Ranjan Jana , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry
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Research Interest

  • Design and development of novel ligands for the metal-catalyzed enantioselective synthesis of medicinal scaffolds.
  • Identification of highly selective kinase inhibitors via late-stage C-H activation/ functionalization of heterocycles.
  • Photo-affinity and activity based protein profiling for the identification of biological target of small molecules.
  • Development of radiopharmaceuticals for PET imaging for the early detection of breast cancer and neurodegenerative diseases.
  • Exploring biocompatiblechemical reactivity for posttranslational modifications (PTMs) of proteins. 

Credentials

  • Ramanujan Fellow
  • Postdoctoral Research (2010-2012) University of Utah, USA with Prof. M. S. Sigman
  • Postdoctoral Research (2008-2010) University of Kansas, USA with Prof. J. A. Tunge
  • Postdoctoral Research (2007-2008) Bar-Ilan University, Israel with Prof. S. Braverman
  • Ph.D (2007) Organic Chemistry, Indian Association for the Cultivation of Science (IACS), Kolkata with Prof. B. C. Ranu

Patents & Publications

PUBLICATIONS

  1. Exceedingly Fast, Direct Access to Dihydroisoquinolino[1,2-b]quinazolinones through a Ruthenium(II)-Catalyzed Redox-Neutral C–H Allylation/Hydroamination Cascade-Bairy, G.; Das, S.; Begam, H. M.; Jana, R., Org. Lett. 2018, ASAP.
  2. Palladium-Catalyzed Ortho C−H Arylation of Aniline Carbamates with Diazonium Salts under Mild Conditions: Expedient Synthesis of Carbazole Alkaloids- Arghya Polley, A.; Varalaxmi, K.; Jana, R., ACS Omega, 2018, 3, 14503-14516.
  3. Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N, or O-Difluoromethylation, N-Ethylation and S-(ethoxycarbonyl) difluoromethylation- Polley, A.; Bairy, G.; Das, P.; Jana, R., Adv. Synth. Catal. 2018, 360, 416-4167.
  4. Sterically Controlled Ru(II)-Catalyzed Divergent Synthesis of 2-Methylindoles and Indolines through a C–H Allylation/Cyclization Cascade- Manna, M. K.; Bairy, G.; Jana, R., J. Org. Chem. 2018, ASAP.
  5. CuI/AgI-Promoted Decarboxylative Alkynylation of ortho-Nitro Benzoic Acids- Hossian, A.; Manna, K.; Das, P.; Jana, R., ChemistrySelect, 2018, 3, 4315-4318.
  6. Ligand-Promoted γ‑C(sp3)-H Arylation and Unsymmetrical Diarylation to Access Unnatural Amino Acid Derivatives- Das, S.; Bairy, G.; Jana, R., Org. Lett. 2018, 20, 2667–2671.
  7. A General Copper/Manganese Cocatalyzed C-H Selenation of Arenes, Heteroarenes, and Alkenes under Air- Singh, B. K.; Bairy, G.; Jana, R., ChemistrySelect, 2017, 2, 9227-9232. 
  8. Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature-Manna, M. K.; Bairy, G.; Jana, R., Org. Biomol. Chem. 2017, 15, 5899-5903.
  9. Palladium-catalyzed decarboxylative, decarbonylative and dehydrogenative C(sp2)-H acylation at room temperature- Hossian, A.; Manna, M. K.; Manna, K.; Jana, R., Org. Biomol. Chem. 2017, 15, 6592-6603.
  10. Ruthenium(II)-Catalyzed Intermolecular Synthesis of 2-Arylindolines through C-H Activation/Oxidative Cyclization Cascade- Manna, M. K.; Bhunia, S. K.; Jana, R., Chem. Commun. 2017, 53, 6906-6909.
  11. Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement- Hossian, A.; Jana, R., Org. Biomol. Chem. 2016, 14, 9768-9779.
  12. Copper(II)-Mediated Intermolecular C(sp2)−H Amination of Benzamides with Electron-Rich Anilines- Singh, B. K.; Polley, A.; Jana, R., J. Org. Chem. 2016, 81, 4295-4303.
  13. Substrate-Dependent Mechanistic Divergence in Decarboxylative Heck Reaction at Room Temperature- Hossian, A.; Bhunia, S. K.; Jana, R., J. Org. Chem. 2016, 81, 2521-2533.
