Sujoy K Das, PhD, FASCh, FRSC

Principal Scientist
Infectious Diseases and Immunology
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Research Focus

Bioinspired and biomimetic synthesis of nanomaterials, Functionalization of nanomaterials with antimicrobial peptide, Antibiofouling and antibacterial coating, Advanced healthcare material development, Photothermal therapy for wound infection

Research Interest

We work at the interface of biology and nanomaterials, with an emphasis on both fundamental and applied research to address the unmet clinical needs and improve human healthcare. Our research focuses largely on treatments for bacterial infections, drug delivery and tissue engineering. Through multidisciplinary approach, we are trying to develop innovative solutions to fight against antimicrobial resistance, and aiming to design biomaterial scaffold with tunable degradation and mechanical properties for tissue engineering application and novel healthcare materials development. We are also working to understand the immunomodulatory role of different biomaterials including nanomaterials to activate the phagocytosis and wound healing. Overall the work is divided into five research directions: 

Nanotechnology against antimicrobial resistance:   

Antimicrobial resistance (AMR) has been identified as one of the greatest threats to human health worldwide and it has been predicted that AMR will lead to over ten million deaths by 2050. However, owing to the evolution of drug-resistant bacteria and lack of development of new antibiotics, the treatment of bacterial infections is becoming increasingly difficult. Bacteria is also transformed to biofilm formation state, and secret extracellular polymeric substances (EPS), which protect the bacteria from antimicrobial treatment, and necessitates the development of novel therapeutics. Advances in nanomaterial based therapeutics provide a promising opportunity to effectively combat these resilient infections. Owing to unique physicochemical properties, nanomaterials can strongly regulate their ability to kill the antibiotic resistant bacteria and also disrupt the bacterial biofilm. Our research group is exploring the nanomaterial based novel therapeutic strategies, particularly by investigating alternatives to conventional antibiotics and understanding the interactions between microbial cells and nanoparticles to design efficient antimicrobial formulation to combat AMR. Recently we demonstrated that antimicrobial peptide functionalized silver nanocomposite and cationic metal nanoparticle conjugated fusogenic nanoemulsion killed the drug resistant bacterial cell and also disrupted the biofilm without affecting the mammalian cells. Currently, we are focusing to understand the molecular mechanism of biofilm disruption. 

Immunomodulatory effect and phagocytosis of bacteria: 

Macrophages play critical functions to regulate host immune system against infectious pathogens. Macrophages switch to M1 phenotype (classically activated macrophages) and M2 phenotype (alternatively activated macrophages) with responses to tissue remodeling, pro-inflammatory and anti-inflammatory reactions in various infectious diseases. In response bacterial infection, M1 macrophages kill the bacterial cells through phagocytosis process and secret pro-inflammatory cytokines and express MHC-II molecules. However, in biofilm infection, this host defense mechanism is evaded through the release of virulence factors and endotoxins and an anti-inflammatory response (M2 phenotype) occurs, promoting continued bacterial survival within the host. On the other hand, under homeostatic conditions, M2 polarized macrophages are efficient at tissue repair and wound healing. We are interested to understand the macrophage response to wound biofilm infection, macrophage plasticity at wound-site and how macrophage function is controlled through interactions with different biomaterials including nanomaterials in the environment of pathogens. 

Chronic wound care management: 

Surgical site infection and non-healing chronic wound formation have become a major global healthcare burden. Bacterial biofilm is a major complication associated with these wounds, where microbial community are colonized on the wound surface and make the microbes resistant to traditional antibiotic treatments. The biofilm formation increases infection risk and also impedes the wound healing process due to the accumulation of inflammatory molecules and free radicals, preventing wound to enter into the reconstruction stage. To address this challenges, our research group is trying to develop biocompatible and biodegradable hydrogel and biomaterial scaffolds incorporating bioactive molecules to eradicate bacterial biofilm and facilitate faster wound healing and tissue regeneration. We are also trying to understand the molecular aspects of wound healing and studying tissue-biomaterial interactions in light of clinically-relevant conditions. In addition, we are also developing target-specific immune-interactive biomaterials to proactively modulate the inflammatory response towards tissue healing, integration, and regeneration process. 

