Partha Chakrabarti , M.D., Ph.D.

Senior Principal Scientist
Cell Biology & Physiology
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Research Focus

Metabolic Syndrome, Diabetes, Obesity, Non-alcoholic fatty liver disease (NAFLD), cancer metabolism.

Research Interest

The overall theme of Metabolic Diseases Laboratory is understanding the molecular basis of Metabolic Syndrome with disparate clinical manifestations including obesity, type 2 diabetes, non-alcoholic fatty liver disease and even certain types of cancer. Our interests extend from clinical inquiry to molecular underpinnings of these diseases and we approach them both at biochemical and physiological levels. To this end we work with genes, proteins, cells, mice and human patients.

Currently we are working on the following broad aspects in the domain of Metabolic Diseases –

  • Mechanisms of hepatic lipid turnover and its implication in NAFLD
  • Linking metabolic derangements to sterile inflammation
  • Impact of reprogramming in cancer cell metabolism
  • Identification of pathogenetic events for developing metabolic syndrome in metabolically unhealthy non-obese (MUNO) subjects.

 

Credentials

  • PhD, Cell and Molecular Biology, Boston University School of Medicine, USA, 2010
  • MD (Biochemistry), Banaras Hindu University, India, 2005
  • MBBS, Calcutta Medical College, University of Calcutta, India, 2000

Honours & Awards

  • Henry J Russek Student Achievement Award for the best graduate research (1st prize) 2009. Boston University.
  • Myrna and Carl Franzblau Student Travel Awards, 2009. Boston University.
  • First prize in MD Biochemistry, Banaras Hindu University, 2005
  • Brig. Ramesh Sinha Memorial Certificate and Gold Medal award for best scientific paper presentation. Association of Medical Biochemist of India conference, 2003.