  14. A Ligand-Enabled, Copper-Promoted Regio- and Chemoselective Hydroxylation of Arenes, Aryl Halides, and Aryl Methyl Ethers- Singh, B. K.; Jana, R., J. Org. Chem. 2016, 81, 831-841.
  15. Through-Space 1,4-Palladium Migration and 1,2-Aryl Shift: Direct Access to Dibenzo[a,c]carbazoles through a Triple C-H Functionalization Cascade- Bhunia, S. K.; Polley, A.; Natarajan, R.; Jana, R., Chem.- Eur. J. 2015, 21, 16786-16791.
  16. Merging C-H Activation and Alkene Difunctionalization at Room Temperature: A Palladium-Catalyzed Divergent Synthesis of Indoles and Indolines- Manna, M. K.; Hossian, A.; Jana, R., Org. Lett. 2015, 17, 672-675.
  17. Chemo-, regio-, and stereoselectiveHeck–Matsuda arylation of allylic alcohols under mild conditions Chaudhari, T. Y.; Hossian, A.; Manna, M. K.; Jana, R., Org. Biomol. Chem. 2015, 13, 4841-4845.
  18. Palladium(0)-Catalyzed Intramolecular Decarboxylative Allylation of ortho Nitrobenzoic Esters- Hossian, A.; Singha, S.; Jana, R., Org. Lett. 2014, 16, 3934-3937.
  19. Synthesis of water-soluble vinyl selenides and their high glutathione peroxidase (GPx)-like antioxidant activity-Braverman, S.; Cherkinsky, M.; Kalendar, Y.; Jana, R.; Sprecher, M.; Goldberg, I. Synthesis, 2014, 46, 119-125.
  20. The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress-Vaden R. M.; Gligorich K. M.; Jana R.; Sigman M. S; Welm B. E. Breast Cancer Res.2014, 16, 472.
  21. Pd(0)-Catalyzed 1,1-Diarylation of Ethylene and Allylic Carbonates- Saini, V.;  Liao, L.; Wang, Q.; Jana, R., Sigman, M. S. Org. Lett. 2013, 15, 5008-5011.
  22. Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives- Jana, R.; Pathak, T. P.; Jensen, K. H.; Sigman, M. S. Org. Lett. 2012, 14, 4074-4077.
  23. Migratory Decarboxylative Coupling of Coumarins: Synthetic and Mechanistic Aspects- Jana, R.; Partridge, J. J.; Tunge, J. A.  Angew. Chem. Int. Ed. 2011, 50, 5157-5161.
  24. A Palladium-Catalyzed Three Component Cross-Coupling of Conjugated Dienes or Terminal Alkenes with Vinyl Triflates and Boronic Acids- Liao, L.; Jana, R.; Urkalan, K. B.; Sigman, M. S. J. Am. Chem. Soc.2011, 133, 5784-5787.
  25. Advances in Transition Metal (Pd, Ni, Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners- Jana, R.; Pathak, T. P.; Sigman, M. S. Chem. Rev. 2011, 111, 1417-1492. (The most read article in 2011).
  26. Mechanistic Origin of the Stereodivergence in Decarboxylative Allylation- Chattopadhyay, K.; Jana, R.; Day, V.; Douglas, J.; Tunge, J. A.  Org. Lett. 2010, 12, 3042-3045.
  27. Formation of N-alkylpyrroles via Intermolecular Redox Amination- Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009, 131, 16626-16627. (Highlighted in Synform).
  28. Mild Decarboxylative Allylation of Coumarins- Jana, R.; Trivedi, R.,; Tunge, J. A.  Org. Lett. 2009, 11, 3434-3436.
  29. A Homogeneous, Recyclable Rhodium(I) Catalyst for the Hydroarylation of Michael Acceptors- Jana, R.; Tunge, J. A. Org. Lett. 2009, 11, 971-974. (Developed a novel catalyst JanaPhos).
  30. An Improved Procedure for the Three Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid- B. C. Ranu; Jana, R.; Sowmiah, S. J. Org. Chem. 2007, 72. 3152- 3154.
  31. Catalysis by Ionic Liquid. A Green Protocol for the Stereoselective Debromination of vicinal– Dibromides by [pmIm]BF4 under Microwave Irradiation – Ranu, B. C.; Jana, R. J. Org. Chem. 2005, 70, 8621-8624.

 

PATENTS

  1. Polymer-supported Transition Metal Catalyst Complexes and Methods of Use- Tunge, J. A.; Subramaniam, B.; Fang, J.; Jana, R. U.S. Patent, No WO 2010057099.