Advanced hemostatic material:

Uncontrolled bleeding or hemorrhage is the leading cause of death during the prehospital period on battlefields and in accidents, accounting for 50–80% of combat casualty deaths because of excessive blood loss and noncompressible injuries. Extensive loss of blood leads to hypothermia, coagulopathy, and multiple organ failure that ends in mortality. Bacterial infection at the wound sites is another major concern, which often delays wound repair and even leads to life-threatening sepsis. Hence, effective hemorrhage control and infection prevention plays a vital role in saving the life of millions of people. To develop a quick blood clotting agent, we are exploring the potential application of nanomaterial and have formulated a novel hemostatic wound dressing scaffold, which stops the bleeding within minutes and speeding the wound healing process. This hemostatic wound dressing product has been demonstrated and validated in animal model for technology evaluation.

Photodynamic and photothermal therapy for wound infection:

The complications related to bacterial infection at wound sites significantly reduces the wound healing time. Excessive use of antibiotics increased the emergence of drug resistant bacteria and therefore, the treatment of biofilm associated chronic wound infections remain a major challenge. Development of new therapies for disruption of bacterial biofilms for faster healing of chronic wounds in need of the hour. Recent advancement in nanotechnology holds a promising approach for the treatment of biofilm associated wound infection through photothermal and photodynamic therapy. The photothermal therapy (PTT) using near-IR (NIR) light converts absorbed light into local heat, which kills the bacterial cells with minimal damage to surrounding tissue. On the other hand, photodynamic therapy (PDT) uses photosensitizers that after being excited by light at a specific wavelength react with the molecular oxygen and create reactive oxygen species in the target tissue, resulting in the cell death. We are exploring the development of biomaterial scoffold for non-invasive photothermal and photodynamic therapy for treatment of bacteria infected chronic wound.

Credentials

  • Principal Scientist (August 2019-Continue), CSIR-Indian Institute of Chemical Biology, Kolkata
  • Senior Scientist (August 2015-August 2019), CSIR-Indian Institute of Chemical Biology, Kolkata
  • Assistant Professor, Biological Science, Academy of Scientific and Innovative Research (AcSIR)
  • Scientist (August 2011-August 2015), CSIR-Central Leather Research Institute, Chennai
  • Postdoc (2009-2011): School of Biotechnology, Dublin City University, Ireland 
  • Postdoc (2008-2009): Biotechnology Centre, Technical University Dresden, Germany 
  • Ph.D. (2003-2008): Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata 
  • M.Sc. (2002): Biochemistry, Calcutta University 

Honours & Awards

  • Fellow of Royal Society of Chemistry (FRSC), UK: 2023
  • Editorial Board Member of Enzyme and Microbial Technology (2019-continue)
  • Fellow of Academy of Science, Chennai (FASCh)
  • Member of Royal Society of Chemistry (MRSC, UK): 2018
  • Editorial Board Member of General Chemistry (2018-till date)
  • Young Scientist Award 2017 in Biological Sciences received from Academy of Science, Chennai 
  • Member of American Chemical Society (ACS, USA):2017
  • Life Member of National Academy of Biological Science, Chennai, India: 2017
  • Guest Editor: Enzyme and Microbial Technology for a Special Issue on “Biosynthetic Nanoparticles and their Applications”
  • Received Certificate of Recognition from Elsevier, and ACS for Reviewing Papers
  • Reviewers of various International Journals viz. ACS, RSC, Scientific Report, Elsevier, Willey, Spinger-Verlag, etc. 
  • Award of appreciation from CSIR-CLRI for publication in high impact factor journals 
  • Member of Institutional (CSIR-CLRI) Statutory Committee of Intellectual Property (IP) Management: 2014-2018
  • Member of Board of Studies of Chettinad University, Chennai: 2014-2017
  • Life Member of Indian Association for the Cultivation of Science, Kolkata, India : 2015
  • Member of Management Council (CSIR-CLRI) during the year 2014-2016
  • DST First Track Young Scientist Research Grant: 2012 
  • Rapid Grant for Young Investigators (RGYB): DBT 2012
  • Member of Society for Science and Nature: 2012 
  • Postdoctoral Research Fellowship: Irish Research Council for Science, Engineering and Technology (IRCSET), EMPOWER Government of Ireland Postdoctoral Fellowship 
  • Postdoctoral Research Fellowship: FCT-Government of Portugal Postdoctoral Fellowship
  • Life Member of Indian Society of Surface Science and Technology, Kolkata, India : 2008

Grants & Supports

ONGOING PROJECTS:

Hemostat – A Lifesaving Bandage for Faster Bleeding Arrest

Funding Agency: BIRAC, Govt. of India

Project cost: 48,00,000 INR

Development of antimicrobial peptide tagged nanoformulation for targeted combination therapy against Pseudomonas aeruginosa

Funding Agency: DSTBT, Govt. of West Bengal

Project cost: 29,00,000 INR

PROJECT COMPLETED:

Biomolecules Immobilized Inorganic Carrier Matrix for Wastewater Treatment

Funding Agency: CSIR, Govt. of India

Project cost: 16,00,000 INR

Duration: April 2012-March 2017

Bioinspired Magnetic and Noble Metal-Based Hybrids Nanomaterials (MNHs): Synthesis, Functionalization and its Application to Biomedical and Environmental Biotechnology

Funding Agency: DBT, Govt. of India

Project cost: 42,00,000 INR (approx.)

