Ramalingam Natarajan , Ph.D.

Principal Scientist
Organic & Medicinal Chemistry

Research Interest

  1. Design and synthesis of novel receptors, through dynamic combinatorial chemistry, towards selective recognition of biologically important targets
  2. Selective and tunable transport of inorganic ions and organic molecules across bilayer membrane by novel synthetic ion channels and carriers
  3. Crystal engineering of functional organic molecules towards biomedical applications


MSc (1998), Anna University, Chennai
PhD (2005) , Indian Institute of Technology, Kanpur (Prof. J Narasimha Moorthy)
Post-doctoral Fellow (2005-2006), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea (Prof. Kimoon Kim)
Post-doctoral Fellow (2006-2007) with Alexander von Humboldt Fellowship at University of Wuerzburg, Germany (Prof. Frank Wuerthner) 
Post-doctoral Fellow (2007-2010), University of Bristol, UK (Prof. Anthony P. Davis)
Research Assistant Professor (2011-2013), Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea (Prof. Kimoon Kim)

Patents & Publications

  1. Enantioselective Michael Addition Reaction Catalysed by Enantiopure Binuclear Nickel (II) Close‐Ended Helicates. Chinnaraja, E.; Arunachalam, R.; Samanta, K.; Natarajan, R.; Subramanian, P. S. Adv. Synth. Catal. 2020, 362, 1144-1155.
  2. Influence of Conformational Change and Interligand Hydrogen Bonding in a Chiral Metal–Organic Cage. Sen, S. K.; Natarajan, R.* Inorg. Chem. 2019, 58, 7180-7188.
  3. Azomethine ylide cycloaddition: a versatile tool for preparing novel pyrrolizidino-spiro-oxindolo hybrids of the doubly conjugated alkamide piperine. Singh, M.; Krishnan, A.V. A.; Mandal, R.; Samanta, J.; Ravichandiran, V; Natarajan, R.; Bharitkar, Y. P; Hazra, A. Mol. Divers. 2019, 1-13. 
  4. Binuclear Double-Stranded Helicates and Their Catalytic Applications in Desymmetrization of Mesodiols. Chinnaraja, E.; Arunachalam, R.; Suresh, E.; Sen, S. K; Natarajan, R.; Subramanian, P. S. Inorg. Chem. 2019, 58, 4465-4479.
  5. Desymmetrization of meso diols using enantiopure zinc (II) dimers: Synthesis and chiroptical properties. Chinnaraja, E.; Arunachalam, R.; Samanta, J.; Natarajan, R.; Subramanian, P. S. Appl. Organomet. Chem. 2019, 33, e4827.
  6. Enantiomeric Resolution of Asymmetric-Carbon-Free Binuclear Double-Stranded Cobalt (III) Helicates and Their Application as Catalysts in Asymmetric Reactions. Arunachalam, R.; Chinnaraja, E.; Valkonen, A.; Rissanen, K.; Sen, S. K.; Natarajan, R.; Subramanian, P. S.  Inorg. Chem. 2018, 57, 11414-11421.
  7. D–A–D Structured Bis-acylhydrazone Exhibiting Aggregation-Induced Emission, Mechanochromic Luminescence, and Al (III) Detection. Santhiya, K.; Sen, S. K.; Natarajan, R.; Shankar, R.; Murugesapandian, B. J. Org. Chem. 2018, 83, 10770-10775.
  8. Synthesis of macrocyclic conjugated ψ-disacharides via nitrile oxide cycloaddition: Alkenyl chain length controlled unprecedented formation of di-oxa heterocycles from monosaccharides. Hossain, J.; Natarajan, R.; Banerjee, A. K.; Majumdar, S. Tetrahedron 2017, 73, 3139-3146.
