Sudipta Das , Ph.D.
Ramalingaswami Fellow
Infectious Diseases and Immunology
Research Interest
- Exploring non-ribosomal functions of ribosomal P proteins in maintaining membrane lipid asymmetry in the plasma membrane of Plasmodium falciparum
- Unravelling molecular mechanism of asymmetric cell division in malaria parasites
- Mechanism of drug resistance in Plasmodium falciparum
- Protein structure and small molecule design
- Targeting hypothetical proteins in the search for better anti-malarial drug targets
- Intrinsically disordered nature of protein and their role in transcription regulation
Credentials
- Ramalingaswami Fellow, 2018-Present
- Senior Postdoctoral Research Scientist, Drexel University, Philadelphia, USA, 2016-2018
- Postdoctoral research scholar, Drexel University College of Medicine, Philadelphia, USA, 2012-2016
- Postdoctoral Fellow, Tata Institute of Fundamental Research, Mumbai, India, 2010-2012
- Ph.D Tata Institute of Fundamental Research, University of Mumbai, 2006-2011
Honours & Awards
- https://twitter.com/DBTIndia/status/1340315698485084161/photo/1
- Ramalingaswami Fellowship, Department of Biotechnology, India, 2018-2023
- Infosys Fellowship, Indian Institute of Science, Bangalore, 2017-2020, not accepted
- Travel award, Gordon Research Conference, Italy, 2011
- Travel award, IFCPAR/CEFIPRA (Indo-French), Pasteur Institute, Lille, France, 2009
- Travel award, Global Infectious Disease Research training workshop, SBRI-USA, 2008
- Research training fellowship, CCMB, Hyderabad, 2003
- Best postdoctoral fellow poster award, Molecular Parasitology Meeting, Drexel University, 2017
- Best postdoctoral fellow poster award, Molecular Parasitology Meeting, Drexel University, 2015
- Outstanding young scientist, Gordon Research Conference, Italy, 2011
- Best Poster, Global Infectious Disease Research training workshop, Hyderabad, 2008
- Topper in M.Sc Microbiology, 2004
Patents & Publications
Publications
- Das S, Manna A, Majumdar O, Dhara L. M-O-M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids. iScience. 2024 Apr 16;27(5):109760. doi: 10.1016/j.isci.2024.109760. PMID: 38726364; PMCID: PMC11079477.
- Das S, Roy B, Chakrabarty S. Non-ribosomal insights into ribosomal P2 protein in Plasmodium falciparum-infected erythrocytes. Microbiologyopen. 2021 Aug;10(4):e1188. doi: 10.1002/mbo3.1188. PMID: 34459544; PMCID: PMC8380560.
- Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis Eva S. Istvan*, Sudipta Das*, Victoria C. Corey, Suyash Bhatnagar, Josh R. Beck, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth A. Winzeler, Akhil B. Vaidya, Daniel E. Goldberg. In Press ELife * Joint first author
- Na+ Influx induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum. PLoS Pathogens, May 26; 12(5):e1005647, 2016. PMID: 27227970 Das S, Bhatanagar S, Morrisey JM, Daly TM, Burns Jr JM, Coppens I, Vaidya AB
- Pyrazoleamide Compounds are Potent Anti-malarials that Target Na+ Homeostasis in Intraerythrocytic Plasmodium falciparum. Nature Communication. 5:5521, 2014, Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, et al., (PMID: 25422853)
- Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2. PLoS Pathogens. 8(8): e1002858, 2012. Das S, Basu H, Korde R, Tewari R, Sharma S (PMID: 22912579)
- Erythrocytic stage dependent regulation of oligomerization of Plasmodium ribosomal protein P2. J. Biol. Chem. 287(49), 41499-41513. 2012 Das S, Rajagopal S, Sivakami S, Sharma S (PMID: 23060439)
- NMR insights into folding and self-association of Plasmodium falciparum P2. PLoS One. 7(5): e36279.2012 Mishra P, Das S, Panicker L, Hosur MV, Sharma S, Hosur RV (PMID: 22567147)
Patents
Title: Novel malarial parasite infected RBC surface protein and its potential usage as a drug target and as a vaccine candidate.
Authors: Shobhona Sharma and Sudipta Das
Patent number: 1773/MUM/2011. Filling ref no. PAA 1227/SG/PC/300611, Filed on: 17/06/2011