Duration: February 2013-August 2016

Synthesis, Characterization and Application of Bio-inspired Magnetic Nanomaterials

Funding Agency: DST, Govt. of India

Project cost: 24,00,000 INR (approx.)

Duration: January 2013-December 2015

Green Chemical Approach for Synthesis of Gold Nanoparticles: Characterization and Mechanistic Aspect 

Funding Agency: IRCSET, Govt. of Ireland

Project cost: 156,000 Euro (approx.)

Duration: November 2009-October 2011

Protein Mediated Synthesis of Gold Nanoparticle: A Green Chemical Approach

Funding Agency: National Access Point, Govt. of Ireland

Project cost: 83,500 Euro (approx.)

Duration: April 2010-March 2011

Patents & Publications

PUBLICATIONS

  1. Antibacterial and Safe Chitosan-Graphene Hydrogel Film: A Promising Nanotherapeutics for Staphylococcus aureus Wound Infection. Priyadarshani Choudhary, Baskaran Ramalingam,≠ Somashree Bose≠ and Sujoy K Das*. Biomat. Sci. 2024. (≠ both have equal authorship) (I.F. 5.8). Selected for Cover Page. DOI: 10.1039/D4BM01276C
  2. Biofilm Microenvironment‐Sensitive Anti‐Virulent and Immunomodulatory Nano‐on‐Nanodroplets to Combat Refractory Biofilm Infection Through Toxin Neutralization and Phagocytosis. Somashree Bose and Sujoy K Das*. Adv. Healthcare Mater. 2024, 2403528 (I.F. 10). https://doi.org/10.1002/adhm.202403528 
  3. A membrane targeted multifunctional cationic nanoparticle conjugated fusogenic nanoemulsion (CFusoN): induced membrane depolarization and lipid solubilization to accelerate the killing of Staphylococcus aureus. Somashree Bose, Yogita Dahat, Deepak Kumar, Saikat Haldar and Sujoy K. Das*. Mater. Horiz., 2024,11, 661-679 (I.F. 13.3). Cover Page (Inside Front) Article. https://doi.org/10.1039/D3MH01102J
  4. Rational Design of Antimicrobial Peptide Conjugated Graphene-Silver Nanoparticle Loaded Chitosan Wound Dressing. Priyadarshani Choudhary, Baskaran Ramalingam, and Sujoy K Das*. Int. J. Biol. Macromol. 2023, 246, 125347 (I.F. 8.2). https://doi.org/10.1016/j.ijbiomac.2023.125347 
  5. Biomimetic strategy for fabrication of bifunctional graphene oxide-biomaterial aerogel as highly porous antifouling material for oil/ water separation. Baskaran Ramalingam, and Sujoy K Das*. Chem. Eng. J. 2023, 475, 145906 (I.F. 15.1). https://doi.org/10.1016/j.cej.2023.145906
  6. Biofabricated graphene-magnetite nanobioaerogel with antibiofilm property: Response surface methodology based optimization for effective removal of heavy metal ions and killing of bacterial pathogens. Baskaran Ramalingam, and Sujoy K Das*. Chem. Eng. J. 2023, 475, 145976 (I.F. 15.1). https://doi.org/10.1016/j.cej.2023.145976
  7. Nanotechnology Based Therapeutic Approaches: An Advanced Strategy to Target the Biofilm of ESKAPE Pathogens. Arpita Mukherjee, Somashree Bose, Anirban Shaoo and and Sujoy K Das*. Mater. Adv., 2023, 4, 2544-2572 (I. F. 5.0). Cover Page (Back) Article.  https://doi.org/10.1039/D2MA00846G
  8. Inhibitory Potential of iRGD Peptide-Conjugated Garcinol-Loaded Biodegradable Nanoparticles in Rat Colorectal Carcinoma. Brahamacharry Paul, Raghuvir H. Gaonkar, Debasmita Dutta, Rajesh Dasi, Biswajit Mukherjee, Shantanu Ganguly, and Sujoy K. Das. Biomater. Adv. 2022, 134, 112714 (I.F. 8.457). https://doi.org/10.1016/j.msec.2022.112714
  9. Antibacterial and Antibiofouling Activities of Antimicrobial Peptide-Functionalized Graphene–Silver Nanocomposites for the Inhibition and Disruption of Staphylococcus aureus Biofilms. Thanusu Parandhaman, Priyadarshani Choudhary, Baskaran Ramalingam, Michael Schmidt, Sridevi Janardhanam, and Sujoy K. Das*. ACS Biomater. Sci. Eng. 2021, 7, 5899–5917 (I.F. 5.7). https://doi.org/10.1021/acsbiomaterials.1c01253 
