Sourish Ghosh,

Senior Scientist
Infectious Diseases and Immunology
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Research Focus

Welcome to our research laboratory, where our central theme revolves around unraveling the mysteries of cell biological processes and the host's defense mechanisms in the context of viral infections. While our interests are diverse, we are particularly drawn to the captivating world of RNA viruses. Our dedicated team is committed to exploring the intricate interplay between viruses and the host cells they infect. By focusing on RNA viruses, though not exclusively, we aim to uncover the underlying molecular and cellular intricacies that govern the entire lifecycle of these viruses—from infection and replication to dissemination. Through our rigorous investigations, we aspire to contribute to the broader comprehension of viral pathogenesis. Our ultimate goal is to shed light on novel antiviral strategies and therapeutic interventions that could potentially revolutionize the field of virology.

Research Interest

Unraveling the Enigma of RNA Virus Persistence  

The laboratory is dedicated to the meticulous study of RNA viruses, tracing their journey marked by a ground-breaking concept: VIRAL PERSISTENCE. This revolutionary idea empowers viruses to seamlessly adapt to the ever-evolving host responses, perpetuating the dynamic struggle between virus and host. From historical references to the intricate puzzle of Long-COVID Syndrome, the evolutionary prowess displayed by viruses remains nothing short of extraordinary.

Our inquiry delves deep into the heart of this exploration, where understanding the unwavering resilience of RNA viruses—spanning across enteric, respiratory, and neurotropic—serves as the pivotal cornerstone for crafting effective strategies against relentless viral challenges. As the battle against emerging diseases rages on, the pursuit of deciphering the mysteries posed by these viruses becomes not just essential, but imperative. Within the confines of our laboratory, we embark on an unwavering quest to unveil the intricate mechanisms that viruses deftly employ to persist within their host environments. 

 

 

Various mechanisms viruses adapt to persist in the host.

If our research and the world of viruses captivate your interest, we invite you to take the next step. Kindly share your comprehensive Curriculum Vitae along with a succinct yet insightful research summary. In the subject line, please use "Research Interest to Sourish".

Ph.D. students with a shared enthusiasm are encouraged to apply in accordance with the established norms of CSIR-Indian Institute of Chemical Biology.

Postdoctoral candidates with their own research grants are encouraged to submit their application, complete with a write-up outlining their area of expertise and a strategic alignment with our lab's interests. Don't forget to attach your Curriculum Vitae to the application.

Please note that while the lab does not entertain applications for short-term trainees or interns, we wholeheartedly welcome candidates with a keen interest in pursuing dissertations.

Credentials

  • Senior Scientist, Infectious Diseases & Immunology, CSIR- Indian Institute of Chemical Biology (2022-present).
  • Research Fellow, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, USA (2021-2022).
  • Research Scholar, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, USA (2016-2021).
  • PhD, National Brain Research Centre, Manesar (2010-2016).

Honours & Awards

  • DBT/Wellcome Trust India Alliance Intermediate Fellowship (2024-2029)
  • Ramalingaswami Re-entry Fellowship, DBT-India, 2021.
  • ASV 2019 Postdoctoral Travel Award American Society for Virology (2019).
  • Summer Mentor Award Office of Intramural Training & Education, National Institutes of Health (2019).
  • Visiting Fellow fellowship from 2016-2021, National Institutes of Health (2016).
  • DBT Travel Award, Department of Biotechnology, India (2015). 

Fellow / Membership-

  • American Society of Virology (2017-present).
  • Faculty 1000, Associate (2015-present).

Grants & Supports

  • Tuning Lipid Droplets for Antiviral Interventions in Brain, Role: Principal Investigator, Funding Agency: Department of Biotechnology, Tenure: 2024-2027, Grant Number: BT/PR51484/MED/122/359/2024, Grand Award Amount: 0.8 Cr (INR)
  • Role of Mother-Neonate Dyad Interaction in resolving Pediatric Viral Infection, Role: Principal Investigator, Funding Agency: DBT/ India Alliance, Tenure: 2024-2029, Grant Number: IA/I/23/2/506972, Grant Award Amount: 3.54 Cr (INR)
  • Role of small non-coding RNAs sorted inside Extracellular Vesicles for RNA Virus Persistence, Role: Principal Investigator, Funding Agency: DST-SERB, Tenure: 2024-2027, Grant Number: CRG/2023/004359, Grant Award Amount: 0.45 Cr (INR)
  • Vesicular Transmission of Flavivirus & Its role in Neurodegeneration, Role: Principal Investigator, Funding Agency: CSIR-Focused Basic Research (FBR), Tenure: 2024-2026, Grant Number: FBR070305, Grand Award Amount: 0.69 Cr (INR)

Patents & Publications

Selected Publications:

  1. Mondal S, Ghosh S. Liposome-Mediated Anti-Viral Drug Delivery Across Blood-Brain Barrier: Can Lipid Droplet Target Be Game Changers? Cell Mol Neurobiol (2023) 
  2. Ghosh S, Kumar M, Santiana M, Zhang M, Mishra A, Chibly AM, Nakamura H, Tanaka T, Chiorini JA, Hoffman P., Altan-Bonnet N. Enteric viruses replicate in salivary glands and infect through saliva. Nature (2022).
  3. Ghosh S, Dellibovi-Ragheb T, Pak E, Fisher M, Hsu V, Bleck C, Takvorian P, Fehr A, Perlman S, Altan-Bonnet G, Altan-Bonnet N. b-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell (2020). 
  4. Roth AN, Helm EW, Kirsche E, Smith JC, Mirabelli C, Eurell LB, Ghosh S, Kennedy E, Hernandez A, Baldridge MT, Altan-Bonnet N, Wobus CE, Karst SE. A Novel Mouse Model of Norovirus Diarrhea. Nature Communications (2020).
  5. Santiana M., Ghosh S. (equal contribution), Ho B. A., Rajasekaran V., Wen-Li Du W. L., Mutsafi Y., De Je´ sus-Diaz D. A., Sosnovtsev S. V., Levenson E. A., Parra G. I., Takvorian P. M., Cali A., Bleck C., Vlasova A. N., Saif L., Patton J. T., Lopalco P., Corcelli,Green K.Y., and Altan-Bonnet N., Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission. Cell Host & Microbe (2018).
  6. Ghosh S, Mukherjee S, Basu A. Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis. J Neurochem. (2015). 
  7. Ghosh S, Dutta K, Basu A. Chandipura virus induces neuronal death through Fas-mediated extrinsic apoptotic pathway. J Virology. (2013). 

 

For a complete list of publication please visit:

https://scholar.google.com/citations?user=QYDLZ1AAAAAJ&hl=en&oi=ao 

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