Grants & Supports

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Patents & Publications

RESEARCH ARTICLES

  1. Dogra S, Das D, Maity SK, Paul A, Rawat P, Daniel PV, Das K, Mitra S, Chakrabarti P*, Mondal P. Liver Derived S100A6 Propels β Cell Dysfunction in NAFLD. Diabetes. 2022 Jul 28:db220056. doi: 10.2337/db22-0056. Epub ahead of print. PMID: 35899967.
  2. Bej S, Sarkar J, Biswas S, Mitra P, Chakrabarti P, Wolkenhauer O. Identification and epidemiological characterization of Type-2 diabetes sub-population using an unsupervised machine learning approach. Nutr Diabetes. 2022 May 27;12(1):27. doi: 10.1038/s41387-022-00206-2. PMID: 35624098.
  3. Singh P, Ujjainiya R, Prakash S, Naushin S, Sardana V, Bhatheja N, Singh AP, Barman J, Kumar K, Gayali S, Khan R, Rawat BS, Tallapaka KB, Anumalla M, Lahiri A, Kar S, Bhosale V, Srivastava M, Mugale MN, Pandey CP, Khan S, Katiyar S, Raj D, Ishteyaque S, Khanka S, Rani A, Promila, Sharma J, Seth A, Dutta M, Saurabh N, Veerapandian M, Venkatachalam G, Bansal D, Gupta D, Halami PM, Peddha MS, Veeranna RP, Pal A, Singh RK, Anandasadagopan SK, Karuppanan P, Rahman SN, Selvakumar G, Venkatesan S, Karmakar MK, Sardana HK, Kothari A, Parihar DS, Thakur A, Saifi A, Gupta N, Singh Y, Reddu R, Gautam R, Mishra A, Mishra A, Gogeri I, Rayasam G, Padwad Y, Patial V, Hallan V, Singh D, Tirpude N, Chakrabarti P, Maity SK, Ganguly D, Sistla R, Balthu NK, A KK, Ranjith S, Kumar BV, Jamwal PS, Wali A, Ahmed S, Chouhan R, Gandhi SG, Sharma N, Rai G, Irshad F, Jamwal VL, Paddar MA, Khan SU, Malik F, Ghosh D, Thakkar G, Barik SK, Tripathi P, Satija YK, Mohanty S, Khan MT, Subudhi U, Sen P, Kumar R, Bhardwaj A, Gupta P, Sharma D, Tuli A, Ray Chaudhuri S, Krishnamurthi S, Prakash L, Rao CV, Singh BN, Chaurasiya A, Chaurasiyar M, Bhadange M, Likhitkar B, Mohite S, Patil Y, Kulkarni M, Joshi R, Pandya V, Mahajan S, Patil A, Samson R, Vare T, Dharne M, Giri A, Mahajan S, Paranjape S, Sastry GN, Kalita J, Phukan T, Manna P, Romi W, Bharali P, Ozah D, Sahu RK, Dutta P, Singh MG, Gogoi G, Tapadar YB, Babu EV, Sukumaran RK, Nair AR, Puthiyamadam A, Valappil PK, Pillai Prasannakumari AV, Chodankar K, Damare S, Agrawal VV, Chaudhary K, Agrawal A, Sengupta S, Dash D. A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys. Comput Biol Med. 2022 Apr 25;146:105419. doi: 10.1016/j.compbiomed.2022.105419. Epub ahead of print. PMID: 35483225.
  4. Aravindakshan MR, Maity SK, Paul A, Chakrabarti P*, Mandal C, Sarkar J. Distinct pathoclinical clusters among patients with uncontrolled type 2 diabetes: results from a prospective study in rural India. BMJ Open Diabetes Res Care. 2022 Feb; 10(1):e002654. doi: 10.1136/bmjdrc-2021-002654. PMID: 35144941.
  5. Das D, Paul A, Maity SK, Chatterjee S, Chakrabarti P*. Subcutaneous amyloidoma models for screening potential anti-fibrillating agents in vivo. STAR Protoc (Cell Press). 2021 Dec 14;2(4):101027. doi: 10.1016/j.xpro.2021.101027. PMID: 34977673.
  6. Das A, Basu S, Bandyopadhyay D, Mukherjee K, Datta D, Chakraborty S, Jana S, Adak M, Bose S, Chakrabarti S, Swarnakar S, Chakrabarti P, Bhattacharyya SN. Inhibition of extracellular vesicle-associated MMP2 abrogates intercellular hepatic miR-122 transfer to liver macrophages and curtails inflammation. iScience (Cell Press). 2021 Nov 11;24(12):103428. doi: 10.1016/j.isci.2021.103428. PMID: 34877493.
  7. Das D, Paul A, Lahiri A, Adak M, Maity SK, Sarkar A, Paul S, Chakrabarti P*. Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. Redox Biol. 2021 45:102043. doi: 10.1016/j.redox.2021.102043. PMID: 34144391.