  10. Biomolecule Assisted Synthesis of Biomimetic Nanocomposite Hydrogel for Hemostatic and Wound Healing Applications. Sujoy K. Das*, Thanusu Parandhaman and Manash Deep Dey. Green Chem., 2021, 23, 629-669 (I.F. 9.48). https://doi.org/10.1039/D0GC03010D
  11. Fabrication of Chitosan-Reinforced Multifunctional Graphene Nanocomposite as Antibacterial Scaffolds for Hemorrhage Control and Wound-Healing Application. Priyadarshani Choudhary, Baskaran Ramalingam and Sujoy K Das*. ACS Biomater. Sci. Eng. 2020, 6, 5911–5929 (I.F. 4.152). https://doi.org/10.1021/acsbiomaterials.0c00923 
  12. Biofabrication of supported metal nanoparticles: exploring the bioinspiration strategy to mitigate the environmental challenges. Thanusu Parandhaman, Manash Deep Dey and Sujoy K. Das*. Green Chem., 2019, 21, 5469-5500 (I.F. 9.48). https://doi.org/10.1039/C9GC02291K 
  13. Bio-Reduced Graphene Oxide as a Nanoscale Antimicrobial Coating for Medical Devices. Priyadarshani Choudhary, and Sujoy K. Das*. ACS Omega 2019, 4, 387-397 (Invited Article). https://doi.org/10.1021/acsomega.8b02787 
  14. Facile Synthesis, Biofilm Eradication and Biocompatibility Studies of Poly-cationic Peptide Functionalized Graphene-Silver Nanocomposite. Thanusu Parandhaman, and Sujoy K. Das*. Biomater. Sci. 2018, 6, 3356-3372 (I.F. 5.83). https://doi.org/10.1039/C8BM01003J 
  15. Microcapsule from Diverse Polyfuctional materials: Synergistic Instructions for Sharp Response by pH change. Nagaraju Pentela, N. Duraipandy, Nikhil Sainath, Thanusu Parandhaman, M. S. Kiran, Sujoy K. Das, S. N. Jaisankar, Debasis Samanta. New J. Chem. 2018, 42, 8366-8373 (I.F. 3.201). Cover Page (Inside Front) Article. https://doi.org/10.1039/C7NJ03744A
  16. Biomaterial Functionalized Graphene-Magnetite Nanocomposite: A Novel Approach for Simultaneous Removal of Dyes and Heavy-Metal Ions. Baskaran Ramalingam, Thanusu Parandhaman, Priyadarshani Choudhary, and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2018, 6, 6328-6341 (I.F. 6.14). https://doi.org/10.1021/acssuschemeng.8b00139
  17. Gallic Acid and Gallates in Human Health and Disease: Do Mitochondria Hold the Key to Success?- Rekha Yamini Kosuru, Amrita Roy, Sujoy K. Das, Soumen Bera. Mol. Nutr. Food Res. 2018, 62, 1700699 (I.F. 5.15). https://doi.org/10.1002/mnfr.201700699 
  18. Fabrication of Non-toxic Reduced Graphene Oxide Protein Nano-framework as Sustained Antimicrobial Coating for Biomedical Application. Priyadarshani Choudhary, Thanusu Parandhaman, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran, Sujoy K. Das*. ACS Appl. Mater. Interfaces, 2017, 9, 38255–38269. (I.F. 8.097) (Highlighted in Nature India). https://doi.org/10.1021/acsami.7b11203 
  19. Fabrication of Nanoporous Sodium Niobate Coating on 316L SS for Orthopaedics. K. Saranya, S. Thirupathi Kumara Raja, R. S. Subhasree, A. Gnanamani, Sujoy K. Das, N. Rajendran. Ceram. Int. 2017, 43, 11569-11579 (I.F. 3.05). https://doi.org/10.1016/j.ceramint.2017.05.104 
  20. Metal Nanoparticle Loaded Magnetic-Chitosan Microsphere: Water Dispersible and Easily Separable Hybrid Metal Nano-Biomaterial for Catalytic Applications. Thanusu Parandhaman, Nagaraju Pentela, Baskaran Ramalingam, Debasis Samanta and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2017, 5, 489−501 (I.F. 6.14). https://doi.org/10.1021/acssuschemeng.6b01862
  21. Fungal surface protein mediated one-pot synthesis of stable and hemocompatible gold nanoparticles. M Kitching, P Choudhary, S Inguva, Y Guo, M Ramani, Sujoy K. Das*, Enrico Marsili*. Enz. Microb. Technol. 2016, 95, 76-84 (I.F. 2.932). https://doi.org/10.1016/j.enzmictec.2016.08.007
