Sudipta Das , Ph.D.

Ramalingaswami Fellow
Infectious Diseases and Immunology
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Research Interest

  • Exploring non-ribosomal functions of ribosomal P proteins in maintaining membrane lipid asymmetry in the plasma membrane of Plasmodium falciparum
  • Unravelling molecular mechanism of asymmetric cell division in malaria parasites
  • Mechanism of drug resistance in Plasmodium falciparum
  • Protein structure and small molecule design
  • Targeting hypothetical proteins in the search for better anti-malarial drug targets
  • Intrinsically disordered nature of protein and their role in transcription regulation

Credentials

  • Ramalingaswami Fellow, 2018-Present
  • Senior Postdoctoral Research Scientist, Drexel University, Philadelphia, USA, 2016-2018
  • Postdoctoral research scholar, Drexel University College of Medicine, Philadelphia, USA, 2012-2016
  • Postdoctoral Fellow, Tata Institute of Fundamental Research, Mumbai, India, 2010-2012
  • Ph.D Tata Institute of Fundamental Research, University of Mumbai, 2006-2011

Honours & Awards

  • Ramalingaswami Fellowship, Department of Biotechnology, India, 2018-2023
  • Infosys Fellowship, Indian Institute of Science, Bangalore, 2017-2020, not accepted
  • Travel award, Gordon Research Conference, Italy, 2011
  • Travel award, IFCPAR/CEFIPRA (Indo-French), Pasteur Institute, Lille, France, 2009
  • Travel award, Global Infectious Disease Research training workshop, SBRI-USA, 2008
  • Research training fellowship, CCMB, Hyderabad, 2003
  • Best postdoctoral fellow poster award, Molecular Parasitology Meeting, Drexel University, 2017
  • Best postdoctoral fellow poster award, Molecular Parasitology Meeting, Drexel University, 2015
  • Outstanding young scientist, Gordon Research Conference, Italy, 2011
  • Best Poster, Global Infectious Disease Research training workshop, Hyderabad, 2008
  • Topper in M.Sc Microbiology, 2004

Patents & Publications

Publications
  1. Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis Eva S. Istvan*, Sudipta Das*, Victoria C. Corey, Suyash Bhatnagar, Josh R. Beck, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth A. Winzeler, Akhil B. Vaidya, Daniel E. Goldberg. In Press ELife * Joint first author
  1. Na+ Influx induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum. PLoS Pathogens, May 26; 12(5):e1005647, 2016. PMID: 27227970 Das S, Bhatanagar S, Morrisey JM, Daly TM, Burns Jr JM, Coppens I, Vaidya AB
  1. Pyrazoleamide Compounds are Potent Anti-malarials that Target Na+ Homeostasis in Intraerythrocytic Plasmodium falciparumNature Communication. 5:5521, 2014, Vaidya AB, Morrisey JM, Zhang Z, Das S, Daly TM, et al., (PMID: 25422853)
  1. Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2. PLoS Pathogens8(8): e1002858, 2012. Das S, Basu H, Korde R, Tewari R, Sharma S (PMID: 22912579)
  1. Erythrocytic stage dependent regulation of oligomerization of Plasmodium ribosomal protein P2. J. Biol. Chem. 287(49), 41499-41513. 2012 Das S, Rajagopal S, Sivakami S, Sharma S (PMID: 23060439)
  1. NMR insights into folding and self-association of Plasmodium falciparum P2. PLoS One. 7(5): e36279.2012 Mishra P, Das S, Panicker L, Hosur MV, Sharma S, Hosur RV (PMID: 22567147)
 
Patents

Title: Novel malarial parasite infected RBC surface protein and its potential usage as a drug target and as a vaccine candidate.

Authors: Shobhona Sharma and Sudipta Das 

Patent number: 1773/MUM/2011. Filling ref no. PAA 1227/SG/PC/300611, Filed on: 17/06/2011