  9. Cofacial Organic Click Cage to Intercalate Polycyclic Aromatic Hydrocarbons. Samanta, J.; Natarajan, R.* Org. Lett. 2016, 18, 3394-3397.
  10. Tandem Chemoselective 1, 2‐/1, 4‐Migration of the Thio Group in Keto Thioesters: An Efficient Approach to Substituted Butenolides. Mal, K.; Naskar, S.; Sen, S. K.r; Natarajan, R.; Das, I.;  Adv. Synth. Catal. 2016, 358, 3212-3230.
  11. Phthalate tethered strategy: carbohydrate nitrile oxide cycloaddition to 12–15 member chiral macrocycles with alkenyl chain length controlled orientation of bridged isoxazolines. Majumdar, S.; Hossain, J.; Natarajan, R.; Banerjee, A. K.; Maiti, D. K. RSC Adv. 2015, 5, 106289-106293.
  12. Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade. Bhunia, S. K.; Polley, A.; Natarajan, R.; Jana, R. Chem. Eur. J. 2015, 21, 16786-16791.
  13. Synthesis of bis-pyrrolizidine fused di-spiro oxindole analogs of curcumin via one pot azomethine ylide cycloaddition: Experimental and computational approach towards regio and diastereoselection. Bharitkar, Y. P.; Das, M.; Kumarib, N.; Kumari, M. P.; Hazra, A.; Bhayye, S. S.; Natarajan, R.; Shah, S.; Chatterjee, S.; Mondal, N. B. Org. Lett. 2015, 17, 4440-4443.
  14. Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection. Nayak, D. K.; Baishya, R.; Natarajan, R.; Sen, T.; Debnath, M. C. Dalton Trans, 2015, 46, 16136-16148.
  15. ZnI2-Catalyzed Diastereoselective [4 + 2] Cycloadditions of β,γ-Unsaturated α-Ketothioesters with Olefins. Mal, K.; Das, S.; Maiti, N. C.; Natarajan, R.; Das, I. J. Org. Chem. 2015, 80, 2972-2988.
  16. Cucurbit[7]uril: A High-Affinity Host for Encapsulation of Amino Saccharides and Supramolecular Stabilization of Their α-Anomers in Water.
    Jung, Y; Natarajan, R.*; Ko, Y. H; Kim, K*. Angew. Chem. Int. Ed2014, 54, 1003-1007.
  17. Hollow Nanotubular Toroidal Polymer Microrings. Lee, J. L.; Baek. K.; Kim, M.; Yun, G.; Ko, Y. H.; Lee, N. -S.; Hwang, I; Kim, J.; Natarajan, R.; Park, C. G.; Sung, W.; Kim, K. Nature Chem. 20146, 97-103.
  18. Tunable Porous Organic Crystals: Structural Scope and Adsorption Properties of Nanoporous Steroidal Ureas.
    Natarajan, R.; Bridgland, L.; Sirikilkajorn, A.; Lee, J.-H.; Haddow, M. F.; Magro, G.; Ali, B.; Narayanan, S.; Strickland, P.; Charmant, J. P. H.; Orpen, A. G.; McKewon, N. B.; Bezzu, C. G.; Davis, A.P. J. Am. Chem. Soc. 2013135, 16912-16925.
  19. Tandem catalysis with a bifunctional site-isolated Lewis acid–Brønsted base metal–organic framework, NH2-MIL-101(Al)
    Srirambalaji, R.; Hong, S.; Natarajan, R.; Yoon, M.; Hota, R.; Kim, Y.; Ko, Y. H.; Kim, K. Chem. Commun201248, 11650-11652.
  20. Nanoporous Organic Alloys.
    Natarajan, R.; Magro, G.; Bridgland, L. N.; Sirikulkajorn, A.; Narayanan, S.; Ryan, L. E.; Haddow, M. F.; Orpen, A. G.; Charmant, J. P. H.; Hudson, A. J. Davis, A. P. Angew. Chem., Int. Ed. 201150, 11386-11390.