  22. Effect of gemini surfactant (16-6-16) on the synthesis of silver nanoparticles: A facile approach for antibacterial application. AM Siddiq, T Parandhaman, AF Begam, Sujoy K. Das, Md. Sayem Alam. Enz. Microb. Technol. 2016, 95, 118-127 (I.F. 2.932). https://doi.org/10.1016/j.enzmictec.2016.08.009
  23. Antibacterial Effects of Biosynthesized Silver Nanoparticles on Surface Ultrastructure and Nanomechanical Properties of Gram-Negative Bacteria viz. Escherichia coli and Pseudomonas aeruginosa Baskaran Ramalingam, Thanusu Paranthaman, and Sujoy K. Das*. ACS Appl. Mater. Interfaces 2016, 8, 4963-4976 (I.F. 8.097). https://doi.org/10.1021/acsami.6b00161 
  24. Cationic Surfactant (CTAC) Assisted Synthesis of Silver Nanoparticles with Controlled Size: Optical, Morphological and Bactericidal Studies. Md. Sayem Alam, AM Siddiq, SS Narayanan, Debasis Samanta, Sujoy K. Das. J. Nanoeng. Nanomanufac. 2015, 5, 124-131.  
  25. Facile Synthesis of Silver Nanoparticles Decorated Magnetic-Chitosan Microsphere for Efficient Removal of Dyes and Microbial Contaminants. Baskaran Ramalingam, Md. Motiar R Khan, Bholanath Mondal, Asit Baran Mandal*, and Sujoy K. Das*. ACS Sustainable Chem. Eng. 2015, 3, 2291–2302 (I.F. 6.14). https://doi.org/10.1021/acssuschemeng.5b00577
  26. Green Synthesis of Nanomaterials with Special Reference to Environmental and Biomedical Application. Sujoy K. Das* and Asit Baran Mandal*. Current Sci. 2015, 108, 1999-2002 (I.F. 0.843). Cover Page Article. https://www.jstor.org/stable/24905565 
  27. Total Elimination of Polluting Chrome Shavings, Chrome, and Dye Exhaust Liquors of Tannery by a Method Using Keratin Hydrolysate. Govindaswamy Ramamurthy, Baskaran Ramalingam, Mohammed Farhan Katheem, Thottapalli Parvathaleswara Sastry, Sundaramurthy Inbasekaran, Vasiya Thanveer, Sengamalai Jayaramachandran, Sujoy K. Das, and Asit Baran Mandal. ACS Sustainable Chem. Eng. 2015, 3, 1348-1358 (I.F. 6.14). https://doi.org/10.1021/acssuschemeng.5b00071
  28. Antimicrobial Behavior of Biosynthesized Silica–Silver Nanocomposite for Water Disinfection: A Mechanistic Perspective. Thanusu Paranthaman, Anisha Das, B. Ramalingam, Debasis Samanta, T. P. Sastry, Asit Baran Mandal*, and Sujoy K. Das*. J. Hazard. Mater. 2015, 290, 117-126 (I.F. 6.434). https://doi.org/10.1016/j.jhazmat.2015.02.061  
  29. Impact of Surface Functionalization of AgNPs on Binding and Conformational Change of Hemoglobin (Hb) and Hemolytic Behavior. L. Bhavani Devi, Sujoy K. Das, and Asit Baran Mandal*. J. Phys. Chem. C 2014, 118, 29739–29749 (I.F. 4.484). https://doi.org/10.1021/jp5075048
  30. Understanding the Biosynthesis and Catalytic Activity of Pd, Pt, and Ag Nanoparticles in Hydrogenation and Suzuki Coupling Reactions at the Nano-Biointerface. Sujoy K. Das*, Thanusu Paranthaman, Pentela Nagaraju, A. K. M. Maidul Islam, Asit Baran Mandal*, and Manabendra Mukherjee. J. Phys. Chem. C 2014, 118, 24623–24632 (I.F. 4.484). https://doi.org/10.1021/jp508211t
  31. Synthesis and Association of Ag(0) Nanoparticles in Aqueous Nonionic Surfactant Triton X-100 Solution: A Facile Approach for Antibacterial Activity. Md. Sayem Alam, A. Mohammed Siddiq, S. Sriman Narayanan, Sujoy K. Das, Debasis Samanta and Asit Baran Mandal. Materials Focus 2014, 3,156-162. 
  32. Bio-inspired Fabrication of Silver Nanoparticles on Naostructured Silica: Characterization and Application as a Highly Efficient Hydrogenation Catalyst. Sujoy K. Das*, Md. Motiar R. Khan, Arun K. Guha, Nityananda Naskar. Green Chem. 2013, 15, 2548-2557 (I.F. 8.586). https://doi.org/10.1039/C3GC40310F 