  8. Mukherjee M, Das D, Sarkar J, Banerjee N, Jana J, Bhat J, Reddy G J, Bharatam J, Chattopadhyay S, Chatterjee S, Chakrabarti P*. Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping. iScience (Cell Press). 2021 May 21;24(6):102573. DOI: https://doi.org/10.1016/j.isci.2021.102573
  9. Majumder P, Chanda K, Das D, Singh BK, Chakrabarti P, Jana NR, Mukhopadhyay D. A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes. Biochem J. 2021 Aug 19. 478(17):3297-3317. doi: 10.1042/BCJ20210175. PMID: 34409981.
  10. Misra S, Bagchi A, Sarkar A, Niyogi S, Bhattacharjee D, Chatterjee S, Mondal S, Chattopadhyay A, Saha A, Chatterjee S, Sinhamahapatra P, Chakrabarti P, Chatterjee M, Ghosh A. Methotrexate and theaflavin-3, 3'-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS. Inflammopharmacology. 2021 Aug 5. 29(5):1427-1442. doi: 10.1007/s10787-021-00857-0. PMID: 34350509.
  11. Biswas N, Mallick P, Maity S K, Bhowmik D, Ghosh Mitra A, Saha S, Roy A, Chakrabarti P, Paul S, Chakrabarti S. Genomic Surveillance and Phylodynamic Analyses Reveal the Emergence of Novel Mutations and Co-mutation Patterns Within SARS-CoV-2 Variants Prevalent in India. Front Microbiol. 2021, 12: 2060. DOI=10.3389/fmicb.2021.703933
  12. Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S, Khan R, Rawat BS, Tallapaka KB, Anumalla M, Chandak GR, Lahiri A, Kar S, Mulay SR, Mugale MN, Srivastava M, Khan S, Srivastava A, Tomar B, Veerapandian M, Venkatachalam G, Vijayakumar SR, Agarwal A, Gupta D, Halami PM, Peddha MS, Sundaram GM, Veeranna RP, Pal A, Agarwal VK, Maurya AK, Singh RK, Raman AK, Anandasadagopan SK, Karuppanan P, Venkatesan S, Sardana HK, Kothari A, Jain R, Thakur A, Parihar DS, Saifi A, Kaur J, Kumar V, Mishra A, Gogeri I, Rayasam G, Singh P, Chakraborty R, Chaturvedi G, Karunakar P, Yadav R, Singhmar S, Singh D, Sarkar S, Bhattacharya P, Acharya S, Singh V, Verma S, Soni D, Seth S, Vashisht S, Thakran S, Fatima F, Singh AP, Sharma A, Sharma B, Subramanian M, Padwad YS, Hallan V, Patial V, Singh D, Tripude NV, Chakrabarti P, Maity SK, Ganguly D, Sarkar J, Ramakrishna S, Kumar BN, Kumar KA, Gandhi SG, Jamwal PS, Chouhan R, Jamwal VL, Kapoor N, Ghosh D, Thakkar G, Subudhi U, Sen P, Chaudhury SR, Kumar R, Gupta P, Tuli A, Sharma D, Ringe RP, D A, Kulkarni M, Shanmugam D, Dharne MS, Dastager SG, Joshi R, Patil AP, Mahajan SN, Khan AH, Wagh V, Yadav RK, Khilari A, Bhadange M, Chaurasiya AH, Kulsange SE, Khairnar K, Paranjape S, Kalita J, Sastry NG, Phukan T, Manna P, Romi W, Bharali P, Ozah D, Sahu RK, Babu EV, Sukumaran R, Nair AR, Valappil PK, Puthiyamadam A, Velayudhanpillai A, Chodankar K, Damare S, Madhavi Y, Aggarwal VV, Dahiya S, Agrawal A, Dash D, Sengupta S. Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2. Elife. 2021 Apr 20;10:e66537. doi: 10.7554/eLife.66537. PMID: 33876727.
  13. Palit S, Banerjee S, Mahata T, Niyogi S, Das T, Mandi CS, Chakrabarti P, Dutta S. Interaction of a triantennary quinoline glycoconjugate with Asialoglycoprotein receptor. ChemMedChem. 2021 16(14):2211-2216. doi: 10.1002/cmdc.202100158. PMID: 33860988.
  14. Mukherjee S, Adhikary S, Gadad SS, Mondal P, Sen S, Choudhari R, Singh V, Adhikari S, Mandal P, Chaudhuri S, Sengupta A, Lakshmanaswamy R, Chakrabarti P, Roy S, Das C. Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization. Cell Death Dis. 2020;11(12):1073. doi: 10.1038/s41419-020-03129-x. PMID: 33323928.
  15. Ghosh I, Mukhopadhyay P, Das K, Anne M B, Ali Mondal S, Basu M, Nargis T, Pandit K, Chakrabarti P, Ghosh S. Incretins in fibrocalculous pancreatic diabetes: A unique subtype of pancreatogenic diabetes. J Diabetes. 2021 Jun;13(6):506-511. doi: 10.1111/1753-0407.13139. PMID: 33247879.