    Highlight: Rational Design of Multifunctional Nanopores by Mixing Matching Molecules. Mastalerz, M. Angew. Chem., Int. Ed.201251, 584-586..
  21. Water Chains in Hydrophobic Crystal Channels: Nanoporous Materials as Supramolecular Analogs of Carbon Nanotubes.
    Natarajan, R.; Charmant, J. P. H.; Orpen, A. G.; Davis, A. P. Angew. Chem., Int. Ed. 201049, 5125-5129.
  22. Influence of Weaker Interactions on the Self-Assembly of Rigid Molecular Scaffolds Based on Tetraarylbimesityls.
    Moorthy, J. N.; Natarajan, R.; Savitha, G.; Venugopalan, P. Cryst. Growth Des. 20066, 919-924
  23. Anion Driven Self-Assembly of Tetrapyridyl Ligand with a Twist.
    Moorthy, J. N.; Natarajan, R.; Savitha, G.; Suchopar, A.; Richards, R. M. J. Mol. Struct. 2006796, 216-222.
  24. Three-Dimensional Organic Scaffolds with a Twist: Synthesis and Self-Assembly.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. J. Org. Chem. 200570, 8568-8571.
  25. Corundum, Diamond and PtS Metal-Organic Frameworks (MOFs) with a Difference: Self-Assembly with a Unique Pair of 3-Connecting D2d-Symmetric 3,3’,5,5’-Tetrakis(4-pyridyl)bimesityl.
    Natarajan, R.; Savitha, G.; Dominiak, P.; Wozniak, K.; Moorthy, J. N. Angew. Chem., Int. Ed. 200544, 2115-2119.
  26. Identification of New Supramolecular Synthon in o-Anisaldehydes: Molecular Self-Assembly into Tapes and Staircases.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. J. Mol. Struct. 2005741, 107-114.
  27. Self-Assembly of a Unique Extended-Tetrahedral 3,3’,5,5’-Tetrakis(4-pyridyl) Ligand into Discrete Supramolecular Cubes by Face Directed Metal Coordination.
    Natarajan, R.; Savitha, G.; Moorthy, J. N.Cryst. Growth Des. 20055, 69-72.
  28. Polymorphism of an o-Anisaldehyde: A Novel Example of Channel-Type Organization Sustained by Weak C-H∙∙∙O and C-H∙∙∙N Hydrogen Bonds.
    Moorthy, J. N.; Natarajan, R.; Mal, P.; Venugopalan, P. New J. Chem. 2004, 1416-1419.
  29. Characterization of Planar Cyclic Form of Water Hexamer in an Organic Supramolecular Complex: An Unusual Self-Assembly of Bimesityl-3,3’-dicarboxylic Acid.
    Moorthy, J. N.; Natarajan, R.; Venugopalan, P. Angew. Chem., Int. Ed. 200241, 3417-3420.
  30. Helical Self-Assembly of Substituted Benzoic Acids: Influence of Weaker X∙∙∙X and C-H∙∙∙X Interactions.
    Moorthy, J. N.; Natarajan, R.; Mal, P.; Venugopalan, P. J. Am. Chem. Soc. 2002124, 6530-6531.
  31. Efficient Photocyclization of o-Alkylbenzaldehydes in the Solid State: Direct Observation of E-Xylyenols en route to Benzocyclobutenols.
    Moorthy, J. N.; Mal, P.; Natarajan, R.; Venugopalan, P. J. Org. Chem. 200166, 7013-7019.
  32. Solid-State Photochromism and Photoreactivity of o- and p-Anisaldehydes. Remarkable Stabilization of o-Xylyenols.
    Moorthy, J. N.; Mal. P.; Natarajan, R.; Venugopalan, P. Org. Lett. 20013, 1579-1582.
  33. Indium Trichloride-Catalyzed Imino Diels-Alder Reactions: Synthesis of New Indolylquinoline Derivatives.
    Babu, G.; Nagarajan, R.; Natarajan, R.; Perumal, P. T. Synthesis2000, 661-666.