Prem Tripathi , Ph.D.

Scientist
Cell Biology & Physiology
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Research Interest

  • Role of endogenous neuronal progenitors in neurogenesis following neurodegeneration
  • Disease models such as epilepsy and autism using in-vivo approaches.
  • Development of immunobiosensor for detection of neurodegenerative diseases.
  • Functional dissection of H3K27 demethylase in hippocampus and dentate gyrus development.

Credentials

  • PhD, Scuola Normale Superiore, Pisa, Italy (2007-2010)
  • Postdoctoral Research, European Institute of Oncology, Campus IFOM IEO, Milan, Italy (2010-2013).
  • Postdoctoral Researcher, Seattle Children’s Research Institute, Seattle, United States (2014-2015)
  • Assistant Professor, Amity University, Noida, India (2016- 2017)

Honours & Awards

  • Awarded three years Postdoctoral Scholarship from AIRC, Italy (2011- 13).
  • Full fellowship to participate in Developmental Neurobiology course, Japan (2012).
  • Awarded 3.5 years full fellowship from SNS, Pisa, Italy for doctoral studies (2007- 10).
  • Fellowship to participate to the Gordon research conferences (GRC), on Mechanisms of epilepsy & neuronal Synchronization, Waterville, USA (2008).
  • Full fellowship to participate in workshop on Gradient & Signaling, Okinawa, Japan (2008).

Patents & Publications

Publications
  • Seungshin H, Tripathi PP, Mihalas AB, Hevner RF, Beier DR (2017) C-terminal region truncation of RELN disrupts an interaction with VLDLR causing abnormal development of the cerebral cortex and hippocampus. The Journal of neuroscience 37(4):960-971.
  • Tripathi PP*, Bozzi Y (2015) The role of dopaminergic and serotonergic systems in neurodevelopmental discorders: a focus on epilepsy and seizure BioImpacts (* corresponding author(Article selected for cover page story)
  • Provenzano G, Clementi E, Genovesi S, Scali M, Tripathi PP, Sgado P, Bozzi Y (2014) GH Dysfunction in Engrailed-2 Knockout Mice, a Model for Autism Spectrum Frontiers in pediatrics 2:92.
  • Sgado P, Genovesi S, Kalinovsky A, Zunino G, Macchi F, Allegra M, Murenu E, Provenzano G, Tripathi PP, Casarosa S, Joyner AL, Bozzi Y (2013) Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant  mice:  implications  for  autism  spectrum     Experimental neurology  247:496-505.
  • Tripathi PP, Di Giovannantonio LG, Sanguinetti E, Acampora D, Allegra M, Caleo M, Wurst W, Simeone A, Bozzi Y (2014) Increased dopaminergic innervation in the brain  of  conditional  mutant  mice overexpressing Otx2: effects on locomotor behavior and seizure Neuroscience 261:173-183.
  • Burgold T, Voituron N*, Caganova M*, Tripathi PP*, Menuet C, Tusi BK, Spreafico  F,  Bevengut  M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G (2012) The H3K27 demethylase  JMJD3 is  required for  maintenance of  the embryonic  respiratory neuronal network, neonatal breathing, and CELL reports 2:1244-1258. (*Authors contributed equally to work)
  • Thangavelu SR, Tripathi PP, Arya U, Mishra HK, Subramaniam  JRPD  (2011)  ALS  associated  mutant SOD1 impairs the motor neurons and astrocytes and wild type astrocyte secreted-factors  reverse  the impaired motor Annals of neurosciences 18:48-55.
  • Tripathi PP, Santorufo G, Brilli E, Borrelli E, Bozzi Y (2010) Kainic acid-induced seizures activate GSK- 3beta in the hippocampus of D2R-/- Neuroreport 21:846-850.
  • Tripathi PP, Sgado P, Scali M, Viaggi C, Casarosa S, Simon HH, Vaglini F, Corsini GU, Bozzi Y (2009) Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout Neuroscience 159:842-849.
  • Tripathi PP, ; Corsini, G.U.; Simone, A.; Bozzi, Y.; (2009) Developmental basis of seizure susceptibility: A focus on dopaminergic and serotonergic systems. Current trends in Neurology 3:93-101.
  • Teixidor GT, Gorkin RA, 3rd, Tripathi PP, Bisht GS, Kulkarni M, Maiti TK, Battacharyya TK, Subramaniam JR, Sharma A, Park BY, Madou M (2008) Carbon microelectromechanical systems as a substratum for cell Biomedical materials (Bristol, England) 3:034116.
  • Tripathi PP, Di Giovannantonio LG, Viegi A, Wurst W, Simeone A, Bozzi Y (2008) Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience  28:9271-9276.
Patents

Gandhi S, Tripathi PP. FTO/AuNPs- based nanosensor for Chlorpyrifos detection in fruits and vegetables”. Patent application number 2017/11044750, National filing date 14 December 2017.