  16. Paul D, Sahana MH, Mandal P, Chakrabarti P, Goswami RK. Biselyngbyolides A & C: their total synthesis and anticancer activities. Org Biomol Chem. 2020 Sep 23;18(36):7151-7164. doi: 10.1039/d0ob00576b. PMID: 32966514.
  17. Pathak BK, Das D, Bhakta S, Chakrabarti P, Sengupta J. Resveratrol as a nontoxic excipient stabilizes insulin in a bioactive hexameric form.  J Comput Aided Mol Des. 2020. 34(8):915-927 doi: 10.1007/s10822-020-00311-3
  18. Basu S, Barad M, Yadav D, Nandy A, Mukherjee B, Sarkar J, Chakrabarti P, Mukhopadhyay S, Biswas D. DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6509-6520. doi: 10.1073/pnas.1912375117
  19. Banerjee  D, Chaudhuri RD, Niyogi S, Roy Chowdhuri S, Poddar Sarkar M, Chatterjee R, Chakrabarti P, Sarkar S. Metabolic Impairment in Response to Early Induction of C/EBPβ Leads to Compromised Cardiac Function During Pathological Hypertrophy. J Mol Cell Cardiol.  2020 139:148-163. DOI: 10.1016/j.yjmcc.2020.01.004
  20. Mukherjee S, Sen S, Adhikary S, Sengupta A , Mandal P, Dasgupta D, Chakrabarti P, Roy S, Das C. A Novel Role of Tumor Suppressor ZMYND8 in Inducing Differentiation of Breast Cancer Cells Through Its Dual-Histone Binding Function. J Biosci. 2020 45:2. DOI: 10.1007/s12038-019-9980-5
  21. Sarkar J, Maity SK, Sen A, Nargis T, Ray D, Chakrabarti P*. Impaired compensatory hyperinsulinaemia among non-obese Type 2 Diabetes patients: A cross-sectional study. Ther Adv Endocrinol Metab. 2019 10:2042018819889024. doi: https://doi.org/10.1177/2042018819889024
  22. Sarkar J, Nargis T, Tantia O, Ghosh S, Chakrabarti P*. Increased Plasma Dipeptidyl Peptidase-4 (DPP4) Activity is an Obesity-independent Parameter for Glycemic Deregulation in Type 2 Diabetes Patients. Front Endocrinol, 2019. 10:505. doi: 10.3389/fendo.2019.00505. eCollection 2019.
  23. Niyogi S, Ghosh M, Adak M, Chakrabarti P*. PEDF Promotes Nuclear Degradation of ATGL through COP1. Biochem Biophy Res Commun. 2019. 512(4):806-811
  24. Banerjee I, De M, Dey G, Bharti R, Chattopadhyay S, Ali N, Chakrabarti P, Reis RL, Kundu SC, Mandal M. A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model. Biomater Sci. 2019. 7(3):1161-1178
  25. Palit S, Mukherjee S, Niyogi S, Banerjee A, Patra D, Chakraborty A, Chakrabarti S, Chakrabarti P*, Dutta S*. Quinoline-glycomimetic conjugates reducing lipogenesis and lipid accumulation in hepatocytes. ChemBiochem. 2018 19 (16): 1720-1726
  26. Adak A, Das D, Niyogi S, Challa N, Ray D, Chakrabarti P*. Inflammasome activation in Kupffer cells confers a protective response in nonalcoholic steatohepatitis through pigment epithelium–derived factor expression. FASEB J. 2018. https://doi.org/10.1096/fj.201800190
  27. Khan MW, Layden BT, Chakrabarti P*. Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability. Biochim Biophys Acta (BBA). 2018. 17; 1864(6 Pt A):2040-2052. (selected for BBA collection on ‘Programmed Cell Death’ 2018)
  28. Nargis T, Kumar K,  Raj Ghosh AR, Sharma A, Rudra D, Sen D, Chakrabarti S, Mukhopadhyay S, Ganguly D, Chakrabarti P*. KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes. Mol Metab. 2017. 6(11):1529-1539 doi: https://doi.org/10.1016/j.molmet.2017.09.004 (Featured in Molecular Metabolism, Vol 6, No 11, November, 2017)
  29. Basu M, Sengupta I, Khan MW, Srivastava DK, Chakrabarti P, Roy S, Das C. Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes (2017) Biochem J. 474(11):1919-1934. doi: 10.1042/BCJ20170223.
  30. Basu M, Khan MW, Chakrabarti P, Das C. Chromatin reader ZMYND8 is a key target of all trans retinoic acid-mediated inhibition of cancer cell proliferation. (2017) Biochim Biophys Acta (BBA). 1860: 450–459 doi: 10.1016/j.bbagrm.2017.02.004