  33. Nano-Silica Fabricatd with Silver Nanoparticles: Antifouling Adsorbent for Efficient Dye Removal, Effective Water Disinfection and Biofouling Control. Sujoy K. Das*, Md. Motiar R. Khan, Thanusu Paranthaman, Fathima R. Laffir, Arun K. Guha, G. Sekaran, and Asit Baran Mandal*. Nanoscale 2013, 5, 5549–5560 (I.F. 7.233), https://doi.org/10.1039/C3NR00856H [Highlighted in several International Nanotechnology blogs and forum like Nature India, Genesis Nano Technology, Nanowerk, Great thing from small things, BioPortFolio, Before It's News, Nanochemistry, and Times of India].
  34. Silver-Nano Biohybrid Material: Synthesis, Characterization and Application in Water Purification. Sujoy K. Das*, Md. Motiar R. Khan, Arun K. Guha, Akhil R. Das, and Asit Baran Mandal. Bioresource Technol. 2012, 124, 495-499 (I.F. 5.807). https://doi.org/10.1016/j.biortech.2012.08.071 
  35. “Click” Polymerization on Self-assembled Monolayer: A Convenient Approach to Functionalize Various Surfaces with Polytriazole. Debasis Samanta, P. Murugan, S. J. Ananthakrishnan, N. Somanathan, Sujoy K. Das, S. N. Jaisankar, and Asit Baran Mandal. Chem. Comm. 2012, 48, 12068-12070 (I.F. 6.29). https://doi.org/10.1039/C2CC36712B 
  36. Biomineralization Mechanism of Gold by Zygomycete Fungi Rhizopus oryzae. Sujoy K. Das*, Jinni Liang, Michael Schmidt, Fathima Lafir, and Enrico Marsili*. ACS Nano 2012, 6, 6165-6173 (I.F. 13.709). https://doi.org/10.1021/nn301502s [Highlighted in Mycology Research Today].
  37. Synthesis, Characterization and Catalytic Application of Bioinspired Gold Nanoparticles. Sujoy K. Das, Calum Dickinson, Fathima Lafir, Dermot F. Broughan, and Enrico Marsili. Green Chem. 2012, 14, 1322-1334 (I.F. 8.586). https://doi.org/10.1039/C2GC16676C
  38. Biotechnological Potential of Soil Isolate, Flavobacterium mizutaii for Removal of Azo Dyes: Kinetics, Isotherm, and Microscopic Study. Sujoy K. Das*, Ishita Shome, and Arun K. Guha. Sep. Sci. Technol. 2012, 47, 1913-1925 (I.F. 1.24). https://doi.org/10.1080/01496395.2012.663446 
  39. Surface Functionalization of Aspergillus versicolor Mycelia: in situ Fabrication of Cadmium Sulphide Nanoparticles and Removal of Cadmium Ions from Aqueous Solution. Sujoy K. Das*, Ishita Shome, and Arun K. Guha. RSC Adv. 2012, 2, 3000-3007 (I.F. 2.936). https://doi.org/10.1039/C2RA01273A 
  40. A Green Chemical Approach for the Synthesis of Gold Nanoparticles: Characterization and Mechanistic Aspect. Sujoy K. Das, and Enrico Marsili. Rev. Environ. Sci. Bio/Technol. 2010, 9, 199-204 (I.F. 5.716). https://doi.org/10.1007/s11157-010-9188-5 
  41. Microbial Synthesis of Multi-Shaped Gold Nanostructures. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. Small 2010, 6, 1012–1021 (I.F. 9.59). https://doi.org/10.1002/smll.200902011 [Highlighted in Nature India].  
  42. Interaction of Malathion, an Organophosphorus Pesticide with Rhizopus oryzae Biomass. Subhankar Chatterjee, Sujoy K. Das, Rajdeep Chakravarty, Adrita Chakrabarti, Subrata Ghosh and Arun K. Guha. J. Hazard. Mater. 2010, 174, 47-53 (I.F. 6.434). https://doi.org/10.1016/j.jhazmat.2009.09.014
  43. A Study on Lead Adsorption by Mucor ruxii Biomass. Shraboni S. Majumdar≠, Sujoy K. Das≠, Rajdeep Chatterjee, Tarashankar Bandyopadhyoy, and Arun K. Guha. Desalination 2010, 251, 96-102 (I.F. 6.603). https://doi.org/10.1016/j.desal.2009.09.137
  44. Gold Nanoparticles: Microbial Synthesis and Application in Water Hygiene Management. Sujoy K. Das*, Akhil R. Das, and Arun K. Guha. Langmuir 2009, 25, 8192- 8199 (I.F. 3.789). [Highlighted in Nature India, UKessays.com] https://doi.org/10.1021/la900585p 
