in Micelles. Picosecond Time-Resolved Fluorescence Anisotropy Studies, Journal of Physical Chemistry (1995), 99, 10708-15.