  31. Ghosh M, Niyogi S, Bhattacharyya M, Adak M, Nayak DK, Chakrabarti S, Chakrabarti P*. Ubiquitin Ligase COP1 Controls Hepatic Fat Metabolism by Targeting ATGL for Degradation. (2016) Diabetes. 65(12):3561-3572
  32. Ghosh AR, Bhattacharya R, Bhattacharya S, Nargis T, Rahaman O, Duttagupta P, Raychaudhuri D, Chen Liu CS, Roy S, Ghosh P, Khanna S, Chaudhuri T, Tantia O, Haak S, Bandyopadhyay S, Mukhopadhyay S, Chakrabarti P, Ganguly D. Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation. (2016) Diabetes. 65(11):3440-3452.
  33. Biswas D, Ghosh M, Kumar S and Chakrabarti P *. PPARα-ATGL pathway improves muscle mitochondrial metabolism: implication in aging. (2016) FASEB J. 30(11):3822-3834 doi: 10.1096/fj.201600571RR.
  34. Khan MW, Biswas D, Ghosh M, Mandloi S, Chakrabarti S and Chakrabarti P*. mTORC2 controls cancer cell survival by modulating gluconeogenesis. (2015) Cell Death Discovery 1, 15016; doi:10.1038/cddiscovery.2015.16
  35. Singh M, Shin YK, Yang X, Zehr B, Chakrabarti P, Kandror KV. 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. (2015) J Biol Chem. 290 (28):17331-8. doi: 10.1074/jbc.M114.631895.
  36. Paul S, Banerjee N, Chatterjee A, Sau TJ, Das JK,  Mishra PK, Chakrabarti P,  Bandyopadhyay A and Giri AK. Arsenic-induced promoter hypomethylation and over-expression of ERCC2 reduces DNA repair capacity in humans by non-disjunction of the ERCC2-Cdk7 complex. (2014) Metallomics, 6(4):864-73. doi: 10.1039/c3mt00328k.
  37. Chakrabarti P*, Kim JY, Singh M, Shin Y-K, Kim J, Kumbrink J, Wu Y, Lee M-J, Kirsch KH, Fried SK, and Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionary conserved mTORC1-Egr1-ATGL-mediated pathway. (2013) Mol Cell Biol, 33:3659-66 (Featured in World Biomedical Frontiers, Feb 2014, http://biomedfrontiers.org/diabetes-2014-1-16/) doi: 10.1128/MCB.01584-12.
  38. Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells. (2011) PLoS One, 6: e28146 doi: 10.1371/journal.pone.0028146.
  39. Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR and Kandror KV. SIRT1 controls lipolysis in adipocytes via FoxO1-mwdiated expression of ATGL. (2011) J Lipid Res, 52:1693-701. doi: 10.1194/jlr.M014647.
  40. Chakrabarti P, English T, Shi J, Smas SM and Kandror KV. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis and promotes fat storage. (2010) Diabetes, 59: 775-781. doi: 10.2337/db09-1602.
  41. Chakrabarti P and Kandror KV. FoxO1 controls insulin-dependent ATGL expression and lipolysis in adipocytes. (2009) J. Biol. Chem. 284, 13296-13300. (Featured in Nature Lipodomics gateway http://www.lipidmaps.org/update/2009/090527/full/lipidmaps.2009.8.html) doi: 10.1074/jbc.C800241200.
  42. Chakrabarti P, Anno T, Manning B, Luo Z and Kandror KV. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. (2008) Mol. Endocrinol. 22: 2260-2267.
  43. Gupta R, Chakrabarti P, Dikshit M and Dash D. Late signaling in the activated platelets upregulates tyrosine phosphatase SHP1 and impairs platelet adhesive functions: Regulation by calcium and Src kinase. (2007) Biochim. Biophys. Acta, 1773: 131-140.
  44. Chakrabarti P, Panda BK and Dash D. Detection of Gγ(Aγδβ)0 thalassemia in North India. (2006) Clin Chim Acta, 364: 363-364.
  45. Chakrabarti P, Gupta R, Misra A, Rai M, Singh VP and Dash D. Spectrum of b-thalassemia mutations in North-Indian states: a b-thalassemia trait with two mutations in cis. (2005) Clin Biochem, 38: 576-578.
  46. Chakrabarti P, Karim ZA, Gupta R,Vadhawan V,Mukhopadhyay S and Dash D.Biochemical characterization of Glanzmann’s Thrombasthenia, a rare genetic disorder affecting platelet function. (2004) Ind J Med Biochem, 8:56-60.