  45. Adsorption Behavior of Lindane on Rhizopus oryzae Biomass: Physico-Chemical Studies’-Subrata Ghosh, Sujoy K. Das, Arun K. Guha, and Asis K. Sanyal. J. Hazard. Mater. 2009, 172, 485-490 (I.F. 6.434). https://doi.org/10.1016/j.jhazmat.2009.06.156
  46. Structural and and Nanomechanical Properties of Termitomyces clypeatus Cell Wall and Interaction with Chromium. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. J. Phys. Chem. B 2009,113, 1485–1492 (I.F. 3.146). https://doi.org/10.1021/jp808760f 
  47. Biosorption of Hexavalent Chromium by Termitomyces clypeatus Biomass: Kinetics and Transmission Electron Microscopic Study. Sujoy K. Das, Arun K. Guha. J. Hazard. Mater. 2009,167, 685-691 (I.F. 6.434). https://doi.org/10.1016/j.jhazmat.2009.01.037 
  48. Adsorption Behavior of Mercury on Functionalized Aspergillus versicolor Mycelia: Atomic Force Microscopic Study. Sujoy K. Das, Akhil R. Das and Arun K. Guha. Langmuir 2009, 25, 360-366 (I.F. 3.789). https://doi.org/10.1021/la802749t 
  49. Jute Stick Powder as a Potential Biomass for the Removal of Congo Red and Rhodamine B from their Aqueous Solution. Gopal C. Panda,≠ Sujoy K. Das,≠ Arun K. Guha. J. Hazard. Mater. 2009, 164, 374–379. (≠ both have equal authorship) (I.F. 6.434). https://doi.org/10.1016/j.jhazmat.2008.08.015 
  50. Interaction of Chromium with Resistant Strain Aspergillus versicolor: Investigation with Atomic Force Microscopy and Other Physical Studies. Sujoy K. Das, Manabendra Mukherjee and Arun K. Guha. Langmuir 2008, 24, 8643-8650 (I.F. 3.789). https://doi.org/10.1021/la800958u
  51. Adsorption of Rhodamine B on Rhizopus oryzae: Role of Functional Groups and Cell Wall Components. Sujoy K. Das, Piyasa Ghosh, Indrajit Ghosh and Arun K. Guha. Colloids Surf. B: Biointerfaces 2008, 65, 30-34 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2008.02.020
  52. Adsorption Behavior of Copper Ions on Mucor rouxii Biomass through Microscopic and FTIR Analysis. Shraboni S. Majumdar, Sujoy K. Das, Tapan Saha, Gopal C. Panda, Tarashankar Bandyopadhyoy, Arun K. Guha. Colloids Surf. B: Biointerfaces 2008, 63, 138–145 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2007.11.022
  53. Biosorption of Cadmium and Nickel by Functionalized Husk of Lathyrus Sativus. Gopal C. Panda, Sujoy K. Das and Arun K.Guha. Colloids Surf. B: Biointerfaces 2008, 62, 173-179 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2007.09.034
  54. A Study on the Adsorption Mechanism of Mercury on Aspergillus versicolor Biomass. Sujoy K. Das, Akhil R. Das, and Arun K. Guha. Environ. Sci. Technol. 2007, 41, 8281-8287 (I.F. 6.653). https://doi.org/10.1021/es070814g
  55. Biosorption of Chromium by Termitomyces clypeatus. Sujoy K. Das, Arun K. Guha. Colloids Surf. B: Biointerfaces 2007, 60, 46–54 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2007.05.021 
  56. Adsorption of Nickel on Husk of Lathyrus sativus: Behavior and Binding Mechanism. Gopal C. Panda, Sujoy K. Das, Tarashankar Bandopadhyay and Arun K.Guha. Colloids Surf. B: Biointerfaces 2007, 57, 135-142 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2007.01.022 
  57. Adsorption of Cadmium on Husk of Lathyrus sativus: Physico-chemical Study. Gopal C. Panda, Sujoy K. Das, Sandipan Chatterjee, Palash.B. Maity, Tarashankar Bandopadhyay and Arun K. Guha. Colloids Surf. B: Biointerfaces 2006, 50, 49-54 (I.F. 3.887). https://doi.org/10.1016/j.colsurfb.2006.03.022 
  58. Adsorption Behavior of Rhodamine B on Rhizopus oryzae Biomass. Sujoy K. Das, Jayati Bhowal, Akhil R. Das, and Arun K. Guha. Langmuir 2006, 22, 7265-7272 (I.F. 3.789). https://doi.org/10.1021/la0526378

