Sanjay Dutta , Ph.D.

Senior Scientist
Organic & Medicinal Chemistry
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Credentials

  • Research Associate, (2011-2012), The Scripps Research Institute, La Jolla, California,USA (Prof M. G Finn)
  • Post-doctoral Research Scholar (2007-2010), University of California-San Diego, California, USA (Prof. Thomas Hermann)
  • Ph.D (2007) Organic Chemistry/Bio-organic Chemistry, University of Missouri, Columbia MO, USA (Prof. Kent S. Gates)

Patents & Publications

PUBLICATIONS

  1. Abhi Das*, Gopinatha Suresh Kumar and Sanjay Dutta* “Interaction of aloe active compounds with calf thymus DNA” J Mol Recognit. 2019, e2786, 1-9, doi/10.1002/jmr.2786
  2. Tridib Mahata, Jeet Chakraborty, Ajay Kanungo, Dipendu Patra, Gautam Basu* and Sanjay Dutta* “Intercalator induced DNA superstructure formation: doxorubicin and a synthetic quinoxaline derivative” Biochemistry 2018, 57, 5557−5563
  3. Subhadeep Palit,# Sanghamitra Mukherjee,# Sougata Niyogi,# Anindyajit Banerjee, Dipendu Patra, Amit Chakraborty, Saikat Chakrabarti, Partha Chakrabarti* and Sanjay Dutta* “Quinoline-glycomimetic conjugates reducing lipogenesis and lipid accumulation in hepatocytes” ChemBioChem, 2018, DOI: 10.1002/cbic.201800271.( #These authors contributed equally.)
  4. Carlos A. Sanhueza, Michael M. Baksh, Benjamin Thuma, Marc D. Roy, Sanjay Dutta, Cathy Preville, Boris A. Chrunyk, Kevin Beaumont, Robert Dullea, Mark Ammirati, Shenping Liu, David Gebhard, James E. Finley, Christopher T. Salatto, Amanda King-Ahmad, Ingrid Stock, Karen Atkinson, Benjamin Reidich, Wen Lin, Rajesh Kumar, Meihua Tu, Elnaz Menhaji-Klotz, David A. Price, Spiros Liras,M. G. Finn,*and Vincent Mascitti* Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor J. Am. Chem. Soc. 2017, 139, 3528-3536.
  5. Tridib Mahata, Ajay Kanungo, Sudakshina Ganguly, Eswar Kalyan Modugula, Susobhan Choudhury, Samir Kumar Pal, Gautam Basu,* and Sanjay Dutta* The Benzyl Moiety in a Quinoxaline-Based Scaffold Acts as a DNA Intercalation Switch.  (Angew. Chem. Int. Ed. 2016, 55, 7733-7736, doi:10.1002/anie.201511881.)
  6. Ajay Kanungo,‡ Dipendu Patra,‡ Sanghamitra Mukherjee, Tridib Mahata, Prakas R. Maulika and Sanjay Dutta* Synthesis of a Visibly Emissive 9-nitro-2,3-dihydro-1H-pyrimido[1,2-a]quinoxalin-5-amine Scaffold with Large Stokes Shift and Live Cell Imaging, RSC Adv., 2015, 5, 70958-70967. DOI: 10.1039/C5RA12960E. ( ‡These authors contributed equally.)
  7. Rynearson KD, Dutta S, Tran K, Dibrov SM & Hermann T. Synthesis of oxazole analogs of streptolidine lactam (2013) Eur. J. Org Chem., 7337-7342.
  8. On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA.  Johnson K. M, Price N. E, Wang J, Fekry M. I, Dutta S, Seiner D. R, Wang Y, Gates K. S  J. Am. Chem. Soc., 2013, 135, 1015-25
  9. Glycomimetic Ligands for the Human Asialoglycoprotein Receptor.  Mamidyala, S.  K§.; Dutta, S§.; Chrunyk, B. A.; Préville, C.; Wang, H.; Withka, J. M.; McColl, A.; Subashi, T. A.; Hawrylik, S. J.; Griffor, M. C.; Kim, S.; Pfefferkorn, J. A.; Price, D. A.; Menhaji-Klotz, E.; Mascitti, V. and Finn. M.G.  J. Am. Chem. Soc., 2012, 134, 1978–1981.(§These authors contributed equally.)
  10. Synthesis and crystal structure of a novel heterocycle, 2-oxa-4,7-diazabicyclo[3.3.1]non-3-ene.  Dutta, S.; Dibrov, SM.; Ho, BT.; Higginson, C. J.; & Hermann T. J. Chem.Cryst. 2012, 42, 119-129.
  11. Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the Z,E-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator. Fekry, M.; Szekely, J.; Dutta, S.; Breydo, L.; Zang, H.; Gates, K. S. J. Am. Chem. Soc. 2011, 132.
  12. A crystallographic study of a highly substituted imidazolinone, (3S,4S,5R)-3-(((S)-4-((1H-indol-3-yl)methyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidin-2-one  Dutta, S, Dibrov SM, Higginson CJ & Hermann T. J. Chem.Cryst. 2011, 4
  13. 1-Cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid. Dibrov, S.; Dutta, S. and Hermann, T. Acta Cryst. (2009). E65, o2136.
  14. Conformational inhibition of the HCV IRES RNA. Parsons, J.; Castaldi, M. P.; Dutta, S.; Dibrov, S. M.; Wyles, D. L. and Hermann, T. Nature. Chem. Biol, 2009, 5, 823-825. (Reported in News and Views by D. W Begley & G Varani in the same Journal)
  15. Synthesis and Biological Evaluation of New 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide Derivatives and Their Reduced Analogue. Solano, B.; Junnotula, V.; Martin, Adoracion.; Villar, R.; Burguette, A.; Vicente, E.; Silanes, S. P.; Aldana, I.; Mongoe, A.; Dutta, S.; Sarkar, U.; Gates, K. S.     J. Med. Chem., 2007, 50 (22), pp 5485–5492
  16. Interstrand crosslinks generated by abasic sites in duplex DNA. Dutta, S.; Chowdhury, G.; and Gates, K. S. J. Am. Chem. Soc. 2007, 129, 1852-1853
  17. DNA Damage by Fasicularin. Dutta, S.; Abe, H.; Aoyagi, S.; Kibayashi, C.; and Gates, K. S. J. Am. Chem. Soc. 2005, 127, 15004-15005
  18. Biologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNA. Gates, K. S.; Nooner, T and Dutta, S. Chem. Res. Toxicol, 2004, 17, 839-856
  19. Chemical Properties of the Leinamycin-Guanine Adduct in DNA. Nooner, T.; Dutta, S and Gates, K. S. Chem. Res. Toxicol, 2004, 17, 942-949