REVIEWS 

  1. Nargis T and Chakrabarti P*. Significance of circulatory DPP4 activity in metabolic diseases. (2018) IUBMB Life; 70:112-119. (DOI: 10.1002/iub.1709)
  2. Khan MW and Chakrabarti P*. Gluconeogenesis combats cancer: opening new doors in cancer biology. Cell Death and Disease (2015) 6, e1872 ; doi:10.1038/cddis.2015.245
  3. Chakrabarti P *, Kandror KV. The Role of mTOR in Lipid Homeostasis and Diabetes Progression. (2015) Curr Opin Endocrinol Diabetes Obes. 22: 340-46. DOI:10.1097/MED.0000000000000187
  4. Chakrabarti P *, Kandror KV. Adipose Triglyceride Lipase: A New Target in the Regulation of Lipolysis by Insulin. (2011) Current Diabetes Review, 7: 270-277, DOI: http://dx.doi.org/10.2174/157339911796397866
  5. Chakrabarti P*. Promoting adipose specificity: the adiponectin promoter. (2010) Endocrinology, 151: 2408-2410 (Invited News and Views review).

Book Chapter:

  1. Das D, Adak M, Chakrabarti P*. Ex Vivo Dual-Hit Method for Inflammasome Activation in Liver. Methods Mol Biol. 2022; 2455:255-265. doi: 10.1007/978-1-0716-2128-8_20. PMID: 35213000. Devanand Sarkar (Eds): Non-Alcoholic Steatohepatitis, (Chapter 20). Springer Nature. 

Patent:

  1. Quinazolinones Derivatives For Treatment Of Non-Alcoholic Fatty Liver Disease, Preparation And Use Thereof. Talukdar Arindam, Chakrabarti Partha, Sarkar Dipayan, Chowdhury Saheli, Goon Sunny, Das Subrata, Das Nirmal, Sarkar Dipika. International Application No. PCT/IN2021/050621, dated 25 June 2021; Priority Application No.: 202011027502 dated 29 June 2020. WO2022003712
  2. Preparation of Quinazolinediones and Use Thereof For Treatment of Non-Alcoholic Fatty Liver Disease.  Talukdar Arindam, Chakrabarti Partha, Sarkar Dipayan, Chowdhury Saheli, Goon Sunny, Sen Abhishek, Ghosh Dastidar Uddipta, Patra Binita, Hoque Israful. Patent no. 202111061087.  Filing date 25.12.2021.  Agency/Countey: IN
  3. Thermostable bioactive insulin formulation and a process for preparing the same for the treatment of type 1 and type 2 diabetes. Chatterjee Subhransu, Chakrabarti Partha, Chattopadhyay Samit. Patent number: 202131023259; Filing date: 23.5.2022; Agency/Countey: IN
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