    * Corresponding Author, # Equal Contribution

PATENTS

  1. A Novel Composition of Cationic Metal Nanoparticle Conjugated Nanoemulsion and a Process for the Preparation Thereof. Sujoy K. Das, Deepak Kumar, Snehasikta Swarnakar, Somashree Bose, Yogita Dahat, Indian Patent Application: 202111045225; Filed on: 05/10/2021.
  2. A Novel Multifunctional Graphene Reinforced Biomaterial as Hemostatic and Wound Dressing Material and its Process for Preparation Thereof. Sujoy K Das, Subhasree R Subramanian, Priyadarshani Choudhary, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran. Indian Patent Application: 201711044089; Filed on: 08/12/2017.
  3. A novel Polycationic Peptide Conjugated Graphene-Metal Nanocomposite and A Process for Preparation thereof. Sujoy K Das, Thanusu Paranthaman, Debasis Samanta, Md. Sayem Alam, G. Sekaran, and Asit Baran Mandal. Indian Patent Application: 1886DEL2015, Filed on: 26/06/2015.
  4. Novel Ruthenium Benzylidene Poly[N-Isopropylacrylamide] Compounds and A Process for the Preparation Thereof. Debasis Samanta, P. Nagaraju, P. Murugan, Md. Sayem Alam, Sujoy K. Das, Asit Baran Mandal. Indian Patent Application: 2725DEL2014, Filed on: 8/10/2014

 

EDITORIAL NOTE

Biosynthetic nanoparticles for biotechnological and biomedical applications. Enrico Marsili, Sujoy K. Das. Enz. Microb. Technol. 2016, 95, 1-3.

BOOK CHAPER

  1. Sustainable Nanostructured Materials for Culturing of Various Biological Cells. Manash Deep Dey, Rpak Mukhopadhyay, and Sujoy K Das*. In "Dynamics of Advanced Sustainable Nanomaterials and their Related Nanocomposites at the Bio-Nano Interface", Elsevier, 2019
  2. Bioinspired Metal Nanoparticle: Synthesis, Properties and Application. Sujoy K. Das and Enrico Marsili. Nanomaterials, ISBN 978-953-307-913-4. InTech, 2011

Products

Technology & Product Development

1. Microneedle Patch: Innovative Painless Drug Delivery:

Microneedle patch has been selected as one of the top 10 emerging technologies by World Economic Forum for painless drug delivery. Microneedle patch has the potential to be a transformative technology for pain less delivery of antibiotics, vaccines and biologics to enhance the efficacy of therapeutics and vaccines. 

We have developed hydrogel based drug loaded tip dissolving microneedle parch for the treatment of skin infection caused by Staphylococcus aureus. This microneedle parch contains micron size needles (800 µm length), which penetrate the top layer of skin and prevent pain by avoiding contact with nerve endings. The needles dissolve upon contact with body fluid in the compromised skin and deliver the drug efficiently at the local infection site.

2. Antibacterial Hemostatic Dressing: Stop Bleeding & Prevent Bacterial Infection:

Uncontrolled bleeding during road accidents, battle field casualties, gunshot, or other traumatic injuries are the leading cause of preventable death. Hemostatic dressing plays essential role in bleeding management by promoting blood clotting.

New generation antibacterial hemostatic dressing has been developed (Indian Patent App. No 201711044089, and Indian Patent No 346127) for rapid bleeding arrest, and prevents bacterial infection. The hemostatic dressing interacts with the blood cells and accelerate the blood coagulation through stimulating the plasmatic contact activation system. It activates the platelets associated with Factor XII and XI results in fibrin formation and blood clotting

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